Details for: SOX4

Gene ID: 6659

Symbol: SOX4

Ensembl ID: ENSG00000124766

Description: SRY-box transcription factor 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 518.9487
    Cell Significance Index: -80.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 204.9728
    Cell Significance Index: -51.9900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 192.8158
    Cell Significance Index: -79.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 170.7395
    Cell Significance Index: -80.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 159.6526
    Cell Significance Index: -64.8600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 152.4927
    Cell Significance Index: -78.4400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 120.3239
    Cell Significance Index: -80.7400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 67.9869
    Cell Significance Index: -64.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 65.8256
    Cell Significance Index: -81.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.8386
    Cell Significance Index: -82.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.6852
    Cell Significance Index: -45.1100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 13.1715
    Cell Significance Index: 81.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 10.7405
    Cell Significance Index: 282.4200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 10.4355
    Cell Significance Index: 83.3200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 9.0229
    Cell Significance Index: 230.5100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 8.3870
    Cell Significance Index: 107.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 8.2962
    Cell Significance Index: 288.2900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.6394
    Cell Significance Index: 83.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.9951
    Cell Significance Index: 451.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 5.9753
    Cell Significance Index: 335.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 5.7669
    Cell Significance Index: 120.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.3422
    Cell Significance Index: 684.8400
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 4.9928
    Cell Significance Index: 28.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.9560
    Cell Significance Index: 680.6000
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.9396
    Cell Significance Index: 29.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 4.6135
    Cell Significance Index: 283.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.9391
    Cell Significance Index: 293.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.6120
    Cell Significance Index: 103.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.1872
    Cell Significance Index: 1740.6100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.1486
    Cell Significance Index: 35.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.0654
    Cell Significance Index: 144.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.9479
    Cell Significance Index: 133.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.9210
    Cell Significance Index: 526.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.5020
    Cell Significance Index: 307.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.3524
    Cell Significance Index: 1040.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.1007
    Cell Significance Index: 271.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.0092
    Cell Significance Index: 57.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.9421
    Cell Significance Index: 101.9700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.4934
    Cell Significance Index: 35.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0819
    Cell Significance Index: 56.2000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0656
    Cell Significance Index: 18.8300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0137
    Cell Significance Index: 9.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9454
    Cell Significance Index: 66.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8863
    Cell Significance Index: 144.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8255
    Cell Significance Index: 163.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8125
    Cell Significance Index: 88.3800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.6484
    Cell Significance Index: 74.0200
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.6406
    Cell Significance Index: 4.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6262
    Cell Significance Index: 32.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5800
    Cell Significance Index: 57.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4900
    Cell Significance Index: 10.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4657
    Cell Significance Index: 10.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2904
    Cell Significance Index: 49.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2422
    Cell Significance Index: 8.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2114
    Cell Significance Index: 75.8400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1816
    Cell Significance Index: 3.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1136
    Cell Significance Index: 21.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0605
    Cell Significance Index: 113.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0034
    Cell Significance Index: 2.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0007
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0208
    Cell Significance Index: -13.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0303
    Cell Significance Index: -0.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0342
    Cell Significance Index: -63.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0382
    Cell Significance Index: -1.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0385
    Cell Significance Index: -59.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0388
    Cell Significance Index: -29.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0511
    Cell Significance Index: -37.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0551
    Cell Significance Index: -74.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0755
    Cell Significance Index: -15.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0986
    Cell Significance Index: -62.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1077
    Cell Significance Index: -60.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1570
    Cell Significance Index: -71.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1577
    Cell Significance Index: -16.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2302
    Cell Significance Index: -66.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2390
    Cell Significance Index: -28.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2454
    Cell Significance Index: -51.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2574
    Cell Significance Index: -12.0000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2647
    Cell Significance Index: -6.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3138
    Cell Significance Index: -8.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3522
    Cell Significance Index: -40.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3764
    Cell Significance Index: -12.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4116
    Cell Significance Index: -47.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5071
    Cell Significance Index: -73.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5912
    Cell Significance Index: -15.8200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6627
    Cell Significance Index: -9.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6970
    Cell Significance Index: -43.9300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.7117
    Cell Significance Index: -6.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7902
    Cell Significance Index: -82.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7957
    Cell Significance Index: -19.8900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.8560
    Cell Significance Index: -8.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8591
    Cell Significance Index: -68.0400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.9149
    Cell Significance Index: -5.6600
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.9761
    Cell Significance Index: -5.7300
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.9778
    Cell Significance Index: -6.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.0373
    Cell Significance Index: -79.6000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -1.0637
    Cell Significance Index: -6.9200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.1262
    Cell Significance Index: -7.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.2503
    Cell Significance Index: -84.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2920
    Cell Significance Index: -79.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3292
    Cell Significance Index: -39.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors, which are characterized by their ability to bind to specific DNA sequences and regulate gene expression. SOX4 is a dimeric transcription factor that interacts with other transcriptional regulators to modulate gene expression. Its expression is widespread in various tissues, including the immune system, where it is highly expressed in hematopoietic stem cells, immune cells, and neuronal cells. **Pathways and Functions:** SOX4 is involved in various developmental and homeostatic processes, including: 1. **Cell Proliferation and Differentiation**: SOX4 regulates cell proliferation and differentiation in the immune system by modulating the expression of genes involved in these processes. 2. **Morphogenesis**: SOX4 is involved in the development of various organs and tissues, including the heart, brain, and immune system. 3. **Gene Expression**: SOX4 regulates the expression of genes involved in various biological processes, including glucose homeostasis, apoptosis, and cell signaling. 4. **Immune System Development**: SOX4 plays a crucial role in the development and function of the immune system, including the differentiation of hematopoietic stem cells into immune cells. **Clinical Significance:** Dysregulation of SOX4 expression has been implicated in various diseases, including: 1. **Immune System Disorders**: SOX4 dysfunction has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: SOX4 overexpression has been observed in various types of cancer, including leukemia and lymphoma. 3. **Neurological Disorders**: SOX4 dysfunction has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. **Significantly Expressed Cells:** SOX4 is highly expressed in various cell types, including: 1. **Hematopoietic Stem Cells**: SOX4 is essential for the development and function of hematopoietic stem cells. 2. **Immune Cells**: SOX4 is highly expressed in immune cells, including T cells, B cells, and dendritic cells. 3. **Neuronal Cells**: SOX4 is expressed in neuronal cells, including neurons and glial cells. **Proteins:** SOX4_HUMAN is the protein encoded by the SOX4 gene. In conclusion, SOX4 is a versatile transcription factor that plays a crucial role in various developmental and homeostatic processes, including immune system development and function. Its dysregulation has been implicated in various diseases, highlighting the importance of SOX4 in maintaining immune system homeostasis. Further research is needed to fully understand the mechanisms of SOX4 regulation and its clinical significance in human disease.

Genular Protein ID: 3685295334

Symbol: SOX4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q06945

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 58 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8268656

Title: Characterization and mapping of the human SOX4 gene.

PubMed ID: 8268656

DOI: 10.1007/bf00361388

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1614875

Title: A conserved family of genes related to the testis determining gene, SRY.

PubMed ID: 1614875

DOI: 10.1093/nar/20.11.2887

PubMed ID: 16631117

Title: Ubc9 interacts with SOX4 and represses its transcriptional activity.

PubMed ID: 16631117

DOI: 10.1016/j.bbrc.2006.03.194

PubMed ID: 26291311

Title: KAT5-mediated SOX4 acetylation orchestrates chromatin remodeling during myoblast differentiation.

PubMed ID: 26291311

DOI: 10.1038/cddis.2015.190

PubMed ID: 34342803

Title: The 9aaTAD Activation Domains in the Yamanaka Transcription Factors Oct4, Sox2, Myc, and Klf4.

PubMed ID: 34342803

DOI: 10.1007/s12015-021-10225-8

PubMed ID: 30661772

Title: De Novo SOX4 Variants Cause a Neurodevelopmental Disease Associated with Mild Dysmorphism.

PubMed ID: 30661772

DOI: 10.1016/j.ajhg.2018.12.014

Sequence Information:

  • Length: 474
  • Mass: 47263
  • Checksum: CB75B76ABF507A07
  • Sequence:
    • MVQQTNNAEN TEALLAGESS DSGAGLELGI ASSPTPGSTA STGGKADDPS WCKTPSGHIK 
RPMNAFMVWS QIERRKIMEQ SPDMHNAEIS KRLGKRWKLL KDSDKIPFIR EAERLRLKHM 
ADYPDYKYRP RKKVKSGNAN SSSSAAASSK PGEKGDKVGG SGGGGHGGGG GGGSSNAGGG 
GGGASGGGAN SKPAQKKSCG SKVAGGAGGG VSKPHAKLIL AGGGGGGKAA AAAAASFAAE 
QAGAAALLPL GAAADHHSLY KARTPSASAS ASSAASASAA LAAPGKHLAE KKVKRVYLFG 
GLGTSSSPVG GVGAGADPSD PLGLYEEEGA GCSPDAPSLS GRSSAASSPA AGRSPADHRG 
YASLRAASPA PSSAPSHASS SASSHSSSSS SSGSSSSDDE FEDDLLDLNP SSNFESMSLG 
SFSSSSALDR DLDFNFEPGS GSHFEFPDYC TPEVSEMISG DWLESSISNL VFTY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.