Details for: GUK1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 515.0913
Cell Significance Index: -80.1200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 418.7375
Cell Significance Index: -106.2100 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 273.1901
Cell Significance Index: -112.5400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 250.9741
Cell Significance Index: -101.9600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 247.2027
Cell Significance Index: -116.7100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 223.4318
Cell Significance Index: -114.9300 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 174.9123
Cell Significance Index: -117.3700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 107.6730
Cell Significance Index: -102.8000 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 74.2525
Cell Significance Index: -91.5500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 32.2225
Cell Significance Index: -98.9700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 30.7878
Cell Significance Index: -121.4900 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 18.9574
Cell Significance Index: -41.4900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.0726
Cell Significance Index: -45.7400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 5.7946
Cell Significance Index: 270.1700 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 5.2362
Cell Significance Index: 92.5300 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 4.5165
Cell Significance Index: 51.3100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 4.2388
Cell Significance Index: 199.2200 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 3.7250
Cell Significance Index: 109.4000 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 3.7193
Cell Significance Index: 34.2500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.3837
Cell Significance Index: 416.0600 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.9288
Cell Significance Index: 1599.4700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.9216
Cell Significance Index: 526.6800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.8378
Cell Significance Index: 389.7100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.7857
Cell Significance Index: 207.6200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.7838
Cell Significance Index: 146.1600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.3291
Cell Significance Index: 1029.7600 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 2.3263
Cell Significance Index: 19.9900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 2.1682
Cell Significance Index: 136.6600 - Cell Name: lactocyte (CL0002325)
Fold Change: 2.1364
Cell Significance Index: 276.0100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.0107
Cell Significance Index: 54.7300 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1.8402
Cell Significance Index: 11.3300 - Cell Name: peg cell (CL4033014)
Fold Change: 1.7716
Cell Significance Index: 40.9300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.7593
Cell Significance Index: 191.3600 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.6170
Cell Significance Index: 207.2900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.5510
Cell Significance Index: 109.6900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.4138
Cell Significance Index: 166.7400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.3688
Cell Significance Index: 88.3100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.1854
Cell Significance Index: 21.9100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.1067
Cell Significance Index: 222.0000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.0099
Cell Significance Index: 28.9500 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.8910
Cell Significance Index: 23.4300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.6385
Cell Significance Index: 33.2600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6334
Cell Significance Index: 103.0100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.6083
Cell Significance Index: 31.6000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.5442
Cell Significance Index: 14.5300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4921
Cell Significance Index: 444.3100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3861
Cell Significance Index: 10.7900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3663
Cell Significance Index: 72.7000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1677
Cell Significance Index: 60.1600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1445
Cell Significance Index: 109.4100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.1405
Cell Significance Index: 103.0100 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.0588
Cell Significance Index: 1.2300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0286
Cell Significance Index: 53.8000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0117
Cell Significance Index: 0.2000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0424
Cell Significance Index: -4.3300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0526
Cell Significance Index: -8.9800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0674
Cell Significance Index: -124.2100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0743
Cell Significance Index: -114.4300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.0859
Cell Significance Index: -16.3500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0901
Cell Significance Index: -122.4800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0943
Cell Significance Index: -59.9100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1094
Cell Significance Index: -3.8000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1219
Cell Significance Index: -90.3200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.1244
Cell Significance Index: -12.3100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1726
Cell Significance Index: -97.3600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2010
Cell Significance Index: -91.2200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.2197
Cell Significance Index: -137.2200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3202
Cell Significance Index: -92.1300 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.3844
Cell Significance Index: -5.7600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.5169
Cell Significance Index: -75.1400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5514
Cell Significance Index: -63.1700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.5992
Cell Significance Index: -36.8300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6181
Cell Significance Index: -48.9500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.6258
Cell Significance Index: -131.8000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.6329
Cell Significance Index: -73.7600 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.6350
Cell Significance Index: -7.5700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.6393
Cell Significance Index: -17.1000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7699
Cell Significance Index: -24.6600 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.7801
Cell Significance Index: -19.9300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.8856
Cell Significance Index: -59.5500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.1194
Cell Significance Index: -116.5600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -1.2670
Cell Significance Index: -57.4300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.3101
Cell Significance Index: -17.8800 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -1.4002
Cell Significance Index: -8.4600 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -1.4206
Cell Significance Index: -10.9500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.4561
Cell Significance Index: -111.7400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -1.5115
Cell Significance Index: -90.7500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -1.5129
Cell Significance Index: -104.6300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.7379
Cell Significance Index: -106.5500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -1.8487
Cell Significance Index: -53.2700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.8970
Cell Significance Index: -106.4500 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -2.0274
Cell Significance Index: -17.0300 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -2.1585
Cell Significance Index: -36.9900 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -2.2175
Cell Significance Index: -22.9600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -2.2604
Cell Significance Index: -48.9700 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -2.2727
Cell Significance Index: -66.9400 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -2.5123
Cell Significance Index: -43.3100 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -2.5264
Cell Significance Index: -32.3600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -2.5868
Cell Significance Index: -69.3200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -2.6069
Cell Significance Index: -115.3100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2015647191
Symbol: KGUA_HUMAN
Name: Guanylate kinase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8647247
Title: Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation.
PubMed ID: 8647247
PubMed ID: 8663313
Title: Cloning, characterization, and modeling of mouse and human guanylate kinases.
PubMed ID: 8663313
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 197968
Title: Reassessment of the interactions of guanylate kinase and 6-thioguanosine 5'-phosphate.
PubMed ID: 197968
PubMed ID: 6248551
Title: Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase.
PubMed ID: 6248551
PubMed ID: 6306664
Title: 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication.
PubMed ID: 6306664
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 29515371
Title: Control of the Nucleotide Cycle in Photoreceptor Cell Extracts by Retinal Degeneration Protein 3.
PubMed ID: 29515371
PubMed ID: 31201273
Title: Solution structure and functional investigation of human guanylate kinase reveals allosteric networking and a crucial role for the enzyme in cancer.
PubMed ID: 31201273
Sequence Information:
- Length: 197
- Mass: 21726
- Checksum: C49573212A0DA825
- Sequence:
MSGPRPVVLS GPSGAGKSTL LKRLLQEHSG IFGFSVSHTT RNPRPGEENG KDYYFVTREV MQRDIAAGDF IEHAEFSGNL YGTSKVAVQA VQAMNRICVL DVDLQGVRNI KATDLRPIYI SVQPPSLHVL EQRLRQRNTE TEESLVKRLA AAQADMESSK EPGLFDVVII NDSLDQAYAE LKEALSEEIK KAQRTGA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.