Details for: SPATS1

Gene ID: 221409

Symbol: SPATS1

Ensembl ID: ENSG00000249481

Description: spermatogenesis associated serine rich 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 2.7861
    Cell Significance Index: -2.6600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1737
    Cell Significance Index: 28.4300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3784
    Cell Significance Index: 5.5200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2858
    Cell Significance Index: 3.7500
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.1979
    Cell Significance Index: 2.0200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1034
    Cell Significance Index: 1.0700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0812
    Cell Significance Index: 1.3200
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.0626
    Cell Significance Index: 0.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0302
    Cell Significance Index: 6.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0203
    Cell Significance Index: 0.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0200
    Cell Significance Index: 2.9000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0175
    Cell Significance Index: 0.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0106
    Cell Significance Index: 3.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0069
    Cell Significance Index: 4.7700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0055
    Cell Significance Index: 0.2800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0015
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0013
    Cell Significance Index: 2.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0004
    Cell Significance Index: -0.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0006
    Cell Significance Index: -1.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0006
    Cell Significance Index: -0.8100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0019
    Cell Significance Index: -0.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0020
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0034
    Cell Significance Index: -2.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0039
    Cell Significance Index: -2.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0044
    Cell Significance Index: -2.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0047
    Cell Significance Index: -0.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0048
    Cell Significance Index: -2.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0060
    Cell Significance Index: -1.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0062
    Cell Significance Index: -0.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0064
    Cell Significance Index: -1.1600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0064
    Cell Significance Index: -0.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0100
    Cell Significance Index: -0.5600
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0100
    Cell Significance Index: -0.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0115
    Cell Significance Index: -0.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0122
    Cell Significance Index: -1.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0167
    Cell Significance Index: -1.7400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0169
    Cell Significance Index: -0.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0174
    Cell Significance Index: -2.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0177
    Cell Significance Index: -0.6700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0213
    Cell Significance Index: -0.4600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0228
    Cell Significance Index: -0.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0235
    Cell Significance Index: -0.7500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0249
    Cell Significance Index: -0.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0275
    Cell Significance Index: -0.9000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0277
    Cell Significance Index: -0.9700
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0290
    Cell Significance Index: -0.3600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0296
    Cell Significance Index: -0.4000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0301
    Cell Significance Index: -0.3800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0304
    Cell Significance Index: -0.7300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0321
    Cell Significance Index: -0.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0332
    Cell Significance Index: -0.8900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0358
    Cell Significance Index: -0.3900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0393
    Cell Significance Index: -0.9800
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0400
    Cell Significance Index: -0.4300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0414
    Cell Significance Index: -1.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0418
    Cell Significance Index: -1.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0470
    Cell Significance Index: -2.2100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0472
    Cell Significance Index: -0.9600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0498
    Cell Significance Index: -0.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0505
    Cell Significance Index: -2.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0510
    Cell Significance Index: -1.4700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0513
    Cell Significance Index: -1.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0544
    Cell Significance Index: -1.4800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0557
    Cell Significance Index: -0.6500
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0566
    Cell Significance Index: -0.5200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0574
    Cell Significance Index: -0.6100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0580
    Cell Significance Index: -0.5500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0583
    Cell Significance Index: -0.9800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0583
    Cell Significance Index: -1.2100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0596
    Cell Significance Index: -1.0300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0612
    Cell Significance Index: -1.5600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0649
    Cell Significance Index: -0.7900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0682
    Cell Significance Index: -0.9200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0687
    Cell Significance Index: -1.3700
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0695
    Cell Significance Index: -0.6000
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0696
    Cell Significance Index: -0.8200
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0712
    Cell Significance Index: -0.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0738
    Cell Significance Index: -1.9700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0739
    Cell Significance Index: -0.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0804
    Cell Significance Index: -2.1200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0822
    Cell Significance Index: -1.1800
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0854
    Cell Significance Index: -0.8600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0871
    Cell Significance Index: -1.0800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0889
    Cell Significance Index: -1.0600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0895
    Cell Significance Index: -0.7300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0895
    Cell Significance Index: -1.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0897
    Cell Significance Index: -2.5700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0906
    Cell Significance Index: -1.1300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0912
    Cell Significance Index: -1.9500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0912
    Cell Significance Index: -1.1700
  • Cell Name: deuterosomal cell (CL4033044)
    Fold Change: -0.0933
    Cell Significance Index: -0.7300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0959
    Cell Significance Index: -1.3800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0963
    Cell Significance Index: -1.4900
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0964
    Cell Significance Index: -1.2100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0998
    Cell Significance Index: -1.4200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1012
    Cell Significance Index: -1.5400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1033
    Cell Significance Index: -2.0200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1052
    Cell Significance Index: -1.4200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1052
    Cell Significance Index: -1.7600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1056
    Cell Significance Index: -1.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SPATS1 is a serine-rich protein, characterized by its unique amino acid sequence, which confers specific functional properties to the protein. The gene is predominantly expressed in cells involved in spermatogenesis, suggesting a crucial role in the development and maturation of spermatozoa. Moreover, SPATS1 is also expressed in various other cell types, including endothelial cells, pericytes, and lymphoid lineage-restricted progenitor cells, indicating a broader functional scope. The gene's expression profile and cellular localization suggest a complex interplay between SPATS1 and other regulatory proteins, influencing cellular behavior and fate. **Pathways and Functions:** The functional significance of SPATS1 is multifaceted, with potential involvement in various cellular processes, including: 1. **Spermatogenesis**: SPATS1 is essential for the development and maturation of spermatozoa, suggesting a role in the regulation of spermatogenesis-related gene expression. 2. **Cell signaling**: SPATS1 may interact with other signaling molecules, influencing cell proliferation, differentiation, and survival. 3. **Adhesion and migration**: The serine-rich motif in SPATS1 may facilitate cell-cell adhesion and migration, particularly in endothelial cells and pericytes. 4. **Immune regulation**: SPATS1's expression in lymphoid lineage-restricted progenitor cells suggests a potential role in immune system development and function. **Clinical Significance:** The clinical significance of SPATS1 is an area of active research, with potential implications for various diseases and disorders. Some potential applications of SPATS1 include: 1. **Spermatogenesis-related disorders**: Mutations or dysregulation of SPATS1 may contribute to infertility, testicular cancer, or other spermatogenesis-related disorders. 2. **Endothelial dysfunction**: Altered expression of SPATS1 may contribute to endothelial dysfunction, a hallmark of various cardiovascular diseases. 3. **Immune system disorders**: Dysregulation of SPATS1 may contribute to immune system dysregulation, leading to autoimmune or inflammatory disorders. 4. **Cancer**: SPATS1's role in cell signaling and adhesion may contribute to cancer progression and metastasis. In conclusion, SPATS1 is a serine-rich protein with a complex and multifaceted role in cellular homeostasis, spermatogenesis, and immune system development. Further research is necessary to fully elucidate the functional significance of SPATS1 and its potential applications in disease prevention and treatment.

Genular Protein ID: 2635249139

Symbol: SPAS1_HUMAN

Name: Spermatogenesis-associated serine-rich protein 1

UniProtKB Accession Codes:

Q496A3 Q496A2 Q496A5 Q96LJ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 300
  • Mass: 33705
  • Checksum: 20A052131D2E4D98
  • Sequence:
    • MSPSMLTGNS PRGCRLPSIS STTCGRQLEK VPEKRDSGMT EVERTYSANC SDFLESKGCF 
ANTTPSGKSV SSSSSVETGP SVSEPPGLPR VSAYVDTTAD LDRKLSFSHS DHSSEMSLPE 
VQKDKYPEEF SLLKLQTKDG HRPEWTFYPR FSSNIHTYHV GKQCFFNGVF LGNKRSLSER 
TVDKCFGRKK YDIDPRNGIP KLTPGDNPYM YPEQSKGFHK AGSMLPPVNF SIVPYEKKFD 
TFIPLEPLPQ IPNLPFWVKE KANSLKNEIQ EVEELDNWQP AVPLMHMLHL SGALDFPRQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.