Details for: HTR1E

Gene ID: 3354

Symbol: HTR1E

Ensembl ID: ENSG00000168830

Description: 5-hydroxytryptamine receptor 1E

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 4.1907
    Cell Significance Index: 81.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.9888
    Cell Significance Index: 75.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.8111
    Cell Significance Index: 80.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.3557
    Cell Significance Index: 91.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1844
    Cell Significance Index: 819.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0407
    Cell Significance Index: 208.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8605
    Cell Significance Index: 308.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8428
    Cell Significance Index: 24.0500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.2840
    Cell Significance Index: 4.8600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.2485
    Cell Significance Index: 6.0200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.1550
    Cell Significance Index: 2.0100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0883
    Cell Significance Index: 0.8400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0447
    Cell Significance Index: 1.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.5900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0056
    Cell Significance Index: -0.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0085
    Cell Significance Index: -15.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0108
    Cell Significance Index: -16.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0130
    Cell Significance Index: -17.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0260
    Cell Significance Index: -19.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0297
    Cell Significance Index: -18.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0307
    Cell Significance Index: -1.8900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0311
    Cell Significance Index: -0.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0311
    Cell Significance Index: -0.9900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0338
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0377
    Cell Significance Index: -23.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0411
    Cell Significance Index: -23.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0420
    Cell Significance Index: -19.0700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0441
    Cell Significance Index: -0.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0491
    Cell Significance Index: -14.1300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0526
    Cell Significance Index: -1.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0545
    Cell Significance Index: -7.4900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0634
    Cell Significance Index: -0.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0664
    Cell Significance Index: -1.8600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0749
    Cell Significance Index: -0.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0833
    Cell Significance Index: -12.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0976
    Cell Significance Index: -16.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1038
    Cell Significance Index: -18.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1046
    Cell Significance Index: -20.7500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1058
    Cell Significance Index: -2.6400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1116
    Cell Significance Index: -23.5100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1139
    Cell Significance Index: -1.7300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1271
    Cell Significance Index: -1.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1371
    Cell Significance Index: -4.4900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1379
    Cell Significance Index: -1.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1550
    Cell Significance Index: -19.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1621
    Cell Significance Index: -8.5100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1749
    Cell Significance Index: -3.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1774
    Cell Significance Index: -18.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1856
    Cell Significance Index: -14.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1882
    Cell Significance Index: -21.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1938
    Cell Significance Index: -6.7900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.2112
    Cell Significance Index: -2.8200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2154
    Cell Significance Index: -3.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3006
    Cell Significance Index: -16.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3023
    Cell Significance Index: -5.1800
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.3186
    Cell Significance Index: -2.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3197
    Cell Significance Index: -20.1500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3293
    Cell Significance Index: -6.9900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3417
    Cell Significance Index: -2.3200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.3917
    Cell Significance Index: -4.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3997
    Cell Significance Index: -20.8200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.4070
    Cell Significance Index: -8.0100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4157
    Cell Significance Index: -8.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4263
    Cell Significance Index: -11.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4402
    Cell Significance Index: -20.6900
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.4427
    Cell Significance Index: -3.0700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4499
    Cell Significance Index: -18.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4753
    Cell Significance Index: -16.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5552
    Cell Significance Index: -14.2700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5613
    Cell Significance Index: -14.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5775
    Cell Significance Index: -16.6400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.5996
    Cell Significance Index: -3.1400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.6222
    Cell Significance Index: -15.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6251
    Cell Significance Index: -31.5900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.6354
    Cell Significance Index: -12.9300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.6912
    Cell Significance Index: -21.8600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6954
    Cell Significance Index: -8.2900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6981
    Cell Significance Index: -12.0700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7089
    Cell Significance Index: -20.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7202
    Cell Significance Index: -16.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7397
    Cell Significance Index: -16.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7516
    Cell Significance Index: -20.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7787
    Cell Significance Index: -20.8300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7809
    Cell Significance Index: -16.2000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.7938
    Cell Significance Index: -11.5700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7972
    Cell Significance Index: -17.4600
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.8009
    Cell Significance Index: -8.6100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.8021
    Cell Significance Index: -19.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.8138
    Cell Significance Index: -21.7300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.8706
    Cell Significance Index: -14.1000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.8804
    Cell Significance Index: -9.6500
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.9070
    Cell Significance Index: -12.2400
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.9203
    Cell Significance Index: -10.7500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.9262
    Cell Significance Index: -9.3300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.9585
    Cell Significance Index: -12.9300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9643
    Cell Significance Index: -18.8200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.9674
    Cell Significance Index: -13.5600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.9831
    Cell Significance Index: -14.1400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.9929
    Cell Significance Index: -12.3200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.9937
    Cell Significance Index: -14.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HTR1E is a serotonin receptor subtype that exhibits distinct characteristics, including: 1. **Ligand specificity**: HTR1E is specifically activated by 5-hydroxytryptamine (5-HT), the primary neurotransmitter involved in serotonin signaling. 2. **G protein-coupled receptor activity**: HTR1E is a member of the G protein-coupled receptor family, which allows it to interact with G proteins and modulate downstream signaling pathways. 3. **Adenylate cyclase-inhibiting activity**: HTR1E inhibits adenylate cyclase, a key enzyme involved in the production of cyclic AMP (cAMP), a secondary messenger molecule that regulates various cellular processes. 4. **Expression in multiple cell types**: HTR1E is expressed in various cell types, including erythrocytes, endothelial cells, interneurons, macrophages, and dendritic cells, highlighting its widespread role in the body. **Pathways and Functions** The HTR1E receptor is involved in several signaling pathways, including: 1. **Adenylate cyclase-inhibiting signaling pathway**: HTR1E inhibits adenylate cyclase, leading to decreased cAMP production and subsequent modulation of downstream signaling pathways. 2. **Serotonin receptor signaling pathway**: HTR1E is a key component of the serotonin receptor signaling pathway, which regulates various physiological processes, including mood, appetite, and sleep. 3. **G protein-coupled receptor signaling pathway**: HTR1E interacts with G proteins to modulate downstream signaling pathways, including those involved in neurotransmission, immune responses, and vascular function. 4. **Neurotransmitter receptor activity**: HTR1E modulates neurotransmitter release and synaptic transmission, particularly in the context of serotonin signaling. **Clinical Significance** The HTR1E receptor has significant clinical implications, particularly in the treatment of conditions such as: 1. **Depression**: HTR1E antagonists have been explored as potential therapeutic agents for treating depression, as they may modulate serotonin signaling and improve mood. 2. **Anxiety**: HTR1E antagonists have also been investigated as potential treatments for anxiety disorders, as they may modulate serotonin signaling and reduce anxiety-like behaviors. 3. **Cardiovascular disorders**: HTR1E antagonists have been explored as potential therapeutic agents for treating cardiovascular disorders, such as hypertension and atherosclerosis, as they may modulate vascular function and reduce inflammation. In conclusion, the HTR1E gene encodes a serotonin receptor subtype that plays a crucial role in various physiological and pathological processes. Further research is needed to fully understand the mechanisms of HTR1E signaling and its clinical significance, but its potential as a therapeutic target for treating conditions such as depression, anxiety, and cardiovascular disorders is an exciting area of investigation.

Genular Protein ID: 633950615

Symbol: 5HT1E_HUMAN

Name: S31

UniProtKB Accession Codes:

P28566 E1P503 Q9P1Y1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 21 DrugCentral 1 EMBL 9 EMDB 2 Ensembl 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1608964

Title: Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype.

PubMed ID: 1608964

DOI: 10.1073/pnas.89.12.5517

PubMed ID: 1733778

Title: Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase.

PubMed ID: 1733778

DOI: 10.1016/0014-5793(92)80379-u

PubMed ID: 1513320

Title: Human gene S31 encodes the pharmacologically defined serotonin 5-hydroxytryptamine1E receptor.

PubMed ID: 1513320

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15014171

Title: Human-specific amino acid changes found in 103 protein-coding genes.

PubMed ID: 15014171

DOI: 10.1093/molbev/msh100

PubMed ID: 14744596

Title: Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor.

PubMed ID: 14744596

DOI: 10.1016/j.ejphar.2003.11.019

PubMed ID: 18476671

Title: Serotonin receptors.

PubMed ID: 18476671

DOI: 10.1021/cr078224o

PubMed ID: 21422162

Title: Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships.

PubMed ID: 21422162

DOI: 10.1124/jpet.111.179606

PubMed ID: 20945968

Title: Serotonin receptors - from molecular biology to clinical applications.

PubMed ID: 20945968

DOI: 10.33549/physiolres.931903

PubMed ID: 35610220

Title: Structural insights into the ligand binding and Gi coupling of serotonin receptor 5-HT5A.

PubMed ID: 35610220

DOI: 10.1038/s41421-022-00412-3

PubMed ID: 33762731

Title: Structural insights into the lipid and ligand regulation of serotonin receptors.

PubMed ID: 33762731

DOI: 10.1038/s41586-021-03376-8

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 365
  • Mass: 41682
  • Checksum: 4C31DD783A3F7483
  • Sequence:
    • MNITNCTTEA SMAIRPKTIT EKMLICMTLV VITTLTTLLN LAVIMAIGTT KKLHQPANYL 
ICSLAVTDLL VAVLVMPLSI IYIVMDRWKL GYFLCEVWLS VDMTCCTCSI LHLCVIALDR 
YWAITNAIEY ARKRTAKRAA LMILTVWTIS IFISMPPLFW RSHRRLSPPP SQCTIQHDHV 
IYTIYSTLGA FYIPLTLILI LYYRIYHAAK SLYQKRGSSR HLSNRSTDSQ NSFASCKLTQ 
TFCVSDFSTS DPTTEFEKFH ASIRIPPFDN DLDHPGERQQ ISSTRERKAA RILGLILGAF 
ILSWLPFFIK ELIVGLSIYT VSSEVADFLT WLGYVNSLIN PLLYTSFNED FKLAFKKLIR 
CREHT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.