Details for: MARCKS
Gene ID: 4082
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: MARCKS
Ensembl ID: ENSG00000277443
Description: myristoylated alanine rich protein kinase C substrate
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 103rCSI 81.41%PRS 3.65
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CSI 70.84rCSI 81.81%PRS 4.79
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CSI 68.77rCSI 52.99%PRS 4.77
-
CSI 61.54rCSI 78.98%PRS 5.23
-
CSI 55.68rCSI 88.82%PRS 4.62
-
CSI 54.64rCSI 75.9%PRS 5.56
-
CSI 49.18rCSI 51.52%PRS 5.67
-
CSI 46.3rCSI 55.58%PRS 5.28
-
CSI 41.2rCSI 47.64%PRS 3.84
-
CSI 40.27rCSI 73.17%PRS 5.08
-
CSI 38.99rCSI 73.61%PRS 6.58
-
CSI 37.8rCSI 44.39%PRS 6.4
-
CSI 36.7rCSI 38.44%PRS 4.93
-
CSI 36.38rCSI 48.36%PRS 5.78
-
CSI 35.91rCSI 31.58%PRS 3.82
-
CSI 33.45rCSI 51.38%PRS 6.14
-
CSI 32.51rCSI 44.45%PRS 6.01
-
CSI 30.18rCSI 29.1%PRS 2.99
-
CSI 29.11rCSI 27.09%PRS 5.32
-
CSI 27.31rCSI 38.97%PRS 6.02
-
CSI 26.7rCSI 68.63%PRS 9.11
-
CSI 26.06rCSI 50.68%PRS 5.4
-
CSI 25.5rCSI 36.75%PRS 8.58
-
CSI 25.43rCSI 25.02%PRS 5.77
-
CSI 24.99rCSI 20.95%PRS 6.36
-
CSI 24.61rCSI 58.49%PRS 8.06
-
CSI 23.86rCSI 32.6%PRS 5.85
-
CSI 23.81rCSI 21.97%PRS 5.35
-
CSI 23.65rCSI 21%PRS 5.3
-
CSI 23.33rCSI 49.65%PRS 8.6
-
CSI 23.28rCSI 38.12%PRS 4.14
-
CSI 22.97rCSI 22.93%PRS 4.52
-
CSI 21.99rCSI 20.19%PRS 6.02
-
CSI 21.74rCSI 27.67%PRS 6.17
-
CSI 21.13rCSI 26.56%PRS 8.14
-
CSI 20.26rCSI 40.68%PRS 3.96
-
CSI 19.6rCSI 35.67%PRS 25.32
-
CSI 18.77rCSI 28.32%PRS 5.19
-
CSI 17.68rCSI 38.93%PRS 8.25
-
CSI 17.61rCSI 48.38%PRS 8.85
-
CSI 17.09rCSI 39.08%PRS 5.13
-
CSI 17.07rCSI 27.52%PRS 8.6
-
CSI 17.06rCSI 49.35%PRS 11.97
-
CSI 16.69rCSI 21.41%PRS 6.11
-
CSI 16.58rCSI 81.73%PRS 7.16
-
CSI 16.37rCSI 17.08%PRS 5.41
-
CSI 16.04rCSI 24.65%PRS 7.65
-
CSI 15.95rCSI 15.75%PRS 23.01
-
CSI 15.78rCSI 36.8%PRS 13.93
-
CSI 15.74rCSI 42.42%PRS 6.89
-
CSI 15.2rCSI 14.64%PRS 5.48
-
CSI 15.1rCSI 69.77%PRS 11.55
-
CSI 14.99rCSI 29.71%PRS 16.89
-
CSI 14.92rCSI 95.58%PRS 9.35
-
CSI 14.72rCSI 77.38%PRS 12.4
-
CSI 14.61rCSI 13.81%PRS 5.52
-
CSI 14.04rCSI 19.44%PRS 7.62
-
CSI 13.96rCSI 30.72%PRS 1.93
-
CSI 13.9rCSI 35.3%PRS 5.41
-
CSI 13.88rCSI 11.67%PRS 8.88
-
CSI 13.85rCSI 10.26%PRS 4.92
-
CSI 13.41rCSI 53.38%PRS 9.48
-
CSI 13.02rCSI 10.24%PRS 6.3
-
CSI 12.92rCSI 15.92%PRS 17.82
-
CSI 12.85rCSI 33.51%PRS 6.04
-
CSI 12.82rCSI 48.01%PRS 4.57
-
CSI 12.69rCSI 44.53%PRS 9.64
-
CSI 12.51rCSI 42.29%PRS 9.12
-
CSI 12.42rCSI 23.69%PRS 8.49
-
CSI 11.84rCSI 51.96%PRS 10.2
-
CSI 11.67rCSI 12.4%PRS 9.46
-
CSI 11.22rCSI 65.28%PRS 7.95
-
CSI 11.22rCSI 16.56%PRS 8.37
-
CSI 11.19rCSI 24.71%PRS 3.82
-
CSI 11.07rCSI 9.54%PRS 8.76
-
CSI 11.01rCSI 25.1%PRS 5.53
-
CSI 11rCSI 30.93%PRS 7.77
-
CSI 10.96rCSI 19.81%PRS 15.17
-
CSI 10.8rCSI 13.82%PRS 24.31
-
CSI 10.8rCSI 23.77%PRS 5.79
-
CSI 10.71rCSI 17.35%PRS 5.37
-
CSI 10.41rCSI 12.96%PRS 7.68
-
CSI 10.07rCSI 8.18%PRS 5.62
-
CSI 10.02rCSI 15.32%PRS 8.66
-
CSI 9.96rCSI 14.59%PRS 31.12
-
CSI 9.9rCSI 8.67%PRS 7.13
-
CSI 9.89rCSI 16.95%PRS 7.07
-
CSI 9.76rCSI 28.26%PRS 5.99
-
CSI 9.71rCSI 20.15%PRS 5.25
-
CSI 9.57rCSI 7.42%PRS 5.01
-
CSI 9.55rCSI 29.42%PRS 10.41
-
CSI 9.24rCSI 14.11%PRS 9.29
-
CSI 9.05rCSI 11.86%PRS 7.41
-
CSI 8.99rCSI 25.21%PRS 8.34
-
CSI 8.92rCSI 33.96%PRS 5.74
-
CSI 8.91rCSI 21.14%PRS 7.05
-
CSI 8.9rCSI 13.16%PRS 6.08
-
CSI 8.89rCSI 35.87%PRS 5.6
-
CSI 8.89rCSI 13.58%PRS 5.29
-
CSI 8.81rCSI 19.68%PRS 5.97
-
CSI -22.2rCSI -39.1%PRS 7.0%
-
CSI -5.8rCSI -10.1%PRS 4.1%
-
CSI -4.9rCSI -6.5%PRS 7.2%
-
CSI -3.0rCSI -6.8%PRS 3.3%
-
CSI -1.9rCSI -31.5%PRS 26.8%
-
CSI -1.6rCSI -4.9%PRS 3.4%
-
CSI -1.1rCSI -6.4%PRS 3.4%
-
CSI -1.1rCSI -2.7%PRS 4.2%
-
CSI 0.2rCSI 3.8%PRS 30.7%
-
CSI 0.2rCSI 4.2%PRS 44.3%
-
CSI 0.2rCSI 0.4%PRS 2.6%
-
CSI 0.3rCSI 4.3%PRS 17.8%
-
CSI 0.4rCSI 0.7%PRS 3.2%
-
CSI 0.5rCSI 1.3%PRS 9.0%
-
CSI 0.5rCSI 0.9%PRS 7.0%
-
CSI 0.5rCSI 3.3%PRS 18.3%
-
CSI 0.5rCSI 1.2%PRS 2.9%
-
CSI 0.5rCSI 12.1%PRS 8.0%
-
CSI 0.5rCSI 4.8%PRS 30.9%
-
CSI 0.6rCSI 3.3%PRS 17.1%
-
CSI 0.6rCSI 3.0%PRS 7.6%
-
CSI 0.6rCSI 4.1%PRS 7.8%
-
CSI 0.6rCSI 3.5%PRS 7.9%
-
CSI 0.6rCSI 5.4%PRS 7.5%
-
CSI 0.7rCSI 1.8%PRS 5.3%
-
CSI 0.7rCSI 1.1%PRS 5.0%
-
CSI 0.7rCSI 7.3%PRS 21.5%
-
CSI 0.8rCSI 1.8%PRS 5.4%
-
CSI 0.8rCSI 1.1%PRS 7.4%
-
CSI 0.9rCSI 17.2%PRS 5.6%
-
CSI 0.9rCSI 1.6%PRS 3.2%
-
CSI 0.9rCSI 18.7%PRS 5.1%
-
CSI 1.0rCSI 3.4%PRS 17.2%
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CSI 1.0rCSI 9.6%PRS 23.7%
-
CSI 1.0rCSI 7.7%PRS 6.5%
-
CSI 1.1rCSI 7.3%PRS 7.9%
-
CSI 1.1rCSI 9.0%PRS 5.6%
-
CSI 1.1rCSI 5.4%PRS 8.4%
-
CSI 1.2rCSI 2.5%PRS 10.9%
-
CSI 1.2rCSI 1.3%PRS 11.0%
-
CSI 1.2rCSI 9.4%PRS 7.7%
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CSI 1.4rCSI 3.8%PRS 5.9%
-
CSI 1.4rCSI 2.9%PRS 12.9%
-
CSI 1.4rCSI 6.7%PRS 14.3%
-
CSI 1.4rCSI 6.0%PRS 14.6%
-
CSI 1.5rCSI 3.5%PRS 6.9%
-
CSI 1.5rCSI 21.0%PRS 4.2%
-
CSI 1.5rCSI 7.8%PRS 10.6%
-
CSI 1.6rCSI 9.2%PRS 8.1%
-
CSI 1.6rCSI 7.4%PRS 23.9%
-
CSI 1.7rCSI 12.2%PRS 2.6%
-
CSI 1.7rCSI 11.8%PRS 17.2%
-
CSI 1.7rCSI 5.5%PRS 3.9%
-
CSI 1.8rCSI 19.5%PRS 18.3%
-
CSI 1.8rCSI 2.9%PRS 4.8%
-
CSI 1.9rCSI 2.7%PRS 5.6%
-
CSI 1.9rCSI 2.5%PRS 6.4%
-
CSI 2.0rCSI 11.6%PRS 28.6%
-
CSI 2.0rCSI 13.1%PRS 38.7%
-
CSI 2.0rCSI 52.6%PRS 28.7%
-
CSI 2.0rCSI 14.6%PRS 7.1%
-
CSI 2.1rCSI 7.8%PRS 3.3%
-
CSI 2.1rCSI 7.0%PRS 4.4%
-
CSI 2.1rCSI 9.8%PRS 13.3%
-
CSI 2.1rCSI 2.7%PRS 6.7%
-
CSI 2.2rCSI 3.2%PRS 5.3%
-
CSI 2.2rCSI 4.5%PRS 8.6%
-
CSI 2.2rCSI 6.4%PRS 10.8%
-
CSI 2.2rCSI 3.0%PRS 9.3%
-
CSI 2.2rCSI 11.7%PRS 9.4%
-
CSI 2.3rCSI 29.3%PRS 29.9%
-
CSI 2.3rCSI 37.3%PRS 48.1%
-
CSI 2.3rCSI 14.4%PRS 17.9%
-
CSI 2.4rCSI 13.2%PRS 19.6%
-
CSI 2.4rCSI 5.8%PRS 3.1%
-
CSI 2.4rCSI 46.0%PRS 19.2%
-
CSI 2.4rCSI 5.7%PRS 8.5%
-
CSI 2.5rCSI 7.1%PRS 10.3%
-
CSI 2.6rCSI 4.1%PRS 5.3%
-
CSI 2.7rCSI 5.0%PRS 10.6%
-
CSI 2.7rCSI 4.4%PRS 4.1%
-
CSI 2.7rCSI 42.4%PRS 13.8%
-
CSI 2.9rCSI 4.4%PRS 6.1%
-
CSI 2.9rCSI 5.4%PRS 4.0%
-
CSI 2.9rCSI 7.4%PRS 5.0%
-
CSI 2.9rCSI 8.2%PRS 9.4%
-
CSI 2.9rCSI 50.2%PRS 22.4%
-
CSI 2.9rCSI 65.5%PRS 29.8%
-
CSI 2.9rCSI 28.6%PRS 16.3%
-
CSI 3.0rCSI 5.6%PRS 11.9%
-
CSI 3.0rCSI 4.4%PRS 6.9%
-
CSI 3.0rCSI 72.5%PRS 19.9%
-
CSI 3.1rCSI 4.2%PRS 8.1%
-
CSI 3.1rCSI 5.1%PRS 6.2%
-
CSI 3.2rCSI 10.9%PRS 23.6%
-
CSI 3.2rCSI 14.8%PRS 7.6%
-
CSI 3.2rCSI 10.1%PRS 3.7%
-
CSI 3.2rCSI 2.8%PRS 6.5%
-
CSI 3.3rCSI 2.9%PRS 4.7%
-
CSI 3.3rCSI 12.8%PRS 11.5%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 451757011
Symbol: MARCS_HUMAN
Name: Myristoylated alanine-rich C-kinase substrate
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1860846
Title: The human myristoylated alanine-rich C kinase substrate (MARCKS) gene (MACS). Analysis of its gene product, promoter, and chromosomal localization.
PubMed ID: 1860846
PubMed ID: 1427823
Title: Molecular cloning and chromosomal mapping of a cDNA encoding human 80K-L protein: major substrate for protein kinase C.
PubMed ID: 1427823
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1396720
Title: Relationship between the major protein kinase C substrates acidic 80-kDa protein-kinase-C substrate (80K) and myristoylated alanine-rich C-kinase substrate (MARCKS). Members of a gene family or equivalent genes in different species.
PubMed ID: 1396720
PubMed ID: 2116001
Title: Tumor necrosis factor alpha modifies agonist-dependent responses in human neutrophils by inducing the synthesis and myristoylation of a specific protein kinase C substrate.
PubMed ID: 2116001
PubMed ID: 2034276
Title: Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane.
PubMed ID: 2034276
DOI: 10.1038/351320a0
PubMed ID: 8557118
Title: PRK1 phosphorylates MARCKS at the PKC sites: serine 152, serine 156 and serine 163.
PubMed ID: 8557118
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 17924679
Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
PubMed ID: 17924679
DOI: 10.1021/pr070152u
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23704996
Title: MARCKS protein is phosphorylated and regulates calcium mobilization during human acrosomal exocytosis.
PubMed ID: 23704996
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25255805
Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.
PubMed ID: 25255805
DOI: 10.1038/ncomms5919
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 36009319
Title: MARCKS Is an Essential Regulator of Reactive Oxygen Species Production in the Monocytic Cell Type.
PubMed ID: 36009319
PubMed ID: 37949888
Title: Myristoylated, alanine-rich C-kinase substrate (MARCKS) regulates toll-like receptor 4 signaling in macrophages.
PubMed ID: 37949888
Sequence Information:
- Length: 332
- Mass: 31555
- Checksum: 0AB247801EF8FCBF
- Sequence:
MGAQFSKTAA KGEAAAERPG EAAVASSPSK ANGQENGHVK VNGDASPAAA ESGAKEELQA NGSAPAADKE EPAAAGSGAA SPSAAEKGEP AAAAAPEAGA SPVEKEAPAE GEAAEPGSPT AAEGEAASAA SSTSSPKAED GATPSPSNET PKKKKKRFSF KKSFKLSGFS FKKNKKEAGE GGEAEAPAAE GGKDEAAGGA AAAAAEAGAA SGEQAAAPGE EAAAGEEGAA GGDPQEAKPQ EAAVAPEKPP ASDETKAAEE PSKVEEKKAE EAGASAAACE APSAAGPGAP PEQEAAPAEE PAAAAASSAC AAPSQEAQPE CSPEAPPAEA AE
Genular Protein ID: 2679317751
Symbol: Q6NVI1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 157
- Mass: 14859
- Checksum: 35A77F72AED1F922
- Sequence:
MGAQFSKTAA KGEAAAERPG EAAVASSPSK ANGQENGHVK VNGDASPAAA ESGAKEELQA NGSAPAADKE EPAAAGSGAA SPSAAEKGEP AAAAAPEAGA SPVEKEAPAE GEAAEPGSPT AAEGEAASAA SSTSSPKAED GATPSPSNET PKKKKKK