Details for: ZNF239

Gene ID: 8187

Symbol: ZNF239

Ensembl ID: ENSG00000196793

Description: zinc finger protein 239

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna binding
    (GO:0003723)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 42.6243
    Cell Significance Index: -6.6300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 25.4294
    Cell Significance Index: -6.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.3692
    Cell Significance Index: -6.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.7101
    Cell Significance Index: -7.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.2947
    Cell Significance Index: 140.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.6878
    Cell Significance Index: -6.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8310
    Cell Significance Index: 158.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7917
    Cell Significance Index: 16.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6126
    Cell Significance Index: 60.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4224
    Cell Significance Index: 9.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4193
    Cell Significance Index: 25.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3951
    Cell Significance Index: 42.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3707
    Cell Significance Index: 334.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3339
    Cell Significance Index: 54.3000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2593
    Cell Significance Index: 4.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1991
    Cell Significance Index: 39.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1649
    Cell Significance Index: 11.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1444
    Cell Significance Index: 99.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1086
    Cell Significance Index: 38.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0907
    Cell Significance Index: 2.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0764
    Cell Significance Index: 15.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0552
    Cell Significance Index: 2.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0512
    Cell Significance Index: 1.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0486
    Cell Significance Index: 2.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0364
    Cell Significance Index: 1.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0331
    Cell Significance Index: 4.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0318
    Cell Significance Index: 0.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0280
    Cell Significance Index: 1.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0213
    Cell Significance Index: 1.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0157
    Cell Significance Index: 8.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0054
    Cell Significance Index: 0.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0040
    Cell Significance Index: 0.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0040
    Cell Significance Index: 0.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0033
    Cell Significance Index: 0.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0025
    Cell Significance Index: 0.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0011
    Cell Significance Index: 0.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -1.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0014
    Cell Significance Index: -1.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0026
    Cell Significance Index: -0.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0026
    Cell Significance Index: -3.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0051
    Cell Significance Index: -0.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0054
    Cell Significance Index: -0.7000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0063
    Cell Significance Index: -0.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0067
    Cell Significance Index: -4.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0067
    Cell Significance Index: -5.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0070
    Cell Significance Index: -4.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0088
    Cell Significance Index: -6.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0108
    Cell Significance Index: -4.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0117
    Cell Significance Index: -6.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0123
    Cell Significance Index: -7.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0124
    Cell Significance Index: -0.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0129
    Cell Significance Index: -0.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0149
    Cell Significance Index: -1.9200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0156
    Cell Significance Index: -0.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0182
    Cell Significance Index: -5.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0242
    Cell Significance Index: -3.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0249
    Cell Significance Index: -4.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0267
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0311
    Cell Significance Index: -3.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0338
    Cell Significance Index: -0.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0344
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0352
    Cell Significance Index: -7.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0366
    Cell Significance Index: -3.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0366
    Cell Significance Index: -2.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0373
    Cell Significance Index: -2.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0376
    Cell Significance Index: -1.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0412
    Cell Significance Index: -1.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0463
    Cell Significance Index: -2.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0467
    Cell Significance Index: -1.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0499
    Cell Significance Index: -2.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0531
    Cell Significance Index: -6.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0531
    Cell Significance Index: -3.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0621
    Cell Significance Index: -6.4700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0660
    Cell Significance Index: -1.4000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0779
    Cell Significance Index: -1.1200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0805
    Cell Significance Index: -1.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0831
    Cell Significance Index: -6.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0956
    Cell Significance Index: -3.1300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0980
    Cell Significance Index: -3.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1029
    Cell Significance Index: -6.6400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1051
    Cell Significance Index: -2.2700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1068
    Cell Significance Index: -1.4300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1118
    Cell Significance Index: -2.2100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1138
    Cell Significance Index: -1.9500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1156
    Cell Significance Index: -2.8000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1188
    Cell Significance Index: -2.8500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1217
    Cell Significance Index: -1.2600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1230
    Cell Significance Index: -0.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1234
    Cell Significance Index: -3.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1242
    Cell Significance Index: -4.3500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1249
    Cell Significance Index: -3.5700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1263
    Cell Significance Index: -3.1500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1285
    Cell Significance Index: -1.4000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1285
    Cell Significance Index: -2.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1286
    Cell Significance Index: -2.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1308
    Cell Significance Index: -4.5500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1314
    Cell Significance Index: -1.9800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1317
    Cell Significance Index: -2.0900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1490
    Cell Significance Index: -1.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF239 is a 477 amino acid protein that belongs to the zinc finger protein family, which is characterized by the presence of one or more zinc finger motifs. These motifs are responsible for the protein's ability to bind to DNA and regulate gene expression. ZNF239 is specifically expressed in germ cells, enterocytes, GABAergic interneurons, and other cell types, suggesting its involvement in various cellular processes, including development, differentiation, and maintenance. **Pathways and Functions:** ZNF239 is involved in several key pathways that regulate gene expression, including: 1. **DNA-binding transcription factor activity**: ZNF239 binds to specific DNA sequences, regulating the transcription of target genes. 2. **RNA polymerase II-specific**: ZNF239 interacts with RNAPII, modulating the transcription of RNAPII-dependent genes. 3. **Negative regulation of transcription by RNAPII**: ZNF239 inhibits the transcription of RNAPII-dependent genes, ensuring the proper regulation of gene expression. 4. **Regulation of transcription by RNAPII**: ZNF239 activates the transcription of RNAPII-dependent genes, promoting the expression of specific genes. ZNF239's functional role in these pathways is crucial for maintaining the balance of gene expression in various cell types. Its ability to regulate transcriptional activity ensures that genes are expressed or repressed in a timely and spatially appropriate manner, which is essential for cellular development, differentiation, and maintenance. **Clinical Significance:** Dysregulation of ZNF239 expression has been implicated in various diseases, including: 1. **Immune system dysregulation**: Alterations in ZNF239 expression have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where immune system dysregulation plays a key role. 2. **Cancer**: ZNF239's role in regulating gene expression makes it a potential target for cancer therapy. Dysregulation of ZNF239 expression has been observed in various types of cancer, including breast, lung, and colon cancer. 3. **Neurological disorders**: ZNF239's expression in GABAergic interneurons makes it a potential target for the treatment of neurological disorders, such as epilepsy and Parkinson's disease. In conclusion, ZNF239 is a transcriptional regulator that plays a critical role in maintaining the balance of gene expression in various cell types. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its functional role in the context of immune system dysregulation and disease. Further research is needed to fully elucidate the mechanisms by which ZNF239 regulates gene expression and to explore its potential as a therapeutic target.

Genular Protein ID: 1283141188

Symbol: ZN239_HUMAN

Name: Zinc finger protein 239

UniProtKB Accession Codes:

Q16600 Q5T1G9 Q8TAS5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 4 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 12 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8587123

Title: Human and mouse Kruppel-like (MOK2) orthologue genes encode two different zinc finger proteins.

PubMed ID: 8587123

DOI: 10.1007/bf00173158

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 458
  • Mass: 51591
  • Checksum: 94753A790CB5F559
  • Sequence:
    • MASTITGSQD CIVNHRGEVD GEPELDISPC QQWGEASSPI SRNRDSVMTL QSGCFENIES 
ETYLPLKVSS QIDTQDSSVK FCKNEPQDHQ ESRRLFVMEE STERKVIKGE SCSENLQVKL 
VSDGQELASP LLNGEATCQN GQLKESLDPI DCNCKDIHGW KSQVVSCSQQ RAHTEEKPCD 
HNNCGKILNT SPDGHPYEKI HTAEKQYECS QCGKNFSQSS ELLLHQRDHT EEKPYKCEQC 
GKGFTRSSSL LIHQAVHTDE KPYKCDKCGK GFTRSSSLLI HHAVHTGEKP YKCDKCGKGF 
SQSSKLHIHQ RVHTGEKPYE CEECGMSFSQ RSNLHIHQRV HTGERPYKCG ECGKGFSQSS 
NLHIHRCIHT GEKPYQCYEC GKGFSQSSDL RIHLRVHTGE KPYHCGKCGK GFSQSSKLLI 
HQRVHTGEKP YECSKCGKGF SQSSNLHIHQ RVHKKDPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.