Details for: NDUFB2

Gene ID: 4708

Symbol: NDUFB2

Ensembl ID: ENSG00000090266

Description: NADH:ubiquinone oxidoreductase subunit B2

Associated with

  • Complex i biogenesis
    (R-HSA-6799198)
  • Metabolism
    (R-HSA-1430728)
  • Respiratory electron transport
    (R-HSA-611105)
  • Respiratory electron transport, atp synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    (R-HSA-163200)
  • The citric acid (tca) cycle and respiratory electron transport
    (R-HSA-1428517)
  • Aerobic respiration
    (GO:0009060)
  • Mitochondrial electron transport, nadh to ubiquinone
    (GO:0006120)
  • Mitochondrial inner membrane
    (GO:0005743)
  • Mitochondrial respiratory chain complex i
    (GO:0005747)
  • Mitochondrial respiratory chain complex i assembly
    (GO:0032981)
  • Nadh dehydrogenase (ubiquinone) activity
    (GO:0008137)
  • Proton motive force-driven mitochondrial atp synthesis
    (GO:0042776)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.6
    Marker Score: 3600
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.94
    Marker Score: 2103
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.83
    Marker Score: 10261
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.55
    Marker Score: 8959
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.52
    Marker Score: 12503
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.42
    Marker Score: 6236
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.39
    Marker Score: 5620
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 3.29
    Marker Score: 44167
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.28
    Marker Score: 9071
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.25
    Marker Score: 1197
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.22
    Marker Score: 4193
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.17
    Marker Score: 4882
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.15
    Marker Score: 36560.5
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.13
    Marker Score: 16428
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.11
    Marker Score: 30836
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.08
    Marker Score: 3725.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.08
    Marker Score: 2745
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.06
    Marker Score: 170934
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.04
    Marker Score: 1001
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.04
    Marker Score: 9543
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.04
    Marker Score: 3166.5
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.02
    Marker Score: 2845
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3
    Marker Score: 19109
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.99
    Marker Score: 19521
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.99
    Marker Score: 3168
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.98
    Marker Score: 22154
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.96
    Marker Score: 25752
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.96
    Marker Score: 23093
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.95
    Marker Score: 1178
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.95
    Marker Score: 7206
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.92
    Marker Score: 6658
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.92
    Marker Score: 2958
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.91
    Marker Score: 3516
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.91
    Marker Score: 4119
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.89
    Marker Score: 3306
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.88
    Marker Score: 2050
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.88
    Marker Score: 992
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.87
    Marker Score: 99434
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.86
    Marker Score: 8163
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.85
    Marker Score: 4530
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.82
    Marker Score: 37253
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.82
    Marker Score: 2224
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.81
    Marker Score: 4510
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.79
    Marker Score: 6341
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.79
    Marker Score: 13388
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.77
    Marker Score: 5403
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.76
    Marker Score: 8065
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.76
    Marker Score: 5182
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.72
    Marker Score: 3273
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.7
    Marker Score: 69270
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.7
    Marker Score: 5489
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.69
    Marker Score: 1393
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.68
    Marker Score: 8451
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.68
    Marker Score: 11544
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.65
    Marker Score: 633
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.64
    Marker Score: 1768
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.64
    Marker Score: 1359.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.63
    Marker Score: 10153
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.62
    Marker Score: 29520
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.59
    Marker Score: 1229
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.58
    Marker Score: 2474
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.57
    Marker Score: 2749
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.57
    Marker Score: 16727
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.55
    Marker Score: 2554
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.55
    Marker Score: 3510
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.55
    Marker Score: 2977
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 2.55
    Marker Score: 1058
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.55
    Marker Score: 5321
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.54
    Marker Score: 21894
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.53
    Marker Score: 1843
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.51
    Marker Score: 4377
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 2.51
    Marker Score: 2085
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.5
    Marker Score: 3541
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.49
    Marker Score: 2411
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.47
    Marker Score: 3638
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.47
    Marker Score: 2745
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.46
    Marker Score: 15745
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 2.46
    Marker Score: 899
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.46
    Marker Score: 14580
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.45
    Marker Score: 1848
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.44
    Marker Score: 7253
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.44
    Marker Score: 3767
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.44
    Marker Score: 2741
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.43
    Marker Score: 723
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.42
    Marker Score: 1090.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.42
    Marker Score: 1131
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.42
    Marker Score: 4835
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.41
    Marker Score: 1583
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.4
    Marker Score: 635
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.38
    Marker Score: 755
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.38
    Marker Score: 1586.5
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.38
    Marker Score: 616
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.37
    Marker Score: 4029
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.36
    Marker Score: 6122
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.36
    Marker Score: 2115
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.36
    Marker Score: 1072
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 2.35
    Marker Score: 753
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.35
    Marker Score: 5538
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.35
    Marker Score: 2211
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.35
    Marker Score: 1475

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Other Information

**Key characteristics:** - NDUFB2 is a large protein (880 amino acids) that is present in the mitochondrial inner membrane. - It is a member of the NADH:ubiquinone oxidoreductase family of enzymes. - It is involved in the transfer of electrons from NADH to the coenzyme Q. - It is a key enzyme in the citric acid cycle, where it catalyzes the transfer of electrons from NADH to oxaloacetate. - It is also involved in the respiratory electron transport chain, where it transfers electrons to the electron carrier complex Q. **Pathways and functions:** - NDUFB2 is involved in aerobic respiration, the citric acid (tca) cycle, and respiratory electron transport. - It is a key enzyme in the citric acid cycle, where it is responsible for the transfer of electrons from NADH to oxaloacetate. - It is also involved in the respiratory electron transport chain, where it transfers electrons to the electron carrier complex Q. - It is also involved in the production of ATP through oxidative phosphorylation. **Clinical significance:** - Mutations in NDUFB2 have been linked to several human diseases, including mitochondrial disorders and cancer. - These mutations can disrupt the function of the NDUFB2 protein, leading to the accumulation of NADH and the production of reactive oxygen species, which can damage cells and tissues. - Understanding the role of NDUFB2 in human health and disease is important for the development of new therapeutic strategies for these conditions.

Genular Protein ID: 1387562679

Symbol: NDUB2_HUMAN

Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial

UniProtKB Accession Codes:

O95178 Q6FGI6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 4 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9878551

Title: cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed.

PubMed ID: 9878551

DOI: 10.1006/bbrc.1998.9786

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 12611891

Title: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.

PubMed ID: 12611891

DOI: 10.1074/jbc.c300064200

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27626371

Title: Accessory subunits are integral for assembly and function of human mitochondrial complex I.

PubMed ID: 27626371

DOI: 10.1038/nature19754

Sequence Information:

  • Length: 105
  • Mass: 12058
  • Checksum: 5698368608CDC16F
  • Sequence:
    • MSALTRLASF ARVGGRLFRS GCARTAGDGG VRHAGGGVHI EPRYRQFPQL TRSQVFQSEF 
FSGLMWFWIL WRFWHDSEEV LGHFPYPDPS QWTDEELGIP PDDED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.