Details for: ZNF182

Gene ID: 7569

Symbol: ZNF182

Ensembl ID: ENSG00000147118

Description: zinc finger protein 182

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 47.7032
    Cell Significance Index: -7.4200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 28.0709
    Cell Significance Index: -7.1200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 18.4975
    Cell Significance Index: -7.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 15.9013
    Cell Significance Index: -6.4600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.7348
    Cell Significance Index: -6.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.1316
    Cell Significance Index: -7.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.0125
    Cell Significance Index: -8.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.9310
    Cell Significance Index: -7.6200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.4036
    Cell Significance Index: 23.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2896
    Cell Significance Index: 245.4300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.1560
    Cell Significance Index: -2.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8194
    Cell Significance Index: 81.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6996
    Cell Significance Index: 631.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4990
    Cell Significance Index: 54.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4653
    Cell Significance Index: 75.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4397
    Cell Significance Index: 26.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3219
    Cell Significance Index: 37.5100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.3103
    Cell Significance Index: 4.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2787
    Cell Significance Index: 14.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2734
    Cell Significance Index: 18.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1966
    Cell Significance Index: 4.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1779
    Cell Significance Index: 35.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1599
    Cell Significance Index: 10.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1297
    Cell Significance Index: 1.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1078
    Cell Significance Index: 5.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0971
    Cell Significance Index: 19.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0896
    Cell Significance Index: 4.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0882
    Cell Significance Index: 2.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0748
    Cell Significance Index: 4.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0738
    Cell Significance Index: 13.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0733
    Cell Significance Index: 26.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0693
    Cell Significance Index: 9.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0688
    Cell Significance Index: 1.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0680
    Cell Significance Index: 4.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0586
    Cell Significance Index: 32.0300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0583
    Cell Significance Index: 40.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0500
    Cell Significance Index: 7.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0433
    Cell Significance Index: 1.5200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0338
    Cell Significance Index: 1.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0335
    Cell Significance Index: 1.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0310
    Cell Significance Index: 13.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0218
    Cell Significance Index: 2.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0075
    Cell Significance Index: 0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0038
    Cell Significance Index: 7.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0011
    Cell Significance Index: 0.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0011
    Cell Significance Index: 1.9600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0006
    Cell Significance Index: 0.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0004
    Cell Significance Index: 0.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0002
    Cell Significance Index: 0.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0026
    Cell Significance Index: -1.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0028
    Cell Significance Index: -3.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0074
    Cell Significance Index: -3.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0088
    Cell Significance Index: -1.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0088
    Cell Significance Index: -6.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0088
    Cell Significance Index: -6.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0120
    Cell Significance Index: -6.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0120
    Cell Significance Index: -1.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0138
    Cell Significance Index: -8.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0147
    Cell Significance Index: -1.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0170
    Cell Significance Index: -2.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0211
    Cell Significance Index: -2.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0263
    Cell Significance Index: -7.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0338
    Cell Significance Index: -1.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0376
    Cell Significance Index: -0.7800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0385
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0403
    Cell Significance Index: -8.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0446
    Cell Significance Index: -0.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0461
    Cell Significance Index: -2.0400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0554
    Cell Significance Index: -0.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0556
    Cell Significance Index: -7.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0565
    Cell Significance Index: -3.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0566
    Cell Significance Index: -2.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0581
    Cell Significance Index: -1.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0599
    Cell Significance Index: -3.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0607
    Cell Significance Index: -1.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0685
    Cell Significance Index: -2.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0699
    Cell Significance Index: -7.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0745
    Cell Significance Index: -5.5500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0767
    Cell Significance Index: -1.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0832
    Cell Significance Index: -3.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0843
    Cell Significance Index: -6.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0904
    Cell Significance Index: -2.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0981
    Cell Significance Index: -2.5800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1015
    Cell Significance Index: -1.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1151
    Cell Significance Index: -2.9400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1190
    Cell Significance Index: -1.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1191
    Cell Significance Index: -3.1800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1194
    Cell Significance Index: -4.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1409
    Cell Significance Index: -2.7500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1410
    Cell Significance Index: -1.4600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1413
    Cell Significance Index: -3.0000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1434
    Cell Significance Index: -3.0700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1475
    Cell Significance Index: -2.1000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1493
    Cell Significance Index: -4.2600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1523
    Cell Significance Index: -2.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1560
    Cell Significance Index: -2.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1600
    Cell Significance Index: -3.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1604
    Cell Significance Index: -5.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1668
    Cell Significance Index: -5.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger Domain:** ZNF182 possesses a zinc finger domain, a conserved structural motif that enables the protein to bind to DNA and regulate transcription. 2. **Transcriptional Regulation:** ZNF182 acts as a transcription factor, specifically binding to RNA polymerase II cis-regulatory regions to modulate gene expression. 3. **Cell Type-Specific Expression:** ZNF182 is predominantly expressed in cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, germ cells, and intestinal epithelial cells, highlighting its role in neural and epithelial development. 4. **Metal Ion Binding:** ZNF182's zinc finger domain allows it to bind metal ions, which is essential for its DNA-binding activity. **Pathways and Functions:** ZNF182 is involved in various cellular processes, including: 1. **Transcriptional Regulation:** ZNF182 regulates gene expression by binding to RNA polymerase II cis-regulatory regions, influencing the transcription of target genes. 2. **Cellular Differentiation:** ZNF182 plays a crucial role in the development and maintenance of neural and epithelial cells, ensuring proper cellular differentiation and function. 3. **Apoptosis:** ZNF182 may also be involved in regulating apoptosis, a process of programmed cell death, in various cell types. 4. **DNA Damage Response:** ZNF182's metal ion-binding capacity may enable it to participate in the DNA damage response, helping to maintain genomic integrity. **Clinical Significance:** ZNF182's dysregulation has been implicated in various diseases, including: 1. **Neurological Disorders:** Alterations in ZNF182 expression have been linked to neurological disorders, such as Alzheimer's disease, Parkinson's disease, and schizophrenia. 2. **Cancer:** ZNF182's role in regulating cell growth and differentiation makes it a potential target for cancer therapy. 3. **Gastrointestinal Diseases:** Abnormalities in ZNF182 expression have been associated with gastrointestinal diseases, such as colorectal cancer and inflammatory bowel disease. 4. **Neurodevelopmental Disorders:** ZNF182's involvement in neural development suggests its potential role in neurodevelopmental disorders, such as autism spectrum disorder. In conclusion, ZNF182 is a multifunctional transcription factor that plays a crucial role in regulating gene expression in various cellular contexts. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying ZNF182's functions and its potential as a therapeutic target.

Genular Protein ID: 1650029815

Symbol: ZN182_HUMAN

Name: Zinc finger protein 182

UniProtKB Accession Codes:

P17025 A2IDD7 Q3KP67 Q96QH7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

PubMed ID: 23647072

Title: Exome sequencing reveals new causal mutations in children with epileptic encephalopathies.

PubMed ID: 23647072

DOI: 10.1111/epi.12201

Sequence Information:

  • Length: 639
  • Mass: 73646
  • Checksum: 6976EB14399390A5
  • Sequence:
    • MTPASASGED SGSFYSWQKA KREQGLVTFE DVAVDFTQEE WQYLNPPQRT LYRDVMLETY 
SNLVFVGQQV TKPNLILKLE VEECPAEGKI PFWNFPEVCQ VDEQIERQHQ DDQDKCLLMQ 
VGFSDKKTII TKSARDCHEF GNILHLSTNL VASIQRPDKH ESFGNNMVDN LDLFSRSSAE 
NKYDNGCAKL FFHTEYEKTN PGMKPYGYKE CGKGLRRKKG LSLHQRIKNG EKPFECTACR 
KTFSKKSHLI VHWRTHTGEK PFGCTECGKA FSQKSQLIIH LRTHTGERPF ECPECGKAFR 
EKSTVIIHYR THTGEKPYEC NECGKAFTQK SNLIVHQKTH TGEKTYECTK CGESFIQKLD 
LIIHHSTHTG KKPHECNECK KTFSDKSTLI IHQRTHTGEK PHKCTECGKS FNEKSTLIVH 
QRTHTGEKPY ECDVCGKTFT QKSNLGVHQR THSGEKPFEC NECEKAFSQK SYLMLHQRGH 
TGEKPYECNE CEKAFSQKSY LIIHQRTHTE EKPYKCNECG KAFREKSKLI IHQRIHTGEK 
PYECPVCWKA FSQKSQLIIH QRTHTGEKPY ACTECGKAFR EKSTFTVHQR THTGEKPYKC 
TECGKAFTQK SNLIVHQRTH AGKKAHGRGH TRKSKFMAH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.