Genular: Defining Cellular Identity and Function

Details for: TRIM31

Gene ID: 11074

Symbol: TRIM31

Ensembl ID: ENSG00000204616

Description: tripartite motif containing 31

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Interferon gamma signaling
(R-HSA-877300)
Interferon signaling
(R-HSA-913531)
Antiviral innate immune response
(GO:0140374)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Mitochondrion
(GO:0005739)
Negative regulation of nlrp3 inflammasome complex assembly
(GO:1900226)
Negative regulation of viral entry into host cell
(GO:0046597)
Negative regulation of viral transcription
(GO:0032897)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of dna-templated transcription
(GO:0045893)
Protein binding
(GO:0005515)
Protein k48-linked ubiquitination
(GO:0070936)
Protein k63-linked ubiquitination
(GO:0070534)
Protein ubiquitination
(GO:0016567)
Transcription coactivator activity
(GO:0003713)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin protein ligase activity
(GO:0061630)
Viral release from host cell
(GO:0019076)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.07
Marker Score: 3,043
Cell Name: enterocyte (CL0000584)
Fold Change: 1.45
Marker Score: 6,937
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.43
Marker Score: 4,486
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.42
Marker Score: 2,937
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.38
Marker Score: 874
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.29
Marker Score: 1,016
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 1.19
Marker Score: 1,830
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.05
Marker Score: 800
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.03
Marker Score: 6,578
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 511
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 464
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,408
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,412
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.94
Marker Score: 1,531
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5,254
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,742
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.92
Marker Score: 227
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 328
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,291
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.82
Marker Score: 329
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 700
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.76
Marker Score: 503
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.69
Marker Score: 2,912
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.65
Marker Score: 168
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.64
Marker Score: 611
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.6
Marker Score: 480
Cell Name: goblet cell (CL0000160)
Fold Change: 0.59
Marker Score: 3,947
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.58
Marker Score: 578
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 149
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.56
Marker Score: 233
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.51
Marker Score: 736
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.5
Marker Score: 183
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.45
Marker Score: 169
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.43
Marker Score: 412
Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 0.4
Marker Score: 117
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.4
Marker Score: 114
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.38
Marker Score: 218
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 374
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.37
Marker Score: 863
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.35
Marker Score: 112
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.34
Marker Score: 767
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.33
Marker Score: 175
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.33
Marker Score: 621
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.3
Marker Score: 2,618
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.3
Marker Score: 79
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.29
Marker Score: 178
Cell Name: stem cell (CL0000034)
Fold Change: 0.28
Marker Score: 657
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.26
Marker Score: 76
Cell Name: club cell (CL0000158)
Fold Change: 0.26
Marker Score: 306
Cell Name: malignant cell (CL0001064)
Fold Change: 0.26
Marker Score: 3,513
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: mast cell (CL0000097)
Fold Change: 0.22
Marker Score: 128
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.21
Marker Score: 69
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.19
Marker Score: 148
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.19
Marker Score: 93
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.18
Marker Score: 57
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.18
Marker Score: 498
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.16
Marker Score: 254
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.16
Marker Score: 101
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.15
Marker Score: 40
Cell Name: precursor cell (CL0011115)
Fold Change: 0.14
Marker Score: 35
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.14
Marker Score: 143
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.14
Marker Score: 389
Cell Name: plasma cell (CL0000786)
Fold Change: 0.14
Marker Score: 152
Cell Name: paneth cell (CL0000510)
Fold Change: 0.13
Marker Score: 87
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.12
Marker Score: 198
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.12
Marker Score: 56
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.12
Marker Score: 41
Cell Name: podocyte (CL0000653)
Fold Change: 0.12
Marker Score: 44
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.11
Marker Score: 39
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.11
Marker Score: 46
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.11
Marker Score: 111
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.11
Marker Score: 22
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.11
Marker Score: 28
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.1
Marker Score: 49
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1
Marker Score: 75
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.1
Marker Score: 26
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.1
Marker Score: 86
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.1
Marker Score: 68
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.1
Marker Score: 31
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.09
Marker Score: 65
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.09
Marker Score: 47
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.09
Marker Score: 306
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.09
Marker Score: 110
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.09
Marker Score: 34
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.09
Marker Score: 44
Cell Name: B cell (CL0000236)
Fold Change: 0.08
Marker Score: 78
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.08
Marker Score: 53
Cell Name: secretory cell (CL0000151)
Fold Change: 0.08
Marker Score: 140
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.08
Marker Score: 24
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.07
Marker Score: 50
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.07
Marker Score: 22
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.07
Marker Score: 2,465
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.07
Marker Score: 15
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.07
Marker Score: 135
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.06
Marker Score: 16
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.06
Marker Score: 107
Cell Name: glial cell (CL0000125)
Fold Change: 0.06
Marker Score: 67
Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 0.06
Marker Score: 15

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics** TRIM31 is a 294-amino acid protein that belongs to the TRIM family, characterized by three conserved domains: RING (Ring finger), B-box, and coiled-coil. These domains enable TRIM31 to interact with various cellular proteins and regulate multiple cellular processes. TRIM31 is primarily expressed in epithelial cells, including those of the bladder, colon, and kidney, as well as in immune cells such as granulocytes and monocytes. **Pathways and Functions** TRIM31 plays a crucial role in regulating various cellular pathways, including: 1. **Antiviral Innate Immune Response**: TRIM31 acts as an antiviral factor by inhibiting the entry of viruses into host cells, reducing viral transcription, and modulating the innate immune response. 2. **Cytokine Signaling**: TRIM31 regulates cytokine signaling pathways, including the production of interferons, which are essential for the activation of immune responses. 3. **Mitochondrial Function**: TRIM31 interacts with mitochondrial proteins, influencing mitochondrial function and biogenesis. 4. **Protein Regulation**: TRIM31 acts as a ubiquitin ligase, regulating protein degradation and modifying protein function. **Clinical Significance** TRIM31 has been implicated in various diseases, including: 1. **Viral Infections**: TRIM31 has been shown to inhibit the entry of viruses, such as HIV and influenza, into host cells, making it a potential therapeutic target for antiviral therapy. 2. **Cancer**: TRIM31 has been linked to cancer development and progression, particularly in epithelial cancers, where it acts as a tumor suppressor. 3. **Autoimmune Diseases**: TRIM31 has been implicated in autoimmune diseases, such as rheumatoid arthritis, where it regulates immune cell function and cytokine production. In conclusion, TRIM31 is a crucial regulator of innate immunity and antiviral defense mechanisms. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the role of TRIM31 in maintaining host defense and preventing disease. **References** [Insert relevant references to support the discussion] **Recommendations** 1. Further research is needed to elucidate the mechanisms by which TRIM31 regulates antiviral immunity and cytokine signaling. 2. TRIM31 may serve as a potential therapeutic target for antiviral therapy and cancer treatment. 3. Understanding the role of TRIM31 in autoimmune diseases may provide insights into novel therapeutic strategies. By continuing to explore the functions and clinical significance of TRIM31, we can gain a deeper understanding of the intricate mechanisms underlying innate immunity and develop novel therapeutic approaches to prevent and treat diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

TRI31_HUMAN

Genular Protein ID: 592082036

Symbol: TRI31_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BZY9 A6NLX6 A9R9Q4 Q53H52 Q5RI37 Q5SRJ7 Q5SRJ8 Q5SS28 Q96AK4 Q96AP8 Q99579 Q9BZY8

Database IDs:

Citations:

PubMed ID: 11331580

Title: The tripartite motif family identifies cell compartments.

PubMed ID: 11331580

DOI: 10.1093/emboj/20.9.2140

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 18773414

Title: Characterization of TRIM31, upregulated in gastric adenocarcinoma, as a novel RBCC protein.

PubMed ID: 18773414

DOI: 10.1002/jcb.21908

PubMed ID: 27929086

Title: The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3.

PubMed ID: 27929086

DOI: 10.1038/ncomms13727

PubMed ID: 27992402

Title: The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination.

PubMed ID: 27992402

DOI: 10.1038/ni.3641

Sequence Information:

Length: 425
Mass: 48244
Checksum: 8CCC0D07F2DBB52D
Sequence:

MASGQFVNKL QEEVICPICL DILQKPVTID CGHNFCLKCI TQIGETSCGF FKCPLCKTSV 
RKNAIRFNSL LRNLVEKIQA LQASEVQSKR KEATCPRHQE MFHYFCEDDG KFLCFVCRES 
KDHKSHNVSL IEEAAQNYQG QIQEQIQVLQ QKEKETVQVK AQGVHRVDVF TDQVEHEKQR 
ILTEFELLHQ VLEEEKNFLL SRIYWLGHEG TEAGKHYVAS TEPQLNDLKK LVDSLKTKQN 
MPPRQLLEDI KVVLCRSEEF QFLNPTPVPL ELEKKLSEAK SRHDSITGSL KKFKDQLQAD 
RKKDENRFFK SMNKNDMKSW GLLQKNNHKM NKTSEPGSSS AGGRTTSGPP NHHSSAPSHS 
LFRASSAGKV TFPVCLLASY DEISGQGASS QDTKTFDVAL SEELHAALSE WLTAIRAWFC 
EVPSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TRIM31

Associated with

Cells (max top 100)

Other Information

The tripartite motif family identifies cell compartments. PubMed ID: 11331580

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

An unappreciated role for RNA surveillance. PubMed ID: 14759258

Characterization of TRIM31, upregulated in gastric adenocarcinoma, as a novel RBCC protein. PubMed ID: 18773414

The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3. PubMed ID: 27929086

The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination. PubMed ID: 27992402