Details for: MARCKS

Gene ID: 4082

Symbol: MARCKS

Ensembl ID: ENSG00000277443

Description: myristoylated alanine rich protein kinase C substrate

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 328.9617
    Cell Significance Index: -135.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 236.6546
    Cell Significance Index: -111.7300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 220.1931
    Cell Significance Index: -89.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 209.6872
    Cell Significance Index: -107.8600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 166.4550
    Cell Significance Index: -111.7000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 94.3291
    Cell Significance Index: -90.0600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 38.6255
    Cell Significance Index: 399.8500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 29.4291
    Cell Significance Index: -90.3900
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 11.1842
    Cell Significance Index: 86.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 8.0238
    Cell Significance Index: 167.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 7.5937
    Cell Significance Index: 395.5500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 5.7606
    Cell Significance Index: 133.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.4825
    Cell Significance Index: 551.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.4116
    Cell Significance Index: 153.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 4.2739
    Cell Significance Index: 239.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.6197
    Cell Significance Index: 497.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.6013
    Cell Significance Index: 649.2000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.4869
    Cell Significance Index: 32.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.4619
    Cell Significance Index: 91.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.4447
    Cell Significance Index: 178.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.3929
    Cell Significance Index: 239.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.1000
    Cell Significance Index: 397.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.8007
    Cell Significance Index: 1238.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.6258
    Cell Significance Index: 75.2700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.3937
    Cell Significance Index: 18.4500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.2162
    Cell Significance Index: 241.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.1176
    Cell Significance Index: 130.1600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.0400
    Cell Significance Index: 26.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.9350
    Cell Significance Index: 1747.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.9200
    Cell Significance Index: 100.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.9161
    Cell Significance Index: 90.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7142
    Cell Significance Index: 46.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5094
    Cell Significance Index: 299.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5026
    Cell Significance Index: 111.9900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.3991
    Cell Significance Index: 15.2100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.3331
    Cell Significance Index: 24.6400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.1598
    Cell Significance Index: 25.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0717
    Cell Significance Index: 585.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0277
    Cell Significance Index: 206.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0130
    Cell Significance Index: 130.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8991
    Cell Significance Index: 25.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.8068
    Cell Significance Index: 137.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.7754
    Cell Significance Index: 79.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7501
    Cell Significance Index: 122.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2986
    Cell Significance Index: 107.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2897
    Cell Significance Index: 28.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1852
    Cell Significance Index: 35.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1832
    Cell Significance Index: 3.1400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0414
    Cell Significance Index: 0.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0082
    Cell Significance Index: -6.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0227
    Cell Significance Index: -1.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0269
    Cell Significance Index: -50.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0611
    Cell Significance Index: -38.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0884
    Cell Significance Index: -163.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0933
    Cell Significance Index: -68.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1005
    Cell Significance Index: -63.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1020
    Cell Significance Index: -156.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1060
    Cell Significance Index: -22.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1150
    Cell Significance Index: -156.3900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.1274
    Cell Significance Index: -88.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1330
    Cell Significance Index: -100.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1382
    Cell Significance Index: -77.9600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1796
    Cell Significance Index: -20.5000
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.1812
    Cell Significance Index: -1.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2511
    Cell Significance Index: -113.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3270
    Cell Significance Index: -37.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3424
    Cell Significance Index: -5.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3818
    Cell Significance Index: -109.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3863
    Cell Significance Index: -18.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5267
    Cell Significance Index: -61.3800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5433
    Cell Significance Index: -13.0300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6687
    Cell Significance Index: -4.0400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.7516
    Cell Significance Index: -4.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7523
    Cell Significance Index: -109.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9670
    Cell Significance Index: -30.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.0212
    Cell Significance Index: -19.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0249
    Cell Significance Index: -106.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1493
    Cell Significance Index: -70.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.1526
    Cell Significance Index: -24.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.1868
    Cell Significance Index: -79.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -1.1957
    Cell Significance Index: -141.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.2143
    Cell Significance Index: -96.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.2799
    Cell Significance Index: -35.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.4447
    Cell Significance Index: -93.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.5226
    Cell Significance Index: -116.8500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.5400
    Cell Significance Index: -9.4800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -1.6093
    Cell Significance Index: -10.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.8712
    Cell Significance Index: -25.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.9969
    Cell Significance Index: -53.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.0676
    Cell Significance Index: -60.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.1233
    Cell Significance Index: -93.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.1605
    Cell Significance Index: -136.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.2303
    Cell Significance Index: -59.6600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -2.2996
    Cell Significance Index: -23.9600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -2.4906
    Cell Significance Index: -36.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.4908
    Cell Significance Index: -94.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.5503
    Cell Significance Index: -93.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -2.5754
    Cell Significance Index: -84.3200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -2.7637
    Cell Significance Index: -16.4000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -2.8110
    Cell Significance Index: -39.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MARCKS is characterized by its unique myristoylation motif, which allows it to interact with PKC and other signaling proteins. This interaction enables MARCKS to regulate the activity of PKC, modulating its downstream targets and influencing various cellular processes. MARCKS is also rich in alanine residues, which participate in protein-protein interactions and contribute to its structural stability. Its expression is tightly regulated, with fluctuations in MARCKS levels influencing its activity and cellular behavior. **Pathways and Functions:** MARCKS is involved in numerous signaling pathways, including: 1. **Actin cytoskeleton reorganization:** MARCKS interacts with PKC, which phosphorylates and activates myosin light chain kinase (MLCK), leading to actin-myosin interaction and cytoskeleton reorganization. 2. **Insulin secretion:** MARCKS regulates insulin secretion by modulating the activity of PKC, which interacts with the insulin secretory machinery, influencing glucose metabolism and insulin signaling. 3. **Apoptosis:** MARCKS has been implicated in the regulation of apoptosis, with PKC-mediated phosphorylation of MARCKS influencing the activity of pro-apoptotic and anti-apoptotic proteins. 4. **Cell adhesion and migration:** MARCKS interacts with integrins and other adhesion molecules, influencing cell adhesion, migration, and invasion. **Clinical Significance:** MARCKS has been implicated in various diseases, including: 1. **Cancer:** MARCKS overexpression has been observed in various types of cancer, including breast, lung, and colon cancer, where it contributes to tumor progression and metastasis. 2. **Inflammatory disorders:** MARCKS has been implicated in the regulation of inflammatory responses, with altered expression levels contributing to the development of autoimmune diseases, such as rheumatoid arthritis. 3. **Neurological conditions:** MARCKS has been linked to neurodegenerative diseases, including Alzheimer's and Parkinson's disease, where it influences neuronal survival and function. 4. **Immunological disorders:** MARCKS has been implicated in the regulation of immune responses, with altered expression levels contributing to the development of autoimmune diseases and immune-related disorders. In conclusion, MARCKS is a multifunctional protein that plays a critical role in various cellular processes, including cell signaling, cytoskeleton organization, and protein trafficking. Its expression is widespread across different cell types, and alterations in MARCKS levels have been implicated in various diseases, highlighting its importance as a therapeutic target. Further research is needed to fully understand the mechanisms of MARCKS and its role in human disease.

Genular Protein ID: 451757011

Symbol: MARCS_HUMAN

Name: Myristoylated alanine-rich C-kinase substrate

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1860846

Title: The human myristoylated alanine-rich C kinase substrate (MARCKS) gene (MACS). Analysis of its gene product, promoter, and chromosomal localization.

PubMed ID: 1860846

DOI: 10.1016/s0021-9258(18)98698-9

PubMed ID: 1427823

Title: Molecular cloning and chromosomal mapping of a cDNA encoding human 80K-L protein: major substrate for protein kinase C.

PubMed ID: 1427823

DOI: 10.1016/s0888-7543(05)80301-5

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1396720

Title: Relationship between the major protein kinase C substrates acidic 80-kDa protein-kinase-C substrate (80K) and myristoylated alanine-rich C-kinase substrate (MARCKS). Members of a gene family or equivalent genes in different species.

PubMed ID: 1396720

DOI: 10.1111/j.1432-1033.1992.tb17255.x

PubMed ID: 2116001

Title: Tumor necrosis factor alpha modifies agonist-dependent responses in human neutrophils by inducing the synthesis and myristoylation of a specific protein kinase C substrate.

PubMed ID: 2116001

DOI: 10.1073/pnas.87.15.5603

PubMed ID: 2034276

Title: Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane.

PubMed ID: 2034276

DOI: 10.1038/351320a0

PubMed ID: 8557118

Title: PRK1 phosphorylates MARCKS at the PKC sites: serine 152, serine 156 and serine 163.

PubMed ID: 8557118

DOI: 10.1016/0014-5793(95)01454-3

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23704996

Title: MARCKS protein is phosphorylated and regulates calcium mobilization during human acrosomal exocytosis.

PubMed ID: 23704996

DOI: 10.1371/journal.pone.0064551

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 36009319

Title: MARCKS Is an Essential Regulator of Reactive Oxygen Species Production in the Monocytic Cell Type.

PubMed ID: 36009319

DOI: 10.3390/antiox11081600

PubMed ID: 37949888

Title: Myristoylated, alanine-rich C-kinase substrate (MARCKS) regulates toll-like receptor 4 signaling in macrophages.

PubMed ID: 37949888

DOI: 10.1038/s41598-023-46266-x

Sequence Information:

  • Length: 332
  • Mass: 31555
  • Checksum: 0AB247801EF8FCBF
  • Sequence:
  • MGAQFSKTAA KGEAAAERPG EAAVASSPSK ANGQENGHVK VNGDASPAAA ESGAKEELQA 
    NGSAPAADKE EPAAAGSGAA SPSAAEKGEP AAAAAPEAGA SPVEKEAPAE GEAAEPGSPT 
    AAEGEAASAA SSTSSPKAED GATPSPSNET PKKKKKRFSF KKSFKLSGFS FKKNKKEAGE 
    GGEAEAPAAE GGKDEAAGGA AAAAAEAGAA SGEQAAAPGE EAAAGEEGAA GGDPQEAKPQ 
    EAAVAPEKPP ASDETKAAEE PSKVEEKKAE EAGASAAACE APSAAGPGAP PEQEAAPAEE 
    PAAAAASSAC AAPSQEAQPE CSPEAPPAEA AE

Genular Protein ID: 2679317751

Symbol: Q6NVI1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 157
  • Mass: 14859
  • Checksum: 35A77F72AED1F922
  • Sequence:
  • MGAQFSKTAA KGEAAAERPG EAAVASSPSK ANGQENGHVK VNGDASPAAA ESGAKEELQA 
    NGSAPAADKE EPAAAGSGAA SPSAAEKGEP AAAAAPEAGA SPVEKEAPAE GEAAEPGSPT 
    AAEGEAASAA SSTSSPKAED GATPSPSNET PKKKKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.