Details for: CEACAM6

Gene ID: 4680

Symbol: CEACAM6

Ensembl ID: ENSG00000086548

Description: CEA cell adhesion molecule 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 56.6938
    Cell Significance Index: -14.3800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 21.5045
    Cell Significance Index: -14.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.0664
    Cell Significance Index: -18.9300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.7520
    Cell Significance Index: 56.2200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 3.5481
    Cell Significance Index: 36.6000
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.0101
    Cell Significance Index: 8.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8390
    Cell Significance Index: 83.0000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7992
    Cell Significance Index: 86.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6601
    Cell Significance Index: 14.3000
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 0.6095
    Cell Significance Index: 4.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4958
    Cell Significance Index: 34.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2063
    Cell Significance Index: 9.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1787
    Cell Significance Index: 8.3300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.1657
    Cell Significance Index: 1.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1517
    Cell Significance Index: 4.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1394
    Cell Significance Index: 4.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1219
    Cell Significance Index: 110.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1036
    Cell Significance Index: 2.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0878
    Cell Significance Index: 66.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0817
    Cell Significance Index: 15.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0650
    Cell Significance Index: 35.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0586
    Cell Significance Index: 36.6100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0150
    Cell Significance Index: 0.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0141
    Cell Significance Index: 1.6200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0128
    Cell Significance Index: 0.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0087
    Cell Significance Index: 0.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0064
    Cell Significance Index: 0.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0060
    Cell Significance Index: 1.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0029
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0056
    Cell Significance Index: -4.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0077
    Cell Significance Index: -14.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0079
    Cell Significance Index: -1.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0081
    Cell Significance Index: -4.5500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0169
    Cell Significance Index: -0.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0184
    Cell Significance Index: -33.9000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0223
    Cell Significance Index: -34.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0238
    Cell Significance Index: -1.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0254
    Cell Significance Index: -34.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0270
    Cell Significance Index: -17.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0283
    Cell Significance Index: -1.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0324
    Cell Significance Index: -0.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0359
    Cell Significance Index: -4.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0385
    Cell Significance Index: -13.8000
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0405
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0485
    Cell Significance Index: -5.5400
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0501
    Cell Significance Index: -0.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0507
    Cell Significance Index: -23.0000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0625
    Cell Significance Index: -0.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0629
    Cell Significance Index: -12.4800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0687
    Cell Significance Index: -0.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0810
    Cell Significance Index: -16.2600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0977
    Cell Significance Index: -1.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1102
    Cell Significance Index: -15.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1171
    Cell Significance Index: -17.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1417
    Cell Significance Index: -4.5400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1547
    Cell Significance Index: -3.2100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1643
    Cell Significance Index: -2.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1789
    Cell Significance Index: -23.1100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1924
    Cell Significance Index: -2.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2100
    Cell Significance Index: -14.1200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2279
    Cell Significance Index: -5.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2360
    Cell Significance Index: -6.9500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2719
    Cell Significance Index: -9.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2766
    Cell Significance Index: -16.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2919
    Cell Significance Index: -18.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2935
    Cell Significance Index: -21.8700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2991
    Cell Significance Index: -7.4700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3357
    Cell Significance Index: -3.4800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3395
    Cell Significance Index: -5.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3464
    Cell Significance Index: -21.2900
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.3474
    Cell Significance Index: -1.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3756
    Cell Significance Index: -19.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3957
    Cell Significance Index: -22.2100
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.4046
    Cell Significance Index: -2.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4168
    Cell Significance Index: -19.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4307
    Cell Significance Index: -11.5200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4661
    Cell Significance Index: -16.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4673
    Cell Significance Index: -20.6700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4951
    Cell Significance Index: -14.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5003
    Cell Significance Index: -16.3800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5126
    Cell Significance Index: -16.3300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5324
    Cell Significance Index: -14.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5451
    Cell Significance Index: -20.6400
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.5580
    Cell Significance Index: -4.6200
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.5917
    Cell Significance Index: -6.5800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5927
    Cell Significance Index: -14.7800
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.5932
    Cell Significance Index: -5.3700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.6158
    Cell Significance Index: -6.7600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6383
    Cell Significance Index: -12.4800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6599
    Cell Significance Index: -16.4600
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.6676
    Cell Significance Index: -6.2800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.6906
    Cell Significance Index: -9.4700
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: -0.7053
    Cell Significance Index: -4.9500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.7240
    Cell Significance Index: -15.1100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.7449
    Cell Significance Index: -11.2300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.7543
    Cell Significance Index: -11.6700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.7552
    Cell Significance Index: -15.0600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7732
    Cell Significance Index: -16.4100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.7784
    Cell Significance Index: -15.3200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7868
    Cell Significance Index: -17.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CEACAM6 is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is characterized by its ability to form homophilic and heterophilic interactions with other CEACAM molecules and other adhesion molecules. CEACAM6 is highly expressed on the surface of epithelial cells, including type I pneumocytes, squamous epithelial cells, and glandular cells of the esophagus. Its expression is also observed in malignant cells, suggesting its potential role in cancer progression. **Pathways and Functions:** CEACAM6 is involved in various cellular processes, including: 1. **Immune regulation:** CEACAM6 plays a crucial role in the regulation of immune responses, particularly in the context of neutrophil activation and degranulation. It interacts with other immune molecules, such as Fcγ receptors, to modulate immune cell function. 2. **Cell adhesion and migration:** CEACAM6 mediates homophilic and heterophilic cell-cell adhesion, facilitating the migration of cells, including neutrophils and epithelial cells, in response to inflammatory signals. 3. **Apoptosis regulation:** CEACAM6 has been shown to regulate apoptosis in certain cell types, suggesting its potential role in cancer progression and immune evasion. 4. **Endothelial cell-matrix adhesion:** CEACAM6 interacts with fibronectin, a key component of the extracellular matrix, to regulate endothelial cell adhesion and migration. **Clinical Significance:** CEACAM6 has been implicated in various immune-related disorders, including: 1. **Asthma and chronic obstructive pulmonary disease (COPD):** CEACAM6 expression is altered in patients with asthma and COPD, suggesting its potential role in airway inflammation and remodeling. 2. **Cancer:** CEACAM6 is overexpressed in various types of cancer, including lung, colon, and breast cancer, where it may contribute to tumor progression and metastasis. 3. **Neutrophil-related disorders:** CEACAM6 has been implicated in neutrophil-related disorders, such as neutrophilic asthma and autoimmune disorders, where it may contribute to immune dysregulation. In conclusion, CEACAM6 is a multifaceted gene that plays a crucial role in immune regulation, cell adhesion, and migration. Its dysregulation has been implicated in various immune-related disorders, including asthma, COPD, cancer, and neutrophil-related disorders. Further research is needed to fully elucidate the mechanisms by which CEACAM6 regulates immune responses and to explore its therapeutic potential in these diseases.

Genular Protein ID: 4164654688

Symbol: CEAM6_HUMAN

Name: Carcinoembryonic antigen-related cell adhesion molecule 6

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3220478

Title: Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains.

PubMed ID: 3220478

DOI: 10.1016/0888-7543(88)90160-7

PubMed ID: 3337731

Title: Primary structure of nonspecific crossreacting antigen (NCA), a member of carcinoembryonic antigen (CEA) gene family, deduced from cDNA sequence.

PubMed ID: 3337731

DOI: 10.1016/0006-291x(88)90490-1

PubMed ID: 2830274

Title: Characterization of a cDNA clone for the nonspecific cross-reacting antigen (NCA) and a comparison of NCA and carcinoembryonic antigen.

PubMed ID: 2830274

DOI: 10.1016/s0021-9258(18)69055-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 2803308

Title: Cell adhesion activity of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: homophilic and heterophilic adhesion.

PubMed ID: 2803308

DOI: 10.1016/0006-291x(89)91679-3

PubMed ID: 2317824

Title: Expression of complementary DNA and genomic clones for carcinoembryonic antigen and nonspecific cross-reacting antigen in Chinese hamster ovary and mouse fibroblast cells and characterization of the membrane-expressed products.

PubMed ID: 2317824

PubMed ID: 2022629

Title: A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains.

PubMed ID: 2022629

DOI: 10.1016/s0021-9258(18)92930-3

PubMed ID: 1378450

Title: CD66 nonspecific cross-reacting antigens are involved in neutrophil adherence to cytokine-activated endothelial cells.

PubMed ID: 1378450

DOI: 10.1083/jcb.118.2.457

PubMed ID: 8776764

Title: Preparation and characterization of two human carcinoembryonic antigen family proteins of neutrophils, CD66b and c, in silkworm larvae.

PubMed ID: 8776764

DOI: 10.1006/prep.1996.0065

PubMed ID: 10436421

Title: Four carcinoembryonic antigen subfamily members, CEA, NCA, BGP and CGM2, selectively expressed in the normal human colonic epithelium, are integral components of the fuzzy coat.

PubMed ID: 10436421

DOI: 10.1159/000030075

PubMed ID: 10910050

Title: Human carcinoembryonic antigen functions as a general inhibitor of anoikis.

PubMed ID: 10910050

PubMed ID: 11590190

Title: Identification and comparison of residues critical for cell-adhesion activities of two neutrophil CD66 antigens, CEACAM6 and CEACAM8.

PubMed ID: 11590190

PubMed ID: 14724575

Title: CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells.

PubMed ID: 14724575

DOI: 10.1038/sj.onc.1207036

PubMed ID: 16204051

Title: Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen).

PubMed ID: 16204051

DOI: 10.1158/0008-5472.can-05-0420

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 26483485

Title: Diverse oligomeric states of CEACAM IgV domains.

PubMed ID: 26483485

DOI: 10.1073/pnas.1509511112

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

Sequence Information:

  • Length: 344
  • Mass: 37237
  • Checksum: 4322C5D6E25849F5
  • Sequence:
  • MGPPSAPPCR LHVPWKEVLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE VLLLAHNLPQ 
    NRIGYSWYKG ERVDGNSLIV GYVIGTQQAT PGPAYSGRET IYPNASLLIQ NVTQNDTGFY 
    TLQVIKSDLV NEEATGQFHV YPELPKPSIS SNNSNPVEDK DAVAFTCEPE VQNTTYLWWV 
    NGQSLPVSPR LQLSNGNMTL TLLSVKRNDA GSYECEIQNP ASANRSDPVT LNVLYGPDVP 
    TISPSKANYR PGENLNLSCH AASNPPAQYS WFINGTFQQS TQELFIPNIT VNNSGSYMCQ 
    AHNSATGLNR TTVTMITVSG SAPVLSAVAT VGITIGVLAR VALI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.