Details for: PTP4A2

Gene ID: 8073

Symbol: PTP4A2

Ensembl ID: ENSG00000184007

Description: protein tyrosine phosphatase 4A2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 467.1310
    Cell Significance Index: -72.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 304.2461
    Cell Significance Index: -77.1700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 219.6881
    Cell Significance Index: -90.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 183.6599
    Cell Significance Index: -86.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 179.0738
    Cell Significance Index: -72.7500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 163.1073
    Cell Significance Index: -83.9000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 129.4294
    Cell Significance Index: -86.8500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 77.6335
    Cell Significance Index: -74.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 68.4372
    Cell Significance Index: -84.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 26.3022
    Cell Significance Index: -70.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.6147
    Cell Significance Index: -69.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 22.0170
    Cell Significance Index: -86.8800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.0424
    Cell Significance Index: -19.7900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 8.4698
    Cell Significance Index: 52.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.4061
    Cell Significance Index: 119.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.9952
    Cell Significance Index: 297.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.7138
    Cell Significance Index: 669.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 3.5739
    Cell Significance Index: 388.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.3870
    Cell Significance Index: 416.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.0573
    Cell Significance Index: 158.8200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.8599
    Cell Significance Index: 184.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.7294
    Cell Significance Index: 128.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.6857
    Cell Significance Index: 125.2200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.3679
    Cell Significance Index: 21.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.3565
    Cell Significance Index: 67.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.1427
    Cell Significance Index: 1170.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.0470
    Cell Significance Index: 281.1100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.0273
    Cell Significance Index: 37.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4915
    Cell Significance Index: 192.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.4479
    Cell Significance Index: 75.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3859
    Cell Significance Index: 163.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2650
    Cell Significance Index: 253.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1581
    Cell Significance Index: 25.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9967
    Cell Significance Index: 440.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8880
    Cell Significance Index: 40.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6603
    Cell Significance Index: 46.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5956
    Cell Significance Index: 17.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5417
    Cell Significance Index: 53.5900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.5350
    Cell Significance Index: 9.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5278
    Cell Significance Index: 90.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4350
    Cell Significance Index: 156.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4253
    Cell Significance Index: 32.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3485
    Cell Significance Index: 241.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2812
    Cell Significance Index: 53.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2217
    Cell Significance Index: 5.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1490
    Cell Significance Index: 19.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1476
    Cell Significance Index: 3.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0758
    Cell Significance Index: 15.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0551
    Cell Significance Index: 1.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0517
    Cell Significance Index: 39.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0178
    Cell Significance Index: 33.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0081
    Cell Significance Index: -5.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0112
    Cell Significance Index: -8.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0175
    Cell Significance Index: -0.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0232
    Cell Significance Index: -42.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0300
    Cell Significance Index: -46.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0370
    Cell Significance Index: -0.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0404
    Cell Significance Index: -25.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0458
    Cell Significance Index: -28.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0474
    Cell Significance Index: -64.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0573
    Cell Significance Index: -26.0200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0852
    Cell Significance Index: -9.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0998
    Cell Significance Index: -56.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1336
    Cell Significance Index: -13.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1903
    Cell Significance Index: -40.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2111
    Cell Significance Index: -24.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2263
    Cell Significance Index: -36.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2480
    Cell Significance Index: -71.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2829
    Cell Significance Index: -4.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2843
    Cell Significance Index: -41.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4012
    Cell Significance Index: -46.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5321
    Cell Significance Index: -14.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5528
    Cell Significance Index: -31.0200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5789
    Cell Significance Index: -9.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5821
    Cell Significance Index: -35.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5864
    Cell Significance Index: -8.0000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6091
    Cell Significance Index: -15.5600
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.6116
    Cell Significance Index: -3.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6308
    Cell Significance Index: -33.1200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.7257
    Cell Significance Index: -7.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7658
    Cell Significance Index: -20.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7820
    Cell Significance Index: -81.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7945
    Cell Significance Index: -50.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8039
    Cell Significance Index: -63.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.8104
    Cell Significance Index: -21.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9289
    Cell Significance Index: -27.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.9636
    Cell Significance Index: -33.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9844
    Cell Significance Index: -31.5300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.9895
    Cell Significance Index: -40.5400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.1146
    Cell Significance Index: -23.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.1235
    Cell Significance Index: -30.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.1389
    Cell Significance Index: -76.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.1995
    Cell Significance Index: -23.4100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.3471
    Cell Significance Index: -33.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.4071
    Cell Significance Index: -86.2700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.5261
    Cell Significance Index: -44.9500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.5657
    Cell Significance Index: -23.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.6070
    Cell Significance Index: -71.0800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.6746
    Cell Significance Index: -17.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.7658
    Cell Significance Index: -45.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Protein Tyrosine Phosphatase Activity:** PTP4A2 exhibits phosphatase activity towards tyrosine residues, which is essential for regulating protein function and signaling pathways. 2. **Cellular Localization:** PTP4A2 is localized to the cytosol, plasma membrane, and nucleus, indicating its involvement in various cellular processes. 3. **Signaling Pathways:** PTP4A2 is implicated in multiple signaling pathways, including those related to cell proliferation, differentiation, and survival. 4. **Regulation of Protein Function:** PTP4A2 regulates the activity of various proteins, including receptor tyrosine kinases, G-protein coupled receptors, and transcription factors. **Pathways and Functions:** 1. **Metabolic Pathways:** PTP4A2 is involved in the regulation of metabolic pathways, including glycolysis, gluconeogenesis, and amino acid metabolism. 2. **Cell Proliferation and Differentiation:** PTP4A2 regulates cell proliferation and differentiation by modulating the activity of key signaling proteins, such as PI3K/AKT and MAPK/ERK. 3. **Immune Response:** PTP4A2 is expressed in immune cells and plays a role in regulating immune responses, including the activation of T cells and the production of cytokines. 4. **Cancer Development:** PTP4A2 has been implicated in cancer development, particularly in tumors of epithelial origin, where it regulates cell proliferation, invasion, and metastasis. **Clinical Significance:** 1. **Cancer Therapy:** PTP4A2 is a promising target for cancer therapy, as its inhibition can lead to the suppression of tumor growth and metastasis. 2. **Immune-Mediated Diseases:** PTP4A2 is involved in the regulation of immune responses, and its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological Disorders:** PTP4A2 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where it regulates synaptic function and neuronal survival. 4. **Regenerative Medicine:** PTP4A2 is expressed in stem cells and plays a role in regulating their function, making it a potential target for regenerative therapies. In conclusion, PTP4A2 is a multifunctional gene that plays a crucial role in regulating various cellular processes, including signal transduction, metabolism, and cell proliferation. Its dysregulation has been implicated in various diseases, making it a promising target for therapeutic intervention. Further research is needed to fully elucidate the functions of PTP4A2 and its role in human disease.

Genular Protein ID: 2045716420

Symbol: TP4A2_HUMAN

Name: Protein tyrosine phosphatase type IVA 2

UniProtKB Accession Codes:

Q12974 A8K9I8 B4DM39 D3DPP0 E9PGJ6 O00649 Q15197 Q15259 Q15260 Q15261 R4GN50

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 15 Ensembl 5 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 Rhea 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8529999

Title: A 100-kb physical and transcriptional map around the EDH17B2 gene: identification of three novel genes and a pseudogene of a human homologue of the rat PRL-1 tyrosine phosphatase.

PubMed ID: 8529999

DOI: 10.1007/bf00197407

PubMed ID: 9018080

Title: Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases.

PubMed ID: 9018080

DOI: 10.1016/s0304-3835(96)04459-x

PubMed ID: 8661118

Title: Characterization and genomic mapping of genes and pseudogenes of a new human protein tyrosine phosphatase.

PubMed ID: 8661118

DOI: 10.1006/geno.1996.0336

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7490091

Title: Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21.

PubMed ID: 7490091

DOI: 10.1006/geno.1995.1185

PubMed ID: 10940933

Title: Subcellular localization of intracellular protein tyrosine phosphatases in T cells.

PubMed ID: 10940933

DOI: 10.1002/1521-4141(2000)30:8<2412::aid-immu2412>3.0.co;2-j

PubMed ID: 11447212

Title: Interaction of farnesylated PRL-2, a protein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II.

PubMed ID: 11447212

DOI: 10.1074/jbc.m010400200

PubMed ID: 11734337

Title: Analysis of stromal-epithelial interactions in prostate cancer identifies PTPCAAX2 as a potential oncogene.

PubMed ID: 11734337

DOI: 10.1016/s0304-3835(01)00703-0

PubMed ID: 12235145

Title: The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis.

PubMed ID: 12235145

DOI: 10.1074/jbc.m206407200

PubMed ID: 12516958

Title: Pentamidine is an inhibitor of PRL phosphatases with anticancer activity.

PubMed ID: 12516958

PubMed ID: 14643450

Title: Enhanced cell cycle progression and down regulation of p21(Cip1/Waf1) by PRL tyrosine phosphatases.

PubMed ID: 14643450

DOI: 10.1016/s0304-3835(03)00517-2

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 167
  • Mass: 19127
  • Checksum: E97B88BF87B87943
  • Sequence:
    • MNRPAPVEIS YENMRFLITH NPTNATLNKF TEELKKYGVT TLVRVCDATY DKAPVEKEGI 
HVLDWPFDDG APPPNQIVDD WLNLLKTKFR EEPGCCVAVH CVAGLGRAPV LVALALIECG 
MKYEDAVQFI RQKRRGAFNS KQLLYLEKYR PKMRLRFRDT NGHCCVQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.