Details for: ABCB11

Gene ID: 8647

Symbol: ABCB11

Ensembl ID: ENSG00000073734

Description: ATP binding cassette subfamily B member 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 11.1987
    Cell Significance Index: 188.3600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 10.4824
    Cell Significance Index: 176.5800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 9.2003
    Cell Significance Index: 135.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.2415
    Cell Significance Index: 49.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6542
    Cell Significance Index: 22.5700
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.1556
    Cell Significance Index: 6.6600
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.9399
    Cell Significance Index: 3.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7425
    Cell Significance Index: 147.3600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.7219
    Cell Significance Index: -1.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4739
    Cell Significance Index: 21.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4580
    Cell Significance Index: 25.7000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.3217
    Cell Significance Index: 2.5400
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.3076
    Cell Significance Index: 3.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2557
    Cell Significance Index: 4.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1161
    Cell Significance Index: 3.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1015
    Cell Significance Index: 6.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0974
    Cell Significance Index: 4.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0741
    Cell Significance Index: 13.3500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0597
    Cell Significance Index: 0.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0440
    Cell Significance Index: 5.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0418
    Cell Significance Index: 14.9900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0362
    Cell Significance Index: 0.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0339
    Cell Significance Index: 1.7600
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.0281
    Cell Significance Index: 0.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0184
    Cell Significance Index: 1.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0137
    Cell Significance Index: 2.7500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0115
    Cell Significance Index: 0.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0057
    Cell Significance Index: 0.9800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0010
    Cell Significance Index: 1.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0006
    Cell Significance Index: 0.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0005
    Cell Significance Index: 0.0600
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0014
    Cell Significance Index: -1.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0023
    Cell Significance Index: -1.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0025
    Cell Significance Index: -1.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0046
    Cell Significance Index: -3.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0057
    Cell Significance Index: -3.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0060
    Cell Significance Index: -3.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0068
    Cell Significance Index: -3.0900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0069
    Cell Significance Index: -0.1100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0070
    Cell Significance Index: -0.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0071
    Cell Significance Index: -0.8300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0087
    Cell Significance Index: -0.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0098
    Cell Significance Index: -0.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0107
    Cell Significance Index: -3.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0152
    Cell Significance Index: -2.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0180
    Cell Significance Index: -3.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0190
    Cell Significance Index: -1.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0211
    Cell Significance Index: -2.9000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0230
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0233
    Cell Significance Index: -2.6700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0247
    Cell Significance Index: -0.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0248
    Cell Significance Index: -1.9000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0272
    Cell Significance Index: -2.8400
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0277
    Cell Significance Index: -0.3100
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.0289
    Cell Significance Index: -0.2100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0302
    Cell Significance Index: -0.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0360
    Cell Significance Index: -1.2600
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0366
    Cell Significance Index: -0.2300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0435
    Cell Significance Index: -0.5500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0463
    Cell Significance Index: -0.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0470
    Cell Significance Index: -1.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0504
    Cell Significance Index: -2.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0507
    Cell Significance Index: -1.3800
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0535
    Cell Significance Index: -0.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0535
    Cell Significance Index: -3.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0545
    Cell Significance Index: -2.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0569
    Cell Significance Index: -1.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0584
    Cell Significance Index: -1.5600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0587
    Cell Significance Index: -1.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0599
    Cell Significance Index: -2.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0605
    Cell Significance Index: -1.6900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0653
    Cell Significance Index: -0.9100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0656
    Cell Significance Index: -1.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0689
    Cell Significance Index: -2.6100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0690
    Cell Significance Index: -1.0400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0733
    Cell Significance Index: -1.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0736
    Cell Significance Index: -2.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0757
    Cell Significance Index: -2.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0813
    Cell Significance Index: -2.1800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0825
    Cell Significance Index: -1.3600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0831
    Cell Significance Index: -1.7700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0842
    Cell Significance Index: -1.8200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0852
    Cell Significance Index: -1.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0858
    Cell Significance Index: -1.4700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0859
    Cell Significance Index: -1.4800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0906
    Cell Significance Index: -2.2600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0920
    Cell Significance Index: -1.3400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0925
    Cell Significance Index: -1.6000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0968
    Cell Significance Index: -1.4500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0971
    Cell Significance Index: -3.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0980
    Cell Significance Index: -2.8100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0989
    Cell Significance Index: -2.1000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1001
    Cell Significance Index: -2.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1025
    Cell Significance Index: -2.2200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1043
    Cell Significance Index: -3.8300
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1077
    Cell Significance Index: -1.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1085
    Cell Significance Index: -3.2000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1144
    Cell Significance Index: -1.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Transporter:** ABCB11 is a member of the ATP-binding cassette (ABC) transporter superfamily, characterized by its ability to pump substrates across cell membranes using energy from ATP hydrolysis. 2. **Bile Acid Export:** ABCB11 is primarily responsible for the efflux of bile acids, including cholic acid and chenodeoxycholic acid, into the bile canaliculi. 3. **Xenobiotic Export:** ABCB11 also exports xenobiotics, such as bile acids, steroids, and other lipophilic compounds, from hepatocytes and bile duct epithelial cells. 4. **Regulation of Lipid Metabolism:** ABCB11 plays a critical role in regulating lipid metabolism by controlling the efflux of bile acids and influencing the synthesis of bile acids and bile salts. 5. **Cellular Localization:** ABCB11 is primarily localized to the apical plasma membrane of hepatocytes and bile duct epithelial cells, where it regulates bile acid and xenobiotic transport. **Pathways and Functions:** 1. **Bile Acid Biosynthesis and Metabolism:** ABCB11 regulates the synthesis and metabolism of bile acids by controlling the efflux of bile acids into the bile canaliculi. 2. **Lipid Homeostasis:** ABCB11 influences lipid homeostasis by regulating the efflux of bile acids and influencing the synthesis of bile acids and bile salts. 3. **Xenobiotic Export:** ABCB11 exports xenobiotics, such as bile acids, steroids, and other lipophilic compounds, from hepatocytes and bile duct epithelial cells. 4. **Cholesterol Homeostasis:** ABCB11 regulates cholesterol homeostasis by controlling the efflux of bile acids, which in turn influences the synthesis of cholesterol. 5. **Oxidative Stress Response:** ABCB11 plays a role in protecting against oxidative stress by regulating the efflux of bile acids and influencing the synthesis of bile acids and bile salts. **Clinical Significance:** 1. **PFIC2 and BRIC2:** Mutations in the ABCB11 gene have been associated with PFIC2 and BRIC2, two rare genetic disorders characterized by cholestasis, liver disease, and other systemic complications. 2. **Bile Acid Dysregulation:** Dysregulation of ABCB11 function can lead to bile acid dysregulation, which can cause cholestasis, liver damage, and other systemic complications. 3. **Lipid Metabolic Disorders:** ABCB11 dysfunction can influence lipid metabolic disorders, such as hypercholesterolemia and hypertriglyceridemia. 4. **Cancer and Xenobiotic Resistance:** ABCB11 may also play a role in cancer and xenobiotic resistance by regulating the efflux of xenobiotics and influencing the synthesis of bile acids and bile salts. In conclusion, the ABCB11 gene plays a critical role in regulating bile acid and lipid metabolism, as well as protecting against oxidative stress. Dysregulation of ABCB11 function can lead to severe liver disease, cholestasis, and other systemic complications, highlighting the importance of this gene in maintaining human health.

Genular Protein ID: 1059111043

Symbol: ABCBB_HUMAN

Name: ATP-binding cassette sub-family B member 11

UniProtKB Accession Codes:

O95342 Q53TL2 Q9UNB2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 62 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EMBL 5 EMDB 8 Ensembl 1 ExpressionAtlas 1 GO 39 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 20 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9806540

Title: A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis.

PubMed ID: 9806540

DOI: 10.1038/3034

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 16332456

Title: Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep.

PubMed ID: 16332456

DOI: 10.1016/j.bbalip.2005.10.006

PubMed ID: 15901796

Title: Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin.

PubMed ID: 15901796

DOI: 10.1124/jpet.105.084830

PubMed ID: 17082223

Title: Two N-linked glycans are required to maintain the transport activity of the bile salt export pump (ABCB11) in MDCK II cells.

PubMed ID: 17082223

DOI: 10.1152/ajpgi.00415.2006

PubMed ID: 18985798

Title: Cloning of the dog bile salt export pump (BSEP; ABCB11) and functional comparison with the human and rat proteins.

PubMed ID: 18985798

DOI: 10.1002/bdd.629

PubMed ID: 18245269

Title: Involvement of multiple efflux transporters in hepatic disposition of fexofenadine.

PubMed ID: 18245269

DOI: 10.1124/mol.107.041459

PubMed ID: 19228692

Title: Activity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content.

PubMed ID: 19228692

DOI: 10.1074/jbc.m808667200

PubMed ID: 20398791

Title: Short- and medium-chain fatty acids enhance the cell surface expression and transport capacity of the bile salt export pump (BSEP/ABCB11).

PubMed ID: 20398791

DOI: 10.1016/j.bbalip.2010.04.002

PubMed ID: 22262466

Title: AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function.

PubMed ID: 22262466

DOI: 10.1002/hep.25591

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 32203132

Title: Cryo-EM structure of human bile salts exporter ABCB11.

PubMed ID: 32203132

DOI: 10.1038/s41422-020-0302-0

PubMed ID: 10579978

Title: Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis.

PubMed ID: 10579978

DOI: 10.1016/s0016-5085(99)70287-8

PubMed ID: 11829140

Title: Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population.

PubMed ID: 11829140

DOI: 10.1007/s10038-002-8653-6

PubMed ID: 11815775

Title: FIC1 and BSEP defects in Taiwanese patients with chronic intrahepatic cholestasis with low gamma-glutamyltranspeptidase levels.

PubMed ID: 11815775

DOI: 10.1067/mpd.2002.119993

PubMed ID: 15300568

Title: Benign recurrent intrahepatic cholestasis type 2 is caused by mutations in ABCB11.

PubMed ID: 15300568

DOI: 10.1053/j.gastro.2004.04.065

PubMed ID: 15077010

Title: Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy.

PubMed ID: 15077010

DOI: 10.1097/00008571-200402000-00003

PubMed ID: 15791618

Title: Two common PFIC2 mutations are associated with the impaired membrane trafficking of BSEP/ABCB11.

PubMed ID: 15791618

DOI: 10.1002/hep.20627

PubMed ID: 16039748

Title: Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis.

PubMed ID: 16039748

DOI: 10.1016/j.jhep.2005.05.020

PubMed ID: 16763017

Title: Genetic variability, haplotype structures, and ethnic diversity of hepatic transporters MDR3 (ABCB4) and bile salt export pump (ABCB11).

PubMed ID: 16763017

DOI: 10.1124/dmd.105.008854

PubMed ID: 16799996

Title: Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver.

PubMed ID: 16799996

DOI: 10.1002/hep.21214

PubMed ID: 17264802

Title: Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury.

PubMed ID: 17264802

DOI: 10.1097/01.fpc.0000230418.28091.76

PubMed ID: 18829893

Title: Short-chain ubiquitination is associated with the degradation rate of a cell-surface-resident bile salt export pump (BSEP/ABCB11).

PubMed ID: 18829893

DOI: 10.1124/mol.108.049288

PubMed ID: 20010382

Title: Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): functional characterization and interindividual variability.

PubMed ID: 20010382

DOI: 10.1097/fpc.0b013e3283349eb0

PubMed ID: 24969679

Title: Diagnosis of ABCB11 gene mutations in children with intrahepatic cholestasis using high resolution melting analysis and direct sequencing.

PubMed ID: 24969679

DOI: 10.3892/mmr.2014.2349

PubMed ID: 24711118

Title: Differential effects of membrane cholesterol content on the transport activity of multidrug resistance-associated protein 2 (ABCC2) and of the bile salt export pump (ABCB11).

PubMed ID: 24711118

DOI: 10.1124/mol.114.092262

PubMed ID: 29507376

Title: Clinical phenotype and molecular analysis of a homozygous ABCB11 mutation responsible for progressive infantile cholestasis.

PubMed ID: 29507376

DOI: 10.1038/s10038-018-0431-1

PubMed ID: 30431138

Title: Functional analysis of the correlation between ABCB11 gene mutation and primary intrahepatic stone.

PubMed ID: 30431138

DOI: 10.3892/mmr.2018.9661

Sequence Information:

  • Length: 1321
  • Mass: 146407
  • Checksum: 61EE2173E2351D80
  • Sequence:
    • MSDSVILRSI KKFGEENDGF ESDKSYNNDK KSRLQDEKKG DGVRVGFFQL FRFSSSTDIW 
LMFVGSLCAF LHGIAQPGVL LIFGTMTDVF IDYDVELQEL QIPGKACVNN TIVWTNSSLN 
QNMTNGTRCG LLNIESEMIK FASYYAGIAV AVLITGYIQI CFWVIAAARQ IQKMRKFYFR 
RIMRMEIGWF DCNSVGELNT RFSDDINKIN DAIADQMALF IQRMTSTICG FLLGFFRGWK 
LTLVIISVSP LIGIGAATIG LSVSKFTDYE LKAYAKAGVV ADEVISSMRT VAAFGGEKRE 
VERYEKNLVF AQRWGIRKGI VMGFFTGFVW CLIFLCYALA FWYGSTLVLD EGEYTPGTLV 
QIFLSVIVGA LNLGNASPCL EAFATGRAAA TSIFETIDRK PIIDCMSEDG YKLDRIKGEI 
EFHNVTFHYP SRPEVKILND LNMVIKPGEM TALVGPSGAG KSTALQLIQR FYDPCEGMVT 
VDGHDIRSLN IQWLRDQIGI VEQEPVLFST TIAENIRYGR EDATMEDIVQ AAKEANAYNF 
IMDLPQQFDT LVGEGGGQMS GGQKQRVAIA RALIRNPKIL LLDMATSALD NESEAMVQEV 
LSKIQHGHTI ISVAHRLSTV RAADTIIGFE HGTAVERGTH EELLERKGVY FTLVTLQSQG 
NQALNEEDIK DATEDDMLAR TFSRGSYQDS LRASIRQRSK SQLSYLVHEP PLAVVDHKST 
YEEDRKDKDI PVQEEVEPAP VRRILKFSAP EWPYMLVGSV GAAVNGTVTP LYAFLFSQIL 
GTFSIPDKEE QRSQINGVCL LFVAMGCVSL FTQFLQGYAF AKSGELLTKR LRKFGFRAML 
GQDIAWFDDL RNSPGALTTR LATDASQVQG AAGSQIGMIV NSFTNVTVAM IIAFSFSWKL 
SLVILCFFPF LALSGATQTR MLTGFASRDK QALEMVGQIT NEALSNIRTV AGIGKERRFI 
EALETELEKP FKTAIQKANI YGFCFAFAQC IMFIANSASY RYGGYLISNE GLHFSYVFRV 
ISAVVLSATA LGRAFSYTPS YAKAKISAAR FFQLLDRQPP ISVYNTAGEK WDNFQGKIDF 
VDCKFTYPSR PDSQVLNGLS VSISPGQTLA FVGSSGCGKS TSIQLLERFY DPDQGKVMID 
GHDSKKVNVQ FLRSNIGIVS QEPVLFACSI MDNIKYGDNT KEIPMERVIA AAKQAQLHDF 
VMSLPEKYET NVGSQGSQLS RGEKQRIAIA RAIVRDPKIL LLDEATSALD TESEKTVQVA 
LDKAREGRTC IVIAHRLSTI QNADIIAVMA QGVVIEKGTH EELMAQKGAY YKLVTTGSPI 
S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.