Details for: NDUFB2

Gene ID: 4708

Symbol: NDUFB2

Ensembl ID: ENSG00000090266

Description: NADH:ubiquinone oxidoreductase subunit B2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 663.0547
    Cell Significance Index: -103.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 385.7384
    Cell Significance Index: -97.8400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 284.5265
    Cell Significance Index: -117.2100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 253.1648
    Cell Significance Index: -102.8500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 240.9755
    Cell Significance Index: -113.7700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 220.8073
    Cell Significance Index: -113.5800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 170.4415
    Cell Significance Index: -114.3700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 109.2545
    Cell Significance Index: -104.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 91.7794
    Cell Significance Index: -113.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 29.7741
    Cell Significance Index: -117.4900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 28.9016
    Cell Significance Index: -88.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 26.6755
    Cell Significance Index: -71.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.5993
    Cell Significance Index: 214.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.2715
    Cell Significance Index: 224.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.5990
    Cell Significance Index: 83.1500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.3879
    Cell Significance Index: 27.0500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.3778
    Cell Significance Index: 31.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.2082
    Cell Significance Index: 150.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.0256
    Cell Significance Index: 545.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.7777
    Cell Significance Index: 1516.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.7292
    Cell Significance Index: 335.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.6617
    Cell Significance Index: 72.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.5521
    Cell Significance Index: 300.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.4927
    Cell Significance Index: 342.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.4548
    Cell Significance Index: 64.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.4055
    Cell Significance Index: 179.2800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.1416
    Cell Significance Index: 24.3300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.1199
    Cell Significance Index: 62.2600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.0099
    Cell Significance Index: 42.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.8134
    Cell Significance Index: 234.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5638
    Cell Significance Index: 70.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.5387
    Cell Significance Index: 680.2800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.4695
    Cell Significance Index: 27.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4297
    Cell Significance Index: 74.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2893
    Cell Significance Index: 165.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1917
    Cell Significance Index: 84.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1465
    Cell Significance Index: 73.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0335
    Cell Significance Index: 65.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9553
    Cell Significance Index: 155.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7917
    Cell Significance Index: 21.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6833
    Cell Significance Index: 35.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6820
    Cell Significance Index: 116.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6517
    Cell Significance Index: 64.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6210
    Cell Significance Index: 124.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.5902
    Cell Significance Index: 432.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4362
    Cell Significance Index: 86.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4037
    Cell Significance Index: 14.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3568
    Cell Significance Index: 270.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2891
    Cell Significance Index: 55.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.2840
    Cell Significance Index: 22.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1821
    Cell Significance Index: 6.4000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1348
    Cell Significance Index: 2.0200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.1341
    Cell Significance Index: 0.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1155
    Cell Significance Index: 41.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0364
    Cell Significance Index: 0.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0222
    Cell Significance Index: -41.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0295
    Cell Significance Index: -21.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0296
    Cell Significance Index: -3.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0544
    Cell Significance Index: -100.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0574
    Cell Significance Index: -35.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0680
    Cell Significance Index: -104.6800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0950
    Cell Significance Index: -129.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1081
    Cell Significance Index: -68.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1295
    Cell Significance Index: -73.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1612
    Cell Significance Index: -73.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1833
    Cell Significance Index: -5.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2099
    Cell Significance Index: -44.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2181
    Cell Significance Index: -6.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2680
    Cell Significance Index: -30.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3402
    Cell Significance Index: -97.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4891
    Cell Significance Index: -14.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5139
    Cell Significance Index: -59.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5512
    Cell Significance Index: -33.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5693
    Cell Significance Index: -82.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6956
    Cell Significance Index: -17.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7298
    Cell Significance Index: -15.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8348
    Cell Significance Index: -64.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.9024
    Cell Significance Index: -103.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.9069
    Cell Significance Index: -25.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9697
    Cell Significance Index: -13.2300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -1.1022
    Cell Significance Index: -16.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1182
    Cell Significance Index: -116.4300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.1396
    Cell Significance Index: -14.6000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.2362
    Cell Significance Index: -21.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.3068
    Cell Significance Index: -90.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.3151
    Cell Significance Index: -73.8000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.3733
    Cell Significance Index: -16.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.4237
    Cell Significance Index: -30.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.5232
    Cell Significance Index: -102.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.7667
    Cell Significance Index: -47.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7681
    Cell Significance Index: -108.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.9791
    Cell Significance Index: -87.5400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.1036
    Cell Significance Index: -61.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.2101
    Cell Significance Index: -59.1200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.2774
    Cell Significance Index: -19.1300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -2.2903
    Cell Significance Index: -47.7700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.4146
    Cell Significance Index: -41.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.4221
    Cell Significance Index: -91.7200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -2.4468
    Cell Significance Index: -26.6000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -2.4956
    Cell Significance Index: -34.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NDUFB2 is a mitochondrial protein that belongs to the NADH dehydrogenase (ubiquinone) complex, also known as Complex I. This complex is the first enzyme in the mitochondrial electron transport chain, responsible for the transfer of electrons from NADH to ubiquinone. NDUFB2 is a beta subunit of this complex, and its expression is highly regulated in various tissues, including the thyroid, kidney, and brain. **Pathways and Functions:** NDUFB2 is integral to several key pathways involved in energy metabolism, including: 1. **Aerobic Respiration:** NDUFB2 plays a crucial role in the electron transport chain, generating ATP through the process of chemiosmosis. 2. **Mitochondrial Electron Transport:** This complex is responsible for the transfer of electrons from NADH to ubiquinone, producing a proton motive force that drives ATP synthesis. 3. **NADH to Ubiquinone:** NDUFB2 facilitates the transfer of electrons from NADH to ubiquinone, which is essential for the production of ATP. 4. **Heat Production by Uncoupling Proteins:** NDUFB2 is also involved in the production of heat by uncoupling proteins, which are proteins that dissipate the proton motive force generated by the electron transport chain. **Clinical Significance:** Dysregulation of NDUFB2 has been implicated in various diseases, including: 1. **Mitochondrial Myopathies:** Mutations in the NDUFB2 gene have been linked to mitochondrial myopathies, a group of disorders characterized by muscle weakness and fatigue. 2. **Neurodegenerative Diseases:** Altered expression of NDUFB2 has been observed in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. 3. **Cancer:** NDUFB2 has been shown to be overexpressed in certain types of cancer, including breast and lung cancer. 4. **Thyroid Disease:** NDUFB2 has been implicated in thyroid disease, including hypothyroidism and hyperthyroidism. In conclusion, NDUFB2 is a critical component of the mitochondrial electron transport chain, playing a vital role in energy metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in human health and disease. Further research is needed to fully understand the mechanisms by which NDUFB2 regulates energy metabolism and to develop therapeutic strategies for the treatment of related diseases.

Genular Protein ID: 1387562679

Symbol: NDUB2_HUMAN

Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial

UniProtKB Accession Codes:

O95178 Q6FGI6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 4 Ensembl 3 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9878551

Title: cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed.

PubMed ID: 9878551

DOI: 10.1006/bbrc.1998.9786

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 12611891

Title: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.

PubMed ID: 12611891

DOI: 10.1074/jbc.c300064200

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27626371

Title: Accessory subunits are integral for assembly and function of human mitochondrial complex I.

PubMed ID: 27626371

DOI: 10.1038/nature19754

Sequence Information:

  • Length: 105
  • Mass: 12058
  • Checksum: 5698368608CDC16F
  • Sequence:
    • MSALTRLASF ARVGGRLFRS GCARTAGDGG VRHAGGGVHI EPRYRQFPQL TRSQVFQSEF 
FSGLMWFWIL WRFWHDSEEV LGHFPYPDPS QWTDEELGIP PDDED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.