Details for: GUK1

Gene ID: 2987

Symbol: GUK1

Ensembl ID: ENSG00000143774

Description: guanylate kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 515.0913
    Cell Significance Index: -80.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 418.7375
    Cell Significance Index: -106.2100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 273.1901
    Cell Significance Index: -112.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 250.9741
    Cell Significance Index: -101.9600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 247.2027
    Cell Significance Index: -116.7100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 223.4318
    Cell Significance Index: -114.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 174.9123
    Cell Significance Index: -117.3700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 107.6730
    Cell Significance Index: -102.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 74.2525
    Cell Significance Index: -91.5500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 32.2225
    Cell Significance Index: -98.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 30.7878
    Cell Significance Index: -121.4900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.9574
    Cell Significance Index: -41.4900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.0726
    Cell Significance Index: -45.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.7946
    Cell Significance Index: 270.1700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 5.2362
    Cell Significance Index: 92.5300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.5165
    Cell Significance Index: 51.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.2388
    Cell Significance Index: 199.2200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.7250
    Cell Significance Index: 109.4000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.7193
    Cell Significance Index: 34.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.3837
    Cell Significance Index: 416.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.9288
    Cell Significance Index: 1599.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.9216
    Cell Significance Index: 526.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.8378
    Cell Significance Index: 389.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.7857
    Cell Significance Index: 207.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.7838
    Cell Significance Index: 146.1600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.3291
    Cell Significance Index: 1029.7600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.3263
    Cell Significance Index: 19.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.1682
    Cell Significance Index: 136.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.1364
    Cell Significance Index: 276.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.0107
    Cell Significance Index: 54.7300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.8402
    Cell Significance Index: 11.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.7716
    Cell Significance Index: 40.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7593
    Cell Significance Index: 191.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.6170
    Cell Significance Index: 207.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.5510
    Cell Significance Index: 109.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4138
    Cell Significance Index: 166.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3688
    Cell Significance Index: 88.3100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1854
    Cell Significance Index: 21.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1067
    Cell Significance Index: 222.0000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0099
    Cell Significance Index: 28.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8910
    Cell Significance Index: 23.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6385
    Cell Significance Index: 33.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6334
    Cell Significance Index: 103.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6083
    Cell Significance Index: 31.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5442
    Cell Significance Index: 14.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4921
    Cell Significance Index: 444.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3861
    Cell Significance Index: 10.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3663
    Cell Significance Index: 72.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1677
    Cell Significance Index: 60.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1445
    Cell Significance Index: 109.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1405
    Cell Significance Index: 103.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0588
    Cell Significance Index: 1.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0286
    Cell Significance Index: 53.8000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0117
    Cell Significance Index: 0.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0424
    Cell Significance Index: -4.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0526
    Cell Significance Index: -8.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0674
    Cell Significance Index: -124.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0743
    Cell Significance Index: -114.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0859
    Cell Significance Index: -16.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0901
    Cell Significance Index: -122.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0943
    Cell Significance Index: -59.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1094
    Cell Significance Index: -3.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1219
    Cell Significance Index: -90.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1244
    Cell Significance Index: -12.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1726
    Cell Significance Index: -97.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2010
    Cell Significance Index: -91.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2197
    Cell Significance Index: -137.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3202
    Cell Significance Index: -92.1300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3844
    Cell Significance Index: -5.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5169
    Cell Significance Index: -75.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5514
    Cell Significance Index: -63.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5992
    Cell Significance Index: -36.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6181
    Cell Significance Index: -48.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6258
    Cell Significance Index: -131.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6329
    Cell Significance Index: -73.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6350
    Cell Significance Index: -7.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6393
    Cell Significance Index: -17.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7699
    Cell Significance Index: -24.6600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7801
    Cell Significance Index: -19.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8856
    Cell Significance Index: -59.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1194
    Cell Significance Index: -116.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.2670
    Cell Significance Index: -57.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.3101
    Cell Significance Index: -17.8800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.4002
    Cell Significance Index: -8.4600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.4206
    Cell Significance Index: -10.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.4561
    Cell Significance Index: -111.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.5115
    Cell Significance Index: -90.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.5129
    Cell Significance Index: -104.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7379
    Cell Significance Index: -106.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.8487
    Cell Significance Index: -53.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.8970
    Cell Significance Index: -106.4500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.0274
    Cell Significance Index: -17.0300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.1585
    Cell Significance Index: -36.9900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -2.2175
    Cell Significance Index: -22.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.2604
    Cell Significance Index: -48.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.2727
    Cell Significance Index: -66.9400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.5123
    Cell Significance Index: -43.3100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -2.5264
    Cell Significance Index: -32.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -2.5868
    Cell Significance Index: -69.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.6069
    Cell Significance Index: -115.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GUK1 is a member of the guanylate kinase family, which is characterized by the presence of a conserved guanylate kinase domain. This domain is responsible for the enzyme's ability to phosphorylate guanosine nucleotides, resulting in the formation of guanosine 5'-triphosphate (GTP). GUK1 is highly expressed in various cell types, including pancreatic acinar cells, secretory cells, mature T cells, and alveolar capillary endothelial cells. Its expression is also observed in retinal rod cells, indicating a potential role in photoreceptor function. **Pathways and Functions:** GUK1 is involved in several metabolic pathways, including: 1. **Nucleotide Metabolism:** GUK1 plays a crucial role in the interconversion of nucleotide di- and triphosphates, which is essential for the synthesis and degradation of nucleotides. 2. **Guanosine Nucleotide Metabolism:** GUK1 phosphorylates guanosine nucleotides, resulting in the formation of GTP, which is a key regulator of various cellular processes, including cell signaling and immune responses. 3. **Photoreceptor Function:** In retinal rod cells, GUK1 is involved in the regulation of phototransduction, a process that converts light into electrical signals. **Clinical Significance:** GUK1 has been implicated in various diseases, including: 1. **Autoimmune Disorders:** GUK1 has been shown to play a role in the regulation of immune responses, and its dysfunction has been linked to autoimmune disorders, such as rheumatoid arthritis and lupus. 2. **Cancer:** GUK1 has been found to be overexpressed in certain types of cancer, including breast and lung cancer, suggesting a potential role in tumorigenesis. 3. **Neurological Disorders:** GUK1 has been implicated in the regulation of neurotransmitter release and synaptic plasticity, and its dysfunction has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, GUK1 is a multifunctional enzyme that plays a crucial role in nucleotide metabolism, immune function, and photoreceptor function. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of GUK1 and its potential therapeutic applications.

Genular Protein ID: 2015647191

Symbol: KGUA_HUMAN

Name: Guanylate kinase

UniProtKB Accession Codes:

Q16774 B1ANH1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 Rhea 1 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8647247

Title: Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation.

PubMed ID: 8647247

DOI: 10.1016/0014-5793(96)00365-1

PubMed ID: 8663313

Title: Cloning, characterization, and modeling of mouse and human guanylate kinases.

PubMed ID: 8663313

DOI: 10.1074/jbc.271.28.16734

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 197968

Title: Reassessment of the interactions of guanylate kinase and 6-thioguanosine 5'-phosphate.

PubMed ID: 197968

DOI: 10.1016/0006-2952(77)90071-5

PubMed ID: 6248551

Title: Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase.

PubMed ID: 6248551

DOI: 10.1016/s0021-9258(20)79686-9

PubMed ID: 6306664

Title: 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication.

PubMed ID: 6306664

DOI: 10.1073/pnas.80.13.4139

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29515371

Title: Control of the Nucleotide Cycle in Photoreceptor Cell Extracts by Retinal Degeneration Protein 3.

PubMed ID: 29515371

DOI: 10.3389/fnmol.2018.00052

PubMed ID: 31201273

Title: Solution structure and functional investigation of human guanylate kinase reveals allosteric networking and a crucial role for the enzyme in cancer.

PubMed ID: 31201273

DOI: 10.1074/jbc.ra119.009251

Sequence Information:

  • Length: 197
  • Mass: 21726
  • Checksum: C49573212A0DA825
  • Sequence:
    • MSGPRPVVLS GPSGAGKSTL LKRLLQEHSG IFGFSVSHTT RNPRPGEENG KDYYFVTREV 
MQRDIAAGDF IEHAEFSGNL YGTSKVAVQA VQAMNRICVL DVDLQGVRNI KATDLRPIYI 
SVQPPSLHVL EQRLRQRNTE TEESLVKRLA AAQADMESSK EPGLFDVVII NDSLDQAYAE 
LKEALSEEIK KAQRTGA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.