Details for: ENSA

Gene ID: 2029

Symbol: ENSA

Ensembl ID: ENSG00000143420

Description: endosulfine alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 455.0445
    Cell Significance Index: -70.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 263.6379
    Cell Significance Index: -66.8700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 205.3659
    Cell Significance Index: -84.6000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 192.4924
    Cell Significance Index: -90.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 189.0182
    Cell Significance Index: -76.7900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 168.9006
    Cell Significance Index: -86.8800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 135.8524
    Cell Significance Index: -91.1600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 81.1161
    Cell Significance Index: -77.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 67.7397
    Cell Significance Index: -83.5200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.1314
    Cell Significance Index: -77.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 22.4072
    Cell Significance Index: -88.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.1359
    Cell Significance Index: -56.6200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.1004
    Cell Significance Index: -30.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.3831
    Cell Significance Index: 66.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.3153
    Cell Significance Index: 417.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.2928
    Cell Significance Index: 822.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.2023
    Cell Significance Index: 358.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.1175
    Cell Significance Index: 260.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.0508
    Cell Significance Index: 54.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.0481
    Cell Significance Index: 152.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9533
    Cell Significance Index: 387.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7033
    Cell Significance Index: 341.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.6426
    Cell Significance Index: 116.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.6343
    Cell Significance Index: 211.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.6162
    Cell Significance Index: 714.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.6086
    Cell Significance Index: 43.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5856
    Cell Significance Index: 865.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5817
    Cell Significance Index: 74.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5433
    Cell Significance Index: 80.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.4275
    Cell Significance Index: 13.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4266
    Cell Significance Index: 92.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2878
    Cell Significance Index: 176.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1624
    Cell Significance Index: 137.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1211
    Cell Significance Index: 52.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9829
    Cell Significance Index: 51.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9226
    Cell Significance Index: 32.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9071
    Cell Significance Index: 50.9000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6446
    Cell Significance Index: 18.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5878
    Cell Significance Index: 26.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4892
    Cell Significance Index: 48.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4740
    Cell Significance Index: 10.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4314
    Cell Significance Index: 16.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4027
    Cell Significance Index: 24.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2429
    Cell Significance Index: 11.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2370
    Cell Significance Index: 179.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2138
    Cell Significance Index: 14.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2042
    Cell Significance Index: 34.8600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1836
    Cell Significance Index: 3.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1654
    Cell Significance Index: 311.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1601
    Cell Significance Index: 20.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1452
    Cell Significance Index: 223.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1259
    Cell Significance Index: 87.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0934
    Cell Significance Index: 59.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0573
    Cell Significance Index: 105.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0330
    Cell Significance Index: 44.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0014
    Cell Significance Index: 0.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0080
    Cell Significance Index: -5.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0106
    Cell Significance Index: -7.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0575
    Cell Significance Index: -10.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0840
    Cell Significance Index: -52.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0904
    Cell Significance Index: -41.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0914
    Cell Significance Index: -9.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1094
    Cell Significance Index: -61.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1183
    Cell Significance Index: -1.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1531
    Cell Significance Index: -8.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1587
    Cell Significance Index: -2.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2117
    Cell Significance Index: -44.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2365
    Cell Significance Index: -6.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2531
    Cell Significance Index: -15.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2694
    Cell Significance Index: -77.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2935
    Cell Significance Index: -42.6700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2951
    Cell Significance Index: -33.6800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3421
    Cell Significance Index: -2.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4056
    Cell Significance Index: -46.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4303
    Cell Significance Index: -33.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4445
    Cell Significance Index: -51.8000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4815
    Cell Significance Index: -5.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4918
    Cell Significance Index: -6.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5288
    Cell Significance Index: -13.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6651
    Cell Significance Index: -16.9900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.6660
    Cell Significance Index: -8.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7583
    Cell Significance Index: -78.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7798
    Cell Significance Index: -20.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8133
    Cell Significance Index: -64.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8449
    Cell Significance Index: -27.0600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8737
    Cell Significance Index: -10.4200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.9271
    Cell Significance Index: -22.2400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.9450
    Cell Significance Index: -19.7800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.9619
    Cell Significance Index: -10.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9966
    Cell Significance Index: -19.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0450
    Cell Significance Index: -29.8200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.1657
    Cell Significance Index: -21.5500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.2660
    Cell Significance Index: -29.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3022
    Cell Significance Index: -79.8400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.3405
    Cell Significance Index: -8.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.4459
    Cell Significance Index: -31.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.5074
    Cell Significance Index: -37.6800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.5600
    Cell Significance Index: -10.5700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.6182
    Cell Significance Index: -12.9200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.6918
    Cell Significance Index: -25.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell cycle regulation:** ENSA is involved in the regulation of the cell cycle, particularly in the G2/M transition of the mitotic cell cycle. It acts as a negative regulator of protein dephosphorylation, thereby maintaining the proper balance of phosphorylation events. 2. **Protein phosphatase regulation:** ENSA exhibits phosphatase inhibitor activity, which suggests its ability to regulate the activity of protein phosphatases, such as Protein Phosphatase 2A (PP2A). 3. **Ion channel inhibition:** ENSA has been shown to inhibit ion channels, including potassium channels, which implies its role in modulating cellular excitability and calcium signaling. 4. **Protein binding:** ENSA interacts with various proteins, including PP2A, mastl, and other regulatory proteins, highlighting its involvement in protein-protein interactions and signaling cascades. **Pathways and Functions:** 1. **Mitotic cell cycle regulation:** ENSA's involvement in the G2/M transition of the mitotic cell cycle suggests its role in controlling the progression of cells through the cell cycle. 2. **Insulin secretion regulation:** ENSA has been implicated in the regulation of insulin secretion, which implies its potential role in glucose metabolism and diabetes. 3. **Nutrient response:** ENSA's expression is responsive to nutrient availability, suggesting its involvement in the regulation of cellular metabolism and energy homeostasis. 4. **Ion channel-mediated signaling:** ENSA's inhibition of ion channels may play a role in modulating cellular excitability and signaling pathways, particularly in the context of neurological disorders. **Clinical Significance:** 1. **Cancer:** ENSA's involvement in cell cycle regulation and protein phosphorylation suggests its potential role in cancer development and progression. Alterations in ENSA expression may contribute to tumorigenesis and cancer progression. 2. **Neurological disorders:** ENSA's interaction with ion channels and its role in regulating cellular excitability may be relevant to neurological disorders, such as epilepsy and neurodegenerative diseases. 3. **Diabetes:** ENSA's involvement in insulin secretion regulation suggests its potential role in diabetes pathogenesis and management. 4. **Gastrointestinal disorders:** ENSA's expression in pneumocytes and epithelial cells of the esophagus implies its potential role in gastrointestinal disorders, such as gastroesophageal reflux disease (GERD). In conclusion, ENSA is a multifunctional protein that plays a crucial role in various cellular processes, including cell cycle regulation, protein phosphorylation, and ion channel inhibition. Its clinical significance extends to cancer, neurological disorders, diabetes, and gastrointestinal disorders, highlighting the need for further research into the molecular mechanisms underlying ENSA's functions and its potential therapeutic applications.

Genular Protein ID: 3537407234

Symbol: ENSA_HUMAN

Name: Alpha-endosulfine

UniProtKB Accession Codes:

O43768 A8K1Z9 E9PB69 Q5T5H2 Q68D48 Q6FHW0 Q6IAM4 Q6NUL2 Q6VUC6 Q6VUC7 Q6VUC8 Q6VUC9 Q6VUD0 Q6VUD1 Q9NRZ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 8 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 42 Ensembl 10 ExpressionAtlas 1 GO 15 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 9 Pumba 1 RNAct 1 Reactome 1 RefSeq 8 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 4 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9653196

Title: Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive K(ATP) channel: molecular cloning, expression and biological properties.

PubMed ID: 9653196

DOI: 10.1073/pnas.95.14.8387

PubMed ID: 10480622

Title: Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K(ATP) channels.

PubMed ID: 10480622

DOI: 10.2337/diabetes.48.9.1873

PubMed ID: 14728987

Title: The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians.

PubMed ID: 14728987

DOI: 10.1016/j.ymgme.2003.09.013

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17893145

Title: Conformation-specific binding of alpha-synuclein to novel protein partners detected by phage display and NMR spectroscopy.

PubMed ID: 17893145

DOI: 10.1074/jbc.m705283200

PubMed ID: 18973346

Title: Membrane-induced folding of the cAMP-regulated phosphoprotein endosulfine-alpha.

PubMed ID: 18973346

DOI: 10.1021/bi801450t

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 121
  • Mass: 13389
  • Checksum: 7C76315AA17E7542
  • Sequence:
    • MSQKQEEENP AEETGEEKQD TQEKEGILPE RAEEAKLKAK YPSLGQKPGG SDFLMKRLQK 
GQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTP QDLPQRKSSL VTSKLAGGQV 
E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.