Details for: DNAH8

Gene ID: 1769

Symbol: DNAH8

Ensembl ID: ENSG00000124721

Description: dynein axonemal heavy chain 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.0368
    Cell Significance Index: 65.2400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.3159
    Cell Significance Index: -2.8800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.8024
    Cell Significance Index: 20.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5270
    Cell Significance Index: 100.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3875
    Cell Significance Index: 6.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3856
    Cell Significance Index: 23.1500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.2519
    Cell Significance Index: 2.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2463
    Cell Significance Index: 5.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2397
    Cell Significance Index: 26.0800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2234
    Cell Significance Index: 1.3500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.2045
    Cell Significance Index: 2.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2033
    Cell Significance Index: 7.7000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1856
    Cell Significance Index: 3.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1732
    Cell Significance Index: 17.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1713
    Cell Significance Index: 11.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1548
    Cell Significance Index: 139.7800
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.1469
    Cell Significance Index: 0.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1080
    Cell Significance Index: 17.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1077
    Cell Significance Index: 7.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0917
    Cell Significance Index: 18.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0635
    Cell Significance Index: 1.8300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0627
    Cell Significance Index: 1.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0523
    Cell Significance Index: 10.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0512
    Cell Significance Index: 1.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0458
    Cell Significance Index: 1.2800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0366
    Cell Significance Index: 0.5400
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.0316
    Cell Significance Index: 0.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0307
    Cell Significance Index: 21.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0295
    Cell Significance Index: 0.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0246
    Cell Significance Index: 3.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0218
    Cell Significance Index: 7.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0193
    Cell Significance Index: 0.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0117
    Cell Significance Index: 0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0106
    Cell Significance Index: 20.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0081
    Cell Significance Index: 0.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0077
    Cell Significance Index: 14.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0071
    Cell Significance Index: 0.3200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0060
    Cell Significance Index: 0.1900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0059
    Cell Significance Index: 0.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0055
    Cell Significance Index: 8.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0035
    Cell Significance Index: 0.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0032
    Cell Significance Index: 0.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0030
    Cell Significance Index: 4.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0020
    Cell Significance Index: 0.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0001
    Cell Significance Index: -0.0900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0030
    Cell Significance Index: -1.3600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0039
    Cell Significance Index: -0.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0040
    Cell Significance Index: -3.0500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0042
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0044
    Cell Significance Index: -3.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0053
    Cell Significance Index: -2.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0056
    Cell Significance Index: -3.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0059
    Cell Significance Index: -3.7100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0080
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0086
    Cell Significance Index: -1.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0091
    Cell Significance Index: -2.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0124
    Cell Significance Index: -1.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0129
    Cell Significance Index: -0.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0144
    Cell Significance Index: -1.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0174
    Cell Significance Index: -3.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0179
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0195
    Cell Significance Index: -2.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0217
    Cell Significance Index: -2.9800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0237
    Cell Significance Index: -0.3600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0252
    Cell Significance Index: -0.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0255
    Cell Significance Index: -2.6600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0263
    Cell Significance Index: -0.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0305
    Cell Significance Index: -0.9700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0321
    Cell Significance Index: -0.2900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0334
    Cell Significance Index: -0.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0353
    Cell Significance Index: -3.6100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0354
    Cell Significance Index: -0.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0370
    Cell Significance Index: -1.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0394
    Cell Significance Index: -2.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0405
    Cell Significance Index: -2.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0476
    Cell Significance Index: -2.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0481
    Cell Significance Index: -1.2000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0538
    Cell Significance Index: -1.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0548
    Cell Significance Index: -1.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0553
    Cell Significance Index: -2.8700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0600
    Cell Significance Index: -0.8000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0603
    Cell Significance Index: -0.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0650
    Cell Significance Index: -3.0600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0657
    Cell Significance Index: -0.9700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0658
    Cell Significance Index: -0.8000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0674
    Cell Significance Index: -1.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0687
    Cell Significance Index: -1.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0701
    Cell Significance Index: -3.6500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0726
    Cell Significance Index: -1.4400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0732
    Cell Significance Index: -1.7900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0752
    Cell Significance Index: -1.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0794
    Cell Significance Index: -2.1200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0801
    Cell Significance Index: -1.7300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0806
    Cell Significance Index: -1.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0810
    Cell Significance Index: -2.9800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0817
    Cell Significance Index: -2.0400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0872
    Cell Significance Index: -1.0400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0905
    Cell Significance Index: -0.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DNAH8 is a member of the dynein heavy chain family, characterized by its ability to bind to microtubules and regulate their movement. It is specifically expressed in various cell types, including those of the retina, colon, and immune system, where it is involved in the regulation of cell motility and movement. The gene is highly conserved across species, suggesting its importance in maintaining cellular homeostasis. **Pathways and Functions:** DNAH8 is involved in several key pathways, including: 1. **Axonemal Dynein Complex Assembly:** DNAH8 is a critical component of the outer dynein arm, which assembles with other dynein heavy chains to form the dynein complex. This complex is responsible for regulating microtubule dynamics and cell motility. 2. **Microtubule Motor Activity:** DNAH8 binds to microtubules and regulates their movement, facilitating the sliding of microtubules along the axoneme. 3. **Cilium-Dependent Cell Motility:** DNAH8 is essential for the movement of cilia and flagella, which is critical for various cellular processes, including sensing the extracellular environment and regulating cell migration. 4. **Sperm Flagellum Motility:** DNAH8 is also involved in the motility of sperm flagella, ensuring proper fertilization and reproduction. **Clinical Significance:** Dysregulation of DNAH8 has been implicated in various diseases, including: 1. **Ciliopathies:** Mutations in DNAH8 have been associated with ciliopathies, a group of disorders characterized by defects in cilia structure and function. 2. **Retinal Diseases:** DNAH8 dysfunction has been linked to retinal diseases, including retinitis pigmentosa and cone-rod dystrophy. 3. **Immune System Disorders:** DNAH8 has also been implicated in immune system disorders, including primary ciliary dyskinesia and chronic obstructive pulmonary disease (COPD). In conclusion, DNAH8 is a critical gene involved in the structure and function of axonemal dynein complexes, regulating microtubule dynamics and cell motility. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and overall health.

Genular Protein ID: 2415533082

Symbol: DYH8_HUMAN

Name: Axonemal beta dynein heavy chain 8

UniProtKB Accession Codes:

Q96JB1 O00438 Q5JYI2 Q5T2M3 Q5T2M4 Q5TG00 Q9UEM4

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 CarbonylDB 1 ChEBI 2 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 14 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 19 KEGG 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 12 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12297094

Title: The T complex distorter 2 candidate gene, Dnahc8, encodes at least two testis-specific axonemal dynein heavy chains that differ extensively at their amino and carboxyl termini.

PubMed ID: 12297094

DOI: 10.1006/dbio.2002.0769

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 9373155

Title: Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

PubMed ID: 9373155

DOI: 10.1016/s0378-1119(97)00417-4

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 31178125

Title: Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.

PubMed ID: 31178125

DOI: 10.1016/j.ajhg.2019.04.015

PubMed ID: 32681648

Title: Loss-of-function mutation in DNAH8 induces asthenoteratospermia associated with multiple morphological abnormalities of the sperm flagella.

PubMed ID: 32681648

DOI: 10.1111/cge.13815

PubMed ID: 32619401

Title: Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility.

PubMed ID: 32619401

DOI: 10.1016/j.ajhg.2020.06.004

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 24307375

Title: Robust diagnostic genetic testing using solution capture enrichment and a novel variant-filtering interface.

PubMed ID: 24307375

DOI: 10.1002/humu.22490

Sequence Information:

  • Length: 4490
  • Mass: 514664
  • Checksum: E5809E32FF08199B
  • Sequence:
    • MMKLYIDNAA PDKLKGLCIF FVRCRNDVAI NVKTIQEEAL FTVLDASKGL LNGIRDMLAN 
IFLPAVLATN NWGALNQSKQ GESEKHIFTE TINRYLSFLD GARISIEGTV KLKTIDNVNF 
SKLHTFEEVT AAASNSETVH QLEEVLMVWY KQIEQVLIES EQMRKEAGDS GPLTELEHWK 
RMSAKFNYII EQIKGPSCKA VINVLNVAHS KLLKNWRDLD ARITDTANES KDNVRYLYTL 
EKVCQPLYNH DLVSMAHGIQ NLINAIRMIH GVSRYYNTSE RMTSLFIKVT NQMVTACKAY 
ITDGGLNHVW DQETPVVLKK IQDCIFLFKE YQASFHKTRK LISESSGEKS FEVSEMYIFG 
KFEAFCKRLE KITEMITVVQ TYSTLSNSTI EGIDIMAIKF RNIYQGVKKK QYDILDPRRT 
EFDTDFLDFM TKINGLEVQI QAFMNSSFGK ILSSQQALQL LQRFQKLNIP CLGLEINHTI 
ERILQYYVAE LDATKKLYHS QKDDPPLARN MPPIAGKILW VRQLYRRISE PINYFFKNSD 
ILSSPDGKAV IRQYNKISYV LVEFEVVYHT AWIREISQLH YALQATLFVR HPETGKLLVN 
FDPKILEVVR ETKCMIKMKL DVPEQAKRLL KLESKLKADK LYLQGLLQYY DELCQEVPSV 
FVNLMTPKMK KVESVLRQGL TVLTWSSLTL ESFFQEVELV LDMFNQLLKK ISDLCEMHID 
TVLKEIAKTV LISLPESGAT KVEDMLTLNE TYTKEWADIL NHKSKHVEEA VRELISIFEQ 
IYEVKYTGKV GKQSEQRKHV VFGSETGEGE NNDYEANIVN EFDTHDKEDE FKKECKEVFA 
FFSHQLLDSL QKATRLSLDT MKRRIFVASL YGRKQSEDII SFIKSEVHLA IPNVVMIPSL 
DDIQQAINRM IQLTLEVSRG VAHWGQQQIR PIKSVIPSPT TTDVTHQNTG KLLKKEERSF 
EEAIPARKLK NFYPGVAEHK DISKLVLLLS SSVNSLRKAA HEALQDFQKY KTLWTEDRDV 
KVKEFLANNP SLTEIRSEIL HYATFEQEID ELKPIIVVGA LELHTEPMKL ALSIEAKAWK 
MLLCRYLNEE YKKKMSYMIA FINEYLKKLS RPIRDLDDVR FAMEALSCIR DNEIQMDMTL 
GPIEEAYAIL NRFEVEVTKE ESEAVDTLRY SFNKLQSKAV SVQEDLVQVQ PKFKSNLLES 
VEVFREDVIN FAEAYELEGP MVPNIPPQEA SNRLQIFQAS FDDLWRKFVT YSSGEQLFGL 
PVTDYEVLHK TRKELNLLQK LYGLYDTVMS SISGYYEILW GDVDIEKINA ELLEFQNRCR 
KLPKGLKDWQ AFLDLKKRID DFSESCPLLE MMTNKAMKQR HWDRISELTG TPFDVESDSF 
CLRNIMEAPL LKHKDDIEDI CISAIKEKDI EAKLTQVIEN WTNQNLSFAA FKGKGELLLK 
GTESGEIITL MEDSLMVLGS LLSNRYNAPF KKNIQNWVYK LSTSSDIIEE WLVVQNLWVY 
LEAVFVGGDI AKQLPQEAKR FQNIDKSWIK IMQRAHENPN VINCCVGDET MGQLLPHLHE 
QLEVCQKSLT GYLEKKRLLF PRFFFVSDPV LLEILGQASD SHTIQPHLPA VSDNINEVTF 
HAKDYDRIMA VISREGEKIV LDNSVMAKGP VEIWLLDLLK MQMSSLHNII RSAFYQISDS 
GFQLLPFLSH FPAQVGLLGI QMLWTHDSEE ALRNAKDDRK IMQVTNQKFL DILNTLISQT 
THDLSKFDRV KFETLITIHV HQRDIFDDLV KMHIKSPTDF EWLKQSRFYF KEDLDQTVVS 
ITDVDFIYQN EFLGCTDRLV ITPLTDRCYI TLAQALGMNM GGAPAGPAGT GKTETTKDMG 
RCLGKYVVVF NCSDQMDFRG LGRIFKGLAQ SGSWGCFDEF NRIELPVLSV AAQQIYIVLT 
ARKERKKQFI FSDGDCVDLN PEFGIFLTMN PGYAGRQELP ENLKIQFRTV AMMVPDRQII 
MRVKLASCGF LENVILAQKF YVLYKLCEEQ LTKQVHYDFG LRNILSVLRT LGSQKRARPE 
DSELSIVMRG LRDMNLSKLV DEDEPLFLSL INDLFPGLQL DSNTYAELQN AVAHQVQIEG 
LINHPPWNLK LVQLYETSLV RHGLMTLGPS GSGKTTVITI LMKAQTECGR PHREMRMNPK 
AITAPQMFGR LDTATNDWTD GIFSTLWRKT LKAKKGENIF LILDGPVDAI WIENLNSVLD 
DNKTLTLANG DRIPMAPSCK LLFEVHNIEN ASPATVSRMG MVYISSSALS WRPILQAWLK 
KRTAQEAAVF LTLYEKVFED TYTYMKLNLN PKMQLLECNY IVQSLNLLEG LIPSKEEGGV 
SCVEHLHKLF VFGLMWSLGA LLELESREKL EAFLRQHESK LDLPEIPKGS NQTMYEFYVT 
DYGDWEHWNK KLQPYYYPTD SIPEYSSILV PNVDNIRTNF LIDTIAKQHK AVLLTGEQGT 
AKTVMVKAYL KKYDPEVQLS KSLNFSSATE PMMFQRTIES YVDKRIGSTY GPPGGRKMTV 
FIDDINMPVI NEWGDQITNE IVRQMMEMEG MYSLDKPGDF TTIVDVQLIA AMIHPGGGRN 
DIPQRLKRQF TVFNCTLPSN ASIDKIFGII GCGYFDPCRS FKPQICEMIV NLVSVGRVLW 
QWTKVKMLPT PSKFHYIFNL RDLSRIWQGM LTIKAEECAS IPTLLSLFKH ECSRVIADRF 
ITPEDEQWFN AHLTRAVEEN IGSDAASCIL PEPYFVDFLR EMPEPTGDEP EDSVFEVPKI 
YELMPSFDFL AEKLQFYQRQ FNEIIRGTSL DLVFFKDAMT HLIKISRIIR TSCGNALLVG 
VGGSGKQSLS RLASFIAGYQ IFQITLTRSY NVTNLTDDLK ALYKVAGADG KGITFIFTDS 
EIKDEAFLEY LNNLLSSGEI SNLFARDEMD EITQGLISVM KRELPRHPPT FDNLYEYFIS 
RSRKNLHVVL CFSPVGEKFR ARSLKFPGLI SGCTMDWFSR WPREALIAVA SYFLSDYNIV 
CSSEIKRQVV ETMGLFHDMV SESCESYFQR YRRRAHVTPK SYLSFINGYK NIYAEKVKFI 
NEQAERMNIG LDKLMEASES VAKLSQDLAV KEKELAVASI KADEVLAEVT VSAQASAKIK 
NEVQEVKDKA QKIVDEIDSE KVKAESKLEA AKPALEEAEA ALNTIKPNDI ATVRKLAKPP 
HLIMRIMDCV LLLFQKKIDP VTMDPEKSCC KPSWGESLKL MSATGFLWSL QQFPKDTINE 
ETVELLQPYF NMDDYTFESA KKVCGNVAGL LSWTLAMAIF YGINREVLPL KANLAKQEGR 
LAVANAELGK AQALLDEKQA ELDKVQAKFD AAMNEKMDLL NDADTCRKKM QAASTLIDGL 
SGEKIRWTQQ SKEFKAQINR LVGDILLCTG FLSYLGPFNQ IFRNYLLKDQ WEMELRARKI 
PFTENLNLIS MLVDPPTIGE WGLQGLPGDD LSIQNGIIVT KATRYPLLID PQTQGKTWIK 
SKEKENDLQV TSLNHKYFRT HLEDSLSLGR PLLIEDIHEE LDPALDNVLE KNFIKSGTTF 
KVKVGDKECD IMDTFKLYIT TKLPNPAFTP EINAKTSVID FTVTMKGLEN QLLRRVILTE 
KQELEAERVK LLEDVTFNKR KMKELEDNLL YKLSATKGSL VDDESLIGVL RTTKQTAAEV 
SEKLHVAAET EIKINAAQEE FRPAATRGSI LYFLITEMSM VNIMYQTSLA QFLKLFDQSM 
ARSEKSPLPQ KRITNIIEYL TYEVFTYSVR GLYENHKFLF VLLMTLKIDL QRGTVKHREF 
QALIKGGAAL DLKACPPKPY RWILDMTWLN LVELSKLPQF AEIMNQISRN EKGWKSWFDK 
DAPEEEIIPD GYNDSLDTCH KLLLIRSWCP DRTVFQARKY IADSLEEKYT EPVILNLEKT 
WEESDTRTPL ICFLSMGSDP TNQIDALAKK LKLECRTISM GQGQEVHARK LIQMSMQQGG 
WVLLQNCHLG LEFMEELLET LITTEASDDS FRVWITTEPH DRFPITLLQT SLKFTNEPPQ 
GVRAGLKRTF AGINQDLLDI SNLPMWKPML YTVAFLHSTV QERRKFGPLG WNIPYEFNSA 
DFSASVQFIQ NHLDECDIKK GVSWNTVRYM IGEVQYGGRV TDDFDKRLLN CFARVWFSEK 
MFEPSFCFYT GYKIPLCKTL DQYFEYIQSL PSLDNPEVFG LHPNADITYQ SNTASAVLET 
ITNIQPKESG GGVGETREAI VYRLSEDMLS KLPPDYIPHE VKSRLIKMGH LNSMNIFLRQ 
EIDRMQRVIS ILRSSLSDLK LAIEGTIIMS ENLRDALDNM YDARIPQLWK RVSWDSSTLG 
FWFTELLERN AQFSTWIFEG RPNVFWMTGF FNPQGFLTAM RQEVTRAHKG WALDTVTIHN 
EVLRQTKEEI TSPPGEGVYI YGLYMDGAAW DRRNGKLMES TPKVLFTQLP VLHIFAINST 
APKDPKLYVC PIYKKPRRTD LTFITVVYLR TVLSPDHWIL RGVALLCDIK

Genular Protein ID: 173210423

Symbol: A0A075B6F3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A075B6F3

Database IDs:

ARBA 12 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 14 GeneTree 1 HGNC 1 InterPro 19 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 12 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

Sequence Information:

  • Length: 4707
  • Mass: 538594
  • Checksum: 822532AAA6AECA17
  • Sequence:
    • MEKDAEDGAP SEGAEAPPST EEAAPPRSEE EEAPRPPTVE APAEDGFSPS AEDAVSSVVD 
YRDLIPSEEG IVLPDDHEAD LNRVRQRLAP RPVQSVISEV LSLPSSRRSS RYRRSMSGLP 
NLQETLKERQ ARFREARESR RLKIDPSYKY IFEILAENLG LDIVTVEELI LDCPSLEAFT 
NFFAKDGCKT LKFLYQEGDV PGIECGRTIA GATKGAKMMK LYIDNAAPDK LKGLCIFFVR 
CRNDVAINVK TIQEEALFTV LDASKGLLNG IRDMLANIFL PAVLATNNWG ALNQSKQGES 
EKHIFTETIN RYLSFLDGAR ISIEGTVKLK TIDNVNFSKL HTFEEVTAAA SNSETVHQLE 
EVLMVWYKQI EQVLIESEQM RKEAGDSGPL TELEHWKRMS AKFNYIIEQI KGPSCKAVIN 
VLNVAHSKLL KNWRDLDARI TDTANESKDN VRYLYTLEKV CQPLYNHDLV SMAHGIQNLI 
NAIRMIHGVS RYYNTSERMT SLFIKVTNQM VTACKAYITD GGLNHVWDQE TPVVLKKIQD 
CIFLFKEYQA SFHKTRKLIS ESSGEKSFEV SEMYIFGKFE AFCKRLEKIT EMITVVQTYS 
TLSNSTIEGI DIMAIKFRNI YQGVKKKQYD ILDPRRTEFD TDFLDFMTKI NGLEVQIQAF 
MNSSFGKILS SQQALQLLQR FQKLNIPCLG LEINHTIERI LQYYVAELDA TKKLYHSQKD 
DPPLARNMPP IAGKILWVRQ LYRRISEPIN YFFKNSDILS SPDGKAVIRQ YNKISYVLVE 
FEVVYHTAWI REISQLHYAL QATLFVRHPE TGKLLVNFDP KILEVVRETK CMIKMKLDVP 
EQAKRLLKLE SKLKADKLYL QGLLQYYDEL CQEVPSVFVN LMTPKMKKVE SVLRQGLTVL 
TWSSLTLESF FQEVELVLDM FNQLLKKISD LCEMHIDTVL KEIAKTVLIS LPESGATKVE 
DMLTLNETYT KEWADILNHK SKHVEEAVRE LISIFEQIYE VKYTGKVGKQ SEQRKHVVFG 
SETGEGENND YEANIVNEFD THDKEDEFKK ECKEVFAFFS HQLLDSLQKA TRLSLDTMKR 
RIFVASLYGR KQSEDIISFI KSEVHLAIPN VVMIPSLDDI QQAINRMIQL TLEVSRGVAH 
WGQQQIRPIK SVIPSPTTTD VTHQNTGKLL KKEERSFEEA IPARKLKNFY PGVAEHKDIS 
KLVLLLSSSV NSLRKAAHEA LQDFQKYKTL WTEDRDVKVK EFLANNPSLT EIRSEILHYA 
TFEQEIDELK PIIVVGALEL HTEPMKLALS IEAKAWKMLL CRYLNEEYKK KMSYMIAFIN 
EYLKKLSRPI RDLDDVRFAM EALSCIRDNE IQMDMTLGPI EEAYAILNRF EVEVTKEESE 
AVDTLRYSFN KLQSKAVSVQ EDLVQVQPKF KSNLLESVEV FREDVINFAE AYELEGPMVP 
NIPPQEASNR LQIFQASFDD LWRKFVTYSS GEQLFGLPVT DYEVLHKTRK ELNLLQKLYG 
LYDTVMSSIS GYYEILWGDV DIEKINAELL EFQNRCRKLP KGLKDWQAFL DLKKRIDDFS 
ESCPLLEMMT NKAMKQRHWD RISELTGTPF DVESDSFCLR NIMEAPLLKH KDDIEDICIS 
AIKEKDIEAK LTQVIENWTN QNLSFAAFKG KGELLLKGTE SGEIITLMED SLMVLGSLLS 
NRYNAPFKKN IQNWVYKLST SSDIIEEWLV VQNLWVYLEA VFVGGDIAKQ LPQEAKRFQN 
IDKSWIKIMQ RAHENPNVIN CCVGDETMGQ LLPHLHEQLE VCQKSLTGYL EKKRLLFPRF 
FFVSDPVLLE ILGQASDSHT IQPHLPAVSD NINEVTFHAK DYDRIMAVIS REGEKIVLDN 
SVMAKGPVEI WLLDLLKMQM SSLHNIIRSA FYQISDSGFQ LLPFLSHFPA QVGLLGIQML 
WTHDSEEALR NAKDDRKIMQ VTNQKFLDIL NTLISQTTHD LSKFDRVKFE TLITIHVHQR 
DIFDDLVKMH IKSPTDFEWL KQSRFYFKED LDQTVVSITD VDFIYQNEFL GCTDRLVITP 
LTDRCYITLA QALGMNMGGA PAGPAGTGKT ETTKDMGRCL GKYVVVFNCS DQMDFRGLGR 
IFKGLAQSGS WGCFDEFNRI ELPVLSVAAQ QIYIVLTARK ERKKQFIFSD GDCVDLNPEF 
GIFLTMNPGY AGRQELPENL KIQFRTVAMM VPDRQIIMRV KLASCGFLEN VILAQKFYVL 
YKLCEEQLTK QVHYDFGLRN ILSVLRTLGS QKRARPEDSE LSIVMRGLRD MNLSKLVDED 
EPLFLSLIND LFPGLQLDSN TYAELQNAVA HQVQIEGLIN HPPWNLKLVQ LYETSLVRHG 
LMTLGPSGSG KTTVITILMK AQTECGRPHR EMRMNPKAIT APQMFGRLDT ATNDWTDGIF 
STLWRKTLKA KKGENIFLIL DGPVDAIWIE NLNSVLDDNK TLTLANGDRI PMAPSCKLLF 
EVHNIENASP ATVSRMGMVY ISSSALSWRP ILQAWLKKRT AQEAAVFLTL YEKVFEDTYT 
YMKLNLNPKM QLLECNYIVQ SLNLLEGLIP SKEEGGVSCV EHLHKLFVFG LMWSLGALLE 
LESREKLEAF LRQHESKLDL PEIPKGSNQT MYEFYVTDYG DWEHWNKKLQ PYYYPTDSIP 
EYSSILVPNV DNIRTNFLID TIAKQHKAVL LTGEQGTAKT VMVKAYLKKY DPEVQLSKSL 
NFSSATEPMM FQRTIESYVD KRIGSTYGPP GGRKMTVFID DINMPVINEW GDQITNEIVR 
QMMEMEGMYS LDKPGDFTTI VDVQLIAAMI HPGGGRNDIP QRLKRQFTVF NCTLPSNASI 
DKIFGIIGCG YFDPCRSFKP QICEMIVNLV SVGRVLWQWT KVKMLPTPSK FHYIFNLRDL 
SRIWQGMLTI KAEECASIPT LLSLFKHECS RVIADRFITP EDEQWFNAHL TRAVEENIGS 
DAASCILPEP YFVDFLREMP EPTGDEPEDS VFEVPKIYEL MPSFDFLAEK LQFYQRQFNE 
IIRGTSLDLV FFKDAMTHLI KISRIIRTSC GNALLVGVGG SGKQSLSRLA SFIAGYQIFQ 
ITLTRSYNVT NLTDDLKALY KVAGADGKGI TFIFTDSEIK DEAFLEYLNN LLSSGEISNL 
FARDEMDEIT QGLISVMKRE LPRHPPTFDN LYEYFISRSR KNLHVVLCFS PVGEKFRARS 
LKFPGLISGC TMDWFSRWPR EALIAVASYF LSDYNIVCSS EIKRQVVETM GLFHDMVSES 
CESYFQRYRR RAHVTPKSYL SFINGYKNIY AEKVKFINEQ AERMNIGLDK LMEASESVAK 
LSQDLAVKEK ELAVASIKAD EVLAEVTVSA QASAKIKNEV QEVKDKAQKI VDEIDSEKVK 
AESKLEAAKP ALEEAEAALN TIKPNDIATV RKLAKPPHLI MRIMDCVLLL FQKKIDPVTM 
DPEKSCCKPS WGESLKLMSA TGFLWSLQQF PKDTINEETV ELLQPYFNMD DYTFESAKKV 
CGNVAGLLSW TLAMAIFYGI NREVLPLKAN LAKQEGRLAV ANAELGKAQA LLDEKQAELD 
KVQAKFDAAM NEKMDLLNDA DTCRKKMQAA STLIDGLSGE KIRWTQQSKE FKAQINRLVG 
DILLCTGFLS YLGPFNQIFR NYLLKDQWEM ELRARKIPFT ENLNLISMLV DPPTIGEWGL 
QGLPGDDLSI QNGIIVTKAT RYPLLIDPQT QGKTWIKSKE KENDLQVTSL NHKYFRTHLE 
DSLSLGRPLL IEDIHEELDP ALDNVLEKNF IKSGTTFKVK VGDKECDIMD TFKLYITTKL 
PNPAFTPEIN AKTSVIDFTV TMKGLENQLL RRVILTEKQE LEAERVKLLE DVTFNKRKMK 
ELEDNLLYKL SATKGSLVDD ESLIGVLRTT KQTAAEVSEK LHVAAETEIK INAAQEEFRP 
AATRGSILYF LITEMSMVNI MYQTSLAQFL KLFDQSMARS EKSPLPQKRI TNIIEYLTYE 
VFTYSVRGLY ENHKFLFVLL MTLKIDLQRG TVKHREFQAL IKGGAALDLK ACPPKPYRWI 
LDMTWLNLVE LSKLPQFAEI MNQISRNEKG WKSWFDKDAP EEEIIPDGYN DSLDTCHKLL 
LIRSWCPDRT VFQARKYIAD SLEEKYTEPV ILNLEKTWEE SDTRTPLICF LSMGSDPTNQ 
IDALAKKLKL ECRTISMGQG QEVHARKLIQ MSMQQGGWVL LQNCHLGLEF MEELLETLIT 
TEASDDSFRV WITTEPHDRF PITLLQTSLK FTNEPPQGVR AGLKRTFAGI NQDLLDISNL 
PMWKPMLYTV AFLHSTVQER RKFGPLGWNI PYEFNSADFS ASVQFIQNHL DECDIKKGVS 
WNTVRYMIGE VQYGGRVTDD FDKRLLNCFA RVWFSEKMFE PSFCFYTGYK IPLCKTLDQY 
FEYIQSLPSL DNPEVFGLHP NADITYQSNT ASAVLETITN IQPKESGGGV GETREAIVYR 
LSEDMLSKLP PDYIPHEVKS RLIKMGHLNS MNIFLRQEID RMQRVISILR SSLSDLKLAI 
EGTIIMSENL RDALDNMYDA RIPQLWKRVS WDSSTLGFWF TELLERNAQF STWIFEGRPN 
VFWMTGFFNP QGFLTAMRQE VTRAHKGWAL DTVTIHNEVL RQTKEEITSP PGEGVYIYGL 
YMDGAAWDRR NGKLMESTPK VLFTQLPVLH IFAINSTAPK DPKLYVCPIY KKPRRTDLTF 
ITVVYLRTVL SPDHWILRGV ALLCDIK

Genular Protein ID: 569158698

Symbol: Q8IU65_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IU65 A6NKM5

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 2 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PeptideAtlas 1 PharmGKB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12297094

Title: The T complex distorter 2 candidate gene, Dnahc8, encodes at least two testis-specific axonemal dynein heavy chains that differ extensively at their amino and carboxyl termini.

PubMed ID: 12297094

DOI: 10.1006/dbio.2002.0769

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 217
  • Mass: 23949
  • Checksum: B58B1178491A7B9C
  • Sequence:
    • MEKDAEDGAP SEGAEAPPST EEAAPPRSEE EEAPRPPTVE APAEDGFSPS AEDAVSSVVD 
YRDLIPSEEG IVLPDDHEAD LNRVRQRLAP RPVQSVISEV LSLPSSRRSS RYRRSMSGLP 
NLQETLKERQ ARFREARESR RLKIDPSYKY IFEILAENLG LDIVTVEELI LDCPSLEAFT 
NFFAKDGCKT LKFLYQEGDV PGIECGRTIA GATKGAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.