Details for: KCNJ11
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6262
Cell Significance Index: 61.9500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.5355
Cell Significance Index: 11.4100 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.4483
Cell Significance Index: 6.4200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3736
Cell Significance Index: 337.3600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.3463
Cell Significance Index: 216.2700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3052
Cell Significance Index: 49.6400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2875
Cell Significance Index: 31.2700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2466
Cell Significance Index: 170.5900 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.2240
Cell Significance Index: 4.9100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2026
Cell Significance Index: 12.1600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1875
Cell Significance Index: 35.6900 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.1499
Cell Significance Index: 3.2100 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.1406
Cell Significance Index: 3.4300 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 0.1345
Cell Significance Index: 2.1700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1310
Cell Significance Index: 9.0600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0996
Cell Significance Index: 2.8700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0766
Cell Significance Index: 1.6600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0749
Cell Significance Index: 15.0300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0668
Cell Significance Index: 3.0300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.0608
Cell Significance Index: 17.5100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.0409
Cell Significance Index: 4.6700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0347
Cell Significance Index: 1.2200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0315
Cell Significance Index: 1.0100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.0160
Cell Significance Index: 0.9800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0149
Cell Significance Index: 5.3400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0119
Cell Significance Index: 2.0300 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0075
Cell Significance Index: 0.1600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.0066
Cell Significance Index: 0.1700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0053
Cell Significance Index: 0.0900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0020
Cell Significance Index: 0.0500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.0016
Cell Significance Index: 1.1600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0014
Cell Significance Index: -0.7700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0017
Cell Significance Index: -3.1400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0021
Cell Significance Index: -3.9300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0026
Cell Significance Index: -3.9300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0029
Cell Significance Index: -3.9300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0032
Cell Significance Index: -2.4100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0042
Cell Significance Index: -3.0900 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0044
Cell Significance Index: -2.4300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0056
Cell Significance Index: -1.1900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0057
Cell Significance Index: -3.6000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0065
Cell Significance Index: -0.4400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0083
Cell Significance Index: -3.7700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0086
Cell Significance Index: -0.4000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0097
Cell Significance Index: -0.9900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0113
Cell Significance Index: -2.2400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0117
Cell Significance Index: -1.3400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0143
Cell Significance Index: -2.5700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0149
Cell Significance Index: -0.7800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0178
Cell Significance Index: -2.4500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0223
Cell Significance Index: -1.7200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0229
Cell Significance Index: -3.3300 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.0233
Cell Significance Index: -0.3700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0239
Cell Significance Index: -1.7800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0250
Cell Significance Index: -2.9100 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0252
Cell Significance Index: -0.3800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0276
Cell Significance Index: -3.3900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0276
Cell Significance Index: -3.5600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0327
Cell Significance Index: -3.4100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0337
Cell Significance Index: -3.9800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0344
Cell Significance Index: -1.5200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0378
Cell Significance Index: -1.0800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0394
Cell Significance Index: -2.4200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0400
Cell Significance Index: -2.0800 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0415
Cell Significance Index: -0.8800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0420
Cell Significance Index: -2.6500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0430
Cell Significance Index: -1.1700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0446
Cell Significance Index: -1.6900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0463
Cell Significance Index: -1.4800 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0482
Cell Significance Index: -2.1000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0485
Cell Significance Index: -3.8400 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0502
Cell Significance Index: -1.7600 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0538
Cell Significance Index: -1.7600 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0553
Cell Significance Index: -1.1100 - Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.0563
Cell Significance Index: -0.7600 - Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: -0.0566
Cell Significance Index: -0.7300 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.0578
Cell Significance Index: -0.7300 - Cell Name: neuron (CL0000540)
Fold Change: -0.0601
Cell Significance Index: -0.5700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0606
Cell Significance Index: -3.4000 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0645
Cell Significance Index: -1.6100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0652
Cell Significance Index: -3.0700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0710
Cell Significance Index: -1.9800 - Cell Name: ependymal cell (CL0000065)
Fold Change: -0.0721
Cell Significance Index: -0.8500 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0731
Cell Significance Index: -3.7000 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0734
Cell Significance Index: -0.8000 - Cell Name: thymocyte (CL0000893)
Fold Change: -0.0744
Cell Significance Index: -0.9400 - Cell Name: fast muscle cell (CL0000190)
Fold Change: -0.0756
Cell Significance Index: -0.9900 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0769
Cell Significance Index: -1.5200 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0828
Cell Significance Index: -1.7900 - Cell Name: slow muscle cell (CL0000189)
Fold Change: -0.0849
Cell Significance Index: -1.2700 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0894
Cell Significance Index: -3.2800 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0921
Cell Significance Index: -2.3000 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.0947
Cell Significance Index: -0.9800 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.0958
Cell Significance Index: -2.0000 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0985
Cell Significance Index: -2.9000 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0988
Cell Significance Index: -2.3700 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.1014
Cell Significance Index: -1.3100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1073
Cell Significance Index: -3.7300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1099
Cell Significance Index: -2.3000 - Cell Name: neural cell (CL0002319)
Fold Change: -0.1123
Cell Significance Index: -1.3100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2731039901
Symbol: KCJ11_HUMAN
Name: ATP-sensitive inward rectifier potassium channel 11
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7502040
Title: Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.
PubMed ID: 7502040
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9831708
Title: Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cells.
PubMed ID: 9831708
PubMed ID: 12524280
Title: Molecular basis for Kir6.2 channel inhibition by adenine nucleotides.
PubMed ID: 12524280
PubMed ID: 17652641
Title: A novel mutation causing DEND syndrome: a treatable channelopathy of pancreas and brain.
PubMed ID: 17652641
PubMed ID: 18596924
Title: Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations.
PubMed ID: 18596924
DOI: 10.1172/jci35414
PubMed ID: 19357197
Title: Sar1-GTPase-dependent ER exit of KATP channels revealed by a mutation causing congenital hyperinsulinism.
PubMed ID: 19357197
DOI: 10.1093/hmg/ddp179
PubMed ID: 20022885
Title: Interaction between mutations in the slide helix of Kir6.2 associated with neonatal diabetes and neurological symptoms.
PubMed ID: 20022885
DOI: 10.1093/hmg/ddp554
PubMed ID: 10338089
Title: Congenital hyperinsulinism: molecular basis of a heterogeneous disease.
PubMed ID: 10338089
DOI: 10.1002/(sici)1098-1004(1999)13:5<351::aid-humu3>3.0.co;2-r
PubMed ID: 17855752
Title: A mutation in the ATP-binding site of the Kir6.2 subunit of the KATP channel alters coupling with the SUR2A subunit.
PubMed ID: 17855752
PubMed ID: 18280666
Title: Functional modulation of the ATP-sensitive potassium channel by extracellular signal-regulated kinase-mediated phosphorylation.
PubMed ID: 18280666
PubMed ID: 22701567
Title: Whole-exome sequencing and high throughput genotyping identified KCNJ11 as the thirteenth MODY gene.
PubMed ID: 22701567
PubMed ID: 28842488
Title: Conserved functional consequences of disease-associated mutations in the slide-helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel.
PubMed ID: 28842488
PubMed ID: 7847376
Title: Homozygosity mapping, to chromosome 11p, of the gene for familial persistent hyperinsulinemic hypoglycemia of infancy.
PubMed ID: 7847376
PubMed ID: 8923010
Title: Mutation of the pancreatic islet inward rectifier Kir6.2 also leads to familial persistent hyperinsulinemic hypoglycemia of infancy.
PubMed ID: 8923010
PubMed ID: 8897013
Title: Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in white Caucasian subjects or evidence of abnormal function when expressed in vitro.
PubMed ID: 8897013
DOI: 10.1007/bf02658512
PubMed ID: 9032109
Title: Sequence variants in the pancreatic islet beta-cell inwardly rectifying K+ channel Kir6.2 (Bir) gene: identification and lack of role in Caucasian patients with NIDDM.
PubMed ID: 9032109
PubMed ID: 10204114
Title: Molecular biology of adenosine triphosphate-sensitive potassium channels.
PubMed ID: 10204114
PubMed ID: 10391210
Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.
PubMed ID: 10391210
DOI: 10.1038/10297
PubMed ID: 12364426
Title: Acute insulin response tests for the differential diagnosis of congenital hyperinsulinism.
PubMed ID: 12364426
PubMed ID: 15448106
Title: Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy.
PubMed ID: 15448106
PubMed ID: 15448107
Title: Kir6.2 mutations are a common cause of permanent neonatal diabetes in a large cohort of French patients.
PubMed ID: 15448107
PubMed ID: 15292329
Title: Permanent neonatal diabetes due to paternal germline mosaicism for an activating mutation of the KCNJ11 gene encoding the Kir6.2 subunit of the beta-cell potassium adenosine triphosphate channel.
PubMed ID: 15292329
DOI: 10.1210/jc.2004-0568
PubMed ID: 15579781
Title: Hyperinsulinism of infancy: novel ABCC8 and KCNJ11 mutations and evidence for additional locus heterogeneity.
PubMed ID: 15579781
DOI: 10.1210/jc.2004-1233
PubMed ID: 15115830
Title: Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.
PubMed ID: 15115830
DOI: 10.1056/nejmoa032922
PubMed ID: 15583126
Title: Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features.
PubMed ID: 15583126
PubMed ID: 15807877
Title: Genotypes of the pancreatic beta-cell K-ATP channel and clinical phenotypes of Japanese patients with persistent hyperinsulinaemic hypoglycaemia of infancy.
PubMed ID: 15807877
PubMed ID: 15718250
Title: Relapsing diabetes can result from moderately activating mutations in KCNJ11.
PubMed ID: 15718250
DOI: 10.1093/hmg/ddi086
PubMed ID: 15580558
Title: KCNJ11 activating mutations in Italian patients with permanent neonatal diabetes.
PubMed ID: 15580558
DOI: 10.1002/humu.20124
PubMed ID: 15562009
Title: Genotype-phenotype correlations in children with congenital hyperinsulinism due to recessive mutations of the adenosine triphosphate-sensitive potassium channel genes.
PubMed ID: 15562009
DOI: 10.1210/jc.2004-1604
PubMed ID: 15784703
Title: The C42R mutation in the Kir6.2 (KCNJ11) gene as a cause of transient neonatal diabetes, childhood diabetes, or later-onset, apparently type 2 diabetes mellitus.
PubMed ID: 15784703
DOI: 10.1210/jc.2005-0096
PubMed ID: 15998776
Title: Severe congenital hyperinsulinism caused by a mutation in the Kir6.2 subunit of the adenosine triphosphate-sensitive potassium channel impairing trafficking and function.
PubMed ID: 15998776
DOI: 10.1210/jc.2005-0202
PubMed ID: 16731833
Title: Mutations at the same residue (R50) of Kir6.2 (KCNJ11) that cause neonatal diabetes produce different functional effects.
PubMed ID: 16731833
DOI: 10.2337/db05-1640
PubMed ID: 16609879
Title: Mutations in KCNJ11, which encodes Kir6.2, are a common cause of diabetes diagnosed in the first 6 months of life, with the phenotype determined by genotype.
PubMed ID: 16609879
PubMed ID: 16429405
Title: Mutation spectra of ABCC8 gene in Spanish patients with Hyperinsulinism of Infancy (HI).
PubMed ID: 16429405
DOI: 10.1002/humu.9401
PubMed ID: 16332676
Title: A novel KCNJ11 mutation associated with congenital hyperinsulinism reduces the intrinsic open probability of beta-cell ATP-sensitive potassium channels.
PubMed ID: 16332676
PubMed ID: 16357843
Title: Molecular and immunohistochemical analyses of the focal form of congenital hyperinsulinism.
PubMed ID: 16357843
PubMed ID: 17213273
Title: Prevalence of permanent neonatal diabetes in Slovakia and successful replacement of insulin with sulfonylurea therapy in KCNJ11 and ABCC8 mutation carriers.
PubMed ID: 17213273
DOI: 10.1210/jc.2006-2490
Sequence Information:
- Length: 390
- Mass: 43526
- Checksum: 00F4E7D94432F282
- Sequence:
MLSRKGIIPE EYVLTRLAED PAKPRYRARQ RRARFVSKKG NCNVAHKNIR EQGRFLQDVF TTLVDLKWPH TLLIFTMSFL CSWLLFAMAW WLIAFAHGDL APSEGTAEPC VTSIHSFSSA FLFSIEVQVT IGFGGRMVTE ECPLAILILI VQNIVGLMIN AIMLGCIFMK TAQAHRRAET LIFSKHAVIA LRHGRLCFML RVGDLRKSMI ISATIHMQVV RKTTSPEGEV VPLHQVDIPM ENGVGGNSIF LVAPLIIYHV IDANSPLYDL APSDLHHHQD LEIIVILEGV VETTGITTQA RTSYLADEIL WGQRFVPIVA EEDGRYSVDY SKFGNTVKVP TPLCTARQLD EDHSLLEALT LASARGPLRK RSVPMAKAKP KFSISPDSLS
Genular Protein ID: 4122914515
Symbol: A0A804HHV7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
Sequence Information:
- Length: 303
- Mass: 33249
- Checksum: 24A69A32290BDD26
- Sequence:
MAWWLIAFAH GDLAPSEGTA EPCVTSIHSF SSAFLFSIEV QVTIGFGGRM VTEECPLAIL ILIVQNIVGL MINAIMLGCI FMKTAQAHRR AETLIFSKHA VIALRHGRLC FMLRVGDLRK SMIISATIHM QVVRKTTSPE GEVVPLHQVD IPMENGVGGN SIFLVAPLII YHVIDANSPL YDLAPSDLHH HQDLEIIVIL EGVVETTGIT TQARTSYLAD EILWGQRFVP IVAEEDGRYS VDYSKFGNTV KVPTPLCTAR QLDEDHSLLE ALTLASARGP LRKRSVPMAK AKPKFSISPD SLS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.