Details for: HNRNPH3

Gene ID: 3189

Symbol: HNRNPH3

Ensembl ID: ENSG00000096746

Description: heterogeneous nuclear ribonucleoprotein H3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.54
    Marker Score: 120386
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.13
    Marker Score: 2668
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 3.02
    Marker Score: 12603.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.01
    Marker Score: 3210
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3
    Marker Score: 2349.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.82
    Marker Score: 1175
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.69
    Marker Score: 35498.5
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.62
    Marker Score: 2736
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.48
    Marker Score: 6054
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.44
    Marker Score: 899
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.42
    Marker Score: 15727.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.41
    Marker Score: 3715.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.41
    Marker Score: 5080
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.37
    Marker Score: 4958
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.36
    Marker Score: 2224
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.36
    Marker Score: 1481
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.3
    Marker Score: 2454
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.28
    Marker Score: 3881
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.23
    Marker Score: 555
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.21
    Marker Score: 555
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.2
    Marker Score: 2164
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.18
    Marker Score: 2320
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.18
    Marker Score: 10718
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.16
    Marker Score: 2426
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.11
    Marker Score: 5747.5
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.11
    Marker Score: 1269
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.1
    Marker Score: 2212
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.08
    Marker Score: 2510
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.08
    Marker Score: 2985
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.08
    Marker Score: 5824
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.07
    Marker Score: 701
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.07
    Marker Score: 7665
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.07
    Marker Score: 494
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.05
    Marker Score: 1922
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.04
    Marker Score: 1925
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.01
    Marker Score: 2357
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.01
    Marker Score: 20355
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.01
    Marker Score: 1582
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2
    Marker Score: 2942.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.99
    Marker Score: 2574
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.99
    Marker Score: 1561
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.98
    Marker Score: 7683
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.98
    Marker Score: 22332
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.98
    Marker Score: 3723
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.98
    Marker Score: 104710
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.98
    Marker Score: 699
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.97
    Marker Score: 1659.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.97
    Marker Score: 19825.5
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.97
    Marker Score: 3484
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.96
    Marker Score: 1117
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.96
    Marker Score: 3976
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.95
    Marker Score: 4595.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.95
    Marker Score: 7965
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.93
    Marker Score: 2045
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.93
    Marker Score: 3164.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.92
    Marker Score: 1279.5
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.9
    Marker Score: 898
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.9
    Marker Score: 661
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.88
    Marker Score: 711
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.87
    Marker Score: 986.5
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.87
    Marker Score: 5545.5
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.87
    Marker Score: 933
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.86
    Marker Score: 837
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.86
    Marker Score: 988
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.86
    Marker Score: 7294
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.85
    Marker Score: 5033.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.84
    Marker Score: 7935.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.83
    Marker Score: 1973
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.83
    Marker Score: 1086
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.83
    Marker Score: 10827.5
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.82
    Marker Score: 3820
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.82
    Marker Score: 1372
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.82
    Marker Score: 1324
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.81
    Marker Score: 1373
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.81
    Marker Score: 1825
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.81
    Marker Score: 1970
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.81
    Marker Score: 21039
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.8
    Marker Score: 991
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.8
    Marker Score: 536
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.8
    Marker Score: 4536
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.79
    Marker Score: 1730.5
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.78
    Marker Score: 725
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.78
    Marker Score: 815
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.77
    Marker Score: 719
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.77
    Marker Score: 388
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.76
    Marker Score: 1330
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.76
    Marker Score: 2169.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.76
    Marker Score: 60833
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.75
    Marker Score: 505
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.73
    Marker Score: 1592
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.73
    Marker Score: 602
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.72
    Marker Score: 1861
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.72
    Marker Score: 1900
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.72
    Marker Score: 17022.5
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.71
    Marker Score: 453
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.7
    Marker Score: 662
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.7
    Marker Score: 5357
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.69
    Marker Score: 495
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.69
    Marker Score: 388
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.69
    Marker Score: 1591

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Other Information

**Key characteristics:** - HNRNPH3 is a large protein with a molecular weight of approximately 1200 kDa. - It is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family of proteins. - HNRNPH3 is expressed in a variety of cell types, including fibroblasts, endothelial cells, and neuronal cells. **Pathways and functions:** - HNRNPH3 is involved in epithelial cell differentiation by promoting the expression of epithelial genes. - It is also involved in mRNA splicing by interacting with the spliceosome and facilitating the inclusion or exclusion of exons in the final mRNA. - HNRNPH3 is involved in the regulation of rna splicing by interacting with the RNA-binding protein RBP2. - It also plays a role in the control of cell proliferation and differentiation. **Clinical significance:** - Mutations in HNRNPH3 have been linked to several human diseases, including breast cancer, prostate cancer, and developmental disorders. - Aberrant expression of HNRNPH3 has been associated with cancer development and progression. - Targeting HNRNPH3 has been explored as a therapeutic strategy for cancer.

Genular Protein ID: 3786241681

Symbol: HNRH3_HUMAN

Name: Heterogeneous nuclear ribonucleoprotein H3

UniProtKB Accession Codes:

P31942 A8K682 B3KRE1 Q9BSX1 Q9NP53 Q9NP96 Q9NPA7 Q9NPI4 Q9UFU4 Q9Y4J5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 18 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 RefSeq 16 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8999868

Title: Cloning of human 2H9 heterogeneous nuclear ribonucleoproteins. Relation with splicing and early heat shock-induced splicing arrest.

PubMed ID: 8999868

DOI: 10.1074/jbc.272.3.1827

PubMed ID: 10858537

Title: The hnRNP 2H9 gene, which is involved in the splicing reaction, is a multiply spliced gene.

PubMed ID: 10858537

DOI: 10.1016/s0167-4781(00)00092-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 11152131

Title: A post-translational modification of nuclear proteins, N(G),N(G)-dimethyl-Arg, found in a natural HLA class I peptide ligand.

PubMed ID: 11152131

DOI: 10.1110/ps.9.11.2210

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 346
  • Mass: 36926
  • Checksum: F7D14C2947930E9E
  • Sequence:
    • MDWVMKHNGP NDASDGTVRL RGLPFGCSKE EIVQFFQGLE IVPNGITLTM DYQGRSTGEA 
FVQFASKEIA ENALGKHKER IGHRYIEIFR SSRSEIKGFY DPPRRLLGQR PGPYDRPIGG 
RGGYYGAGRG SMYDRMRRGG DGYDGGYGGF DDYGGYNNYG YGNDGFDDRM RDGRGMGGHG 
YGGAGDASSG FHGGHFVHMR GLPFRATEND IANFFSPLNP IRVHIDIGAD GRATGEADVE 
FVTHEDAVAA MSKDKNNMQH RYIELFLNST PGGGSGMGGS GMGGYGRDGM DNQGGYGSVG 
RMGMGNNYSG GYGTPDGLGG YGRGGGGSGG YYGQGGMSGG GWRGMY

Genular Protein ID: 3344114557

Symbol: Q53F48_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53F48

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 Pfam 1 PharmGKB 1 RefSeq 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 346
  • Mass: 36926
  • Checksum: 19D14623E739043E
  • Sequence:
    • MDWVMKHNGP NDASDGTVRL RGLPFGCSKE EIVQFFQGLE IVPNGITLTM DYQGRSTGEA 
FVQFASKEIA ENALGKHKER IGHRYIEIFR SSRSEIKGFY DPPRRLLGQR PGPYDRPIGG 
RGGYYGAGRG SMYDRMRRGG DGYDGGYGGF DDYGGYNNYG YGNDGFDDRM RDGRGMGGHG 
YGGAGDASSG FHGGHFVHMR GLPFRATEND IANFFSPLNP IRVHIDIGAD GRATGEADVE 
FVTHEDAVAA MSKDKNNMQH RYIKLFLNST PGGGSGMGGS GMGGYGRDGM DNQGGYGSVG 
RMGMGNNYSG GYGTPDGLGG YGRGGGGSGG YYGQGGMSGG GWRGMY

Genular Protein ID: 2301082490

Symbol: B4DHY1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DHY1

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 3 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 ProteomicsDB 1 RefSeq 2 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 238
  • Mass: 24884
  • Checksum: 6C7BC558EC241BA0
  • Sequence:
    • MDWVMKHNGP NDASDGTVRL RGLPFGCSKE EIVQFFQGYG GFDDYGGYNN YGYGNDGFDD 
RMRDGRGMGG HGYGGAGDAS SGFHGGHFVH MRGLPFRATE NDIANFFSPL NPIRVHIDIG 
ADGRATGEAD VEFVTHEDAV AAMSKDKNNM QHRYIELFLN STPGGGSGMG GSGMGGYGRD 
GMDNQGGYGS VGRMGMGNNY SGGYGTPDGL GGYGRGGGGS GGYYGQGGMS GGGWRGMY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.