Details for: MARCKS
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: embryonic stem cell (CL0002322)
Fold Change: 328.9617
Cell Significance Index: -135.5200 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 236.6546
Cell Significance Index: -111.7300 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 220.1931
Cell Significance Index: -89.4600 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 209.6872
Cell Significance Index: -107.8600 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 166.4550
Cell Significance Index: -111.7000 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 94.3291
Cell Significance Index: -90.0600 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 38.6255
Cell Significance Index: 399.8500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 29.4291
Cell Significance Index: -90.3900 - Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 11.1842
Cell Significance Index: 86.9200 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 8.0238
Cell Significance Index: 167.9500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 7.5937
Cell Significance Index: 395.5500 - Cell Name: peg cell (CL4033014)
Fold Change: 5.7606
Cell Significance Index: 133.0900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 4.4825
Cell Significance Index: 551.1700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 4.4116
Cell Significance Index: 153.3000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 4.2739
Cell Significance Index: 239.8300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 3.6197
Cell Significance Index: 497.0900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 3.6013
Cell Significance Index: 649.2000 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 3.4869
Cell Significance Index: 32.1100 - Cell Name: granulosa cell (CL0000501)
Fold Change: 3.4619
Cell Significance Index: 91.0300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 3.4447
Cell Significance Index: 178.9400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 3.3929
Cell Significance Index: 239.9600 - Cell Name: odontoblast (CL0000060)
Fold Change: 3.1000
Cell Significance Index: 397.4000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.8007
Cell Significance Index: 1238.2700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.6258
Cell Significance Index: 75.2700 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 2.3937
Cell Significance Index: 18.4500 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 2.2162
Cell Significance Index: 241.0500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 2.1176
Cell Significance Index: 130.1600 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.0400
Cell Significance Index: 26.1300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.9350
Cell Significance Index: 1747.1600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.9200
Cell Significance Index: 100.8100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.9161
Cell Significance Index: 90.0600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.7142
Cell Significance Index: 46.6600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.5094
Cell Significance Index: 299.5400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.5026
Cell Significance Index: 111.9900 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.3991
Cell Significance Index: 15.2100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.3331
Cell Significance Index: 24.6400 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.1598
Cell Significance Index: 25.4000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.0717
Cell Significance Index: 585.3000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0277
Cell Significance Index: 206.1700 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.0130
Cell Significance Index: 130.8700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.8991
Cell Significance Index: 25.9100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.8068
Cell Significance Index: 137.7600 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.7754
Cell Significance Index: 79.2100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7501
Cell Significance Index: 122.0000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2986
Cell Significance Index: 107.1000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2897
Cell Significance Index: 28.6600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1852
Cell Significance Index: 35.2400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1832
Cell Significance Index: 3.1400 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0414
Cell Significance Index: 0.4700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0082
Cell Significance Index: -6.0800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0227
Cell Significance Index: -1.0300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0269
Cell Significance Index: -50.5700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0611
Cell Significance Index: -38.1400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0884
Cell Significance Index: -163.0400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0933
Cell Significance Index: -68.4000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1005
Cell Significance Index: -63.8400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.1020
Cell Significance Index: -156.9600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1060
Cell Significance Index: -22.3200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.1150
Cell Significance Index: -156.3900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.1274
Cell Significance Index: -88.0800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.1330
Cell Significance Index: -100.6800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1382
Cell Significance Index: -77.9600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1796
Cell Significance Index: -20.5000 - Cell Name: endocardial cell (CL0002350)
Fold Change: -0.1812
Cell Significance Index: -1.0700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2511
Cell Significance Index: -113.9800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3270
Cell Significance Index: -37.4600 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3424
Cell Significance Index: -5.7300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3818
Cell Significance Index: -109.8500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3863
Cell Significance Index: -18.0100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.5267
Cell Significance Index: -61.3800 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.5433
Cell Significance Index: -13.0300 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.6687
Cell Significance Index: -4.0400 - Cell Name: glioblast (CL0000030)
Fold Change: -0.7516
Cell Significance Index: -4.7200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.7523
Cell Significance Index: -109.3500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.9670
Cell Significance Index: -30.9700 - Cell Name: preadipocyte (CL0002334)
Fold Change: -1.0212
Cell Significance Index: -19.9300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.0249
Cell Significance Index: -106.7200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.1493
Cell Significance Index: -70.4600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.1526
Cell Significance Index: -24.9700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.1868
Cell Significance Index: -79.8000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -1.1957
Cell Significance Index: -141.0100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.2143
Cell Significance Index: -96.1700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -1.2799
Cell Significance Index: -35.7700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -1.4447
Cell Significance Index: -93.2100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.5226
Cell Significance Index: -116.8500 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -1.5400
Cell Significance Index: -9.4800 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: -1.6093
Cell Significance Index: -10.4700 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.8712
Cell Significance Index: -25.5300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -1.9969
Cell Significance Index: -53.3200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -2.0676
Cell Significance Index: -60.9000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -2.1233
Cell Significance Index: -93.9200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -2.1605
Cell Significance Index: -136.1700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -2.2303
Cell Significance Index: -59.6600 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -2.2996
Cell Significance Index: -23.9600 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: -2.4906
Cell Significance Index: -36.1600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -2.4908
Cell Significance Index: -94.3200 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -2.5503
Cell Significance Index: -93.6200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -2.5754
Cell Significance Index: -84.3200 - Cell Name: radial glial cell (CL0000681)
Fold Change: -2.7637
Cell Significance Index: -16.4000 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -2.8110
Cell Significance Index: -39.4000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 451757011
Symbol: MARCS_HUMAN
Name: Myristoylated alanine-rich C-kinase substrate
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1860846
Title: The human myristoylated alanine-rich C kinase substrate (MARCKS) gene (MACS). Analysis of its gene product, promoter, and chromosomal localization.
PubMed ID: 1860846
PubMed ID: 1427823
Title: Molecular cloning and chromosomal mapping of a cDNA encoding human 80K-L protein: major substrate for protein kinase C.
PubMed ID: 1427823
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1396720
Title: Relationship between the major protein kinase C substrates acidic 80-kDa protein-kinase-C substrate (80K) and myristoylated alanine-rich C-kinase substrate (MARCKS). Members of a gene family or equivalent genes in different species.
PubMed ID: 1396720
PubMed ID: 2116001
Title: Tumor necrosis factor alpha modifies agonist-dependent responses in human neutrophils by inducing the synthesis and myristoylation of a specific protein kinase C substrate.
PubMed ID: 2116001
PubMed ID: 2034276
Title: Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane.
PubMed ID: 2034276
DOI: 10.1038/351320a0
PubMed ID: 8557118
Title: PRK1 phosphorylates MARCKS at the PKC sites: serine 152, serine 156 and serine 163.
PubMed ID: 8557118
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 17924679
Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
PubMed ID: 17924679
DOI: 10.1021/pr070152u
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23704996
Title: MARCKS protein is phosphorylated and regulates calcium mobilization during human acrosomal exocytosis.
PubMed ID: 23704996
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25255805
Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.
PubMed ID: 25255805
DOI: 10.1038/ncomms5919
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 36009319
Title: MARCKS Is an Essential Regulator of Reactive Oxygen Species Production in the Monocytic Cell Type.
PubMed ID: 36009319
PubMed ID: 37949888
Title: Myristoylated, alanine-rich C-kinase substrate (MARCKS) regulates toll-like receptor 4 signaling in macrophages.
PubMed ID: 37949888
Sequence Information:
- Length: 332
- Mass: 31555
- Checksum: 0AB247801EF8FCBF
- Sequence:
MGAQFSKTAA KGEAAAERPG EAAVASSPSK ANGQENGHVK VNGDASPAAA ESGAKEELQA NGSAPAADKE EPAAAGSGAA SPSAAEKGEP AAAAAPEAGA SPVEKEAPAE GEAAEPGSPT AAEGEAASAA SSTSSPKAED GATPSPSNET PKKKKKRFSF KKSFKLSGFS FKKNKKEAGE GGEAEAPAAE GGKDEAAGGA AAAAAEAGAA SGEQAAAPGE EAAAGEEGAA GGDPQEAKPQ EAAVAPEKPP ASDETKAAEE PSKVEEKKAE EAGASAAACE APSAAGPGAP PEQEAAPAEE PAAAAASSAC AAPSQEAQPE CSPEAPPAEA AE
Genular Protein ID: 2679317751
Symbol: Q6NVI1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 157
- Mass: 14859
- Checksum: 35A77F72AED1F922
- Sequence:
MGAQFSKTAA KGEAAAERPG EAAVASSPSK ANGQENGHVK VNGDASPAAA ESGAKEELQA NGSAPAADKE EPAAAGSGAA SPSAAEKGEP AAAAAPEAGA SPVEKEAPAE GEAAEPGSPT AAEGEAASAA SSTSSPKAED GATPSPSNET PKKKKKK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.