Details for: VPS28

Gene ID: 51160

Symbol: VPS28

Ensembl ID: ENSG00000160948

Description: VPS28 subunit of ESCRT-I

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 429.4249
    Cell Significance Index: -66.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 240.3769
    Cell Significance Index: -60.9700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 200.1954
    Cell Significance Index: -82.4700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 181.3384
    Cell Significance Index: -73.6700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 181.0123
    Cell Significance Index: -85.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 160.1523
    Cell Significance Index: -82.3800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 128.1776
    Cell Significance Index: -86.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 78.2410
    Cell Significance Index: -74.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 58.6517
    Cell Significance Index: -72.3200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.2194
    Cell Significance Index: -54.1700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.0390
    Cell Significance Index: -79.0800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.7598
    Cell Significance Index: -57.6200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.3753
    Cell Significance Index: -18.3300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 7.6395
    Cell Significance Index: 64.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 6.5059
    Cell Significance Index: 758.1900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.5484
    Cell Significance Index: 81.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.3251
    Cell Significance Index: 155.0300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.6221
    Cell Significance Index: 33.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.5954
    Cell Significance Index: 356.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.4365
    Cell Significance Index: 51.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.2417
    Cell Significance Index: 404.1100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.2158
    Cell Significance Index: 20.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.0249
    Cell Significance Index: 1105.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.0158
    Cell Significance Index: 130.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.0040
    Cell Significance Index: 246.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.9790
    Cell Significance Index: 93.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.9616
    Cell Significance Index: 51.5800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.8881
    Cell Significance Index: 21.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8132
    Cell Significance Index: 94.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.6635
    Cell Significance Index: 213.2600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.6351
    Cell Significance Index: 48.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5216
    Cell Significance Index: 113.4000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.4942
    Cell Significance Index: 11.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.4131
    Cell Significance Index: 624.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.3741
    Cell Significance Index: 47.7500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3410
    Cell Significance Index: 36.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2275
    Cell Significance Index: 64.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1968
    Cell Significance Index: 84.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1598
    Cell Significance Index: 136.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1335
    Cell Significance Index: 20.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1314
    Cell Significance Index: 111.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1221
    Cell Significance Index: 24.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1047
    Cell Significance Index: 142.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8662
    Cell Significance Index: 45.1200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7322
    Cell Significance Index: 7.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5363
    Cell Significance Index: 91.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5324
    Cell Significance Index: 106.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5146
    Cell Significance Index: 102.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4677
    Cell Significance Index: 13.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2275
    Cell Significance Index: 81.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2093
    Cell Significance Index: 13.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1772
    Cell Significance Index: 33.7200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1248
    Cell Significance Index: 2.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1000
    Cell Significance Index: 5.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0849
    Cell Significance Index: 62.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0698
    Cell Significance Index: 52.8400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0593
    Cell Significance Index: 41.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0532
    Cell Significance Index: 0.8900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0407
    Cell Significance Index: 0.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0066
    Cell Significance Index: 0.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0049
    Cell Significance Index: 0.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0042
    Cell Significance Index: 0.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0065
    Cell Significance Index: -0.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0073
    Cell Significance Index: -13.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0120
    Cell Significance Index: -0.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0352
    Cell Significance Index: -64.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0429
    Cell Significance Index: -65.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0582
    Cell Significance Index: -79.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0816
    Cell Significance Index: -51.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0872
    Cell Significance Index: -64.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1263
    Cell Significance Index: -71.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1329
    Cell Significance Index: -15.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1349
    Cell Significance Index: -4.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1423
    Cell Significance Index: -64.6100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1508
    Cell Significance Index: -2.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1682
    Cell Significance Index: -105.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1988
    Cell Significance Index: -8.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2872
    Cell Significance Index: -82.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3729
    Cell Significance Index: -54.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4071
    Cell Significance Index: -28.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4172
    Cell Significance Index: -87.8800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5069
    Cell Significance Index: -12.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5742
    Cell Significance Index: -45.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5920
    Cell Significance Index: -35.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6961
    Cell Significance Index: -53.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7506
    Cell Significance Index: -78.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7877
    Cell Significance Index: -44.2000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8143
    Cell Significance Index: -8.4300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.1471
    Cell Significance Index: -16.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.1478
    Cell Significance Index: -15.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.2646
    Cell Significance Index: -27.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.2669
    Cell Significance Index: -31.6700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.3570
    Cell Significance Index: -23.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3588
    Cell Significance Index: -83.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.4086
    Cell Significance Index: -37.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.4677
    Cell Significance Index: -43.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.5952
    Cell Significance Index: -70.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.7530
    Cell Significance Index: -61.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.7557
    Cell Significance Index: -50.5900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -1.7657
    Cell Significance Index: -18.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** VPS28 is a subunit of the ESCRT-I complex, which is composed of four subunits: VPS4, VPS2, VPS6, and VPS28. The ESCRT-I complex is responsible for the formation and maturation of multivesicular bodies (MVBs), which are essential for the sorting of proteins and lipids within the cell. VPS28 has been shown to interact with other ESCRT proteins and is essential for the formation of the ESCRT-I complex. Additionally, VPS28 has been found to play a role in the regulation of protein ubiquitination and the negative regulation of protein catabolic processes. **Pathways and Functions** The ESCRT pathway is a complex process that involves the coordinated action of multiple proteins and cellular compartments. The ESCRT-I complex plays a crucial role in the formation of MVBs, which are involved in the sorting of proteins and lipids within the cell. VPS28 has been shown to interact with other ESCRT proteins and is essential for the formation of the ESCRT-I complex. The ESCRT-I complex is involved in various cellular processes, including: * Autophagy: The ESCRT-I complex is involved in the formation of autophagosomes, which are double-membraned vesicles that engulf and degrade cellular components. * Endosomal sorting: The ESCRT-I complex is responsible for the sorting of proteins and lipids within the endosome. * Viral budding: The ESCRT-I complex is involved in the formation of viral particles, including HIV. * Membrane trafficking: The ESCRT-I complex is involved in the transport of proteins and lipids across the cell membrane. **Clinical Significance** VPS28 has been implicated in various diseases, including HIV infection. Research has shown that VPS28 is highly expressed in HIV-infected cells, suggesting its potential role in the assembly and maturation of the viral particle. The ESCRT-I complex has been shown to play a crucial role in the formation of MVBs, which are involved in the sorting of proteins and lipids within the cell. Disruption of the ESCRT pathway has been shown to have a significant impact on HIV replication and pathogenesis. In addition to its role in HIV infection, VPS28 has been implicated in other diseases, including cancer and neurodegenerative disorders. Research has shown that VPS28 is involved in the regulation of protein ubiquitination and the negative regulation of protein catabolic processes. Disruption of the ESCRT pathway has been shown to have a significant impact on cellular homeostasis and the development of disease. In conclusion, VPS28 is a crucial component of the ESCRT-I complex, which plays a key role in various cellular processes, including autophagy, endosomal sorting, and viral budding. The ESCRT-I complex has been implicated in various diseases, including HIV infection, cancer, and neurodegenerative disorders. Further research is needed to fully understand the role of VPS28 in immune response and HIV life cycle, as well as its potential therapeutic applications.

Genular Protein ID: 2440950023

Symbol: VPS28_HUMAN

Name: Vacuolar protein sorting-associated protein 28 homolog

UniProtKB Accession Codes:

Q9UK41 Q86VK0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 12 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 8 ExpressionAtlas 1 GO 20 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11916981

Title: Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates.

PubMed ID: 11916981

DOI: 10.1083/jcb.200112080

PubMed ID: 14505570

Title: The protein network of HIV budding.

PubMed ID: 14505570

DOI: 10.1016/s0092-8674(03)00714-1

PubMed ID: 15218037

Title: The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding.

PubMed ID: 15218037

DOI: 10.1074/jbc.m405226200

PubMed ID: 18005716

Title: Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding.

PubMed ID: 18005716

DOI: 10.1016/j.chom.2007.06.003

PubMed ID: 17853893

Title: Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.

PubMed ID: 17853893

DOI: 10.1038/sj.emboj.7601850

PubMed ID: 18539118

Title: Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex.

PubMed ID: 18539118

DOI: 10.1016/j.devcel.2008.04.004

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21757351

Title: UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting.

PubMed ID: 21757351

DOI: 10.1016/j.cub.2011.06.028

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30929741

Title: Truncating mutations in UBAP1 cause hereditary spastic paraplegia.

PubMed ID: 30929741

DOI: 10.1016/j.ajhg.2019.03.001

Sequence Information:

  • Length: 221
  • Mass: 25425
  • Checksum: B2E1697B82D02AB8
  • Sequence:
    • MFHGIPATPG IGAPGNKPEL YEEVKLYKNA REREKYDNMA ELFAVVKTMQ ALEKAYIKDC 
VSPSEYTAAC SRLLVQYKAA FRQVQGSEIS SIDEFCRKFR LDCPLAMERI KEDRPITIKD 
DKGNLNRCIA DVVSLFITVM DKLRLEIRAM DEIQPDLREL METMHRMSHL PPDFEGRQTV 
SQWLQTLSGM SASDELDDSQ VRQMLFDLES AYNAFNRFLH A

Genular Protein ID: 2969835868

Symbol: A0A0S2Z5H5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z5H5

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SUPFAM 2

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 204
  • Mass: 23482
  • Checksum: 2489F07B32CE7E01
  • Sequence:
    • MFHGIPATPG IGAPGNKPEL YEEVKLYKNA REREKYDNMA ELFAVVKTMQ ALEKAYIKDC 
VSPSEQVQGS EISSIDEFCR KFRLDCPLAM ERIKEDRPIT IKDDKGNLNR CIADVVSLFI 
TVMDKLRLEI RAMDEIQPDL RELMETMHRM SHLPPDFEGR QTVSQWLQTL SGMSASDELD 
DSQVRQMLFD LESAYNAFNR FLHA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.