Details for: TPI1

Gene ID: 7167

Symbol: TPI1

Ensembl ID: ENSG00000111669

Description: triosephosphate isomerase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 770.8690
    Cell Significance Index: -119.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 416.1749
    Cell Significance Index: -105.5600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 351.5496
    Cell Significance Index: -144.8200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 304.6242
    Cell Significance Index: -143.8200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 272.1112
    Cell Significance Index: -139.9700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 215.4623
    Cell Significance Index: -144.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 108.7833
    Cell Significance Index: -134.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 38.2685
    Cell Significance Index: -117.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 35.5419
    Cell Significance Index: -140.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 19.1905
    Cell Significance Index: -42.0000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.9098
    Cell Significance Index: -42.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 10.9026
    Cell Significance Index: 572.4300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.8058
    Cell Significance Index: 170.5100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 5.5125
    Cell Significance Index: 42.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.3661
    Cell Significance Index: 141.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.5073
    Cell Significance Index: 2461.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.4992
    Cell Significance Index: 211.4600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.3223
    Cell Significance Index: 34.5100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 4.0178
    Cell Significance Index: 51.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.7396
    Cell Significance Index: 129.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.7370
    Cell Significance Index: 440.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.6528
    Cell Significance Index: 76.4600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 3.5971
    Cell Significance Index: 30.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.2322
    Cell Significance Index: 443.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.1892
    Cell Significance Index: 408.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.1879
    Cell Significance Index: 58.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.0901
    Cell Significance Index: 144.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.9017
    Cell Significance Index: 523.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.8283
    Cell Significance Index: 347.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.7709
    Cell Significance Index: 206.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.7598
    Cell Significance Index: 356.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.6867
    Cell Significance Index: 73.1300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.6115
    Cell Significance Index: 28.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.2528
    Cell Significance Index: 996.0200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.8793
    Cell Significance Index: 21.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.7565
    Cell Significance Index: 124.2300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.7397
    Cell Significance Index: 16.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5897
    Cell Significance Index: 157.2600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.4504
    Cell Significance Index: 33.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3391
    Cell Significance Index: 86.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0609
    Cell Significance Index: 55.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7864
    Cell Significance Index: 156.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7789
    Cell Significance Index: 156.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6009
    Cell Significance Index: 37.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.4819
    Cell Significance Index: 364.7500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4476
    Cell Significance Index: 7.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3563
    Cell Significance Index: 60.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3527
    Cell Significance Index: 10.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2725
    Cell Significance Index: 199.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2380
    Cell Significance Index: 45.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2277
    Cell Significance Index: 8.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2217
    Cell Significance Index: 10.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2053
    Cell Significance Index: 33.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1512
    Cell Significance Index: 2.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0846
    Cell Significance Index: 2.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0519
    Cell Significance Index: 18.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0136
    Cell Significance Index: -1.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0146
    Cell Significance Index: -27.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0447
    Cell Significance Index: -33.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0674
    Cell Significance Index: -124.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0682
    Cell Significance Index: -105.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0799
    Cell Significance Index: -49.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0908
    Cell Significance Index: -123.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1448
    Cell Significance Index: -91.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1583
    Cell Significance Index: -89.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1712
    Cell Significance Index: -77.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1941
    Cell Significance Index: -22.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.1960
    Cell Significance Index: -135.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3077
    Cell Significance Index: -64.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4004
    Cell Significance Index: -11.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.5101
    Cell Significance Index: -146.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7755
    Cell Significance Index: -112.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7833
    Cell Significance Index: -62.0400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.8242
    Cell Significance Index: -12.3500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.8733
    Cell Significance Index: -99.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.8883
    Cell Significance Index: -103.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9039
    Cell Significance Index: -24.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9164
    Cell Significance Index: -23.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9389
    Cell Significance Index: -20.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.9694
    Cell Significance Index: -58.2000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -1.0541
    Cell Significance Index: -16.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.1047
    Cell Significance Index: -61.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.1803
    Cell Significance Index: -72.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2636
    Cell Significance Index: -40.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.2916
    Cell Significance Index: -134.4900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.3145
    Cell Significance Index: -15.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.4048
    Cell Significance Index: -94.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.4844
    Cell Significance Index: -102.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.5606
    Cell Significance Index: -119.7600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.7542
    Cell Significance Index: -30.2400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.0735
    Cell Significance Index: -28.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.2005
    Cell Significance Index: -37.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.3492
    Cell Significance Index: -144.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.5249
    Cell Significance Index: -74.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.8762
    Cell Significance Index: -127.2200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -3.0215
    Cell Significance Index: -42.3500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -3.0655
    Cell Significance Index: -51.5600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -3.1555
    Cell Significance Index: -115.8400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -3.1966
    Cell Significance Index: -91.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -3.3925
    Cell Significance Index: -128.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TPI1 exhibits several key characteristics that underscore its significance in cellular metabolism: 1. **Enzymatic activity**: TPI1 is a triosephosphate isomerase, catalyzing the isomerization of DHAP to G3P, a reaction that is essential for the progression of glycolysis. 2. **Subcellular localization**: TPI1 is primarily associated with the cytosol, where it can access its substrates and interact with other glycolytic enzymes. 3. **Expression patterns**: TPI1 is expressed in a wide range of cell types, including immune cells, neurons, and muscle cells, suggesting its involvement in various physiological processes. 4. **Regulation**: TPI1 is subject to various regulatory mechanisms, including post-translational modifications and transcriptional control, which allow for fine-tuned expression in response to changing cellular needs. **Pathways and Functions** TPI1 plays a critical role in several metabolic pathways, including: 1. **Glycolysis**: TPI1 catalyzes the conversion of DHAP to G3P, enabling the efficient breakdown of glucose for energy production. 2. **Gluconeogenesis**: TPI1 participates in the gluconeogenic pathway, generating G3P from non-carbohydrate sources, such as lactate and glycerol. 3. **Glyceraldehyde-3-phosphate biosynthetic process**: TPI1 is involved in the generation of G3P from glyceraldehyde, a precursor molecule for glycolysis. 4. **Methylglyoxal biosynthetic process**: TPI1 catalyzes the formation of methylglyoxal, a key intermediate in the glyoxalase pathway. **Clinical Significance** Dysregulation of TPI1 expression or activity has been implicated in various diseases and conditions, including: 1. **Diabetes**: Altered TPI1 expression has been observed in diabetic patients, suggesting a potential role in glucose metabolism and insulin resistance. 2. **Cancer**: TPI1 has been identified as a prognostic marker for various types of cancer, including colorectal and breast cancer. 3. **Neurological disorders**: TPI1 expression has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 4. **Immune system dysregulation**: TPI1 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. In conclusion, TPI1 is a critical enzyme involved in various metabolic pathways, with significant implications for cellular homeostasis and function. Further research into the regulation and clinical significance of TPI1 will provide valuable insights into the molecular mechanisms underlying various diseases and conditions.

Genular Protein ID: 3910351010

Symbol: TPIS_HUMAN

Name: Triose-phosphate isomerase

UniProtKB Accession Codes:

P60174 B7Z5D8 D3DUS9 P00938 Q6FHP9 Q6IS07 Q8WWD0 Q96AG5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CPTAC 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 17 EC 2 EMBL 17 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 NCBIfam 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 27 PDBsum 27 PIR 1 PRIDE 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 2 RefSeq 3 Rhea 2 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 3 TreeFam 1 UCSC 1 UniPathway 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2579079

Title: Human triosephosphate isomerase cDNA and protein structure. Studies of triosephosphate isomerase deficiency in man.

PubMed ID: 2579079

DOI: 10.1016/s0021-9258(19)83687-6

PubMed ID: 4022011

Title: Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family.

PubMed ID: 4022011

DOI: 10.1128/mcb.5.7.1694-1706.1985

PubMed ID: 8723724

Title: A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13.

PubMed ID: 8723724

DOI: 10.1101/gr.6.4.314

PubMed ID: 9074930

Title: Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.

PubMed ID: 9074930

DOI: 10.1101/gr.7.3.268

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 2925688

Title: Transcriptional regulatory sequences of the housekeeping gene for human triosephosphate isomerase.

PubMed ID: 2925688

DOI: 10.1016/s0021-9258(18)83716-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6434534

Title: Primary structure of human triosephosphate isomerase.

PubMed ID: 6434534

DOI: 10.1016/s0021-9258(20)71304-9

PubMed ID: 9150946

Title: Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.

PubMed ID: 9150946

DOI: 10.1002/elps.1150180342

PubMed ID: 9150948

Title: A two-dimensional gel database of human colon carcinoma proteins.

PubMed ID: 9150948

DOI: 10.1002/elps.1150180344

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16807684

Title: Phosphoproteomic analysis of the human pituitary.

PubMed ID: 16807684

DOI: 10.1007/s11102-006-8916-x

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.m700120-mcp200

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 8061610

Title: Crystal structure of recombinant human triosephosphate isomerase at 2.8-A resolution. Triosephosphate isomerase-related human genetic disorders and comparison with the trypanosomal enzyme.

PubMed ID: 8061610

DOI: 10.1002/pro.5560030510

PubMed ID: 16511037

Title: Structure of a high-resolution crystal form of human triosephosphate isomerase: improvement of crystals using the gel-tube method.

PubMed ID: 16511037

DOI: 10.1107/s1744309105008341

PubMed ID: 18562316

Title: Structural basis of human triosephosphate isomerase deficiency: mutation E104D is related to alterations of a conserved water network at the dimer interface.

PubMed ID: 18562316

DOI: 10.1074/jbc.m802145200

PubMed ID: 2876430

Title: Human triose-phosphate isomerase deficiency: a single amino acid substitution results in a thermolabile enzyme.

PubMed ID: 2876430

DOI: 10.1073/pnas.83.20.7903

PubMed ID: 1339398

Title: Human triosephosphate isomerase: substitution of Arg for Gly at position 122 in a thermolabile electromorph variant, TPI-Manchester.

PubMed ID: 1339398

DOI: 10.1007/bf02265287

PubMed ID: 8503454

Title: Human triosephosphate isomerase deficiency resulting from mutation of Phe-240.

PubMed ID: 8503454

PubMed ID: 8571957

Title: Molecular analysis of a series of alleles in humans with reduced activity at the triosephosphate isomerase locus.

PubMed ID: 8571957

PubMed ID: 9338582

Title: Evidence for founder effect of the Glu104Asp substitution and identification of new mutations in triosephosphate isomerase deficiency.

PubMed ID: 9338582

DOI: 10.1002/(sici)1098-1004(1997)10:4<290::aid-humu4>3.0.co;2-l

Sequence Information:

  • Length: 249
  • Mass: 26669
  • Checksum: 73844175635F858E
  • Sequence:
    • MAPSRKFFVG GNWKMNGRKQ SLGELIGTLN AAKVPADTEV VCAPPTAYID FARQKLDPKI 
AVAAQNCYKV TNGAFTGEIS PGMIKDCGAT WVVLGHSERR HVFGESDELI GQKVAHALAE 
GLGVIACIGE KLDEREAGIT EKVVFEQTKV IADNVKDWSK VVLAYEPVWA IGTGKTATPQ 
QAQEVHEKLR GWLKSNVSDA VAQSTRIIYG GSVTGATCKE LASQPDVDGF LVGGASLKPE 
FVDIINAKQ

Genular Protein ID: 1117654037

Symbol: Q53HE2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53HE2

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 7 Gene3D 1 HAMAP 1 IntAct 1 InterPro 5 KEGG 1 MINT 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 1 PharmGKB 1 RefSeq 1 Rhea 2 RuleBase 1 SMR 1 SUPFAM 1 UniPathway 2 iPTMnet 1

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 249
  • Mass: 26713
  • Checksum: 73965259B19F4470
  • Sequence:
    • MAPSRKFFVG GNWKMNGRKQ SLGELIGTLN AAKVPADTEV VCAPPTAYID FARQKLDPKI 
AVAAQNCYKV TNGAFTGEIS PGMIKDCGAT WVVRGHSERR HVFGESDELI GQKVAHALAE 
GLGVIACIGE KLDEREAGIT EKVVFEQTKV IADNVKDWSK VVLAYEPVWA IGTGKTATPQ 
QAQEVHEKLR GWLKSNVSDA VAQSTRIIYG GSVTGATCKE LASQPDVDGF LVGGASLKPE 
FVDIINAKQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.