Details for: SLC15A1

Gene ID: 6564

Symbol: SLC15A1

Ensembl ID: ENSG00000088386

Description: solute carrier family 15 member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 10.2322
    Cell Significance Index: 13.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.7894
    Cell Significance Index: 109.1800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 3.4531
    Cell Significance Index: 29.3500
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 3.2184
    Cell Significance Index: 24.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.6742
    Cell Significance Index: 57.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.2035
    Cell Significance Index: 76.5700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.4067
    Cell Significance Index: 23.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0651
    Cell Significance Index: 63.9400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7577
    Cell Significance Index: 82.4100
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.7434
    Cell Significance Index: 2.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5488
    Cell Significance Index: 54.2900
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.5405
    Cell Significance Index: 4.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5318
    Cell Significance Index: 36.7800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.5099
    Cell Significance Index: 8.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5055
    Cell Significance Index: 26.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5010
    Cell Significance Index: 81.4800
  • Cell Name: chorionic trophoblast cell (CL0011101)
    Fold Change: 0.4852
    Cell Significance Index: 1.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4334
    Cell Significance Index: 86.0200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2682
    Cell Significance Index: 2.4700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.2613
    Cell Significance Index: 6.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2524
    Cell Significance Index: 6.3100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2268
    Cell Significance Index: 4.8300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2067
    Cell Significance Index: 2.1400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1803
    Cell Significance Index: 3.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1784
    Cell Significance Index: 5.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1494
    Cell Significance Index: 134.8700
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.1375
    Cell Significance Index: 0.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1090
    Cell Significance Index: 20.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1039
    Cell Significance Index: 4.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0893
    Cell Significance Index: 1.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0702
    Cell Significance Index: 9.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0665
    Cell Significance Index: 41.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0466
    Cell Significance Index: 5.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0265
    Cell Significance Index: 14.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0219
    Cell Significance Index: 3.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0211
    Cell Significance Index: 9.3400
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.0189
    Cell Significance Index: 0.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0171
    Cell Significance Index: 0.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0132
    Cell Significance Index: 1.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0102
    Cell Significance Index: 1.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0081
    Cell Significance Index: 1.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0074
    Cell Significance Index: 1.3400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0072
    Cell Significance Index: 0.1000
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.0062
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0011
    Cell Significance Index: -2.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0013
    Cell Significance Index: -0.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0015
    Cell Significance Index: -0.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0017
    Cell Significance Index: -1.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0017
    Cell Significance Index: -2.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0020
    Cell Significance Index: -1.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0020
    Cell Significance Index: -2.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0043
    Cell Significance Index: -2.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0062
    Cell Significance Index: -4.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0062
    Cell Significance Index: -1.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0062
    Cell Significance Index: -4.6800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0067
    Cell Significance Index: -0.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0088
    Cell Significance Index: -4.0000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0098
    Cell Significance Index: -0.1400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0099
    Cell Significance Index: -0.1400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0122
    Cell Significance Index: -0.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0130
    Cell Significance Index: -3.7400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0198
    Cell Significance Index: -0.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0308
    Cell Significance Index: -1.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0363
    Cell Significance Index: -4.6900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0379
    Cell Significance Index: -0.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0381
    Cell Significance Index: -3.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0404
    Cell Significance Index: -4.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0408
    Cell Significance Index: -1.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0447
    Cell Significance Index: -5.2700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0478
    Cell Significance Index: -0.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0485
    Cell Significance Index: -1.3000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0497
    Cell Significance Index: -0.3300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0502
    Cell Significance Index: -0.9800
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0527
    Cell Significance Index: -0.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0574
    Cell Significance Index: -3.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0590
    Cell Significance Index: -4.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0608
    Cell Significance Index: -2.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0636
    Cell Significance Index: -5.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0638
    Cell Significance Index: -4.5200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0665
    Cell Significance Index: -2.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0684
    Cell Significance Index: -5.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0691
    Cell Significance Index: -4.2500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0751
    Cell Significance Index: -3.9100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0785
    Cell Significance Index: -0.6000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0794
    Cell Significance Index: -1.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0895
    Cell Significance Index: -4.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0911
    Cell Significance Index: -5.1100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0917
    Cell Significance Index: -1.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0957
    Cell Significance Index: -2.8200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0957
    Cell Significance Index: -0.9900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0992
    Cell Significance Index: -1.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1008
    Cell Significance Index: -4.4600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1015
    Cell Significance Index: -0.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1030
    Cell Significance Index: -3.6100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1074
    Cell Significance Index: -2.7600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1086
    Cell Significance Index: -3.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1154
    Cell Significance Index: -4.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1172
    Cell Significance Index: -3.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1182
    Cell Significance Index: -3.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transport Mechanism:** SLC15A1 is a proton-dependent oligopeptide secondary active transmembrane transporter, which implies that it utilizes the energy from proton gradients to facilitate the transport of peptides and amino acids across the plasma membrane. 2. **Cellular Expression:** SLC15A1 is expressed in a wide range of tissues, including enterocytes of the colon, cardiac endothelial cells, glandular epithelial cells, and immature innate lymphoid cells, highlighting its importance in various physiological processes. 3. **Protein Structure:** The SLC15A1 protein is a transmembrane protein consisting of multiple transmembrane domains, which are essential for its function in transporting peptides and amino acids. **Pathways and Functions:** SLC15A1 plays a critical role in various cellular processes, including: 1. **Dipeptide and Tripeptide Transport:** SLC15A1 mediates the transport of dipeptides and tripeptides across the plasma membrane, which is essential for the absorption of amino acids and peptides in the gut. 2. **Amino Acid Uptake:** SLC15A1 is involved in the uptake of amino acids, particularly in the enterocytes of the colon, where it plays a crucial role in the absorption of dietary amino acids. 3. **Proton-Dependent Transport:** SLC15A1 utilizes the energy from proton gradients to facilitate the transport of peptides and amino acids across the plasma membrane, highlighting its importance in maintaining proton homeostasis. 4. **GABAergic Signaling:** SLC15A1 is also expressed in GABAergic interneurons of the cerebral cortex, where it may play a role in modulating GABAergic signaling. **Clinical Significance:** The dysregulation of SLC15A1 has been implicated in various human diseases, including: 1. **Gastrointestinal Disorders:** Alterations in SLC15A1 expression and function have been linked to gastrointestinal disorders, such as inflammatory bowel disease and celiac disease. 2. **Neurological Disorders:** SLC15A1 has been implicated in neurological disorders, including epilepsy and autism spectrum disorder, where it may play a role in modulating GABAergic signaling. 3. **Cancer:** SLC15A1 has been found to be overexpressed in certain types of cancer, including colorectal cancer, where it may contribute to tumorigenesis and metastasis. In conclusion, SLC15A1 is a vital gene involved in the transport of peptides and amino acids across cell membranes, playing a critical role in various physiological processes. Its dysregulation has been implicated in various human diseases, highlighting the need for further research into the mechanisms underlying SLC15A1 function and its potential therapeutic applications.

Genular Protein ID: 820144920

Symbol: S15A1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P46059 Q5VW82

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 54 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 55 DrugCentral 1 EMBL 6 EMDB 3 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 55 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7896779

Title: Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization.

PubMed ID: 7896779

DOI: 10.1074/jbc.270.12.6456

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8914574

Title: The human intestinal H+/oligopeptide cotransporter hPEPT1 transports differently-charged dipeptides with identical electrogenic properties.

PubMed ID: 8914574

DOI: 10.1016/s0005-2736(96)00170-8

PubMed ID: 9835627

Title: hPepT1-mediated epithelial transport of bacteria-derived chemotactic peptides enhances neutrophil-epithelial interactions.

PubMed ID: 9835627

DOI: 10.1172/jci4179

PubMed ID: 15521010

Title: hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells.

PubMed ID: 15521010

DOI: 10.1053/j.gastro.2004.07.024

PubMed ID: 18367661

Title: Molecular mechanism of dipeptide and drug transport by the human renal H+/oligopeptide cotransporter hPEPT2.

PubMed ID: 18367661

DOI: 10.1152/ajprenal.00030.2008

PubMed ID: 19685173

Title: Mutagenesis and cysteine scanning of transmembrane domain 10 of the human dipeptide transporter.

PubMed ID: 19685173

DOI: 10.1007/s11095-009-9952-9

PubMed ID: 26320580

Title: Crystal structures of the extracellular domain from PepT1 and PepT2 provide novel insights into mammalian peptide transport.

PubMed ID: 26320580

DOI: 10.1016/j.str.2015.07.016

PubMed ID: 28408210

Title: The Organic Anion-Transporting Peptide 2B1 Is Localized in the Basolateral Membrane of the Human Jejunum and Caco-2 Monolayers.

PubMed ID: 28408210

DOI: 10.1016/j.xphs.2017.04.001

PubMed ID: 12436193

Title: Catalog of 238 variations among six human genes encoding solute carriers (hSLCs) in the Japanese population.

PubMed ID: 12436193

DOI: 10.1007/s100380200088

PubMed ID: 16258023

Title: Genetic variants of the human dipeptide transporter PEPT1.

PubMed ID: 16258023

DOI: 10.1124/jpet.105.094615

Sequence Information:

  • Length: 708
  • Mass: 78806
  • Checksum: A75475789177A907
  • Sequence:
    • MGMSKSHSFF GYPLSIFFIV VNEFCERFSY YGMRAILILY FTNFISWDDN LSTAIYHTFV 
ALCYLTPILG ALIADSWLGK FKTIVSLSIV YTIGQAVTSV SSINDLTDHN HDGTPDSLPV 
HVVLSLIGLA LIALGTGGIK PCVSAFGGDQ FEEGQEKQRN RFFSIFYLAI NAGSLLSTII 
TPMLRVQQCG IHSKQACYPL AFGVPAALMA VALIVFVLGS GMYKKFKPQG NIMGKVAKCI 
GFAIKNRFRH RSKAFPKREH WLDWAKEKYD ERLISQIKMV TRVMFLYIPL PMFWALFDQQ 
GSRWTLQATT MSGKIGALEI QPDQMQTVNA ILIVIMVPIF DAVLYPLIAK CGFNFTSLKK 
MAVGMVLASM AFVVAAIVQV EIDKTLPVFP KGNEVQIKVL NIGNNTMNIS LPGEMVTLGP 
MSQTNAFMTF DVNKLTRINI SSPGSPVTAV TDDFKQGQRH TLLVWAPNHY QVVKDGLNQK 
PEKGENGIRF VNTFNELITI TMSGKVYANI SSYNASTYQF FPSGIKGFTI SSTEIPPQCQ 
PNFNTFYLEF GSAYTYIVQR KNDSCPEVKV FEDISANTVN MALQIPQYFL LTCGEVVFSV 
TGLEFSYSQA PSNMKSVLQA GWLLTVAVGN IIVLIVAGAG QFSKQWAEYI LFAALLLVVC 
VIFAIMARFY TYINPAEIEA QFDEDEKKNR LEKSNPYFMS GANSQKQM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.