Details for: DNAH8

Gene ID: 1769

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: DNAH8

Ensembl ID: ENSG00000124721

Description: dynein axonemal heavy chain 8

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • ependymal cell CL0000065
    CSI 3.03
    rCSI 6.14%
    PRS 99.1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [DNAH8](/details-gene/1769) (Dynein Axonemal Heavy Chain 8) encodes a large protein that is a critical component of the outer dynein arms in motile cilia and flagella. As a microtubule-dependent motor protein, it utilizes ATP hydrolysis to generate the force required for ciliary and flagellar beating. Its function is essential for processes dependent on fluid movement, such as the circulation of cerebrospinal fluid by [ependymal cell](/details-cell/CL0000065) cilia and sperm motility. Consistent with this role, mutations in [DNAH8](/details-gene/1769) have been definitively linked to primary male infertility characterized by sperm flagellar defects and asthenozoospermia [[Link](https://doi.org/10.1111/cge.13815); [Link](https://doi.org/10.1016/j.ajhg.2020.06.004)]. ## Cellular Roles and Expression Landscape The expression profile of [DNAH8](/details-gene/1769) highlights its specialized function in cells equipped with motile cilia or flagella. **Overall**, its most significant expression is observed in the [ependymal cell](/details-cell/CL0000065) (CSI: 3.03), the cell type responsible for lining the ventricles of the brain and circulating cerebrospinal fluid via coordinated ciliary beating. This finding strongly supports its role in central nervous system homeostasis. In addition to its role in the CNS, a substantial body of research confirms the indispensable function of [DNAH8](/details-gene/1769) in male gametes. Although not ranked as the top cell type in this specific analysis, multiple studies have identified it as a testis-specific axonemal dynein heavy chain [[Link](https://doi.org/10.1006/dbio.2002.0769); [Link](https://doi.org/10.1016/s0378-1119(97)00417-4)]. Loss-of-function mutations in [DNAH8](/details-gene/1769) are a known cause of male infertility, leading to multiple morphological abnormalities of the sperm flagella (MMAF) and severely reduced sperm motility (asthenoteratospermia) [[Link](https://doi.org/10.1111/cge.13815)]. This demonstrates that [DNAH8](/details-gene/1769) is crucial for the proper assembly and function of the sperm flagellar axoneme. ## Pathways and Molecular Function The function of [DNAH8](/details-gene/1769) is deeply rooted in the machinery of cellular motility. Gene Ontology annotations place it centrally within the 'Axonemal dynein complex' ([GO:0005858](https://www.ebi.ac.uk/QuickGO/term/GO:0005858)) and specifically as part of the 'Outer dynein arm' ([GO:0036157](https://www.ebi.ac.uk/QuickGO/term/GO:0036157)). Its activity directly contributes to biological processes such as 'Cilium movement involved in cell motility' ([GO:0060294](https://www.ebi.ac.uk/QuickGO/term/GO:0060294)), which is consistent with its high significance in [ependymal cell](/details-cell/CL0000065). Its role in male fertility is underscored by its localization to the 'Sperm flagellum' ([GO:0036126](https://www.ebi.ac.uk/QuickGO/term/GO:0036126)). At the molecular level, [DNAH8](/details-gene/1769) functions as a 'Microtubule motor activity' ([GO:0003777](https://www.ebi.ac.uk/QuickGO/term/GO:0003777)) protein. This is achieved through its ability to bind ATP ([GO:0005524](https://www.ebi.ac.uk/QuickGO/term/GO:0005524)) and perform 'Atp hydrolysis activity' ([GO:0016887](https://www.ebi.ac.uk/QuickGO/term/GO:0016887)), which provides the energy to move along microtubules. Its integration into the larger dynein complex is mediated by binding to dynein intermediate and light intermediate chains ([GO:0045505](https://www.ebi.ac.uk/QuickGO/term/GO:0045505), [GO:0051959](https://www.ebi.ac.uk/QuickGO/term/GO:0051959)). ## Research Directions The well-established role of [DNAH8](/details-gene/1769) in cilia- and flagella-driven motility provides a strong foundation for further investigation into its broader physiological and pathological implications. ### Proposed Hypotheses: 1. Given that loss-of-function mutations in [DNAH8](/details-gene/1769) cause flagellar dysfunction in sperm and the gene is highly significant in [ependymal cell](/details-cell/CL0000065), it is hypothesized that deleterious mutations in [DNAH8](/details-gene/1769) may contribute to neurological disorders associated with impaired cerebrospinal fluid (CSF) flow, such as certain forms of hydrocephalus. 2. The assembly and function of the dynein motor complex are often regulated by post-translational modifications. Therefore, it is hypothesized that defects in the signaling pathways that phosphorylate or otherwise modify the [DNAH8](/details-gene/1769) protein could lead to a clinical phenotype of ciliopathy (e.g., infertility or hydrocephalus) even in the absence of a coding mutation in the gene itself. ### Experimental Approach: To test the hypothesis linking [DNAH8](/details-gene/1769) to CSF dynamics and neurological disorders, a knockout or knock-in mouse model harboring a known pathogenic human mutation could be generated. These mice would be monitored for developmental and adult-onset neurological phenotypes. Key experiments would include non-invasive imaging (e.g., MRI) to assess ventricular volume as an indicator of hydrocephalus, direct measurement of ependymal cilia beat frequency in brain slice cultures using high-speed video microscopy, and analysis of CSF flow dynamics using particle tracking velocimetry. ### Therapeutic Potential: As pathologies associated with [DNAH8](/details-gene/1769) arise from loss-of-function, therapeutic strategies would need to focus on functional restoration rather than inhibition. The gene's large size and critical role in multiple ciliated tissues present significant challenges for therapeutic development. For monogenic infertility, gene therapy represents a theoretical possibility, potentially through ex vivo correction in spermatogonial stem cells, though this remains a distant and highly complex prospect. For neurological conditions, the blood-brain barrier and the difficulty of targeting [ependymal cell](/details-cell/CL0000065) specifically make conventional gene therapy exceedingly difficult. Therefore, [DNAH8](/details-gene/1769) is currently considered a challenging therapeutic target.

Genular Protein ID: 2415533082

Symbol: DYH8_HUMAN

Name: Axonemal beta dynein heavy chain 8

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12297094

Title: The T complex distorter 2 candidate gene, Dnahc8, encodes at least two testis-specific axonemal dynein heavy chains that differ extensively at their amino and carboxyl termini.

PubMed ID: 12297094

DOI: 10.1006/dbio.2002.0769

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 9373155

Title: Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

PubMed ID: 9373155

DOI: 10.1016/s0378-1119(97)00417-4

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 31178125

Title: Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.

PubMed ID: 31178125

DOI: 10.1016/j.ajhg.2019.04.015

PubMed ID: 32681648

Title: Loss-of-function mutation in DNAH8 induces asthenoteratospermia associated with multiple morphological abnormalities of the sperm flagella.

PubMed ID: 32681648

DOI: 10.1111/cge.13815

PubMed ID: 32619401

Title: Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility.

PubMed ID: 32619401

DOI: 10.1016/j.ajhg.2020.06.004

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 24307375

Title: Robust diagnostic genetic testing using solution capture enrichment and a novel variant-filtering interface.

PubMed ID: 24307375

DOI: 10.1002/humu.22490

Sequence Information:

  • Length: 4490
  • Mass: 514664
  • Checksum: E5809E32FF08199B
  • Sequence:
  • MMKLYIDNAA PDKLKGLCIF FVRCRNDVAI NVKTIQEEAL FTVLDASKGL LNGIRDMLAN 
    IFLPAVLATN NWGALNQSKQ GESEKHIFTE TINRYLSFLD GARISIEGTV KLKTIDNVNF 
    SKLHTFEEVT AAASNSETVH QLEEVLMVWY KQIEQVLIES EQMRKEAGDS GPLTELEHWK 
    RMSAKFNYII EQIKGPSCKA VINVLNVAHS KLLKNWRDLD ARITDTANES KDNVRYLYTL 
    EKVCQPLYNH DLVSMAHGIQ NLINAIRMIH GVSRYYNTSE RMTSLFIKVT NQMVTACKAY 
    ITDGGLNHVW DQETPVVLKK IQDCIFLFKE YQASFHKTRK LISESSGEKS FEVSEMYIFG 
    KFEAFCKRLE KITEMITVVQ TYSTLSNSTI EGIDIMAIKF RNIYQGVKKK QYDILDPRRT 
    EFDTDFLDFM TKINGLEVQI QAFMNSSFGK ILSSQQALQL LQRFQKLNIP CLGLEINHTI 
    ERILQYYVAE LDATKKLYHS QKDDPPLARN MPPIAGKILW VRQLYRRISE PINYFFKNSD 
    ILSSPDGKAV IRQYNKISYV LVEFEVVYHT AWIREISQLH YALQATLFVR HPETGKLLVN 
    FDPKILEVVR ETKCMIKMKL DVPEQAKRLL KLESKLKADK LYLQGLLQYY DELCQEVPSV 
    FVNLMTPKMK KVESVLRQGL TVLTWSSLTL ESFFQEVELV LDMFNQLLKK ISDLCEMHID 
    TVLKEIAKTV LISLPESGAT KVEDMLTLNE TYTKEWADIL NHKSKHVEEA VRELISIFEQ 
    IYEVKYTGKV GKQSEQRKHV VFGSETGEGE NNDYEANIVN EFDTHDKEDE FKKECKEVFA 
    FFSHQLLDSL QKATRLSLDT MKRRIFVASL YGRKQSEDII SFIKSEVHLA IPNVVMIPSL 
    DDIQQAINRM IQLTLEVSRG VAHWGQQQIR PIKSVIPSPT TTDVTHQNTG KLLKKEERSF 
    EEAIPARKLK NFYPGVAEHK DISKLVLLLS SSVNSLRKAA HEALQDFQKY KTLWTEDRDV 
    KVKEFLANNP SLTEIRSEIL HYATFEQEID ELKPIIVVGA LELHTEPMKL ALSIEAKAWK 
    MLLCRYLNEE YKKKMSYMIA FINEYLKKLS RPIRDLDDVR FAMEALSCIR DNEIQMDMTL 
    GPIEEAYAIL NRFEVEVTKE ESEAVDTLRY SFNKLQSKAV SVQEDLVQVQ PKFKSNLLES 
    VEVFREDVIN FAEAYELEGP MVPNIPPQEA SNRLQIFQAS FDDLWRKFVT YSSGEQLFGL 
    PVTDYEVLHK TRKELNLLQK LYGLYDTVMS SISGYYEILW GDVDIEKINA ELLEFQNRCR 
    KLPKGLKDWQ AFLDLKKRID DFSESCPLLE MMTNKAMKQR HWDRISELTG TPFDVESDSF 
    CLRNIMEAPL LKHKDDIEDI CISAIKEKDI EAKLTQVIEN WTNQNLSFAA FKGKGELLLK 
    GTESGEIITL MEDSLMVLGS LLSNRYNAPF KKNIQNWVYK LSTSSDIIEE WLVVQNLWVY 
    LEAVFVGGDI AKQLPQEAKR FQNIDKSWIK IMQRAHENPN VINCCVGDET MGQLLPHLHE 
    QLEVCQKSLT GYLEKKRLLF PRFFFVSDPV LLEILGQASD SHTIQPHLPA VSDNINEVTF 
    HAKDYDRIMA VISREGEKIV LDNSVMAKGP VEIWLLDLLK MQMSSLHNII RSAFYQISDS 
    GFQLLPFLSH FPAQVGLLGI QMLWTHDSEE ALRNAKDDRK IMQVTNQKFL DILNTLISQT 
    THDLSKFDRV KFETLITIHV HQRDIFDDLV KMHIKSPTDF EWLKQSRFYF KEDLDQTVVS 
    ITDVDFIYQN EFLGCTDRLV ITPLTDRCYI TLAQALGMNM GGAPAGPAGT GKTETTKDMG 
    RCLGKYVVVF NCSDQMDFRG LGRIFKGLAQ SGSWGCFDEF NRIELPVLSV AAQQIYIVLT 
    ARKERKKQFI FSDGDCVDLN PEFGIFLTMN PGYAGRQELP ENLKIQFRTV AMMVPDRQII 
    MRVKLASCGF LENVILAQKF YVLYKLCEEQ LTKQVHYDFG LRNILSVLRT LGSQKRARPE 
    DSELSIVMRG LRDMNLSKLV DEDEPLFLSL INDLFPGLQL DSNTYAELQN AVAHQVQIEG 
    LINHPPWNLK LVQLYETSLV RHGLMTLGPS GSGKTTVITI LMKAQTECGR PHREMRMNPK 
    AITAPQMFGR LDTATNDWTD GIFSTLWRKT LKAKKGENIF LILDGPVDAI WIENLNSVLD 
    DNKTLTLANG DRIPMAPSCK LLFEVHNIEN ASPATVSRMG MVYISSSALS WRPILQAWLK 
    KRTAQEAAVF LTLYEKVFED TYTYMKLNLN PKMQLLECNY IVQSLNLLEG LIPSKEEGGV 
    SCVEHLHKLF VFGLMWSLGA LLELESREKL EAFLRQHESK LDLPEIPKGS NQTMYEFYVT 
    DYGDWEHWNK KLQPYYYPTD SIPEYSSILV PNVDNIRTNF LIDTIAKQHK AVLLTGEQGT 
    AKTVMVKAYL KKYDPEVQLS KSLNFSSATE PMMFQRTIES YVDKRIGSTY GPPGGRKMTV 
    FIDDINMPVI NEWGDQITNE IVRQMMEMEG MYSLDKPGDF TTIVDVQLIA AMIHPGGGRN 
    DIPQRLKRQF TVFNCTLPSN ASIDKIFGII GCGYFDPCRS FKPQICEMIV NLVSVGRVLW 
    QWTKVKMLPT PSKFHYIFNL RDLSRIWQGM LTIKAEECAS IPTLLSLFKH ECSRVIADRF 
    ITPEDEQWFN AHLTRAVEEN IGSDAASCIL PEPYFVDFLR EMPEPTGDEP EDSVFEVPKI 
    YELMPSFDFL AEKLQFYQRQ FNEIIRGTSL DLVFFKDAMT HLIKISRIIR TSCGNALLVG 
    VGGSGKQSLS RLASFIAGYQ IFQITLTRSY NVTNLTDDLK ALYKVAGADG KGITFIFTDS 
    EIKDEAFLEY LNNLLSSGEI SNLFARDEMD EITQGLISVM KRELPRHPPT FDNLYEYFIS 
    RSRKNLHVVL CFSPVGEKFR ARSLKFPGLI SGCTMDWFSR WPREALIAVA SYFLSDYNIV 
    CSSEIKRQVV ETMGLFHDMV SESCESYFQR YRRRAHVTPK SYLSFINGYK NIYAEKVKFI 
    NEQAERMNIG LDKLMEASES VAKLSQDLAV KEKELAVASI KADEVLAEVT VSAQASAKIK 
    NEVQEVKDKA QKIVDEIDSE KVKAESKLEA AKPALEEAEA ALNTIKPNDI ATVRKLAKPP 
    HLIMRIMDCV LLLFQKKIDP VTMDPEKSCC KPSWGESLKL MSATGFLWSL QQFPKDTINE 
    ETVELLQPYF NMDDYTFESA KKVCGNVAGL LSWTLAMAIF YGINREVLPL KANLAKQEGR 
    LAVANAELGK AQALLDEKQA ELDKVQAKFD AAMNEKMDLL NDADTCRKKM QAASTLIDGL 
    SGEKIRWTQQ SKEFKAQINR LVGDILLCTG FLSYLGPFNQ IFRNYLLKDQ WEMELRARKI 
    PFTENLNLIS MLVDPPTIGE WGLQGLPGDD LSIQNGIIVT KATRYPLLID PQTQGKTWIK 
    SKEKENDLQV TSLNHKYFRT HLEDSLSLGR PLLIEDIHEE LDPALDNVLE KNFIKSGTTF 
    KVKVGDKECD IMDTFKLYIT TKLPNPAFTP EINAKTSVID FTVTMKGLEN QLLRRVILTE 
    KQELEAERVK LLEDVTFNKR KMKELEDNLL YKLSATKGSL VDDESLIGVL RTTKQTAAEV 
    SEKLHVAAET EIKINAAQEE FRPAATRGSI LYFLITEMSM VNIMYQTSLA QFLKLFDQSM 
    ARSEKSPLPQ KRITNIIEYL TYEVFTYSVR GLYENHKFLF VLLMTLKIDL QRGTVKHREF 
    QALIKGGAAL DLKACPPKPY RWILDMTWLN LVELSKLPQF AEIMNQISRN EKGWKSWFDK 
    DAPEEEIIPD GYNDSLDTCH KLLLIRSWCP DRTVFQARKY IADSLEEKYT EPVILNLEKT 
    WEESDTRTPL ICFLSMGSDP TNQIDALAKK LKLECRTISM GQGQEVHARK LIQMSMQQGG 
    WVLLQNCHLG LEFMEELLET LITTEASDDS FRVWITTEPH DRFPITLLQT SLKFTNEPPQ 
    GVRAGLKRTF AGINQDLLDI SNLPMWKPML YTVAFLHSTV QERRKFGPLG WNIPYEFNSA 
    DFSASVQFIQ NHLDECDIKK GVSWNTVRYM IGEVQYGGRV TDDFDKRLLN CFARVWFSEK 
    MFEPSFCFYT GYKIPLCKTL DQYFEYIQSL PSLDNPEVFG LHPNADITYQ SNTASAVLET 
    ITNIQPKESG GGVGETREAI VYRLSEDMLS KLPPDYIPHE VKSRLIKMGH LNSMNIFLRQ 
    EIDRMQRVIS ILRSSLSDLK LAIEGTIIMS ENLRDALDNM YDARIPQLWK RVSWDSSTLG 
    FWFTELLERN AQFSTWIFEG RPNVFWMTGF FNPQGFLTAM RQEVTRAHKG WALDTVTIHN 
    EVLRQTKEEI TSPPGEGVYI YGLYMDGAAW DRRNGKLMES TPKVLFTQLP VLHIFAINST 
    APKDPKLYVC PIYKKPRRTD LTFITVVYLR TVLSPDHWIL RGVALLCDIK

Genular Protein ID: 173210423

Symbol: A0A075B6F3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

Sequence Information:

  • Length: 4707
  • Mass: 538594
  • Checksum: 822532AAA6AECA17
  • Sequence:
  • MEKDAEDGAP SEGAEAPPST EEAAPPRSEE EEAPRPPTVE APAEDGFSPS AEDAVSSVVD 
    YRDLIPSEEG IVLPDDHEAD LNRVRQRLAP RPVQSVISEV LSLPSSRRSS RYRRSMSGLP 
    NLQETLKERQ ARFREARESR RLKIDPSYKY IFEILAENLG LDIVTVEELI LDCPSLEAFT 
    NFFAKDGCKT LKFLYQEGDV PGIECGRTIA GATKGAKMMK LYIDNAAPDK LKGLCIFFVR 
    CRNDVAINVK TIQEEALFTV LDASKGLLNG IRDMLANIFL PAVLATNNWG ALNQSKQGES 
    EKHIFTETIN RYLSFLDGAR ISIEGTVKLK TIDNVNFSKL HTFEEVTAAA SNSETVHQLE 
    EVLMVWYKQI EQVLIESEQM RKEAGDSGPL TELEHWKRMS AKFNYIIEQI KGPSCKAVIN 
    VLNVAHSKLL KNWRDLDARI TDTANESKDN VRYLYTLEKV CQPLYNHDLV SMAHGIQNLI 
    NAIRMIHGVS RYYNTSERMT SLFIKVTNQM VTACKAYITD GGLNHVWDQE TPVVLKKIQD 
    CIFLFKEYQA SFHKTRKLIS ESSGEKSFEV SEMYIFGKFE AFCKRLEKIT EMITVVQTYS 
    TLSNSTIEGI DIMAIKFRNI YQGVKKKQYD ILDPRRTEFD TDFLDFMTKI NGLEVQIQAF 
    MNSSFGKILS SQQALQLLQR FQKLNIPCLG LEINHTIERI LQYYVAELDA TKKLYHSQKD 
    DPPLARNMPP IAGKILWVRQ LYRRISEPIN YFFKNSDILS SPDGKAVIRQ YNKISYVLVE 
    FEVVYHTAWI REISQLHYAL QATLFVRHPE TGKLLVNFDP KILEVVRETK CMIKMKLDVP 
    EQAKRLLKLE SKLKADKLYL QGLLQYYDEL CQEVPSVFVN LMTPKMKKVE SVLRQGLTVL 
    TWSSLTLESF FQEVELVLDM FNQLLKKISD LCEMHIDTVL KEIAKTVLIS LPESGATKVE 
    DMLTLNETYT KEWADILNHK SKHVEEAVRE LISIFEQIYE VKYTGKVGKQ SEQRKHVVFG 
    SETGEGENND YEANIVNEFD THDKEDEFKK ECKEVFAFFS HQLLDSLQKA TRLSLDTMKR 
    RIFVASLYGR KQSEDIISFI KSEVHLAIPN VVMIPSLDDI QQAINRMIQL TLEVSRGVAH 
    WGQQQIRPIK SVIPSPTTTD VTHQNTGKLL KKEERSFEEA IPARKLKNFY PGVAEHKDIS 
    KLVLLLSSSV NSLRKAAHEA LQDFQKYKTL WTEDRDVKVK EFLANNPSLT EIRSEILHYA 
    TFEQEIDELK PIIVVGALEL HTEPMKLALS IEAKAWKMLL CRYLNEEYKK KMSYMIAFIN 
    EYLKKLSRPI RDLDDVRFAM EALSCIRDNE IQMDMTLGPI EEAYAILNRF EVEVTKEESE 
    AVDTLRYSFN KLQSKAVSVQ EDLVQVQPKF KSNLLESVEV FREDVINFAE AYELEGPMVP 
    NIPPQEASNR LQIFQASFDD LWRKFVTYSS GEQLFGLPVT DYEVLHKTRK ELNLLQKLYG 
    LYDTVMSSIS GYYEILWGDV DIEKINAELL EFQNRCRKLP KGLKDWQAFL DLKKRIDDFS 
    ESCPLLEMMT NKAMKQRHWD RISELTGTPF DVESDSFCLR NIMEAPLLKH KDDIEDICIS 
    AIKEKDIEAK LTQVIENWTN QNLSFAAFKG KGELLLKGTE SGEIITLMED SLMVLGSLLS 
    NRYNAPFKKN IQNWVYKLST SSDIIEEWLV VQNLWVYLEA VFVGGDIAKQ LPQEAKRFQN 
    IDKSWIKIMQ RAHENPNVIN CCVGDETMGQ LLPHLHEQLE VCQKSLTGYL EKKRLLFPRF 
    FFVSDPVLLE ILGQASDSHT IQPHLPAVSD NINEVTFHAK DYDRIMAVIS REGEKIVLDN 
    SVMAKGPVEI WLLDLLKMQM SSLHNIIRSA FYQISDSGFQ LLPFLSHFPA QVGLLGIQML 
    WTHDSEEALR NAKDDRKIMQ VTNQKFLDIL NTLISQTTHD LSKFDRVKFE TLITIHVHQR 
    DIFDDLVKMH IKSPTDFEWL KQSRFYFKED LDQTVVSITD VDFIYQNEFL GCTDRLVITP 
    LTDRCYITLA QALGMNMGGA PAGPAGTGKT ETTKDMGRCL GKYVVVFNCS DQMDFRGLGR 
    IFKGLAQSGS WGCFDEFNRI ELPVLSVAAQ QIYIVLTARK ERKKQFIFSD GDCVDLNPEF 
    GIFLTMNPGY AGRQELPENL KIQFRTVAMM VPDRQIIMRV KLASCGFLEN VILAQKFYVL 
    YKLCEEQLTK QVHYDFGLRN ILSVLRTLGS QKRARPEDSE LSIVMRGLRD MNLSKLVDED 
    EPLFLSLIND LFPGLQLDSN TYAELQNAVA HQVQIEGLIN HPPWNLKLVQ LYETSLVRHG 
    LMTLGPSGSG KTTVITILMK AQTECGRPHR EMRMNPKAIT APQMFGRLDT ATNDWTDGIF 
    STLWRKTLKA KKGENIFLIL DGPVDAIWIE NLNSVLDDNK TLTLANGDRI PMAPSCKLLF 
    EVHNIENASP ATVSRMGMVY ISSSALSWRP ILQAWLKKRT AQEAAVFLTL YEKVFEDTYT 
    YMKLNLNPKM QLLECNYIVQ SLNLLEGLIP SKEEGGVSCV EHLHKLFVFG LMWSLGALLE 
    LESREKLEAF LRQHESKLDL PEIPKGSNQT MYEFYVTDYG DWEHWNKKLQ PYYYPTDSIP 
    EYSSILVPNV DNIRTNFLID TIAKQHKAVL LTGEQGTAKT VMVKAYLKKY DPEVQLSKSL 
    NFSSATEPMM FQRTIESYVD KRIGSTYGPP GGRKMTVFID DINMPVINEW GDQITNEIVR 
    QMMEMEGMYS LDKPGDFTTI VDVQLIAAMI HPGGGRNDIP QRLKRQFTVF NCTLPSNASI 
    DKIFGIIGCG YFDPCRSFKP QICEMIVNLV SVGRVLWQWT KVKMLPTPSK FHYIFNLRDL 
    SRIWQGMLTI KAEECASIPT LLSLFKHECS RVIADRFITP EDEQWFNAHL TRAVEENIGS 
    DAASCILPEP YFVDFLREMP EPTGDEPEDS VFEVPKIYEL MPSFDFLAEK LQFYQRQFNE 
    IIRGTSLDLV FFKDAMTHLI KISRIIRTSC GNALLVGVGG SGKQSLSRLA SFIAGYQIFQ 
    ITLTRSYNVT NLTDDLKALY KVAGADGKGI TFIFTDSEIK DEAFLEYLNN LLSSGEISNL 
    FARDEMDEIT QGLISVMKRE LPRHPPTFDN LYEYFISRSR KNLHVVLCFS PVGEKFRARS 
    LKFPGLISGC TMDWFSRWPR EALIAVASYF LSDYNIVCSS EIKRQVVETM GLFHDMVSES 
    CESYFQRYRR RAHVTPKSYL SFINGYKNIY AEKVKFINEQ AERMNIGLDK LMEASESVAK 
    LSQDLAVKEK ELAVASIKAD EVLAEVTVSA QASAKIKNEV QEVKDKAQKI VDEIDSEKVK 
    AESKLEAAKP ALEEAEAALN TIKPNDIATV RKLAKPPHLI MRIMDCVLLL FQKKIDPVTM 
    DPEKSCCKPS WGESLKLMSA TGFLWSLQQF PKDTINEETV ELLQPYFNMD DYTFESAKKV 
    CGNVAGLLSW TLAMAIFYGI NREVLPLKAN LAKQEGRLAV ANAELGKAQA LLDEKQAELD 
    KVQAKFDAAM NEKMDLLNDA DTCRKKMQAA STLIDGLSGE KIRWTQQSKE FKAQINRLVG 
    DILLCTGFLS YLGPFNQIFR NYLLKDQWEM ELRARKIPFT ENLNLISMLV DPPTIGEWGL 
    QGLPGDDLSI QNGIIVTKAT RYPLLIDPQT QGKTWIKSKE KENDLQVTSL NHKYFRTHLE 
    DSLSLGRPLL IEDIHEELDP ALDNVLEKNF IKSGTTFKVK VGDKECDIMD TFKLYITTKL 
    PNPAFTPEIN AKTSVIDFTV TMKGLENQLL RRVILTEKQE LEAERVKLLE DVTFNKRKMK 
    ELEDNLLYKL SATKGSLVDD ESLIGVLRTT KQTAAEVSEK LHVAAETEIK INAAQEEFRP 
    AATRGSILYF LITEMSMVNI MYQTSLAQFL KLFDQSMARS EKSPLPQKRI TNIIEYLTYE 
    VFTYSVRGLY ENHKFLFVLL MTLKIDLQRG TVKHREFQAL IKGGAALDLK ACPPKPYRWI 
    LDMTWLNLVE LSKLPQFAEI MNQISRNEKG WKSWFDKDAP EEEIIPDGYN DSLDTCHKLL 
    LIRSWCPDRT VFQARKYIAD SLEEKYTEPV ILNLEKTWEE SDTRTPLICF LSMGSDPTNQ 
    IDALAKKLKL ECRTISMGQG QEVHARKLIQ MSMQQGGWVL LQNCHLGLEF MEELLETLIT 
    TEASDDSFRV WITTEPHDRF PITLLQTSLK FTNEPPQGVR AGLKRTFAGI NQDLLDISNL 
    PMWKPMLYTV AFLHSTVQER RKFGPLGWNI PYEFNSADFS ASVQFIQNHL DECDIKKGVS 
    WNTVRYMIGE VQYGGRVTDD FDKRLLNCFA RVWFSEKMFE PSFCFYTGYK IPLCKTLDQY 
    FEYIQSLPSL DNPEVFGLHP NADITYQSNT ASAVLETITN IQPKESGGGV GETREAIVYR 
    LSEDMLSKLP PDYIPHEVKS RLIKMGHLNS MNIFLRQEID RMQRVISILR SSLSDLKLAI 
    EGTIIMSENL RDALDNMYDA RIPQLWKRVS WDSSTLGFWF TELLERNAQF STWIFEGRPN 
    VFWMTGFFNP QGFLTAMRQE VTRAHKGWAL DTVTIHNEVL RQTKEEITSP PGEGVYIYGL 
    YMDGAAWDRR NGKLMESTPK VLFTQLPVLH IFAINSTAPK DPKLYVCPIY KKPRRTDLTF 
    ITVVYLRTVL SPDHWILRGV ALLCDIK

Genular Protein ID: 569158698

Symbol: Q8IU65_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12297094

Title: The T complex distorter 2 candidate gene, Dnahc8, encodes at least two testis-specific axonemal dynein heavy chains that differ extensively at their amino and carboxyl termini.

PubMed ID: 12297094

DOI: 10.1006/dbio.2002.0769

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 217
  • Mass: 23949
  • Checksum: B58B1178491A7B9C
  • Sequence:
  • MEKDAEDGAP SEGAEAPPST EEAAPPRSEE EEAPRPPTVE APAEDGFSPS AEDAVSSVVD 
    YRDLIPSEEG IVLPDDHEAD LNRVRQRLAP RPVQSVISEV LSLPSSRRSS RYRRSMSGLP 
    NLQETLKERQ ARFREARESR RLKIDPSYKY IFEILAENLG LDIVTVEELI LDCPSLEAFT 
    NFFAKDGCKT LKFLYQEGDV PGIECGRTIA GATKGAK