Details for: RTRAF

Gene ID: 51637

Symbol: RTRAF

Ensembl ID: ENSG00000087302

Description: RNA transcription, translation and transport factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 201.1906
    Cell Significance Index: -82.8800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 178.3647
    Cell Significance Index: -84.2100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 177.0554
    Cell Significance Index: -71.9300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 159.1803
    Cell Significance Index: -81.8800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 125.9794
    Cell Significance Index: -84.5400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 76.8479
    Cell Significance Index: -73.3700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.1073
    Cell Significance Index: -64.5800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 19.3133
    Cell Significance Index: -59.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 4.8013
    Cell Significance Index: 780.8800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.3432
    Cell Significance Index: 90.9100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.1872
    Cell Significance Index: 45.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.1503
    Cell Significance Index: 109.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.1139
    Cell Significance Index: 81.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.8159
    Cell Significance Index: 181.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.5157
    Cell Significance Index: 345.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.5095
    Cell Significance Index: 73.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.4690
    Cell Significance Index: 291.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.3318
    Cell Significance Index: 108.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.3081
    Cell Significance Index: 163.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.2438
    Cell Significance Index: 1225.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.2367
    Cell Significance Index: 25.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1740
    Cell Significance Index: 59.1800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.1342
    Cell Significance Index: 17.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.1187
    Cell Significance Index: 157.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.0277
    Cell Significance Index: 261.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.9479
    Cell Significance Index: 861.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9364
    Cell Significance Index: 238.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8147
    Cell Significance Index: 327.1400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.7588
    Cell Significance Index: 13.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.6397
    Cell Significance Index: 77.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.3537
    Cell Significance Index: 173.5300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.3113
    Cell Significance Index: 12.0800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2227
    Cell Significance Index: 63.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2134
    Cell Significance Index: 63.0300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1718
    Cell Significance Index: 33.5900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.6296
    Cell Significance Index: 11.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4145
    Cell Significance Index: 82.2600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3389
    Cell Significance Index: 4.3400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3095
    Cell Significance Index: 5.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3078
    Cell Significance Index: 30.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2677
    Cell Significance Index: 50.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2612
    Cell Significance Index: 52.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1208
    Cell Significance Index: 6.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1123
    Cell Significance Index: 40.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1055
    Cell Significance Index: 79.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0746
    Cell Significance Index: 3.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0296
    Cell Significance Index: 0.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0285
    Cell Significance Index: 0.7600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0185
    Cell Significance Index: 13.5400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0065
    Cell Significance Index: 4.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0014
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0089
    Cell Significance Index: -1.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0202
    Cell Significance Index: -38.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0311
    Cell Significance Index: -3.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0469
    Cell Significance Index: -86.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0554
    Cell Significance Index: -85.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0696
    Cell Significance Index: -94.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0792
    Cell Significance Index: -58.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0818
    Cell Significance Index: -51.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1265
    Cell Significance Index: -71.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1401
    Cell Significance Index: -63.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1470
    Cell Significance Index: -91.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2303
    Cell Significance Index: -66.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3015
    Cell Significance Index: -34.5400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3292
    Cell Significance Index: -8.4100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3481
    Cell Significance Index: -14.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3947
    Cell Significance Index: -57.3800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4184
    Cell Significance Index: -13.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4268
    Cell Significance Index: -89.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4658
    Cell Significance Index: -26.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5065
    Cell Significance Index: -35.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5220
    Cell Significance Index: -60.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5631
    Cell Significance Index: -43.2200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6155
    Cell Significance Index: -37.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6183
    Cell Significance Index: -17.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6437
    Cell Significance Index: -50.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7655
    Cell Significance Index: -79.7100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7802
    Cell Significance Index: -9.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8897
    Cell Significance Index: -22.2400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.9248
    Cell Significance Index: -4.2700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9462
    Cell Significance Index: -27.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.9601
    Cell Significance Index: -57.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0432
    Cell Significance Index: -63.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.0579
    Cell Significance Index: -47.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.2196
    Cell Significance Index: -16.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.2684
    Cell Significance Index: -27.4800
  • Cell Name: theca cell (CL0000503)
    Fold Change: -1.3294
    Cell Significance Index: -7.8100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.3905
    Cell Significance Index: -23.9700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.4988
    Cell Significance Index: -12.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.5415
    Cell Significance Index: -68.1900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.5750
    Cell Significance Index: -23.6000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.6138
    Cell Significance Index: -9.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.6382
    Cell Significance Index: -42.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.7342
    Cell Significance Index: -46.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.7654
    Cell Significance Index: -62.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.8227
    Cell Significance Index: -69.0200
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -1.8688
    Cell Significance Index: -25.5900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.9020
    Cell Significance Index: -69.8200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -2.0149
    Cell Significance Index: -70.5900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -2.0402
    Cell Significance Index: -21.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RTRAF is a multifunctional gene that exhibits characteristics of a transcription factor, including: 1. **RNA-binding capacity**: RTRAF interacts with various RNA molecules, including messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA), influencing their stability, translation, and transport. 2. **Protein-binding affinity**: RTRAF interacts with multiple proteins, including transcription factors, RNA-binding proteins, and structural proteins, regulating their activities and localization. 3. **Transcriptional control**: RTRAF modulates the expression of target genes by binding to specific DNA sequences and recruiting co-activators or co-repressors. 4. **Cell-type specificity**: RTRAF expression is observed in various cell types, suggesting its involvement in specific cellular processes and development. **Pathways and Functions** RTRAF is involved in several cellular pathways, including: 1. **RNA metabolism**: RTRAF regulates RNA stability, translation, and transport, influencing gene expression and cellular processes. 2. **Transcriptional control**: RTRAF modulates the expression of target genes by binding to specific DNA sequences and recruiting co-activators or co-repressors. 3. **Cell signaling**: RTRAF interacts with signaling molecules, including transcription factors and kinases, to regulate cellular responses to environmental cues. 4. **Immune regulation**: RTRAF expression is observed in immune cells, suggesting its involvement in immune cell development, function, and regulation. **Clinical Significance** RTRAF's involvement in various cellular processes and its expression in diverse cell types suggest its potential role in: 1. **Developmental disorders**: Abnormal RTRAF expression or function may contribute to developmental disorders, such as cancer, neurodegenerative diseases, or congenital anomalies. 2. **Immune-related disorders**: RTRAF's role in immune cell regulation may be relevant in autoimmune diseases, such as rheumatoid arthritis or multiple sclerosis. 3. **Cancer**: RTRAF's involvement in cell growth, differentiation, and survival may contribute to cancer development and progression. 4. **Gene therapy**: RTRAF's RNA-binding capacity and transcriptional control functions make it an attractive target for gene therapy approaches aimed at regulating gene expression and promoting cellular differentiation. In conclusion, RTRAF is a multifunctional gene that plays a critical role in regulating RNA metabolism, transcriptional control, and cell signaling. Its expression in diverse cell types and involvement in various cellular processes suggest its potential role in developmental disorders, immune-related disorders, cancer, and gene therapy. Further research is necessary to fully understand RTRAF's functions and its implications for human health and disease.

Genular Protein ID: 401927494

Symbol: RTRAF_HUMAN

Name: CLE7 homolog

UniProtKB Accession Codes:

Q9Y224

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 15 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11507205

Title: PA subunit from influenza virus polymerase complex interacts with a cellular protein with homology to a family of transcriptional activators.

PubMed ID: 11507205

DOI: 10.1128/jvi.75.18.8597-8604.2001

PubMed ID: 15147888

Title: A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors.

PubMed ID: 15147888

DOI: 10.1016/j.febslet.2004.04.024

PubMed ID: 16950395

Title: hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator.

PubMed ID: 16950395

DOI: 10.1016/j.jmb.2006.07.085

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21823664

Title: Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature hepatitis C virus core protein.

PubMed ID: 21823664

DOI: 10.1021/pr200338d

PubMed ID: 21900157

Title: Cellular human CLE/C14orf166 protein interacts with influenza virus polymerase and is required for viral replication.

PubMed ID: 21900157

DOI: 10.1128/jvi.00684-11

PubMed ID: 21311021

Title: HSPC117 is the essential subunit of a human tRNA splicing ligase complex.

PubMed ID: 21311021

DOI: 10.1126/science.1197847

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24870230

Title: Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors.

PubMed ID: 24870230

DOI: 10.1038/nature13284

PubMed ID: 24608264

Title: hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.

PubMed ID: 24608264

DOI: 10.1371/journal.pone.0090957

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26864902

Title: hCLE/C14orf166, a cellular protein required for viral replication, is incorporated into influenza virus particles.

PubMed ID: 26864902

DOI: 10.1038/srep20744

PubMed ID: 28040436

Title: FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.

PubMed ID: 28040436

DOI: 10.1016/j.biocel.2016.12.013

Sequence Information:

  • Length: 244
  • Mass: 28068
  • Checksum: EB2C3C5577A09A2A
  • Sequence:
    • MFRRKLTALD YHNPAGFNCK DETEFRNFIV WLEDQKIRHY KIEDRGNLRN IHSSDWPKFF 
EKYLRDVNCP FKIQDRQEAI DWLLGLAVRL EYGDNAEKYK DLVPDNSKTA DNATKNAEPL 
INLDVNNPDF KAGVMALANL LQIQRHDDYL VMLKAIRILV QERLTQDAVA KANQTKEGLP 
VALDKHILGF DTGDAVLNEA AQILRLLHIE ELRELQTKIN EAIVAVQAII ADPKTDHRLG 
KVGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.