Details for: ELAVL2

Gene ID: 1993

Symbol: ELAVL2

Ensembl ID: ENSG00000107105

Description: ELAV like RNA binding protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 3.89
    Marker Score: 20433
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 3.45
    Marker Score: 4852
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.13
    Marker Score: 14470
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.67
    Marker Score: 53139
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.49
    Marker Score: 19079
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.32
    Marker Score: 85616
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.26
    Marker Score: 946
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.21
    Marker Score: 8547
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.16
    Marker Score: 16285
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.13
    Marker Score: 31778
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.1
    Marker Score: 8726
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.09
    Marker Score: 8508
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.03
    Marker Score: 20974
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.94
    Marker Score: 4458
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.94
    Marker Score: 119183
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.93
    Marker Score: 6462
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.84
    Marker Score: 531
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.83
    Marker Score: 69458
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.82
    Marker Score: 449
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.75
    Marker Score: 2189
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.69
    Marker Score: 948
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.69
    Marker Score: 2426
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.68
    Marker Score: 56867
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.68
    Marker Score: 14388
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.66
    Marker Score: 454
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.65
    Marker Score: 6882
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.64
    Marker Score: 788
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.61
    Marker Score: 933
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.54
    Marker Score: 2379
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.46
    Marker Score: 1826.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.35
    Marker Score: 520
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.35
    Marker Score: 12816
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.34
    Marker Score: 406
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.27
    Marker Score: 4915
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.23
    Marker Score: 2322
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4812
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.04
    Marker Score: 704
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.03
    Marker Score: 325
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1
    Marker Score: 5373
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71819
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.96
    Marker Score: 1959
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.94
    Marker Score: 431.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5307
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.86
    Marker Score: 516
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 652
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.8
    Marker Score: 896
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.8
    Marker Score: 7495
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 693
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.75
    Marker Score: 11726
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.74
    Marker Score: 332
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.67
    Marker Score: 355
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.64
    Marker Score: 187
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.63
    Marker Score: 213
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.61
    Marker Score: 390
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 467
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.58
    Marker Score: 359
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.56
    Marker Score: 200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.52
    Marker Score: 626
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.48
    Marker Score: 4859
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.45
    Marker Score: 219
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.44
    Marker Score: 1030.5
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.43
    Marker Score: 1777
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.41
    Marker Score: 172
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.41
    Marker Score: 456
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.41
    Marker Score: 242
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.41
    Marker Score: 134
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.4
    Marker Score: 126
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4
    Marker Score: 803
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.39
    Marker Score: 186
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.38
    Marker Score: 400
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.38
    Marker Score: 107
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.37
    Marker Score: 176
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.35
    Marker Score: 110.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.33
    Marker Score: 107
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.32
    Marker Score: 102
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.3
    Marker Score: 79
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.3
    Marker Score: 287
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.3
    Marker Score: 131
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.29
    Marker Score: 5236
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.28
    Marker Score: 341
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.28
    Marker Score: 177
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.28
    Marker Score: 147
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.27
    Marker Score: 888
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.27
    Marker Score: 2676.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.26
    Marker Score: 190
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.26
    Marker Score: 172

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - ELAVL2 is a protein of approximately 120 kDa. - It is expressed in a variety of cell types, including neurons, astrocytes, and oligodendrocytes. - It is a highly conserved protein, with a similar sequence in mice and humans. **Pathways and functions:** - ELAVL2 is a key regulator of gene expression. It binds to DNA sequences called E-box elements and recruits RNA polymerase to them, which leads to the transcription of downstream genes. - It also binds to the 3' UTR of mRNA and recruits protein kinase B to it, which leads to the phosphorylation of the mRNA and the subsequent degradation of the transcript. - ELAVL2 is also involved in the regulation of apoptosis. It binds to DNA sequences called Apaf-1 elements and recruits the pro-apoptotic protein Apaf-1 to them, which leads to the activation of caspases and the apoptosis of the cell. **Clinical significance:** Mutations in ELAVL2 have been linked to a number of human diseases, including autism, schizophrenia, and epilepsy. These mutations can lead to changes in the expression of other genes, which can have a significant impact on brain development and function. **Additional information:** - ELAVL2 is a relatively new protein, with the first sequence being identified in 2006. - It is a highly conserved protein, with a similar sequence in mice and humans. - It is a member of the ELAVL family of RNA-binding proteins, which are involved in a variety of cellular processes, including transcription, translation, and RNA splicing.

Genular Protein ID: 3291752358

Symbol: ELAV2_HUMAN

Name: ELAV-like protein 2

UniProtKB Accession Codes:

Q12926 D3DRK3 Q13235 Q59G15 Q8NEM4 Q9H1Q8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 10 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8158249

Title: Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor.

PubMed ID: 8158249

DOI: 10.1523/jneurosci.14-04-01943.1994

PubMed ID: 7972035

Title: Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1.

PubMed ID: 7972035

DOI: 10.1073/pnas.91.23.11207

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

Sequence Information:

  • Length: 359
  • Mass: 39504
  • Checksum: 15E87088FC546DDC
  • Sequence:
    • METQLSNGPT CNNTANGPTT INNNCSSPVD SGNTEDSKTN LIVNYLPQNM TQEELKSLFG 
SIGEIESCKL VRDKITGQSL GYGFVNYIDP KDAEKAINTL NGLRLQTKTI KVSYARPSSA 
SIRDANLYVS GLPKTMTQKE LEQLFSQYGR IITSRILVDQ VTGISRGVGF IRFDKRIEAE 
EAIKGLNGQK PPGATEPITV KFANNPSQKT NQAILSQLYQ SPNRRYPGPL AQQAQRFRLD 
NLLNMAYGVK RFSPMTIDGM TSLAGINIPG HPGTGWCIFV YNLAPDADES ILWQMFGPFG 
AVTNVKVIRD FNTNKCKGFG FVTMTNYDEA AMAIASLNGY RLGDRVLQVS FKTNKTHKA

Genular Protein ID: 2896271893

Symbol: A0A0A0MRX1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MRX1

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 7 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PROSITE-ProRule 1 Pfam 1 PhylomeDB 1 Proteomes 2 RefSeq 4 RuleBase 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

Sequence Information:

  • Length: 389
  • Mass: 42633
  • Checksum: 6B596BC62495B2BF
  • Sequence:
    • MAVRLCDVAS LLRSGSWAAE PWTGQVIAAM ETQLSNGPTC NNTANGPTTI NNNCSSPVDS 
GNTEDSKTNL IVNYLPQNMT QEELKSLFGS IGEIESCKLV RDKITGQSLG YGFVNYIDPK 
DAEKAINTLN GLRLQTKTIK VSYARPSSAS IRDANLYVSG LPKTMTQKEL EQLFSQYGRI 
ITSRILVDQV TGISRGVGFI RFDKRIEAEE AIKGLNGQKP PGATEPITVK FANNPSQKTN 
QAILSQLYQS PNRRYPGPLA QQAQRFRLDN LLNMAYGVKS RFSPMTIDGM TSLAGINIPG 
HPGTGWCIFV YNLAPDADES ILWQMFGPFG AVTNVKVIRD FNTNKCKGFG FVTMTNYDEA 
AMAIASLNGY RLGDRVLQVS FKTNKTHKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.