Details for: HSBP1

Gene ID: 3281

Symbol: HSBP1

Ensembl ID: ENSG00000230989

Description: heat shock factor binding protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.01
    Marker Score: 3136
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.4
    Marker Score: 29539
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.33
    Marker Score: 4025.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.32
    Marker Score: 43846
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.06
    Marker Score: 105955.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.05
    Marker Score: 4704
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.05
    Marker Score: 23793
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.95
    Marker Score: 1089
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.87
    Marker Score: 2989
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.86
    Marker Score: 2550.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.85
    Marker Score: 10982
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.83
    Marker Score: 7588
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.82
    Marker Score: 4679
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.77
    Marker Score: 1476
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.76
    Marker Score: 23776
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.72
    Marker Score: 1708
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.7
    Marker Score: 5634
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.7
    Marker Score: 5256
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.7
    Marker Score: 17548
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.68
    Marker Score: 6765
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.68
    Marker Score: 3006.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.67
    Marker Score: 149347
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.64
    Marker Score: 6449
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.63
    Marker Score: 13844
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.62
    Marker Score: 2065
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.6
    Marker Score: 2777.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.58
    Marker Score: 4703
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.56
    Marker Score: 19077
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.55
    Marker Score: 1017
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.53
    Marker Score: 3636
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.53
    Marker Score: 2376
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.53
    Marker Score: 4059
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.51
    Marker Score: 10831
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.5
    Marker Score: 8891
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.5
    Marker Score: 4755.5
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 2.48
    Marker Score: 793
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.47
    Marker Score: 2889
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.47
    Marker Score: 5957
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.46
    Marker Score: 4173
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.45
    Marker Score: 2454
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.45
    Marker Score: 3892
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.45
    Marker Score: 83243
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.43
    Marker Score: 1096
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.42
    Marker Score: 1647
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.42
    Marker Score: 1147
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.41
    Marker Score: 5673.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.41
    Marker Score: 14283
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.41
    Marker Score: 2442
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.4
    Marker Score: 1427
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.37
    Marker Score: 6455
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.36
    Marker Score: 3872
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.35
    Marker Score: 2514
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.35
    Marker Score: 1570
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.35
    Marker Score: 1108.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.34
    Marker Score: 23563
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.34
    Marker Score: 770
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.34
    Marker Score: 15249
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.33
    Marker Score: 26294
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.32
    Marker Score: 4715
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.31
    Marker Score: 2178
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.3
    Marker Score: 2773
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.28
    Marker Score: 3130
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.26
    Marker Score: 2395
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.26
    Marker Score: 8380
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.26
    Marker Score: 2586.5
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.26
    Marker Score: 1162
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.25
    Marker Score: 2389
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.25
    Marker Score: 14363
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.25
    Marker Score: 7734
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.24
    Marker Score: 10761.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.24
    Marker Score: 834
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.23
    Marker Score: 19613
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.23
    Marker Score: 9128
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.23
    Marker Score: 5552.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.23
    Marker Score: 5835
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.23
    Marker Score: 791
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.22
    Marker Score: 3143
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.22
    Marker Score: 8719
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.22
    Marker Score: 628
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.21
    Marker Score: 762
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.21
    Marker Score: 3915
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.2
    Marker Score: 2374
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.19
    Marker Score: 1831.5
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.19
    Marker Score: 2064
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.19
    Marker Score: 3227
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.18
    Marker Score: 734
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.18
    Marker Score: 55865
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.18
    Marker Score: 2313
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.17
    Marker Score: 1543
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.17
    Marker Score: 4919
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.17
    Marker Score: 6801
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.16
    Marker Score: 2793
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.16
    Marker Score: 1447
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.16
    Marker Score: 25138.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.16
    Marker Score: 1190
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.16
    Marker Score: 692
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.14
    Marker Score: 1218
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.13
    Marker Score: 1523
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.12
    Marker Score: 1235
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.12
    Marker Score: 5026

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Other Information

**Key characteristics:** * HSBP1 is a chaperone protein that binds to misfolded or damaged proteins, preventing them from misfolding and aggregation. * It is a key regulator of the unfolded protein response (UPR), a cellular pathway that is activated when the body is exposed to stressors that damage proteins. * HSBP1 is also involved in the regulation of apoptosis (programmed cell death). * It is a key regulator of stem cell differentiation and maintenance. **Pathways and functions:** * HSBP1 is involved in the attenuation phase of the UPR, a process that helps cells to adapt to heat stress by reducing protein synthesis and increasing the production of heat shock proteins (HSPs). * It also plays a role in the axonal transport of mitochondria, which are responsible for generating energy for cells. * HSBP1 is also involved in the axonal cytoplasm, where it helps to protect proteins from degradation. * It is also involved in cellular heat acclimation, a process by which cells can adapt to high temperatures by increasing the production of HSPs. * HSBP1 is also involved in the cellular responses to stimuli, such as those caused by heat stress. * It is involved in the cellular responses to stress, such as those caused by heat stress. * HSBP1 is involved in the cellular response to heat stress, including the activation of the heat shock transcription factor (HSF1). * HSBP1-dependent transactivation is a critical step in the activation of HSF1. **Clinical significance:** HSBP1 is a promising target for cancer therapy. Heat shock proteins are overexpressed in many human cancers, and targeting them can inhibit cancer cell growth. HSBP1 inhibitors are currently being tested in clinical trials for the treatment of cancer.

Genular Protein ID: 1448158652

Symbol: HSBP1_HUMAN

Name: Heat shock factor-binding protein 1

UniProtKB Accession Codes:

O75506 Q53XA8 Q7Z5Z3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 4 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9649501

Title: Negative regulation of the heat shock transcriptional response by HSBP1.

PubMed ID: 9649501

DOI: 10.1101/gad.12.13.1962

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18767159

Title: Crystal structure of the hexamer of human heat shock factor binding protein 1.

PubMed ID: 18767159

DOI: 10.1002/prot.22216

Sequence Information:

  • Length: 76
  • Mass: 8544
  • Checksum: 9838423C86B2D402
  • Sequence:
    • MAETDPKTVQ DLTSVVQTLL QQMQDKFQTM SDQIIGRIDD MSSRIDDLEK NIADLMTQAG 
VEELESENKI PATQKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.