Details for: PPA1

Gene ID: 5464

Symbol: PPA1

Ensembl ID: ENSG00000180817

Description: inorganic pyrophosphatase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 513.1948
    Cell Significance Index: -79.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 247.8973
    Cell Significance Index: -62.8800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 218.7900
    Cell Significance Index: -90.1300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 192.7677
    Cell Significance Index: -91.0100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 189.4367
    Cell Significance Index: -76.9600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 175.4230
    Cell Significance Index: -90.2400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 136.2399
    Cell Significance Index: -91.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 81.4355
    Cell Significance Index: -77.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 72.0018
    Cell Significance Index: -88.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.8875
    Cell Significance Index: -66.6700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.4108
    Cell Significance Index: -92.3800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.1284
    Cell Significance Index: -64.9000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.5985
    Cell Significance Index: -31.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 8.2473
    Cell Significance Index: 570.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 4.5152
    Cell Significance Index: 583.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.4213
    Cell Significance Index: 207.8000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.8670
    Cell Significance Index: 89.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.6397
    Cell Significance Index: 656.1300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.5787
    Cell Significance Index: 32.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.4882
    Cell Significance Index: 1904.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.3130
    Cell Significance Index: 407.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.2003
    Cell Significance Index: 168.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.1637
    Cell Significance Index: 235.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.0685
    Cell Significance Index: 143.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.5344
    Cell Significance Index: 179.2400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.5251
    Cell Significance Index: 15.5400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.5131
    Cell Significance Index: 44.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.1774
    Cell Significance Index: 113.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.0920
    Cell Significance Index: 55.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.0006
    Cell Significance Index: 57.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.8638
    Cell Significance Index: 824.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5234
    Cell Significance Index: 209.2100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.4745
    Cell Significance Index: 16.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.3330
    Cell Significance Index: 39.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3266
    Cell Significance Index: 266.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3122
    Cell Significance Index: 154.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2978
    Cell Significance Index: 1171.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.2786
    Cell Significance Index: 218.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2526
    Cell Significance Index: 248.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0995
    Cell Significance Index: 140.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0432
    Cell Significance Index: 65.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0374
    Cell Significance Index: 27.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.9643
    Cell Significance Index: 1815.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8527
    Cell Significance Index: 38.6500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.8251
    Cell Significance Index: 6.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.7352
    Cell Significance Index: 466.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7164
    Cell Significance Index: 19.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6316
    Cell Significance Index: 62.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4211
    Cell Significance Index: 151.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3970
    Cell Significance Index: 300.5100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3210
    Cell Significance Index: 6.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2672
    Cell Significance Index: 50.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2193
    Cell Significance Index: 14.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1081
    Cell Significance Index: 3.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0796
    Cell Significance Index: 4.8900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0224
    Cell Significance Index: 0.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0127
    Cell Significance Index: -23.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0180
    Cell Significance Index: -27.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0185
    Cell Significance Index: -13.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0264
    Cell Significance Index: -16.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0287
    Cell Significance Index: -21.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0378
    Cell Significance Index: -1.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0694
    Cell Significance Index: -1.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0735
    Cell Significance Index: -99.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0911
    Cell Significance Index: -9.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0932
    Cell Significance Index: -52.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1295
    Cell Significance Index: -2.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1410
    Cell Significance Index: -63.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1771
    Cell Significance Index: -10.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1975
    Cell Significance Index: -41.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2186
    Cell Significance Index: -25.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2275
    Cell Significance Index: -3.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2623
    Cell Significance Index: -38.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2677
    Cell Significance Index: -77.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4809
    Cell Significance Index: -56.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5398
    Cell Significance Index: -30.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6061
    Cell Significance Index: -8.2700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6126
    Cell Significance Index: -15.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7195
    Cell Significance Index: -23.0500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7246
    Cell Significance Index: -82.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7479
    Cell Significance Index: -77.8800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7542
    Cell Significance Index: -8.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7556
    Cell Significance Index: -39.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7633
    Cell Significance Index: -60.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7851
    Cell Significance Index: -17.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7909
    Cell Significance Index: -53.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.9677
    Cell Significance Index: -74.2600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -1.0427
    Cell Significance Index: -8.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0933
    Cell Significance Index: -67.0300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -1.3618
    Cell Significance Index: -9.7800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.4168
    Cell Significance Index: -8.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.4549
    Cell Significance Index: -64.3600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.4692
    Cell Significance Index: -22.0200
  • Cell Name: germ cell (CL0000586)
    Fold Change: -1.5204
    Cell Significance Index: -11.4800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.5322
    Cell Significance Index: -28.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.5918
    Cell Significance Index: -33.9000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.6079
    Cell Significance Index: -27.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.6270
    Cell Significance Index: -40.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.7337
    Cell Significance Index: -65.6500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.7400
    Cell Significance Index: -51.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PPA1 is a cytosolic enzyme that exhibits inorganic diphosphate phosphatase activity, utilizing magnesium ions as cofactors to catalyze the hydrolysis of pyrophosphate (PPi) to inorganic phosphate (Pi). This enzyme is highly expressed in various cell types, including basal cells of prostate epithelium, type II pneumocytes, and epithelial cells of the urethra, suggesting its broad involvement in tissue homeostasis. PPA1 has also been detected in erythroid progenitor cells and progenitor cells of mammary luminal epithelium, highlighting its role in hematopoiesis and mammary gland development. **Pathways and Functions:** PPA1 is involved in several critical cellular processes, including: 1. **Metabolism of phosphate-containing compounds:** PPA1 regulates the hydrolysis of PPi to Pi, a crucial step in maintaining phosphate homeostasis and preventing the accumulation of toxic PPi. 2. **Protein synthesis:** PPA1 has been implicated in the regulation of protein synthesis by modulating the availability of Pi, a necessary component for amino acid metabolism and protein folding. 3. **Cytosolic trna aminoacylation:** PPA1 has been shown to regulate the activity of cytosolic trna aminoacylation, a process essential for protein synthesis. 4. **Translation:** PPA1 has been implicated in the regulation of translation, a process critical for protein synthesis and cell growth. **Clinical Significance:** Dysregulation of PPA1 has been linked to various human diseases, including: 1. **Metabolic disorders:** Abnormalities in PPA1 function have been implicated in metabolic disorders, such as hypophosphatemia and hyperphosphatemia. 2. **Cancer:** Altered PPA1 expression has been observed in various cancers, including prostate cancer, suggesting its role in tumorigenesis. 3. **Neurological disorders:** PPA1 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and amyotrophic lateral sclerosis. In conclusion, PPA1 is a critical enzyme involved in the regulation of phosphate homeostasis and protein synthesis. Its dysregulation has been linked to various human diseases, highlighting the importance of PPA1 in maintaining cellular homeostasis and preventing disease. Further research is necessary to fully elucidate the mechanisms underlying PPA1 function and its implications in human disease.

Genular Protein ID: 3228869311

Symbol: IPYR_HUMAN

Name: Inorganic pyrophosphatase

UniProtKB Accession Codes:

Q15181 Q2M348 Q5SQT7 Q6P7P4 Q9UQJ5 Q9Y5B1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 13 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10542310

Title: Cloning and expression profile of human inorganic pyrophosphatase.

PubMed ID: 10542310

DOI: 10.1016/s0167-4781(99)00175-x

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 289
  • Mass: 32660
  • Checksum: E3973C9E6F8CA5CD
  • Sequence:
    • MSGFSTEERA APFSLEYRVF LKNEKGQYIS PFHDIPIYAD KDVFHMVVEV PRWSNAKMEI 
ATKDPLNPIK QDVKKGKLRY VANLFPYKGY IWNYGAIPQT WEDPGHNDKH TGCCGDNDPI 
DVCEIGSKVC ARGEIIGVKV LGILAMIDEG ETDWKVIAIN VDDPDAANYN DINDVKRLKP 
GYLEATVDWF RRYKVPDGKP ENEFAFNAEF KDKDFAIDII KSTHDHWKAL VTKKTNGKGI 
SCMNTTLSES PFKCDPDAAR AIVDALPPPC ESACTVPTDV DKWFHHQKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.