Details for: HSBP1

Gene ID: 3281

Symbol: HSBP1

Ensembl ID: ENSG00000230989

Description: heat shock factor binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 520.2345
    Cell Significance Index: -80.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 271.8384
    Cell Significance Index: -68.9500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 221.7758
    Cell Significance Index: -91.3600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 194.4198
    Cell Significance Index: -91.7900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 192.4643
    Cell Significance Index: -78.1900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 169.7560
    Cell Significance Index: -87.3200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 137.5961
    Cell Significance Index: -92.3300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 82.4620
    Cell Significance Index: -78.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 71.4138
    Cell Significance Index: -88.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 28.7996
    Cell Significance Index: -77.1500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 22.8875
    Cell Significance Index: -90.3200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.4185
    Cell Significance Index: -53.5000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.5985
    Cell Significance Index: -16.6300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 6.2053
    Cell Significance Index: 49.5500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.9137
    Cell Significance Index: 30.2400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.9092
    Cell Significance Index: 53.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.3248
    Cell Significance Index: 113.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.7019
    Cell Significance Index: 77.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.4694
    Cell Significance Index: 1894.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.2176
    Cell Significance Index: 150.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.2045
    Cell Significance Index: 238.8300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.1375
    Cell Significance Index: 28.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.9106
    Cell Significance Index: 357.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.8528
    Cell Significance Index: 65.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.7684
    Cell Significance Index: 499.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.7039
    Cell Significance Index: 93.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.6562
    Cell Significance Index: 72.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.5348
    Cell Significance Index: 348.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.3187
    Cell Significance Index: 108.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.1703
    Cell Significance Index: 113.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.9775
    Cell Significance Index: 36.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8203
    Cell Significance Index: 94.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.7713
    Cell Significance Index: 227.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.7037
    Cell Significance Index: 89.4500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.7024
    Cell Significance Index: 19.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.6312
    Cell Significance Index: 210.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.5429
    Cell Significance Index: 181.9600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.3716
    Cell Significance Index: 17.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3416
    Cell Significance Index: 593.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0183
    Cell Significance Index: 100.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9945
    Cell Significance Index: 70.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8475
    Cell Significance Index: 54.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8404
    Cell Significance Index: 24.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7631
    Cell Significance Index: 34.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7519
    Cell Significance Index: 16.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5472
    Cell Significance Index: 14.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4823
    Cell Significance Index: 91.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4759
    Cell Significance Index: 95.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3896
    Cell Significance Index: 11.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3559
    Cell Significance Index: 70.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2867
    Cell Significance Index: 18.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2603
    Cell Significance Index: 44.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2205
    Cell Significance Index: 13.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2204
    Cell Significance Index: 6.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1888
    Cell Significance Index: 142.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1480
    Cell Significance Index: 108.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1455
    Cell Significance Index: 8.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1392
    Cell Significance Index: 49.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1040
    Cell Significance Index: 1.7400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0520
    Cell Significance Index: 0.6200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0391
    Cell Significance Index: 27.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0218
    Cell Significance Index: -2.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0233
    Cell Significance Index: -17.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0261
    Cell Significance Index: -49.1500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.0454
    Cell Significance Index: -0.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0501
    Cell Significance Index: -1.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0521
    Cell Significance Index: -96.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0607
    Cell Significance Index: -93.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0647
    Cell Significance Index: -40.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0712
    Cell Significance Index: -96.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0942
    Cell Significance Index: -53.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1035
    Cell Significance Index: -65.7200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1181
    Cell Significance Index: -1.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1655
    Cell Significance Index: -34.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1709
    Cell Significance Index: -77.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2257
    Cell Significance Index: -64.9400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2516
    Cell Significance Index: -1.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3449
    Cell Significance Index: -39.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3649
    Cell Significance Index: -42.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4090
    Cell Significance Index: -8.7100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4216
    Cell Significance Index: -10.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4463
    Cell Significance Index: -35.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.4602
    Cell Significance Index: -74.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5384
    Cell Significance Index: -78.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5889
    Cell Significance Index: -15.7800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5895
    Cell Significance Index: -67.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6314
    Cell Significance Index: -35.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6507
    Cell Significance Index: -20.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6919
    Cell Significance Index: -9.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8606
    Cell Significance Index: -89.6100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.8984
    Cell Significance Index: -15.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9807
    Cell Significance Index: -65.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.0070
    Cell Significance Index: -35.3900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.0169
    Cell Significance Index: -6.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.0344
    Cell Significance Index: -79.3800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -1.0544
    Cell Significance Index: -6.8600
  • Cell Name: glioblast (CL0000030)
    Fold Change: -1.2596
    Cell Significance Index: -7.9100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3567
    Cell Significance Index: -39.9600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.3587
    Cell Significance Index: -14.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.4761
    Cell Significance Index: -90.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HSBP1 is a 65-kDa protein that belongs to the heat shock factor-binding protein family. It is highly conserved across species, with high sequence identity between human and mouse orthologs. HSBP1 is predominantly localized in the nucleus, where it interacts with HSF and regulates its transcriptional activity. The protein exhibits a high degree of specificity in binding to HSF, and its interaction with HSF is critical for modulating the transcriptional response to stress. **Pathways and Functions:** HSBP1 is involved in several key pathways that regulate cellular responses to stress: 1. **Heat Shock Response:** HSBP1 modulates the transcriptional activity of HSF, which is a key regulator of the heat shock response. HSF activation leads to the expression of HSPs, which protect cells against heat shock and other forms of cellular stress. 2. **Axonal Transport of Mitochondria:** HSBP1 is also involved in the regulation of axonal transport of mitochondria, which is essential for maintaining mitochondrial homeostasis and preventing mitochondrial dysfunction. 3. **Cellular Responses to Stimuli:** HSBP1 is a key component of the cellular response to various stimuli, including heat shock, oxidative stress, and other forms of cellular insult. 4. **Transcriptional Regulation:** HSBP1 regulates the transcriptional activity of various genes, including those involved in stress response, cell growth, and differentiation. **Clinical Significance:** HSBP1 has significant clinical implications, particularly in the context of cancer, neurodegenerative diseases, and other stress-related disorders: 1. **Cancer:** HSBP1 is overexpressed in various types of cancer, including breast, lung, and colon cancer. Its expression is associated with poor prognosis and reduced survival rates. 2. **Neurodegenerative Diseases:** HSBP1 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 3. **Stress Response:** HSBP1 plays a critical role in the cellular response to stress, and its dysregulation can lead to increased vulnerability to stress-related disorders. In conclusion, HSBP1 is a multifaceted protein that plays a critical role in regulating cellular responses to stress and modulating the transcriptional activity of HSF. Its dysregulation has significant clinical implications, particularly in the context of cancer, neurodegenerative diseases, and other stress-related disorders. Further research is needed to fully elucidate the mechanisms underlying HSBP1's role in stress response and its clinical significance.

Genular Protein ID: 1448158652

Symbol: HSBP1_HUMAN

Name: Heat shock factor-binding protein 1

UniProtKB Accession Codes:

O75506 Q53XA8 Q7Z5Z3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9649501

Title: Negative regulation of the heat shock transcriptional response by HSBP1.

PubMed ID: 9649501

DOI: 10.1101/gad.12.13.1962

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18767159

Title: Crystal structure of the hexamer of human heat shock factor binding protein 1.

PubMed ID: 18767159

DOI: 10.1002/prot.22216

Sequence Information:

  • Length: 76
  • Mass: 8544
  • Checksum: 9838423C86B2D402
  • Sequence:
    • MAETDPKTVQ DLTSVVQTLL QQMQDKFQTM SDQIIGRIDD MSSRIDDLEK NIADLMTQAG 
VEELESENKI PATQKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.