Details for: MAS1

Gene ID: 4142

Symbol: MAS1

Ensembl ID: ENSG00000130368

Description: MAS1 proto-oncogene, G protein-coupled receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.9532
    Cell Significance Index: 15.4200
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.5062
    Cell Significance Index: 5.2400
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.3379
    Cell Significance Index: 13.2000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.7976
    Cell Significance Index: 22.7600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5211
    Cell Significance Index: 7.6000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.4866
    Cell Significance Index: 7.7200
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.3116
    Cell Significance Index: 2.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2928
    Cell Significance Index: 19.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.1965
    Cell Significance Index: -0.4300
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.1867
    Cell Significance Index: 2.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1550
    Cell Significance Index: 8.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1214
    Cell Significance Index: 7.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1072
    Cell Significance Index: 3.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0856
    Cell Significance Index: 16.2900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0819
    Cell Significance Index: 1.1500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0594
    Cell Significance Index: 0.8900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0593
    Cell Significance Index: 0.7900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0569
    Cell Significance Index: 0.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0498
    Cell Significance Index: 1.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0381
    Cell Significance Index: 1.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0329
    Cell Significance Index: 29.7200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.0315
    Cell Significance Index: 0.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0261
    Cell Significance Index: 0.6700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0258
    Cell Significance Index: 0.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0235
    Cell Significance Index: 0.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0176
    Cell Significance Index: 6.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0172
    Cell Significance Index: 1.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0147
    Cell Significance Index: 0.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0117
    Cell Significance Index: 1.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0082
    Cell Significance Index: 0.2300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0074
    Cell Significance Index: 0.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0069
    Cell Significance Index: 0.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0065
    Cell Significance Index: 1.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0051
    Cell Significance Index: 0.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0043
    Cell Significance Index: 0.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0033
    Cell Significance Index: 0.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0017
    Cell Significance Index: 0.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0016
    Cell Significance Index: 0.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0006
    Cell Significance Index: 0.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0003
    Cell Significance Index: 0.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0006
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0008
    Cell Significance Index: -0.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0009
    Cell Significance Index: -1.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0013
    Cell Significance Index: -1.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0015
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0015
    Cell Significance Index: -1.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0016
    Cell Significance Index: -0.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0019
    Cell Significance Index: -1.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0020
    Cell Significance Index: -0.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0021
    Cell Significance Index: -1.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0027
    Cell Significance Index: -2.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0029
    Cell Significance Index: -1.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0029
    Cell Significance Index: -2.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0044
    Cell Significance Index: -0.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0046
    Cell Significance Index: -2.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0049
    Cell Significance Index: -0.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0050
    Cell Significance Index: -0.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0052
    Cell Significance Index: -0.9400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0059
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0066
    Cell Significance Index: -1.3800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0072
    Cell Significance Index: -0.1500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0099
    Cell Significance Index: -0.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0104
    Cell Significance Index: -1.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0108
    Cell Significance Index: -0.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0124
    Cell Significance Index: -1.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0134
    Cell Significance Index: -1.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0152
    Cell Significance Index: -1.9700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0164
    Cell Significance Index: -0.2700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0181
    Cell Significance Index: -0.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0198
    Cell Significance Index: -2.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0198
    Cell Significance Index: -0.2700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0202
    Cell Significance Index: -1.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0214
    Cell Significance Index: -1.1300
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.0222
    Cell Significance Index: -0.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0225
    Cell Significance Index: -1.6800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0235
    Cell Significance Index: -0.2000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0249
    Cell Significance Index: -0.4000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0250
    Cell Significance Index: -2.9500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0271
    Cell Significance Index: -0.3800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0292
    Cell Significance Index: -0.4400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0310
    Cell Significance Index: -0.3400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0325
    Cell Significance Index: -0.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0334
    Cell Significance Index: -2.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0369
    Cell Significance Index: -0.6800
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0374
    Cell Significance Index: -0.3800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0380
    Cell Significance Index: -0.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0421
    Cell Significance Index: -1.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0422
    Cell Significance Index: -2.3700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0424
    Cell Significance Index: -0.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0434
    Cell Significance Index: -1.9200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0488
    Cell Significance Index: -0.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0499
    Cell Significance Index: -1.4700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0500
    Cell Significance Index: -1.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0509
    Cell Significance Index: -1.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0526
    Cell Significance Index: -1.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0531
    Cell Significance Index: -1.7400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0560
    Cell Significance Index: -0.8000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0577
    Cell Significance Index: -0.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0588
    Cell Significance Index: -1.2300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0604
    Cell Significance Index: -0.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAS1 is a member of the Mas-related G protein-coupled receptor (MGRGPR) family, characterized by its ability to interact with G proteins and trigger downstream signaling cascades. Its expression is widespread, with notable presence in the immune system, nervous system, and epithelial tissues. Notably, MAS1 is a positive regulator of various cellular processes, including proliferation, DNA replication, and inflammatory responses. Its expression is also influenced by gonadotropins and xenobiotics, underscoring the gene's sensitivity to environmental and hormonal cues. **Pathways and Functions:** MAS1's signaling pathways are diverse and interconnected, influencing multiple cellular processes. Notably, its involvement in the angiotensin-activated signaling pathway highlights its role in blood pressure regulation and cardiovascular health. Additionally, MAS1's interaction with G proteins and its ability to regulate protein kinase C signaling underscore its potential role in immune cell function and inflammation. Furthermore, its expression in intestinal epithelial cells and goblet cells suggests a role in maintaining gut homeostasis and barrier function. In the context of immune regulation, MAS1's involvement in the negative regulation of protein phosphorylation and its ability to modulate canonical NF-κB signaling pathways position it as a key player in immune cell development and function. Its expression in innate lymphoid cells and its role in regulating inflammatory responses highlight its potential as a therapeutic target in immune-related disorders. **Clinical Significance:** MAS1's dysregulation has been implicated in various human diseases, including cardiovascular disease, hypertension, and cancer. Its expression in cancer cells suggests a potential role in tumor progression and metastasis. Furthermore, MAS1's involvement in immune-related disorders, such as inflammatory bowel disease and autoimmune diseases, highlights its potential as a therapeutic target. In conclusion, MAS1 is a complex gene with far-reaching implications for human health and disease. Its involvement in immune regulation, development, and disease highlights the need for further research into its mechanisms of action and potential therapeutic applications. As an expert immunologist, I emphasize the importance of continued investigation into MAS1's role in human health and disease, with the ultimate goal of developing novel therapeutic strategies for the treatment of MAS1-related disorders. **Significantly Expressed Cells:** * Colon goblet cell * Cardiac endothelial cell * Intestinal crypt stem cell of small intestine * Immature innate lymphoid cell * Goblet cell * Cerebral cortex GABAergic interneuron * Forebrain radial glial cell * Tuft cell of colon * BEST4+ intestinal epithelial cell **Proteins:** * MAS_HUMAN (Proto-oncogene Mas) This gene's significance in the context of immune regulation, development, and disease underscores the need for continued research into MAS1's mechanisms of action and potential therapeutic applications.

Genular Protein ID: 3633438834

Symbol: MAS_HUMAN

Name: Proto-oncogene Mas

UniProtKB Accession Codes:

P04201 E1P5B3 Q2TBC9 Q6FG47

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3708691

Title: Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains.

PubMed ID: 3708691

DOI: 10.1016/0092-8674(86)90785-3

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3419518

Title: The mas oncogene encodes an angiotensin receptor.

PubMed ID: 3419518

DOI: 10.1038/335437a0

PubMed ID: 15809376

Title: G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor.

PubMed ID: 15809376

DOI: 10.1161/01.cir.0000160867.23556.7d

PubMed ID: 16611642

Title: Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS.

PubMed ID: 16611642

DOI: 10.1074/jbc.m601121200

PubMed ID: 26460884

Title: G Protein-Coupled Receptors Directly Bind Filamin A with High Affinity and Promote Filamin Phosphorylation.

PubMed ID: 26460884

DOI: 10.1021/acs.biochem.5b00975

Sequence Information:

  • Length: 325
  • Mass: 37465
  • Checksum: 3368E7B174744B83
  • Sequence:
    • MDGSNVTSFV VEEPTNISTG RNASVGNAHR QIPIVHWVIM SISPVGFVEN GILLWFLCFR 
MRRNPFTVYI THLSIADISL LFCIFILSID YALDYELSSG HYYTIVTLSV TFLFGYNTGL 
YLLTAISVER CLSVLYPIWY RCHRPKYQSA LVCALLWALS CLVTTMEYVM CIDREEESHS 
RNDCRAVIIF IAILSFLVFT PLMLVSSTIL VVKIRKNTWA SHSSKLYIVI MVTIIIFLIF 
AMPMRLLYLL YYEYWSTFGN LHHISLLFST INSSANPFIY FFVGSSKKKR FKESLKVVLT 
RAFKDEMQPR RQKDNCNTVT VETVV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.