Details for: GPX5

Gene ID: 2880

Symbol: GPX5

Ensembl ID: ENSG00000224586

Description: glutathione peroxidase 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: 2.23
    Marker Score: 3851
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2223
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.27
    Marker Score: 1213
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7691
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5347
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.92
    Marker Score: 1486
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.84
    Marker Score: 7120
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 714
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1198
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.72
    Marker Score: 697
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.68
    Marker Score: 546
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 384
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.3
    Marker Score: 79
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.25
    Marker Score: 73
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.25
    Marker Score: 739
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.24
    Marker Score: 75
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.23
    Marker Score: 71
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.21
    Marker Score: 65
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.2
    Marker Score: 72.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.2
    Marker Score: 73
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.18
    Marker Score: 74
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.17
    Marker Score: 78
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.17
    Marker Score: 85
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.13
    Marker Score: 276
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.13
    Marker Score: 42
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.13
    Marker Score: 68
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.12
    Marker Score: 72
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.11
    Marker Score: 74
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.11
    Marker Score: 73
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.09
    Marker Score: 379
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.08
    Marker Score: 63.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.08
    Marker Score: 84
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.08
    Marker Score: 68.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 85.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.07
    Marker Score: 73
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.06
    Marker Score: 65
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 74
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.06
    Marker Score: 75
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.06
    Marker Score: 75
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.06
    Marker Score: 75
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.06
    Marker Score: 73.5
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.06
    Marker Score: 83
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.05
    Marker Score: 69
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.04
    Marker Score: 67
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.04
    Marker Score: 72
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.04
    Marker Score: 60
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.03
    Marker Score: 73
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.03
    Marker Score: 42
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.03
    Marker Score: 50
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 75
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.03
    Marker Score: 66
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.03
    Marker Score: 63.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.03
    Marker Score: 59
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.02
    Marker Score: 85
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.02
    Marker Score: 75
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.02
    Marker Score: 66.5
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.02
    Marker Score: 66
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.02
    Marker Score: 59
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.02
    Marker Score: 78
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.02
    Marker Score: 73
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.02
    Marker Score: 66
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.02
    Marker Score: 29
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.02
    Marker Score: 67
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.02
    Marker Score: 72
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.02
    Marker Score: 71
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 53
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.01
    Marker Score: 71
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.01
    Marker Score: 75
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.01
    Marker Score: 64
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.01
    Marker Score: 73
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.01
    Marker Score: 74
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.01
    Marker Score: 70
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.01
    Marker Score: 86
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.01
    Marker Score: 59
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.01
    Marker Score: 48
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.01
    Marker Score: 48
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0
    Marker Score: 39
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 260
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0
    Marker Score: 56
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0
    Marker Score: 106
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0
    Marker Score: 55
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0
    Marker Score: 87
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0
    Marker Score: 48
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0
    Marker Score: 44
  • Cell Name: mural cell (CL0008034)
    Fold Change: 0
    Marker Score: 74

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Other Information

**Key characteristics:** - GPX5 is a large protein with a molecular weight of approximately 170 kDa. - It is found in a variety of cellular compartments, including the cytoplasm, nucleus, and mitochondria. - GPX5 is a highly conserved protein, with a sequence similarity of over 90% between humans and rodents. - It is a member of the glutathione peroxidase family of enzymes, which are involved in the detoxification of reactive oxygen species. **Pathways and functions:** - GPX5 is involved in cellular redox homeostasis by catalyzing the reduction of hydrogen peroxide to water. - It helps to protect cells from damage caused by reactive oxygen species (ROS), which are produced in high concentrations in cells during oxidative stress. - GPX5 also plays a role in the lipid metabolic process by participating in the detoxification of reactive oxygen species that can damage lipids. - It is involved in the regulation of inflammation and immune responses by reducing the production of inflammatory cytokines. **Clinical significance:** - Mutations in GPX5 have been linked to a number of human diseases, including cancer, neurodegenerative disorders, and metabolic diseases. - GPX5 inhibitors are being investigated as potential treatments for these diseases. - By understanding the role of GPX5 in cellular redox homeostasis and oxidative stress, scientists may be able to develop new therapeutic strategies for diseases that are characterized by oxidative damage.

Genular Protein ID: 1886570969

Symbol: GPX5_HUMAN

Name: Epididymal secretory glutathione peroxidase

UniProtKB Accession Codes:

O75715 A1A4Y0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 4 DNASU 1 DisGeNET 1 DrugBank 3 EC 2 EMBL 6 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PeroxiBase 2 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9639555

Title: The majority of human glutathione peroxidase type 5 (GPX5) transcripts are incorrectly spliced: implications for the role of GPX5 in the male reproductive tract.

PubMed ID: 9639555

DOI: 10.1042/bj3330005

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 221
  • Mass: 25202
  • Checksum: CE3E7BFD53CE979F
  • Sequence:
    • MTTQLRVVHL LPLLLACFVQ TSPKQEKMKM DCHKDEKGTI YDYEAIALNK NEYVSFKQYV 
GKHILFVNVA TYCGLTAQYP ELNALQEELK PYGLVVLGFP CNQFGKQEPG DNKEILPGLK 
YVRPGGGFVP SFQLFEKGDV NGEKEQKVFS FLKHSCPHPS EILGTFKSIS WDPVKVHDIR 
WNFEKFLVGP DGIPVMRWSH RATVSSVKTD ILAYLKQFKT K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.