Details for: RIT2

Gene ID: 6014

Symbol: RIT2

Ensembl ID: ENSG00000152214

Description: Ras like without CAAX 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 5.6573
    Cell Significance Index: 96.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.3916
    Cell Significance Index: 150.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 3.0642
    Cell Significance Index: 206.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.9994
    Cell Significance Index: 113.5800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.8877
    Cell Significance Index: -6.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1828
    Cell Significance Index: 437.8700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.8544
    Cell Significance Index: 52.9200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.6207
    Cell Significance Index: 21.6200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 1.3699
    Cell Significance Index: 14.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8570
    Cell Significance Index: 592.7700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.3553
    Cell Significance Index: 4.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3404
    Cell Significance Index: 20.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1104
    Cell Significance Index: 39.5900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0872
    Cell Significance Index: 0.8300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.0151
    Cell Significance Index: 0.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0132
    Cell Significance Index: 0.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0043
    Cell Significance Index: -8.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0046
    Cell Significance Index: -6.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0055
    Cell Significance Index: -10.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0063
    Cell Significance Index: -9.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0276
    Cell Significance Index: -17.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0281
    Cell Significance Index: -20.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0345
    Cell Significance Index: -18.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0356
    Cell Significance Index: -16.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0371
    Cell Significance Index: -23.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0391
    Cell Significance Index: -22.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0507
    Cell Significance Index: -14.5900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0509
    Cell Significance Index: -1.2200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0565
    Cell Significance Index: -0.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0613
    Cell Significance Index: -12.1700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0614
    Cell Significance Index: -1.0500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0866
    Cell Significance Index: -1.1200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0872
    Cell Significance Index: -2.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0994
    Cell Significance Index: -17.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1046
    Cell Significance Index: -15.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1062
    Cell Significance Index: -18.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1082
    Cell Significance Index: -22.7800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1306
    Cell Significance Index: -1.8700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1313
    Cell Significance Index: -1.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1394
    Cell Significance Index: -19.1500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1403
    Cell Significance Index: -6.1000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1430
    Cell Significance Index: -1.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1561
    Cell Significance Index: -19.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1722
    Cell Significance Index: -9.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1814
    Cell Significance Index: -18.8900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1950
    Cell Significance Index: -6.8300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1974
    Cell Significance Index: -4.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1992
    Cell Significance Index: -22.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2037
    Cell Significance Index: -6.6700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2078
    Cell Significance Index: -4.4100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2174
    Cell Significance Index: -5.4300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2289
    Cell Significance Index: -2.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2318
    Cell Significance Index: -13.0100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2342
    Cell Significance Index: -2.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2525
    Cell Significance Index: -19.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2530
    Cell Significance Index: -7.0700
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.2701
    Cell Significance Index: -2.9800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2779
    Cell Significance Index: -5.5800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3579
    Cell Significance Index: -11.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3730
    Cell Significance Index: -9.9600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.3794
    Cell Significance Index: -4.9200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4137
    Cell Significance Index: -8.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4364
    Cell Significance Index: -20.5100
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.4844
    Cell Significance Index: -4.9800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5282
    Cell Significance Index: -11.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5572
    Cell Significance Index: -19.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5793
    Cell Significance Index: -14.8900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.5829
    Cell Significance Index: -9.4400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5841
    Cell Significance Index: -12.6200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5921
    Cell Significance Index: -21.7400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.6034
    Cell Significance Index: -14.6200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.6114
    Cell Significance Index: -8.1500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.6236
    Cell Significance Index: -13.0200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.6290
    Cell Significance Index: -12.3800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -0.6345
    Cell Significance Index: -6.6300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.6390
    Cell Significance Index: -8.3400
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.6451
    Cell Significance Index: -5.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6716
    Cell Significance Index: -19.3500
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.6837
    Cell Significance Index: -3.5800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.6871
    Cell Significance Index: -8.6700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.7170
    Cell Significance Index: -14.5900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7237
    Cell Significance Index: -16.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7286
    Cell Significance Index: -21.4600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.7374
    Cell Significance Index: -12.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7893
    Cell Significance Index: -19.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7904
    Cell Significance Index: -20.7800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.7999
    Cell Significance Index: -15.9500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8029
    Cell Significance Index: -15.6700
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.8070
    Cell Significance Index: -6.1900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.8156
    Cell Significance Index: -20.7800
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.8301
    Cell Significance Index: -9.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8367
    Cell Significance Index: -22.4200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.8529
    Cell Significance Index: -20.8100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.9048
    Cell Significance Index: -10.8200
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.9137
    Cell Significance Index: -7.2700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9271
    Cell Significance Index: -20.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.9299
    Cell Significance Index: -19.2900
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.9333
    Cell Significance Index: -7.3200
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -1.0153
    Cell Significance Index: -10.9600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -1.0158
    Cell Significance Index: -15.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RIT2 is a small GTPase that belongs to the Ras superfamily, characterized by its ability to bind and hydrolyze GTP. Unlike other Ras proteins, RIT2 lacks the CAAX motif, which is essential for the post-translational modification of Ras proteins. This unique feature allows RIT2 to interact with a broader range of proteins and signaling pathways. **Pathways and Functions:** RIT2 is involved in multiple signaling pathways, including: 1. **Adenylate cyclase-activating G protein-coupled receptor signaling pathway**: RIT2 regulates this pathway by interacting with Gαs proteins, leading to increased cAMP production and subsequent activation of downstream targets. 2. **Mapk cascade**: RIT2 acts as a positive regulator of the Mapk cascade, a key signaling pathway involved in cell proliferation, differentiation, and survival. 3. **Neuron projection development**: RIT2 is essential for the regulation of neuron projection development, influencing the formation of axons and dendrites. 4. **Endocytosis**: RIT2 plays a role in regulating endocytosis, a process critical for cellular uptake of nutrients and signaling molecules. 5. **Semaphorin receptor binding**: RIT2 interacts with semaphorin receptors, influencing the regulation of axon guidance and neuronal development. **Clinical Significance:** RIT2's involvement in various cellular processes makes it a promising candidate for the study of several diseases, including: 1. **Neurodegenerative disorders**: Alterations in RIT2 expression and function have been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Cancer**: RIT2's role in regulating cell growth and survival makes it a potential target for cancer therapy. 3. **Immune disorders**: RIT2's involvement in immune cell development and function suggests its potential role in autoimmune diseases. **Conclusion:** RIT2 is a multifunctional GTPase that plays a critical role in various cellular processes, including signaling pathways, cell growth, and differentiation. Its widespread expression across different cell types and its involvement in multiple signaling pathways make it an attractive candidate for the study of various diseases. Further research is needed to fully understand the mechanisms of RIT2 and its clinical significance. **Future Directions:** 1. **Structural studies**: The crystal structure of RIT2 will provide valuable insights into its interactions with other proteins and signaling pathways. 2. **Functional studies**: Studies using RIT2 knockout or knockdown models will help elucidate its role in cellular processes and disease. 3. **Therapeutic targeting**: The identification of RIT2 as a potential therapeutic target will require further investigation into its role in disease mechanisms and the development of specific inhibitors. In summary, RIT2 is a complex GTPase that plays a crucial role in various cellular processes, including signaling pathways, cell growth, and differentiation. Further research is needed to fully understand its mechanisms and clinical significance, with potential implications for the treatment of various diseases.

Genular Protein ID: 1829160011

Symbol: RIT2_HUMAN

Name: GTP-binding protein Rit2

UniProtKB Accession Codes:

Q99578 B2R9L1 O15295 Q8TD69 Q8WVF6 Q92964

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8824319

Title: Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins.

PubMed ID: 8824319

DOI: 10.1523/jneurosci.16-21-06784.1996

PubMed ID: 8918462

Title: RIC, a calmodulin-binding Ras-like GTPase.

PubMed ID: 8918462

DOI: 10.1002/j.1460-2075.1996.tb00971.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12934100

Title: Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor.

PubMed ID: 12934100

DOI: 10.1038/sj.onc.1206635

PubMed ID: 16122393

Title: Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin.

PubMed ID: 16122393

DOI: 10.1186/1471-2202-6-53

Sequence Information:

  • Length: 217
  • Mass: 24668
  • Checksum: CD2A9ECE4AEAA792
  • Sequence:
    • MEVENEASCS PGSASGGSRE YKVVMLGAGG VGKSAMTMQF ISHQFPDYHD PTIEDAYKTQ 
VRIDNEPAYL DILDTAGQAE FTAMREQYMR GGEGFIICYS VTDRQSFQEA AKFKELIFQV 
RHTYEIPLVL VGNKIDLEQF RQVSTEEGLS LAQEYNCGFF ETSAALRFCI DDAFHGLVRE 
IRKKESMPSL MEKKLKRKDS LWKKLKGSLK KKRENMT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.