Details for: CEACAM7

Gene ID: 1087

Symbol: CEACAM7

Ensembl ID: ENSG00000007306

Description: CEA cell adhesion molecule 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 9.2488
    Cell Significance Index: 138.5900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 6.4681
    Cell Significance Index: 161.5500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 3.1215
    Cell Significance Index: 39.4400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 2.4226
    Cell Significance Index: 26.2600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.9131
    Cell Significance Index: 56.3500
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 1.4924
    Cell Significance Index: 10.7400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.4020
    Cell Significance Index: 33.9600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.1497
    Cell Significance Index: -3.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.1008
    Cell Significance Index: 67.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.5592
    Cell Significance Index: 315.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4655
    Cell Significance Index: 24.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4508
    Cell Significance Index: 20.4400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.4204
    Cell Significance Index: 4.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.4149
    Cell Significance Index: 87.3800
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.3492
    Cell Significance Index: 3.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.3270
    Cell Significance Index: 37.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3235
    Cell Significance Index: 61.5700
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.1288
    Cell Significance Index: 0.9100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1265
    Cell Significance Index: 114.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1071
    Cell Significance Index: 2.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0746
    Cell Significance Index: 7.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0691
    Cell Significance Index: 43.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0641
    Cell Significance Index: 1.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0576
    Cell Significance Index: 3.9900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0450
    Cell Significance Index: 7.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0441
    Cell Significance Index: 4.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0275
    Cell Significance Index: 3.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0241
    Cell Significance Index: 0.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0139
    Cell Significance Index: 0.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0119
    Cell Significance Index: 2.0400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0109
    Cell Significance Index: 0.1600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0089
    Cell Significance Index: 0.1500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0074
    Cell Significance Index: 0.8500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0071
    Cell Significance Index: 0.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0047
    Cell Significance Index: 2.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0022
    Cell Significance Index: 0.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0019
    Cell Significance Index: 0.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0014
    Cell Significance Index: 0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0001
    Cell Significance Index: 0.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0008
    Cell Significance Index: -1.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0010
    Cell Significance Index: -0.0300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0015
    Cell Significance Index: -2.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0020
    Cell Significance Index: -3.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0023
    Cell Significance Index: -3.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0024
    Cell Significance Index: -0.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0026
    Cell Significance Index: -0.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0027
    Cell Significance Index: -2.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0034
    Cell Significance Index: -1.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0061
    Cell Significance Index: -4.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0069
    Cell Significance Index: -4.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0077
    Cell Significance Index: -3.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0081
    Cell Significance Index: -1.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0084
    Cell Significance Index: -0.2300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0089
    Cell Significance Index: -0.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0107
    Cell Significance Index: -0.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0136
    Cell Significance Index: -1.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0149
    Cell Significance Index: -2.9600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0161
    Cell Significance Index: -0.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0177
    Cell Significance Index: -5.0900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0194
    Cell Significance Index: -0.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0201
    Cell Significance Index: -2.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0303
    Cell Significance Index: -4.4100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0337
    Cell Significance Index: -0.4400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0358
    Cell Significance Index: -0.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0438
    Cell Significance Index: -3.3600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0444
    Cell Significance Index: -1.6300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0444
    Cell Significance Index: -0.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0459
    Cell Significance Index: -2.1400
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0460
    Cell Significance Index: -0.4900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0481
    Cell Significance Index: -0.5300
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0496
    Cell Significance Index: -0.3300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0504
    Cell Significance Index: -0.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0528
    Cell Significance Index: -1.8500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0537
    Cell Significance Index: -0.3500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0604
    Cell Significance Index: -0.6300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0612
    Cell Significance Index: -0.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0615
    Cell Significance Index: -3.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0644
    Cell Significance Index: -2.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0664
    Cell Significance Index: -2.1200
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0677
    Cell Significance Index: -0.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0687
    Cell Significance Index: -1.8700
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0697
    Cell Significance Index: -0.6300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0699
    Cell Significance Index: -3.0900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0700
    Cell Significance Index: -0.7100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0706
    Cell Significance Index: -0.7200
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.0741
    Cell Significance Index: -0.4400
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0769
    Cell Significance Index: -0.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0827
    Cell Significance Index: -3.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0850
    Cell Significance Index: -2.2700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0879
    Cell Significance Index: -1.4800
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0881
    Cell Significance Index: -0.6400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0890
    Cell Significance Index: -2.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0934
    Cell Significance Index: -4.3900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0955
    Cell Significance Index: -1.4100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0960
    Cell Significance Index: -1.0200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0977
    Cell Significance Index: -3.0900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0984
    Cell Significance Index: -2.1300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1051
    Cell Significance Index: -2.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CEACAM7 is a member of the CEACAM family, which comprises a group of cell surface glycoproteins that play critical roles in cell adhesion, signaling, and immune regulation. CEACAM7 is characterized by its ability to bind to various ligands, including CD66e, CD66f, and CD66k, which are expressed on the surface of immune cells, epithelial cells, and other cell types. This binding capacity enables CEACAM7 to facilitate cell-cell interactions, modulate immune responses, and influence the trafficking of immune cells. **Pathways and Functions:** CEACAM7 is involved in various cellular pathways, including: 1. **Immune Regulation:** CEACAM7 plays a crucial role in regulating immune responses by interacting with immune cells, such as T cells, dendritic cells, and macrophages. It modulates the activation, proliferation, and differentiation of these cells, thereby influencing the overall immune response. 2. **Cell Adhesion:** CEACAM7 facilitates cell-cell interactions by binding to its ligands, which are expressed on the surface of epithelial cells, immune cells, and other cell types. This binding enables cells to adhere to each other, facilitating tissue organization, immune surveillance, and the maintenance of epithelial integrity. 3. **Metabolism of Proteins:** CEACAM7 is involved in the synthesis of glycosylphosphatidylinositol (GPI)-anchored proteins, which are essential for cell surface protein attachment and signaling. 4. **Signal Transduction:** CEACAM7 interacts with protein tyrosine kinases, which are essential for transmitting signals from the cell surface to the cytoplasm. **Clinical Significance:** CEACAM7 has been implicated in various diseases, including: 1. **Cancer:** CEACAM7 is overexpressed in several types of cancer, including colon, lung, and breast cancers. Its overexpression is associated with poor prognosis, metastasis, and reduced survival rates. 2. **Autoimmune Diseases:** CEACAM7 has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it plays a role in modulating immune responses and tissue damage. 3. **Infectious Diseases:** CEACAM7 has been identified as a receptor for certain pathogens, including influenza and HIV, which enables these pathogens to enter host cells and establish infection. 4. **Metabolic Disorders:** CEACAM7 has been implicated in metabolic disorders, such as obesity and type 2 diabetes, where it plays a role in regulating glucose metabolism and lipid storage. In conclusion, CEACAM7 is a multifunctional protein that plays a critical role in regulating immune responses, cell adhesion, and metabolism. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying its functions and the development of therapeutic strategies targeting CEACAM7.

Genular Protein ID: 2715396219

Symbol: CEAM7_HUMAN

Name: Carcinoembryonic antigen CGM2

UniProtKB Accession Codes:

Q14002 A8K848 O15148 O15149 Q0VAC1 Q13983 Q9UPJ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7806520

Title: CGM2, a member of the carcinoembryonic antigen gene family is down-regulated in colorectal carcinomas.

PubMed ID: 7806520

DOI: 10.1016/s0021-9258(20)30079-x

PubMed ID: 9135022

Title: Down-regulation of carcinoembryonic antigen family member 2 expression is an early event in colorectal tumorigenesis.

PubMed ID: 9135022

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2537643

Title: Analysis of the size of the carcinoembryonic antigen (CEA) gene family: isolation and sequencing of N-terminal domain exons.

PubMed ID: 2537643

DOI: 10.1016/0006-291x(89)92821-0

PubMed ID: 1427854

Title: Identification of three new genes and estimation of the size of the carcinoembryonic antigen family.

PubMed ID: 1427854

DOI: 10.1016/s0888-7543(05)80230-7

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 10436421

Title: Four carcinoembryonic antigen subfamily members, CEA, NCA, BGP and CGM2, selectively expressed in the normal human colonic epithelium, are integral components of the fuzzy coat.

PubMed ID: 10436421

DOI: 10.1159/000030075

PubMed ID: 26323304

Title: Structure of the N-terminal dimerization domain of CEACAM7.

PubMed ID: 26323304

DOI: 10.1107/s2053230x15013576

Sequence Information:

  • Length: 265
  • Mass: 29345
  • Checksum: 16431DD2B0010D30
  • Sequence:
    • MGSPSACPYR VCIPWQGLLL TASLLTFWNL PNSAQTNIDV VPFNVAEGKE VLLVVHNESQ 
NLYGYNWYKG ERVHANYRII GYVKNISQEN APGPAHNGRE TIYPNGTLLI QNVTHNDAGI 
YTLHVIKENL VNEEVTRQFY VFSEPPKPSI TSNNFNPVEN KDIVVLTCQP ETQNTTYLWW 
VNNQSLLVSP RLLLSTDNRT LVLLSATKND IGPYECEIQN PVGASRSDPV TLNVRYESVQ 
ASSPDLSAGT AVSIMIGVLA GMALI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.