Details for: DLX4

Gene ID: 1748

Symbol: DLX4

Ensembl ID: ENSG00000108813

Description: distal-less homeobox 4

Associated with

  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Embryo development
    (GO:0009790)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2000
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.99
    Marker Score: 2004
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1174
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.17
    Marker Score: 2209
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4823
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71836
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48060
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.99
    Marker Score: 668
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.97
    Marker Score: 403
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.96
    Marker Score: 1947.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5346
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.91
    Marker Score: 417.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.85
    Marker Score: 13246
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 613
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.65
    Marker Score: 389
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 480
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 379.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.59
    Marker Score: 344
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.51
    Marker Score: 241
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.44
    Marker Score: 124
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.42
    Marker Score: 742
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4
    Marker Score: 1568
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.38
    Marker Score: 121.5
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.38
    Marker Score: 205.5
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.36
    Marker Score: 207
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.35
    Marker Score: 156
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.34
    Marker Score: 190
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.33
    Marker Score: 174
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 314
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.31
    Marker Score: 444
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.29
    Marker Score: 120
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.23
    Marker Score: 151
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.22
    Marker Score: 346
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.22
    Marker Score: 310
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.2
    Marker Score: 410
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.16
    Marker Score: 197
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.15
    Marker Score: 41
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.14
    Marker Score: 82
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.14
    Marker Score: 109
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.14
    Marker Score: 480
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.13
    Marker Score: 38
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.12
    Marker Score: 40
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.12
    Marker Score: 1631
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.1
    Marker Score: 113.5
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.09
    Marker Score: 172
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.09
    Marker Score: 112
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.08
    Marker Score: 67
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.08
    Marker Score: 199
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.08
    Marker Score: 84
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.08
    Marker Score: 75
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.08
    Marker Score: 15
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.07
    Marker Score: 44
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.07
    Marker Score: 367
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.07
    Marker Score: 78
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.07
    Marker Score: 452
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.07
    Marker Score: 60
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.06
    Marker Score: 60
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.06
    Marker Score: 507
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.06
    Marker Score: 382
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.06
    Marker Score: 162
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 51
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.06
    Marker Score: 130
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.06
    Marker Score: 1413
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.05
    Marker Score: 60
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.05
    Marker Score: 23
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.05
    Marker Score: 14

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Other Information

**Key characteristics:** * DLX4 is a member of the DLX homeobox gene family. * It is expressed in high levels in the developing embryo and during tissue differentiation. * It is involved in the regulation of cell differentiation, epithelial-mesenchymal transition, and apoptosis. * It is a key regulator of intestinal epithelial cell proliferation, differentiation, and survival. **Pathways and functions:** * DLX4 is a key regulator of epithelial cell differentiation in the developing embryo. * It is required for the specification of enterocyte, blood vessel endothelial, and colonic epithelial cells. * It is also involved in the regulation of intestinal stem cell proliferation and differentiation. * DLX4 is a negative regulator of transcription by RNA polymerase II. * It binds to a specific DNA sequence in the Rna polymerase II-specific DNA binding region of the DLX4 gene. * This binding inhibits the transcriptional activity of DLX4. * DLX4 is also a target of Rna polymerase II-mediated negative regulation. * This negative regulation helps to maintain the expression of other genes involved in epithelial cell differentiation. **Clinical significance:** * Mutations in the DLX4 gene have been linked to several human diseases, including colorectal cancer, liver cancer, and heart failure. * DLX4 is a potential therapeutic target for these diseases. * Inhibitors of DLX4 have been shown to inhibit epithelial cell proliferation and tumor growth. **Additional notes:** * DLX4 is a highly conserved gene with a similar sequence in other mammals. * It is expressed in high levels in the developing human gut, suggesting that it plays an important role in maintaining intestinal homeostasis. * DLX4 is a promising target for the treatment of cancer and other diseases that are characterized by abnormal epithelial cell growth.

Genular Protein ID: 3538069558

Symbol: DLX4_HUMAN

Name: Homeobox protein DLX-4

UniProtKB Accession Codes:

Q92988 D3DTX2 D3DTX3 O60480 Q13265 Q6PJK0 Q9HBE0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 3 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8975708

Title: Genomic analysis of a new mammalian distal-less gene: Dlx7.

PubMed ID: 8975708

DOI: 10.1006/geno.1996.0634

PubMed ID: 9467018

Title: Identification of a mutation in DLX3 associated with tricho-dento-osseous (TDO) syndrome.

PubMed ID: 9467018

DOI: 10.1093/hmg/7.3.563

PubMed ID: 11069021

Title: BP1, a new homeobox gene, is frequently expressed in acute leukemias.

PubMed ID: 11069021

DOI: 10.1038/sj.leu.2401912

PubMed ID: 11909945

Title: BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene.

PubMed ID: 11909945

DOI: 10.1128/mcb.22.8.2505-2514.2002

PubMed ID: 11792834

Title: Genomic structure and functional control of the Dlx3-7 bigene cluster.

PubMed ID: 11792834

DOI: 10.1073/pnas.012584999

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9073066

Title: Isolation and identification of homeobox genes from the human placenta including a novel member of the Distal-less family, DLX4.

PubMed ID: 9073066

DOI: 10.1016/s0378-1119(96)00706-8

PubMed ID: 25954033

Title: DLX4 is associated with orofacial clefting and abnormal jaw development.

PubMed ID: 25954033

DOI: 10.1093/hmg/ddv167

Sequence Information:

  • Length: 240
  • Mass: 26263
  • Checksum: 18EE52CF20C126EB
  • Sequence:
    • MTSLPCPLPG RDASKAVFPD LAPVPSVAAA YPLGLSPTTA ASPNLSYSRP YGHLLSYPYT 
EPANPGDSYL SCQQPAALSQ PLCGPAEHPQ ELEADSEKPR LSPEPSERRP QAPAKKLRKP 
RTIYSSLQLQ HLNQRFQHTQ YLALPERAQL AAQLGLTQTQ VKIWFQNKRS KYKKLLKQNS 
GGQEGDFPGR TFSVSPCSPP LPSLWDLPKA GTLPTSGYGN SFGAWYQHHS SDVLASPQMM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.