Details for: F2RL2

Gene ID: 2151

Symbol: F2RL2

Ensembl ID: ENSG00000164220

Description: coagulation factor II thrombin receptor like 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 15.1081
    Cell Significance Index: -2.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 9.1861
    Cell Significance Index: -2.3300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 5.6491
    Cell Significance Index: -2.3000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.6960
    Cell Significance Index: 10.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4992
    Cell Significance Index: 31.4600
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.4931
    Cell Significance Index: 3.6200
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.4726
    Cell Significance Index: 2.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3279
    Cell Significance Index: 9.4000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2148
    Cell Significance Index: 2.5600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1795
    Cell Significance Index: 2.8800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1758
    Cell Significance Index: 3.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1484
    Cell Significance Index: 21.5700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0897
    Cell Significance Index: 10.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0842
    Cell Significance Index: 52.5500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0737
    Cell Significance Index: 1.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0675
    Cell Significance Index: 13.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0501
    Cell Significance Index: 34.6300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0385
    Cell Significance Index: 0.2100
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.0378
    Cell Significance Index: 0.3400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0241
    Cell Significance Index: 0.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0232
    Cell Significance Index: 0.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0120
    Cell Significance Index: 22.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0057
    Cell Significance Index: 3.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0056
    Cell Significance Index: 0.1500
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.0048
    Cell Significance Index: 0.0300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0007
    Cell Significance Index: 0.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0005
    Cell Significance Index: 0.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0002
    Cell Significance Index: 0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0003
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0005
    Cell Significance Index: -0.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0017
    Cell Significance Index: -0.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0018
    Cell Significance Index: -2.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0020
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0025
    Cell Significance Index: -0.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0031
    Cell Significance Index: -1.4200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0031
    Cell Significance Index: -0.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0036
    Cell Significance Index: -0.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0036
    Cell Significance Index: -0.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0040
    Cell Significance Index: -2.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0041
    Cell Significance Index: -0.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0041
    Cell Significance Index: -3.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0065
    Cell Significance Index: -2.3400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0087
    Cell Significance Index: -0.1400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0100
    Cell Significance Index: -0.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0111
    Cell Significance Index: -2.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0128
    Cell Significance Index: -0.7200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0152
    Cell Significance Index: -0.6600
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0157
    Cell Significance Index: -0.1300
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0177
    Cell Significance Index: -0.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0181
    Cell Significance Index: -0.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0186
    Cell Significance Index: -2.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0192
    Cell Significance Index: -2.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0199
    Cell Significance Index: -2.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0210
    Cell Significance Index: -2.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0223
    Cell Significance Index: -2.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0234
    Cell Significance Index: -2.7600
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0270
    Cell Significance Index: -0.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0284
    Cell Significance Index: -2.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0298
    Cell Significance Index: -0.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0307
    Cell Significance Index: -1.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0339
    Cell Significance Index: -0.9500
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0350
    Cell Significance Index: -0.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0353
    Cell Significance Index: -0.7500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0356
    Cell Significance Index: -0.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0363
    Cell Significance Index: -2.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0364
    Cell Significance Index: -2.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0390
    Cell Significance Index: -2.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0394
    Cell Significance Index: -1.8500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0395
    Cell Significance Index: -1.1600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0395
    Cell Significance Index: -0.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0403
    Cell Significance Index: -1.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0418
    Cell Significance Index: -2.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0481
    Cell Significance Index: -2.5000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0484
    Cell Significance Index: -1.9900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0534
    Cell Significance Index: -0.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0554
    Cell Significance Index: -1.9400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0559
    Cell Significance Index: -0.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0564
    Cell Significance Index: -1.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0583
    Cell Significance Index: -2.9500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0590
    Cell Significance Index: -1.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0607
    Cell Significance Index: -1.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0609
    Cell Significance Index: -2.7600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0612
    Cell Significance Index: -0.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0617
    Cell Significance Index: -1.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0622
    Cell Significance Index: -2.7500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0657
    Cell Significance Index: -0.7200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0667
    Cell Significance Index: -2.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0672
    Cell Significance Index: -2.3600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0695
    Cell Significance Index: -0.8600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0711
    Cell Significance Index: -0.5800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0717
    Cell Significance Index: -0.7800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0718
    Cell Significance Index: -1.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0726
    Cell Significance Index: -2.7500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0737
    Cell Significance Index: -1.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0741
    Cell Significance Index: -2.5800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0760
    Cell Significance Index: -0.9000
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0763
    Cell Significance Index: -0.6900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0772
    Cell Significance Index: -1.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** F2RL2 is a gene that encodes a protein with a thrombin receptor-like structure, comprising seven transmembrane domains. This gene is highly conserved across species, suggesting its importance in evolution. F2RL2 is expressed in various cell types, including those involved in immune responses, such as granulocyte monocyte progenitor cells and cerebral cortex GABAergic interneurons. The protein encoded by F2RL2, PAR3, is a member of the PAR family, which is activated by thrombin, a key enzyme in the coagulation cascade. **Pathways and Functions:** F2RL2 is involved in multiple signaling pathways, including: 1. **Thrombin-activated signaling pathway:** PAR3 is activated by thrombin, leading to the activation of downstream signaling molecules, such as Gαq and phospholipase C. 2. **G protein-coupled receptor activity:** F2RL2 encodes a G protein-coupled receptor (GPCR) that responds to ligands, such as thrombin, and triggers downstream signaling events. 3. **Ligand-gated ion channel signaling pathway:** PAR3 can also activate ligand-gated ion channels, leading to changes in cellular excitability. 4. **Positive regulation of insulin secretion:** F2RL2 has been implicated in the regulation of insulin secretion in pancreatic beta cells. 5. **Positive regulation of rho protein signal transduction:** PAR3 can also activate rho protein signal transduction pathways, which are involved in cellular migration and cytoskeleton rearrangement. **Clinical Significance:** F2RL2 has been associated with various diseases and disorders, including: 1. **Blood coagulation disorders:** Alterations in F2RL2 expression have been linked to thrombotic disorders, such as deep vein thrombosis and pulmonary embolism. 2. **Autoimmune diseases:** F2RL2 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where it may contribute to the regulation of immune responses. 3. **Neurological disorders:** F2RL2 has been associated with neurological disorders, such as Alzheimer's disease and schizophrenia, where it may play a role in the regulation of cellular signaling pathways. In conclusion, F2RL2 is a complex gene involved in multiple aspects of immune regulation and coagulation. Its dysregulation has been linked to various diseases and disorders, highlighting the importance of further research into the functions and clinical significance of this gene.

Genular Protein ID: 1317497973

Symbol: PAR3_HUMAN

Name: Proteinase-activated receptor 3

UniProtKB Accession Codes:

O00254 B2R754 B4DQ13 Q52M68 Q7Z3W3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9087410

Title: Protease-activated receptor 3 is a second thrombin receptor in humans.

PubMed ID: 9087410

DOI: 10.1038/386502a0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9614115

Title: The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a PAR gene cluster and characterization in vascular endothelial cells and platelets.

PubMed ID: 9614115

DOI: 10.1074/jbc.273.24.15061

PubMed ID: 10079109

Title: Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.

PubMed ID: 10079109

DOI: 10.1172/jci6042

PubMed ID: 16458856

Title: Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3.

PubMed ID: 16458856

DOI: 10.1016/j.bbrc.2006.01.050

Sequence Information:

  • Length: 374
  • Mass: 42508
  • Checksum: C45C15A695DD1ABB
  • Sequence:
    • MKALIFAAAG LLLLLPTFCQ SGMENDTNNL AKPTLPIKTF RGAPPNSFEE FPFSALEGWT 
GATITVKIKC PEESASHLHV KNATMGYLTS SLSTKLIPAI YLLVFVVGVP ANAVTLWMLF 
FRTRSICTTV FYTNLAIADF LFCVTLPFKI AYHLNGNNWV FGEVLCRATT VIFYGNMYCS 
ILLLACISIN RYLAIVHPFT YRGLPKHTYA LVTCGLVWAT VFLYMLPFFI LKQEYYLVQP 
DITTCHDVHN TCESSSPFQL YYFISLAFFG FLIPFVLIIY CYAAIIRTLN AYDHRWLWYV 
KASLLILVIF TICFAPSNII LIIHHANYYY NNTDGLYFIY LIALCLGSLN SCLDPFLYFL 
MSKTRNHSTA YLTK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.