Details for: GUK1

Gene ID: 2987

Symbol: GUK1

Ensembl ID: ENSG00000143774

Description: guanylate kinase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.05
    Marker Score: 10666.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 4.06
    Marker Score: 7412
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.88
    Marker Score: 38389
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.79
    Marker Score: 9643.5
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.74
    Marker Score: 5420
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.4
    Marker Score: 9701
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.3
    Marker Score: 10409
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.3
    Marker Score: 9251
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.29
    Marker Score: 25663
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.23
    Marker Score: 8929
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.12
    Marker Score: 7109
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.03
    Marker Score: 4468
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.02
    Marker Score: 2691
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.99
    Marker Score: 8718
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.98
    Marker Score: 1191
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.96
    Marker Score: 102563
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.92
    Marker Score: 3144
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.91
    Marker Score: 5818
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.9
    Marker Score: 7081
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.88
    Marker Score: 2529
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.87
    Marker Score: 3194
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.87
    Marker Score: 685.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.86
    Marker Score: 2254.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.86
    Marker Score: 97219
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.85
    Marker Score: 2396
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.84
    Marker Score: 13645
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.84
    Marker Score: 4706
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.83
    Marker Score: 18070
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.83
    Marker Score: 7583.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.82
    Marker Score: 10008
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.82
    Marker Score: 2526
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.81
    Marker Score: 24184
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.8
    Marker Score: 14728
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.79
    Marker Score: 2382
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.79
    Marker Score: 2379
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.79
    Marker Score: 6808
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.79
    Marker Score: 945
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.79
    Marker Score: 4978
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.77
    Marker Score: 2011
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.77
    Marker Score: 2381
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.76
    Marker Score: 5189
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.76
    Marker Score: 10644.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.76
    Marker Score: 6961
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.75
    Marker Score: 153922
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.72
    Marker Score: 11668
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.71
    Marker Score: 1929
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.71
    Marker Score: 2554.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.7
    Marker Score: 2741
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.7
    Marker Score: 2290
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.7
    Marker Score: 3255
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.69
    Marker Score: 1580
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.69
    Marker Score: 929
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.69
    Marker Score: 4558
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.69
    Marker Score: 17200.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.68
    Marker Score: 1562
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.67
    Marker Score: 11527
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.67
    Marker Score: 4243
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.65
    Marker Score: 789
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.63
    Marker Score: 3628
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.62
    Marker Score: 19473.5
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.62
    Marker Score: 1347
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.6
    Marker Score: 5895
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.59
    Marker Score: 3666
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.58
    Marker Score: 1883.5
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.57
    Marker Score: 681.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.56
    Marker Score: 5208
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 2.55
    Marker Score: 672.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.55
    Marker Score: 28735
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.55
    Marker Score: 1716
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.54
    Marker Score: 1097
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.54
    Marker Score: 1992
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.54
    Marker Score: 2431
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.53
    Marker Score: 922.5
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.52
    Marker Score: 1393
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.52
    Marker Score: 1294
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.51
    Marker Score: 2874
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.51
    Marker Score: 1653
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.51
    Marker Score: 7887
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.51
    Marker Score: 2053
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.5
    Marker Score: 2343
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.5
    Marker Score: 4868
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.5
    Marker Score: 2717.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.49
    Marker Score: 16231
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.49
    Marker Score: 3419
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.49
    Marker Score: 3830
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 2.49
    Marker Score: 1213
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.48
    Marker Score: 3603
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.48
    Marker Score: 1284
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 2.46
    Marker Score: 2224
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.46
    Marker Score: 21345
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.45
    Marker Score: 2455
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.45
    Marker Score: 3160
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.43
    Marker Score: 1657
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.43
    Marker Score: 1104
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.42
    Marker Score: 1380
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 2.42
    Marker Score: 786
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.42
    Marker Score: 859
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.41
    Marker Score: 127490
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.4
    Marker Score: 744
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.4
    Marker Score: 61426

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Other Information

**Key characteristics** - GUK1 is a protein of the guanylate kinase family. - It is a transmembrane protein with a molecular weight of approximately 120 kDa. - GUK1 is expressed in a variety of cell types, including pancreatic acinar cells, secretory cells, mature T cells, and retinal rod cells. - It is a key regulator of nucleotide metabolism, and its activity is essential for the maintenance of cellular homeostasis. **Pathways and functions** GUK1 is involved in a variety of pathways and functions, including: - Atp binding - Azathioprine adme - Cytosol - Dgdp biosynthetic process - Drug adme - Gdp metabolic process - Gmp metabolic process - Guanylate kinase activity - Interconversion of nucleotide di- and triphosphates - Metabolism - Metabolism of nucleotides - Nucleobase-containing small molecule interconversion - Phosphorylation - Photoreceptor inner segment - Protein binding - Purine nucleotide metabolic process - Xenobiotic metabolic process **Clinical significance** GUK1 has been implicated in a variety of human diseases, including cancer and autoimmune diseases. For example, mutations in GUK1 have been linked to the development of cancer in several types of cancer cells. In addition, GUK1 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus.

Genular Protein ID: 2015647191

Symbol: KGUA_HUMAN

Name: Guanylate kinase

UniProtKB Accession Codes:

Q16774 B1ANH1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 7 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 Rhea 1 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8647247

Title: Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation.

PubMed ID: 8647247

DOI: 10.1016/0014-5793(96)00365-1

PubMed ID: 8663313

Title: Cloning, characterization, and modeling of mouse and human guanylate kinases.

PubMed ID: 8663313

DOI: 10.1074/jbc.271.28.16734

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 197968

Title: Reassessment of the interactions of guanylate kinase and 6-thioguanosine 5'-phosphate.

PubMed ID: 197968

DOI: 10.1016/0006-2952(77)90071-5

PubMed ID: 6248551

Title: Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase.

PubMed ID: 6248551

DOI: 10.1016/s0021-9258(20)79686-9

PubMed ID: 6306664

Title: 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication.

PubMed ID: 6306664

DOI: 10.1073/pnas.80.13.4139

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29515371

Title: Control of the Nucleotide Cycle in Photoreceptor Cell Extracts by Retinal Degeneration Protein 3.

PubMed ID: 29515371

DOI: 10.3389/fnmol.2018.00052

PubMed ID: 31201273

Title: Solution structure and functional investigation of human guanylate kinase reveals allosteric networking and a crucial role for the enzyme in cancer.

PubMed ID: 31201273

DOI: 10.1074/jbc.ra119.009251

Sequence Information:

  • Length: 197
  • Mass: 21726
  • Checksum: C49573212A0DA825
  • Sequence:
    • MSGPRPVVLS GPSGAGKSTL LKRLLQEHSG IFGFSVSHTT RNPRPGEENG KDYYFVTREV 
MQRDIAAGDF IEHAEFSGNL YGTSKVAVQA VQAMNRICVL DVDLQGVRNI KATDLRPIYI 
SVQPPSLHVL EQRLRQRNTE TEESLVKRLA AAQADMESSK EPGLFDVVII NDSLDQAYAE 
LKEALSEEIK KAQRTGA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.