SOX4 | ENSG00000124766 | NCBI 6659

Details for: SOX4

Gene ID: 6659

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: SOX4

Ensembl ID: ENSG00000124766

Description: SRY-box transcription factor 4

Cell Significance Landscape

Display Count:

Associated with

Deactivation of the beta-catenin transactivating complex
(R-HSA-3769402)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Ascending aorta morphogenesis
(GO:0035910)
Atrial septum primum morphogenesis
(GO:0003289)
Brain development
(GO:0007420)
Camera-type eye morphogenesis
(GO:0048593)
Cardiac right ventricle morphogenesis
(GO:0003215)
Cellular response to glucose stimulus
(GO:0071333)
Chromatin
(GO:0000785)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Endocrine pancreas development
(GO:0031018)
Gene expression
(GO:0010467)
Glial cell development
(GO:0021782)
Glial cell proliferation
(GO:0014009)
Glucose homeostasis
(GO:0042593)
Heart development
(GO:0007507)
Hematopoietic stem cell homeostasis
(GO:0061484)
Kidney morphogenesis
(GO:0060993)
Mesenchyme development
(GO:0060485)
Mirna binding
(GO:0035198)
Mitochondrion
(GO:0005739)
Mitral valve morphogenesis
(GO:0003183)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of myoblast differentiation
(GO:0045662)
Negative regulation of protein ubiquitination
(GO:0031397)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nervous system development
(GO:0007399)
Neuroepithelial cell differentiation
(GO:0060563)
Neuron differentiation
(GO:0030182)
Noradrenergic neuron differentiation
(GO:0003357)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gamma-delta t cell differentiation
(GO:0045588)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of myoblast differentiation
(GO:0045663)
Positive regulation of n-terminal peptidyl-lysine acetylation
(GO:2000761)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of translation
(GO:0045727)
Pro-b cell differentiation
(GO:0002328)
Protein binding
(GO:0005515)
Protein stabilization
(GO:0050821)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of dna damage response, signal transduction by p53 class mediator
(GO:0043516)
Regulation of protein stability
(GO:0031647)
Response to hypoxia
(GO:0001666)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific double-stranded dna binding
(GO:1990837)
Somatic stem cell population maintenance
(GO:0035019)
Spinal cord development
(GO:0021510)
Sympathetic nervous system development
(GO:0048485)
T cell differentiation
(GO:0030217)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription regulator complex
(GO:0005667)
Ventricular septum morphogenesis
(GO:0060412)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

hematopoietic stem cell CL0000037

CSI 86.01

rCSI 57.16%

PRS 6.52
epithelial cell of lower respiratory tract CL0002632

CSI 84.97

rCSI 65.87%

PRS 5.2
early lymphoid progenitor CL0000936

CSI 83.61

rCSI 73.43%

PRS 6.14
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 80.72

rCSI 93.22%

PRS 4.98
neuroblast (sensu Vertebrata) CL0000031

CSI 77.96

rCSI 100%

PRS 5.43
small pre-B-II cell CL0000954

CSI 68.94

rCSI 66.29%

PRS 11.89
neural crest cell CL0011012

CSI 65.39

rCSI 51.68%

PRS 3.79
peripheral nervous system neuron CL2000032

CSI 63.25

rCSI 86.18%

PRS 4.94
common lymphoid progenitor CL0000051

CSI 62.22

rCSI 83.14%

PRS 10.53
fraction A pre-pro B cell CL0002045

CSI 61.62

rCSI 70.54%

PRS 11.4
interneuron CL0000099

CSI 61.57

rCSI 100%

PRS 4.11
pro-B cell CL0000826

CSI 60.83

rCSI 50.38%

PRS 5.48
mesodermal cell CL0000222

CSI 54.63

rCSI 65.58%

PRS 5.48
double negative thymocyte CL0002489

CSI 52.65

rCSI 36.6%

PRS 6.42
megakaryocyte-erythroid progenitor cell CL0000050

CSI 52.18

rCSI 47.13%

PRS 4.83
common myeloid progenitor CL0000049

CSI 50.97

rCSI 41.21%

PRS 5.37
ciliated epithelial cell CL0000067

CSI 50.87

rCSI 44.73%

PRS 3.96
common dendritic progenitor CL0001029

CSI 50.16

rCSI 62.96%

PRS 6.97
plasmacytoid dendritic cell, human CL0001058

CSI 49.65

rCSI 34.67%

PRS 5.77
stem cell CL0000034

CSI 48.86

rCSI 47.12%

PRS 3.13
radial glial cell CL0000681

CSI 47.94

rCSI 66.61%

PRS 5.77
enteric smooth muscle cell CL0002504

CSI 44.14

rCSI 62.99%

PRS 6.25
multi-ciliated epithelial cell CL0005012

CSI 41.96

rCSI 41.87%

PRS 4.69
fallopian tube secretory epithelial cell CL4030006

CSI 41.71

rCSI 40.15%

PRS 5.68
precursor B cell CL0000817

CSI 40.69

rCSI 35.65%

PRS 7.4
double-positive, alpha-beta thymocyte CL0000809

CSI 39.64

rCSI 40.4%

PRS 7.92
epithelial cell of lung CL0000082

CSI 39.44

rCSI 32.69%

PRS 5.18
extravillous trophoblast CL0008036

CSI 38.7

rCSI 47.87%

PRS 4.8
enteroendocrine cell CL0000164

CSI 36.13

rCSI 49.36%

PRS 6.07
pulmonary ionocyte CL0017000

CSI 36.02

rCSI 43.84%

PRS 6.95
respiratory suprabasal cell CL4033048

CSI 34.65

rCSI 44.44%

PRS 6.34
lung ciliated cell CL1000271

CSI 34.61

rCSI 40.02%

PRS 3.99
pancreatic ductal cell CL0002079

CSI 34.07

rCSI 66.26%

PRS 5.6
late pro-B cell CL0002048

CSI 32.62

rCSI 81.73%

PRS 18.08
club cell CL0000158

CSI 32.35

rCSI 47.38%

PRS 6.47
glioblast CL0000030

CSI 31.79

rCSI 50.72%

PRS 4.79
nasal mucosa goblet cell CL0002480

CSI 29.98

rCSI 34.77%

PRS 8.18
bronchus fibroblast of lung CL2000093

CSI 28.2

rCSI 22.91%

PRS 5.82
ionocyte CL0005006

CSI 28

rCSI 30.01%

PRS 5.06
cerebral cortex GABAergic interneuron CL0010011

CSI 27.75

rCSI 81.92%

PRS 6.98
intrahepatic cholangiocyte CL0002538

CSI 27.29

rCSI 65.48%

PRS 10.41
duct epithelial cell CL0000068

CSI 26.6

rCSI 38.92%

PRS 5.8
stromal cell of ovary CL0002132

CSI 26.54

rCSI 72.91%

PRS 9.18
melanocyte CL0000148

CSI 25.94

rCSI 19.21%

PRS 5.09
thymocyte CL0000893

CSI 25.55

rCSI 90.79%

PRS 17.82
transit amplifying cell of colon CL0009011

CSI 25.2

rCSI 29.6%

PRS 6.62
large pre-B-II cell CL0000957

CSI 24.77

rCSI 70.71%

PRS 9.76
hematopoietic precursor cell CL0008001

CSI 24.48

rCSI 25.19%

PRS 8.86
glutamatergic neuron CL0000679

CSI 24.33

rCSI 49.99%

PRS 6.1
cerebral cortex endothelial cell CL1001602

CSI 24.2

rCSI 41.86%

PRS 4.2
luminal epithelial cell of mammary gland CL0002326

CSI 23.92

rCSI 43.47%

PRS 8.41
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 23.46

rCSI 46.76%

PRS 9.38
acinar cell CL0000622

CSI 23.21

rCSI 34.04%

PRS 7.2
brush cell of tracheobronchial tree CL0002075

CSI 23.17

rCSI 68.75%

PRS 9.1
intestinal crypt stem cell of small intestine CL0009017

CSI 22.38

rCSI 60.33%

PRS 7.14
forebrain radial glial cell CL0013000

CSI 22.29

rCSI 71.53%

PRS 8.26
tracheal goblet cell CL1000329

CSI 22.16

rCSI 48.39%

PRS 11.22
keratinocyte CL0000312

CSI 21.67

rCSI 18.16%

PRS 6.58
intestine goblet cell CL0019031

CSI 20.71

rCSI 18.38%

PRS 5.49
respiratory basal cell CL0002633

CSI 20.27

rCSI 21%

PRS 6.44
epithelial cell CL0000066

CSI 19.9

rCSI 30.58%

PRS 7.94
myofibroblast cell CL0000186

CSI 19.79

rCSI 27.41%

PRS 7.91
basal-myoepithelial cell of mammary gland CL0002324

CSI 19.34

rCSI 36.57%

PRS 12.3
brush cell CL0002204

CSI 19.11

rCSI 37.83%

PRS 15.86
secretory cell CL0000151

CSI 19.11

rCSI 19.94%

PRS 5.61
granulocyte monocyte progenitor cell CL0000557

CSI 18.86

rCSI 16.33%

PRS 6.09
macroglial cell CL0000126

CSI 18.28

rCSI 47%

PRS 9.41
plasmacytoid dendritic cell CL0000784

CSI 18.1

rCSI 18.33%

PRS 34.33
paneth cell CL0000510

CSI 17.29

rCSI 25.53%

PRS 8.69
lung secretory cell CL1000272

CSI 17.28

rCSI 42.76%

PRS 5.08
pancreatic D cell CL0000173

CSI 17.23

rCSI 16.95%

PRS 5.99
inflammatory macrophage CL0000863

CSI 17.16

rCSI 29.31%

PRS 11.36
suprabasal keratinocyte CL4033013

CSI 17.15

rCSI 28%

PRS 4.02
goblet cell CL0000160

CSI 16.93

rCSI 16%

PRS 5.73
mesenchymal cell CL0008019

CSI 16.79

rCSI 42.65%

PRS 5.61
colon epithelial cell CL0011108

CSI 16.47

rCSI 17.26%

PRS 5.12
type EC enteroendocrine cell CL0000577

CSI 16.42

rCSI 58.31%

PRS 9.04
group 3 innate lymphoid cell CL0001071

CSI 16.39

rCSI 12.31%

PRS 5.64
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 16.26

rCSI 19.7%

PRS 8.12
immature B cell CL0000816

CSI 16.23

rCSI 12.06%

PRS 8.2
intestinal tuft cell CL0019032

CSI 16.22

rCSI 24.79%

PRS 6.34
interstitial cell of Cajal CL0002088

CSI 16.2

rCSI 20.63%

PRS 6.41
lung endothelial cell CL1001567

CSI 16.18

rCSI 37.72%

PRS 14.44
neuroendocrine cell CL0000165

CSI 15.98

rCSI 61.8%

PRS 11.96
midbrain dopaminergic neuron CL2000097

CSI 15.61

rCSI 100%

PRS 9.84
fibroblast of lung CL0002553

CSI 15.27

rCSI 14.21%

PRS 5.51
hematopoietic multipotent progenitor cell CL0000837

CSI 14.76

rCSI 35.51%

PRS 8.6
cerebral cortex pyramidal neuron CL4023111

CSI 14.41

rCSI 88.69%

PRS 19.75
bronchial goblet cell CL1000312

CSI 14.37

rCSI 57.43%

PRS 12.17
lung neuroendocrine cell CL1000223

CSI 14.03

rCSI 20.75%

PRS 6.31
progenitor cell CL0011026

CSI 13.92

rCSI 29.6%

PRS 10.45
tuft cell of colon CL0009041

CSI 13.44

rCSI 31.3%

PRS 13.04
myeloid lineage restricted progenitor cell CL0000839

CSI 13.39

rCSI 69.12%

PRS 11
intestinal epithelial cell CL0002563

CSI 13.37

rCSI 13.97%

PRS 5.8
Mueller cell CL0000636

CSI 13.23

rCSI 30.19%

PRS 5.1
pancreatic acinar cell CL0002064

CSI 13.16

rCSI 17.5%

PRS 6
skin fibroblast CL0002620

CSI 13.14

rCSI 11.32%

PRS 9.09
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 12.7

rCSI 28.94%

PRS 5.74
colon goblet cell CL0009039

CSI 12.67

rCSI 30.11%

PRS 8.34
basal cell CL0000646

CSI 12.51

rCSI 16.73%

PRS 6

intermediate monocyte CL0002393

CSI -19.2

rCSI -29.0%

PRS 5.4%
ependymal cell CL0000065

CSI -9.4

rCSI -19.0%

PRS 2.0%
mononuclear phagocyte CL0000113

CSI -4.8

rCSI -10.6%

PRS 6.0%
tracheobronchial smooth muscle cell CL0019019

CSI -4.3

rCSI -7.6%

PRS 7.3%
central nervous system neuron CL2000029

CSI -3.4

rCSI -24.7%

PRS 2.7%
retinal blood vessel endothelial cell CL0002585

CSI -2.9

rCSI -4.6%

PRS 6.0%
elicited macrophage CL0000861

CSI -1.7

rCSI -1.5%

PRS 6.3%
skeletal muscle satellite cell CL0000594

CSI -1.6

rCSI -4.6%

PRS 21.7%
CD14-positive, CD16-positive monocyte CL0002397

CSI -1.5

rCSI -1.9%

PRS 7.7%
Kupffer cell CL0000091

CSI -1.4

rCSI -3.2%

PRS 5.3%
tissue-resident macrophage CL0000864

CSI -1.2

rCSI -5.6%

PRS 14.6%
near-projecting glutamatergic cortical neuron CL4023012

CSI -1.1

rCSI -4.2%

PRS 3.5%
vasa recta descending limb cell CL1001285

CSI -0.8

rCSI -6.0%

PRS 24.9%
sst GABAergic cortical interneuron CL4023017

CSI -0.6

rCSI -0.8%

PRS 3.5%
alternatively activated macrophage CL0000890

CSI -0.6

rCSI -0.7%

PRS 8.4%
pvalb GABAergic cortical interneuron CL4023018

CSI -0.4

rCSI -0.6%

PRS 3.0%
podocyte CL0000653

CSI -0.4

rCSI -1.5%

PRS 5.5%
renal interstitial pericyte CL1001318

CSI -0.3

rCSI -0.8%

PRS 6.1%
GABAergic amacrine cell CL4030027

CSI 0.0

rCSI 0.1%

PRS 6.3%
primitive red blood cell CL0002355

CSI 0.1

rCSI 0.6%

PRS 10.8%
renal beta-intercalated cell CL0002201

CSI 0.1

rCSI 0.3%

PRS 7.1%
L6b glutamatergic cortical neuron CL4023038

CSI 0.2

rCSI 0.5%

PRS 3.5%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.2

rCSI 0.3%

PRS 3.3%
lung macrophage CL1001603

CSI 0.2

rCSI 0.5%

PRS 6.2%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 0.3

rCSI 1.6%

PRS 3.5%
serous secreting cell of bronchus submucosal gland CL4033005

CSI 0.4

rCSI 2.0%

PRS 28.4%
endothelial cell of placenta CL0009092

CSI 0.4

rCSI 1.8%

PRS 7.4%
myelocyte CL0002193

CSI 0.4

rCSI 2.6%

PRS 19.0%
collagen secreting cell CL0000667

CSI 0.4

rCSI 2.3%

PRS 27.7%
diffuse bipolar 3b cell CL4033030

CSI 0.5

rCSI 3.0%

PRS 8.1%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.5

rCSI 1.9%

PRS 3.0%
cardiac neuron CL0010022

CSI 0.5

rCSI 1.7%

PRS 4.0%
flat midget bipolar cell CL4033033

CSI 0.6

rCSI 4.0%

PRS 7.2%
diffuse bipolar 2 cell CL4033028

CSI 0.6

rCSI 4.3%

PRS 7.9%
H2 horizontal cell CL0004218

CSI 0.6

rCSI 2.8%

PRS 7.8%
B-2 B cell CL0000822

CSI 0.6

rCSI 12.2%

PRS 33.9%
melanocyte of skin CL1000458

CSI 0.6

rCSI 0.8%

PRS 3.6%
lamp5 GABAergic cortical interneuron CL4023011

CSI 0.6

rCSI 1.0%

PRS 3.3%
corneal epithelial cell CL0000575

CSI 0.6

rCSI 1.7%

PRS 10.6%
enterocyte of epithelium of small intestine CL1000334

CSI 0.7

rCSI 10.2%

PRS 14.3%
lung microvascular endothelial cell CL2000016

CSI 0.7

rCSI 13.0%

PRS 19.8%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 0.7

rCSI 7.2%

PRS 8.9%
pre-conventional dendritic cell CL0002010

CSI 0.7

rCSI 9.1%

PRS 19.2%
B-1 B cell CL0000819

CSI 0.7

rCSI 18.9%

PRS 31.5%
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 0.8

rCSI 8.8%

PRS 23.4%
myeloid dendritic cell, human CL0001057

CSI 0.8

rCSI 4.4%

PRS 17.8%
retinal bipolar neuron CL0000748

CSI 0.8

rCSI 1.5%

PRS 4.2%
osteoblast CL0000062

CSI 0.9

rCSI 21.2%

PRS 45.8%
bronchiolar smooth muscle cell CL4033017

CSI 0.9

rCSI 12.9%

PRS 18.4%
basophil CL0000767

CSI 0.9

rCSI 1.9%

PRS 12.0%
luminal cell of prostate epithelium CL0002340

CSI 0.9

rCSI 4.9%

PRS 10.1%
colon macrophage CL0009038

CSI 1.0

rCSI 4.8%

PRS 12.0%
epithelial cell of urethra CL1000296

CSI 1.0

rCSI 26.1%

PRS 19.4%
uterine smooth muscle cell CL0002601

CSI 1.1

rCSI 7.1%

PRS 39.6%
retinal pigment epithelial cell CL0002586

CSI 1.1

rCSI 2.2%

PRS 6.0%
blood vessel smooth muscle cell CL0019018

CSI 1.2

rCSI 9.5%

PRS 5.8%
pancreatic PP cell CL0002275

CSI 1.2

rCSI 4.7%

PRS 9.9%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 1.2

rCSI 3.8%

PRS 10.8%
cord blood hematopoietic stem cell CL2000095

CSI 1.2

rCSI 23.4%

PRS 43.0%
diffuse bipolar 6 cell CL4033032

CSI 1.2

rCSI 6.4%

PRS 9.6%
parietal epithelial cell CL1000452

CSI 1.3

rCSI 3.4%

PRS 5.5%
helper T cell CL0000912

CSI 1.3

rCSI 1.8%

PRS 8.1%
alveolar macrophage CL0000583

CSI 1.3

rCSI 2.1%

PRS 6.4%
acinar cell of salivary gland CL0002623

CSI 1.4

rCSI 32.5%

PRS 8.4%
colonocyte CL1000347

CSI 1.4

rCSI 2.0%

PRS 7.6%
enteroendocrine cell of colon CL0009042

CSI 1.4

rCSI 6.7%

PRS 15.3%
mature B cell CL0000785

CSI 1.5

rCSI 1.3%

PRS 6.8%
syncytiotrophoblast cell CL0000525

CSI 1.5

rCSI 4.2%

PRS 11.2%
pancreatic epsilon cell CL0005019

CSI 1.5

rCSI 7.1%

PRS 13.8%
paneth cell of colon CL0009009

CSI 1.5

rCSI 15.2%

PRS 16.8%
smooth muscle cell of the pulmonary artery CL0002591

CSI 1.6

rCSI 12.3%

PRS 29.9%
endothelial cell of vascular tree CL0002139

CSI 1.7

rCSI 9.1%

PRS 13.0%
follicular dendritic cell CL0000442

CSI 1.7

rCSI 27.3%

PRS 34.7%
peptic cell CL0000155

CSI 1.7

rCSI 16.8%

PRS 17.4%
IgG plasma cell CL0000985

CSI 1.7

rCSI 2.1%

PRS 9.5%
vasa recta ascending limb cell CL1001131

CSI 1.7

rCSI 7.9%

PRS 24.6%
hair follicular keratinocyte CL2000092

CSI 1.8

rCSI 31.2%

PRS 23.2%
Merkel cell CL0000242

CSI 1.8

rCSI 42.0%

PRS 39.4%
type B pancreatic cell CL0000169

CSI 1.8

rCSI 4.0%

PRS 5.2%
smooth muscle cell of prostate CL1000487

CSI 1.8

rCSI 10.8%

PRS 29.4%
placental villous trophoblast CL2000060

CSI 1.8

rCSI 2.9%

PRS 5.2%
cone retinal bipolar cell CL0000752

CSI 2.0

rCSI 26.1%

PRS 30.5%
IgA plasma cell CL0000987

CSI 2.1

rCSI 2.2%

PRS 10.4%
conjunctival epithelial cell CL1000432

CSI 2.1

rCSI 3.3%

PRS 5.5%
megakaryocyte CL0000556

CSI 2.2

rCSI 9.4%

PRS 10.2%
skeletal muscle satellite stem cell CL0008011

CSI 2.2

rCSI 9.6%

PRS 20.6%
fibroblast of breast CL4006000

CSI 2.2

rCSI 9.1%

PRS 15.1%
renal principal cell CL0005009

CSI 2.3

rCSI 5.8%

PRS 8.0%
myeloid dendritic cell CL0000782

CSI 2.4

rCSI 3.5%

PRS 8.1%
airway submucosal gland duct basal cell CL4033024

CSI 2.4

rCSI 15.3%

PRS 24.1%
renal alpha-intercalated cell CL0005011

CSI 2.4

rCSI 3.2%

PRS 7.5%
VIP GABAergic cortical interneuron CL4023016

CSI 2.5

rCSI 2.9%

PRS 3.3%
mesenchymal stem cell CL0000134

CSI 2.5

rCSI 26.9%

PRS 10.1%
Bergmann glial cell CL0000644

CSI 2.5

rCSI 3.4%

PRS 6.0%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 2.6

rCSI 15.5%

PRS 12.8%
pluripotent stem cell CL0002248

CSI 2.6

rCSI 78.3%

PRS 13.3%
retinal cone cell CL0000573

CSI 2.7

rCSI 4.4%

PRS 4.3%
prostate gland microvascular endothelial cell CL2000059

CSI 2.7

rCSI 65.1%

PRS 20.7%
GABAergic neuron CL0000617

CSI 2.7

rCSI 9.1%

PRS 4.6%
amacrine cell CL0000561

CSI 2.7

rCSI 7.9%

PRS 4.7%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [SOX4](/details-gene/6659) (SRY-Box Transcription Factor 4) is a protein-coding gene located on chromosome 6p22.3 that encodes a critical developmental transcription factor. As a member of the SRY-related HMG-box (SOX) family, [SOX4](/details-gene/6659) plays a pivotal role in regulating gene expression during the development of numerous tissues, including the nervous system, heart, pancreas, and hematopoietic system. Its function is essential for lineage commitment and cell fate decisions in progenitor populations. Expression data highlights its significance in undifferentiated or early-stage cells, such as [hematopoietic stem cells](/details-cell/CL0000037), [neuroblasts](/details-cell/CL0000031), and lymphoid progenitors. Clinically, de novo variants in [SOX4](/details-gene/6659) are associated with a neurodevelopmental disorder ([184430](https://omim.org/entry/184430)), underscoring its importance in human development ([Link](https://doi.org/10.1016/j.ajhg.2018.12.014)). ## Cellular Roles and Expression Landscape The expression profile of [SOX4](/details-gene/6659) strongly indicates its function as a key regulator of stem and progenitor cell biology across multiple lineages. **Overall**, the gene shows the highest significance in primitive and developing cell populations. It is a top marker for [hematopoietic stem cells](/details-cell/CL0000037) (CSI: 86.01), as well as early lymphoid progenitors including [early lymphoid progenitor](/details-cell/CL0000936) (CSI: 83.61) and [common lymphoid progenitor](/details-cell/CL0000051) (CSI: 62.22). Its crucial role in B-lymphocyte development is further underscored by high significance in [pro-B cells](/details-cell/CL0000826) (CSI: 60.83) and [small pre-B-II cells](/details-cell/CL0000954) (CSI: 68.94). Beyond hematopoiesis, [SOX4](/details-gene/6659) is a defining feature of the developing nervous system, with high CSI scores in [neuroblasts](/details-cell/CL0000338) (CSI: 80.72) and [neural crest cells](/details-cell/CL0011012) (CSI: 65.39). It also appears significant in [mesodermal cells](/details-cell/CL0000222) (CSI: 54.63) and [epithelial cells of the lower respiratory tract](/details-cell/CL0002632) (CSI: 84.97), suggesting a broad role in the establishment and maintenance of diverse tissues. Conversely, [SOX4](/details-gene/6659) expression is markedly low or absent in many terminally differentiated cell types. This is particularly evident in mature myeloid cells, including [intermediate monocytes](/details-cell/CL0002393) (CSI: -19.22), [mononuclear phagocytes](/details-cell/CL0000113) (CSI: -4.82), and various [macrophage](/details-cell/CL0000235) populations such as [Kupffer cells](/details-cell/CL0000091). This pattern suggests that downregulation of [SOX4](/details-gene/6659) may be a prerequisite for the terminal differentiation and functional specialization of these lineages. ## Pathways and Molecular Function As a transcription factor, [SOX4](/details-gene/6659) functions primarily within the nucleus to control gene expression programs. Its molecular function is defined by its ability to bind specific DNA sequences in cis-regulatory regions ([GO:0000978](https://www.ebi.ac.uk/QuickGO/term/GO:0000978)), acting as a transcriptional activator ([GO:0001228](https://www.ebi.ac.uk/QuickGO/term/GO:0001228)). The broad developmental roles suggested by its cellular expression landscape are substantiated by its involvement in numerous biological processes. Its high expression in hematopoietic progenitors is consistent with its annotated functions in '[Hematopoietic stem cell homeostasis](/details-ontology/GO:0061484)', '[Pro-b cell differentiation](/details-ontology/GO:0002328)', and '[T cell differentiation](/details-ontology/GO:0030217)'. Similarly, its significance in neuroblasts aligns with its roles in '[Brain development](/details-ontology/GO:0007420)', '[Nervous system development](/details-ontology/GO:0007399)', and '[Neuron differentiation](/details-ontology/GO:0030182)'. [SOX4](/details-gene/6659) is a well-established component of major developmental signaling pathways. It participates in '[Signaling by wnt](/details-pathway/R-HSA-195721)', specifically in '[Tcf dependent signaling in response to wnt](/details-pathway/R-HSA-201681)', which is fundamental to embryogenesis and tissue homeostasis. The gene also shows context-dependent regulatory roles, capable of both promoting ([GO:0008284](https://www.ebi.ac.uk/QuickGO/term/GO:0008284)) and inhibiting ([GO:0008285](https://www.ebi.ac.uk/QuickGO/term/GO:0008285)) cell proliferation, highlighting its complex and context-specific functions. ## Research Directions The expression pattern and functional annotations of [SOX4](/details-gene/6659) point to its role as a master regulator of cell fate in progenitor populations. Future research should focus on elucidating the precise mechanisms by which it controls lineage decisions and its potential contribution to disease when dysregulated. **Testable Hypotheses:** 1. Given its high and specific expression in a narrow window of B-cell development (from [CLP](/details-cell/CL0000051) to [pro-B cell](/details-cell/CL0000826)) and its subsequent downregulation, [SOX4](/details-gene/6659) likely functions as a critical switch that initiates the B-lymphoid transcriptional program while simultaneously suppressing alternative lineage fates (e.g., myeloid). 2. The strong expression of [SOX4](/details-gene/6659) in both hematopoietic and neural progenitors, coupled with its known role in neurodevelopmental disorders, suggests it governs a core "stemness" program. It may regulate shared downstream targets involved in maintaining pluripotency and cell cycle progression that are essential for the expansion of progenitor pools in both systems. **Proposed Experimental Approach:** To test the first hypothesis regarding its role in B-cell lineage commitment, an effective approach would be to use an *in vitro* differentiation model. * **Experiment:** Utilize CRISPR-Cas9 to knock out [SOX4](/details-gene/6659) in primary human CD34+ hematopoietic stem and progenitor cells (HSPCs). These modified HSPCs, alongside wild-type controls, would be cultured in media supplemented with cytokines (e.g., Flt3L, IL-7, SCF) that promote B-lymphoid differentiation. * **Analysis:** The differentiation process would be monitored over time using multi-parameter flow cytometry to quantify the proportions of cells at different developmental stages (e.g., CLP, pre-pro-B, pro-B). A block or delay at the CLP or pre-pro-B stage in the knockout cells would confirm its necessity. Parallel single-cell RNA sequencing (scRNA-seq) at key time points would identify the downstream transcriptional networks controlled by [SOX4](/details-gene/6659) and reveal whether knockout cells aberrantly express genes associated with other lineages. **Therapeutic Potential:** As an intracellular transcription factor, [SOX4](/details-gene/6659) presents a challenging direct target for conventional small molecules or antibody-based therapies. However, its established role in promoting proliferation and its frequent overexpression in various cancers, particularly acute lymphoblastic leukemia (ALL) and solid tumors, mark it as a high-value oncogenic target. The therapeutic strategy would focus on **inhibition**. Because it is highly expressed in progenitor cells but low in many terminally differentiated tissues, a therapeutic window may exist. Future efforts could focus on developing strategies to disrupt its protein-protein interactions (e.g., with beta-catenin in the Wnt pathway) or on identifying and targeting critical downstream effectors that mediate its pro-tumorigenic functions.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

SOX4_HUMAN

Genular Protein ID: 3685295334

Symbol: SOX4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q06945

Database IDs:

Citations:

PubMed ID: 8268656

Title: Characterization and mapping of the human SOX4 gene.

PubMed ID: 8268656

DOI: 10.1007/bf00361388

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1614875

Title: A conserved family of genes related to the testis determining gene, SRY.

PubMed ID: 1614875

DOI: 10.1093/nar/20.11.2887

PubMed ID: 16631117

Title: Ubc9 interacts with SOX4 and represses its transcriptional activity.

PubMed ID: 16631117

DOI: 10.1016/j.bbrc.2006.03.194

PubMed ID: 26291311

Title: KAT5-mediated SOX4 acetylation orchestrates chromatin remodeling during myoblast differentiation.

PubMed ID: 26291311

DOI: 10.1038/cddis.2015.190

PubMed ID: 34342803

Title: The 9aaTAD Activation Domains in the Yamanaka Transcription Factors Oct4, Sox2, Myc, and Klf4.

PubMed ID: 34342803

DOI: 10.1007/s12015-021-10225-8

PubMed ID: 30661772

Title: De Novo SOX4 Variants Cause a Neurodevelopmental Disease Associated with Mild Dysmorphism.

PubMed ID: 30661772

DOI: 10.1016/j.ajhg.2018.12.014

Sequence Information:

Length: 474
Mass: 47263
Checksum: CB75B76ABF507A07
Sequence:

MVQQTNNAEN TEALLAGESS DSGAGLELGI ASSPTPGSTA STGGKADDPS WCKTPSGHIK 
RPMNAFMVWS QIERRKIMEQ SPDMHNAEIS KRLGKRWKLL KDSDKIPFIR EAERLRLKHM 
ADYPDYKYRP RKKVKSGNAN SSSSAAASSK PGEKGDKVGG SGGGGHGGGG GGGSSNAGGG 
GGGASGGGAN SKPAQKKSCG SKVAGGAGGG VSKPHAKLIL AGGGGGGKAA AAAAASFAAE 
QAGAAALLPL GAAADHHSLY KARTPSASAS ASSAASASAA LAAPGKHLAE KKVKRVYLFG 
GLGTSSSPVG GVGAGADPSD PLGLYEEEGA GCSPDAPSLS GRSSAASSPA AGRSPADHRG 
YASLRAASPA PSSAPSHASS SASSHSSSSS SSGSSSSDDE FEDDLLDLNP SSNFESMSLG 
SFSSSSALDR DLDFNFEPGS GSHFEFPDYC TPEVSEMISG DWLESSISNL VFTY

Details for: SOX4

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Characterization and mapping of the human SOX4 gene. PubMed ID: 8268656

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A conserved family of genes related to the testis determining gene, SRY. PubMed ID: 1614875

Ubc9 interacts with SOX4 and represses its transcriptional activity. PubMed ID: 16631117

KAT5-mediated SOX4 acetylation orchestrates chromatin remodeling during myoblast differentiation. PubMed ID: 26291311

The 9aaTAD Activation Domains in the Yamanaka Transcription Factors Oct4, Sox2, Myc, and Klf4. PubMed ID: 34342803

De Novo SOX4 Variants Cause a Neurodevelopmental Disease Associated with Mild Dysmorphism. PubMed ID: 30661772