Details for: ELAVL2

Gene ID: 1993

Symbol: ELAVL2

Ensembl ID: ENSG00000107105

Description: ELAV like RNA binding protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 176.5077
    Cell Significance Index: -44.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.3557
    Cell Significance Index: -44.8100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 4.0417
    Cell Significance Index: 96.9300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 3.2928
    Cell Significance Index: 34.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.0195
    Cell Significance Index: 1083.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.8668
    Cell Significance Index: 176.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9280
    Cell Significance Index: 386.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9196
    Cell Significance Index: 26.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.6972
    Cell Significance Index: 1173.8300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.9762
    Cell Significance Index: 12.6600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.9619
    Cell Significance Index: 7.9400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.7385
    Cell Significance Index: 16.1700
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.5854
    Cell Significance Index: 4.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3390
    Cell Significance Index: 7.3500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.3168
    Cell Significance Index: 3.9500
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.2937
    Cell Significance Index: 0.3800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.2923
    Cell Significance Index: 5.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2845
    Cell Significance Index: 28.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2165
    Cell Significance Index: 12.1500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2138
    Cell Significance Index: 6.1000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2031
    Cell Significance Index: 3.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1824
    Cell Significance Index: 29.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1466
    Cell Significance Index: 64.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0826
    Cell Significance Index: 3.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0441
    Cell Significance Index: 39.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0155
    Cell Significance Index: 2.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0154
    Cell Significance Index: -1.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0190
    Cell Significance Index: -35.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0219
    Cell Significance Index: -41.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0269
    Cell Significance Index: -41.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0324
    Cell Significance Index: -1.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0336
    Cell Significance Index: -45.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0347
    Cell Significance Index: -25.7400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0396
    Cell Significance Index: -0.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0443
    Cell Significance Index: -32.4800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0444
    Cell Significance Index: -0.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0504
    Cell Significance Index: -31.9900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0510
    Cell Significance Index: -0.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0581
    Cell Significance Index: -43.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0646
    Cell Significance Index: -36.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0670
    Cell Significance Index: -6.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0673
    Cell Significance Index: -1.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0720
    Cell Significance Index: -44.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0776
    Cell Significance Index: -35.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0817
    Cell Significance Index: -44.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0823
    Cell Significance Index: -2.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0879
    Cell Significance Index: -6.2200
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0886
    Cell Significance Index: -0.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1074
    Cell Significance Index: -30.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1140
    Cell Significance Index: -2.3700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1142
    Cell Significance Index: -1.6000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1299
    Cell Significance Index: -1.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1328
    Cell Significance Index: -8.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1456
    Cell Significance Index: -26.2400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1685
    Cell Significance Index: -1.0000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1823
    Cell Significance Index: -2.3000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1899
    Cell Significance Index: -1.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1972
    Cell Significance Index: -41.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2055
    Cell Significance Index: -26.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2142
    Cell Significance Index: -42.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2159
    Cell Significance Index: -31.3900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2203
    Cell Significance Index: -2.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2242
    Cell Significance Index: -27.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2380
    Cell Significance Index: -40.6500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2389
    Cell Significance Index: -7.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2768
    Cell Significance Index: -16.6200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2860
    Cell Significance Index: -3.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2873
    Cell Significance Index: -37.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.3235
    Cell Significance Index: -44.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3371
    Cell Significance Index: -39.2900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.3581
    Cell Significance Index: -2.3300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3786
    Cell Significance Index: -7.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3964
    Cell Significance Index: -45.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4023
    Cell Significance Index: -21.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4186
    Cell Significance Index: -33.1600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4206
    Cell Significance Index: -2.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4439
    Cell Significance Index: -46.2200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4711
    Cell Significance Index: -15.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4714
    Cell Significance Index: -10.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4895
    Cell Significance Index: -36.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4930
    Cell Significance Index: -34.1000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4990
    Cell Significance Index: -10.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5467
    Cell Significance Index: -36.7600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.5659
    Cell Significance Index: -8.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5834
    Cell Significance Index: -36.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6002
    Cell Significance Index: -46.0600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.6059
    Cell Significance Index: -6.0000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.6465
    Cell Significance Index: -9.1900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.6595
    Cell Significance Index: -13.7700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6619
    Cell Significance Index: -23.0000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6663
    Cell Significance Index: -7.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6690
    Cell Significance Index: -31.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6711
    Cell Significance Index: -23.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6848
    Cell Significance Index: -35.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7106
    Cell Significance Index: -22.7600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.7319
    Cell Significance Index: -31.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7768
    Cell Significance Index: -36.5100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.7911
    Cell Significance Index: -15.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8458
    Cell Significance Index: -21.7400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.8770
    Cell Significance Index: -21.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ELAVL2 is a 95-kDa RNA-binding protein that belongs to the ELAV family of proteins. It is primarily expressed in neurons, particularly in interneurons, and has been implicated in the regulation of gene expression, mRNA stability, and translation. ELAVL2 is known to interact with specific RNA sequences, including 3'-untranslated regions (3'-UTRs), and has been shown to regulate the translation of target mRNAs. The protein is also involved in the regulation of DNA-templated transcription, ribonucleoprotein complex formation, and RNA binding. **Pathways and Functions:** ELAVL2 is involved in several key pathways, including: 1. **mRNA stability and translation**: ELAVL2 regulates the stability and translation of target mRNAs by binding to specific sequences in the 3'-UTR. 2. **DNA-templated transcription**: ELAVL2 interacts with general transcription factors and regulates the transcription of target genes. 3. **Ribonucleoprotein complex formation**: ELAVL2 is involved in the formation of ribonucleoprotein complexes, which are essential for RNA processing and translation. 4. **RNA binding**: ELAVL2 binds to specific RNA sequences, including microRNAs and other RNAs, and regulates their expression. **Clinical Significance:** ELAVL2 has been implicated in various neurological and immunological diseases, including: 1. **Neurological disorders**: ELAVL2 has been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Immune system dysregulation**: ELAVL2 has been implicated in immune system dysregulation, including autoimmune diseases and cancer. 3. **Neurodevelopmental disorders**: ELAVL2 has been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 4. **Cancer**: ELAVL2 has been implicated in cancer development and progression, particularly in glioblastoma and other brain tumors. In conclusion, ELAVL2 is a critical RNA-binding protein that plays a pivotal role in various cellular processes, including mRNA stability, translation, and regulation of gene expression. Its dysregulation has been implicated in various neurological and immunological diseases, highlighting the importance of further research into the role of ELAVL2 in human health and disease.

Genular Protein ID: 3291752358

Symbol: ELAV2_HUMAN

Name: ELAV-like protein 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8158249

Title: Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor.

PubMed ID: 8158249

DOI: 10.1523/jneurosci.14-04-01943.1994

PubMed ID: 7972035

Title: Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1.

PubMed ID: 7972035

DOI: 10.1073/pnas.91.23.11207

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

Sequence Information:

  • Length: 359
  • Mass: 39504
  • Checksum: 15E87088FC546DDC
  • Sequence:
  • METQLSNGPT CNNTANGPTT INNNCSSPVD SGNTEDSKTN LIVNYLPQNM TQEELKSLFG 
    SIGEIESCKL VRDKITGQSL GYGFVNYIDP KDAEKAINTL NGLRLQTKTI KVSYARPSSA 
    SIRDANLYVS GLPKTMTQKE LEQLFSQYGR IITSRILVDQ VTGISRGVGF IRFDKRIEAE 
    EAIKGLNGQK PPGATEPITV KFANNPSQKT NQAILSQLYQ SPNRRYPGPL AQQAQRFRLD 
    NLLNMAYGVK RFSPMTIDGM TSLAGINIPG HPGTGWCIFV YNLAPDADES ILWQMFGPFG 
    AVTNVKVIRD FNTNKCKGFG FVTMTNYDEA AMAIASLNGY RLGDRVLQVS FKTNKTHKA

Genular Protein ID: 2896271893

Symbol: A0A0A0MRX1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

Sequence Information:

  • Length: 389
  • Mass: 42633
  • Checksum: 6B596BC62495B2BF
  • Sequence:
  • MAVRLCDVAS LLRSGSWAAE PWTGQVIAAM ETQLSNGPTC NNTANGPTTI NNNCSSPVDS 
    GNTEDSKTNL IVNYLPQNMT QEELKSLFGS IGEIESCKLV RDKITGQSLG YGFVNYIDPK 
    DAEKAINTLN GLRLQTKTIK VSYARPSSAS IRDANLYVSG LPKTMTQKEL EQLFSQYGRI 
    ITSRILVDQV TGISRGVGFI RFDKRIEAEE AIKGLNGQKP PGATEPITVK FANNPSQKTN 
    QAILSQLYQS PNRRYPGPLA QQAQRFRLDN LLNMAYGVKS RFSPMTIDGM TSLAGINIPG 
    HPGTGWCIFV YNLAPDADES ILWQMFGPFG AVTNVKVIRD FNTNKCKGFG FVTMTNYDEA 
    AMAIASLNGY RLGDRVLQVS FKTNKTHKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.