Details for: TCP11

Gene ID: 6954

Symbol: TCP11

Ensembl ID: ENSG00000124678

Description: t-complex 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 13.5330
    Cell Significance Index: -2.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 7.8851
    Cell Significance Index: -2.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.6330
    Cell Significance Index: 84.3300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 2.1262
    Cell Significance Index: -2.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7967
    Cell Significance Index: 38.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.3236
    Cell Significance Index: 81.1500
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.9277
    Cell Significance Index: 7.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4861
    Cell Significance Index: 92.5100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4556
    Cell Significance Index: 6.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3175
    Cell Significance Index: 19.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3097
    Cell Significance Index: 4.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2351
    Cell Significance Index: 25.5700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.2260
    Cell Significance Index: 2.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2241
    Cell Significance Index: 22.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1856
    Cell Significance Index: 167.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1387
    Cell Significance Index: 22.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1138
    Cell Significance Index: 7.8700
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.0752
    Cell Significance Index: 0.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0570
    Cell Significance Index: 2.9600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0379
    Cell Significance Index: 0.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0249
    Cell Significance Index: 0.5300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0194
    Cell Significance Index: 0.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0169
    Cell Significance Index: 11.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0142
    Cell Significance Index: 0.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0117
    Cell Significance Index: 2.3400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0103
    Cell Significance Index: 0.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0060
    Cell Significance Index: 2.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0057
    Cell Significance Index: 0.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0023
    Cell Significance Index: 0.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0020
    Cell Significance Index: 0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0018
    Cell Significance Index: 3.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0007
    Cell Significance Index: 0.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0001
    Cell Significance Index: 0.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0001
    Cell Significance Index: -0.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0002
    Cell Significance Index: -0.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0005
    Cell Significance Index: -0.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0010
    Cell Significance Index: -0.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0013
    Cell Significance Index: -0.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0026
    Cell Significance Index: -0.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0028
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0029
    Cell Significance Index: -2.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0029
    Cell Significance Index: -1.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0032
    Cell Significance Index: -2.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0034
    Cell Significance Index: -0.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0036
    Cell Significance Index: -2.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0039
    Cell Significance Index: -1.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0047
    Cell Significance Index: -0.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0059
    Cell Significance Index: -1.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0059
    Cell Significance Index: -1.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0060
    Cell Significance Index: -0.7000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0062
    Cell Significance Index: -0.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0069
    Cell Significance Index: -1.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0071
    Cell Significance Index: -0.5000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0072
    Cell Significance Index: -0.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0082
    Cell Significance Index: -1.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0088
    Cell Significance Index: -0.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0095
    Cell Significance Index: -1.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0108
    Cell Significance Index: -2.2700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0113
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0127
    Cell Significance Index: -1.4600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0131
    Cell Significance Index: -0.1300
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0162
    Cell Significance Index: -0.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0166
    Cell Significance Index: -1.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0168
    Cell Significance Index: -2.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0184
    Cell Significance Index: -1.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0196
    Cell Significance Index: -1.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0203
    Cell Significance Index: -2.0700
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0212
    Cell Significance Index: -0.2400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0215
    Cell Significance Index: -0.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0220
    Cell Significance Index: -1.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0228
    Cell Significance Index: -0.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0233
    Cell Significance Index: -0.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0237
    Cell Significance Index: -1.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0239
    Cell Significance Index: -0.7100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0241
    Cell Significance Index: -0.3800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0249
    Cell Significance Index: -0.4000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0259
    Cell Significance Index: -0.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0272
    Cell Significance Index: -2.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0279
    Cell Significance Index: -0.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0282
    Cell Significance Index: -2.2300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0285
    Cell Significance Index: -0.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0287
    Cell Significance Index: -0.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0288
    Cell Significance Index: -1.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0299
    Cell Significance Index: -2.2300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0302
    Cell Significance Index: -0.5900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0317
    Cell Significance Index: -0.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0323
    Cell Significance Index: -1.4300
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0323
    Cell Significance Index: -0.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0329
    Cell Significance Index: -1.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0346
    Cell Significance Index: -1.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0349
    Cell Significance Index: -1.1100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0351
    Cell Significance Index: -1.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0360
    Cell Significance Index: -1.1800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0377
    Cell Significance Index: -0.9400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0382
    Cell Significance Index: -0.2000
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0383
    Cell Significance Index: -0.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0384
    Cell Significance Index: -2.0000
  • Cell Name: collagen secreting cell (CL0000667)
    Fold Change: -0.0395
    Cell Significance Index: -0.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TCP11 is a member of the t-complex family of proteins, which are characterized by their ability to interact with other proteins and regulate various cellular processes. The TCP11 protein is a transmembrane protein that localizes to the plasma membrane and is involved in the regulation of adenylate cyclase-activating g protein-coupled receptor signaling pathways. It has also been shown to interact with other proteins, including B7ZAT8, to regulate sperm capacitation and the regulation of sperm motility. TCP11 is significantly expressed in multiple cell types, including germ cells, endothelial cells, and intestinal epithelial cells. **Pathways and Functions:** TCP11 is involved in several critical cellular pathways, including: 1. **Spermatogenesis:** TCP11 plays a crucial role in the regulation of spermatogenesis, a complex process involving the development of sperm cells from germ cells. TCP11 is involved in the regulation of sperm capacitation, a process essential for fertilization to occur. 2. **Adenylate cyclase-activating g protein-coupled receptor signaling pathway:** TCP11 interacts with other proteins to regulate this signaling pathway, which is involved in various cellular processes, including cell proliferation and differentiation. 3. **Regulation of sperm capacitation:** TCP11 has been shown to interact with other proteins to regulate sperm capacitation, a process essential for fertilization to occur. 4. **Sperm flagellum and sperm midpiece:** TCP11 is involved in the regulation of sperm motility, which is essential for fertilization to occur. **Clinical Significance:** The dysregulation of TCP11 has been implicated in various diseases, including: 1. **Infertility:** TCP11 plays a crucial role in spermatogenesis, and its dysregulation can lead to infertility. 2. **Sperm motility disorders:** TCP11 is involved in the regulation of sperm motility, and its dysregulation can lead to sperm motility disorders. 3. **Cancer:** TCP11 has been shown to interact with other proteins to regulate cellular proliferation and differentiation, and its dysregulation can contribute to cancer development. In conclusion, TCP11 is a critical gene involved in various cellular processes, including spermatogenesis, sperm capacitation, and the regulation of adenylate cyclase-activating g protein-coupled receptor signaling pathways. Further research is necessary to fully understand the mechanisms by which TCP11 contributes to these processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3572763530

Symbol: TCP11_HUMAN

Name: T-complex protein 11 homolog

UniProtKB Accession Codes:

Q8WWU5 B2RCE9 B3KQ27 B7Z7B5 B7Z7G1 B7Z7H4 B7Z7S8 E7EP29 J3KNG1 Q8NF85 Q9NQZ9 Q9NR39

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 18 Ensembl 9 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 RNAct 1 RefSeq 7 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11756566

Title: Molecular characterization of the TCP11 gene which is the human homologue of the mouse gene encoding the receptor of fertilization promoting peptide.

PubMed ID: 11756566

DOI: 10.1093/molehr/8.1.24

PubMed ID: 12545228

Title: Cloning, expression and alternative splicing of a novel isoform of human TCP11b gene.

PubMed ID: 12545228

PubMed ID: 12905703

Title: Cloning, expression, and alternative splicing of the novel isoform of hTCP11 gene.

PubMed ID: 12905703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21597245

Title: Human t-complex protein 11 (TCP11), a testis-specific gene product, is a potential determinant of the sperm morphology.

PubMed ID: 21597245

DOI: 10.1620/tjem.224.111

Sequence Information:

  • Length: 503
  • Mass: 56141
  • Checksum: F567492970A3F68B
  • Sequence:
    • MPDVKESVPP KYPGDSEGRS CKPETSGPPQ EDKSGSEDPP PFLSVTGLTE TVNEVSKLSN 
KIGMNCDYYM EEKVLPPSSL EGKVKETVHN AFWDHLKEQL SATPPDFSCA LELLKEIKEI 
LLSLLLPRQN RLRIEIEEAL DMDLLKQEAE HGALKVLYLS KYVLNMMALL CAPVRDEAVQ 
KLENITDPVW LLRGIFQVLG RMKMDMVNYT IQSLQPHLQE HSIQYERAKF QELLNKQPSL 
LNHTTKWLTQ AAGDLTMSPP TCPDTSDSSS VAGPSPNEAA NNPEPLSPTM VLCQGFLNLL 
LWDLENEEFP ETLLMDRTRL QELKSQLHQL TVMASVLLVA SSFSGSVLFG SPQFVDKLKR 
ITKSLLEDFH SRPEEAILTV SEQVSQEIHQ SLKNMGLVAL SSDNTASLMG QLQNIAKKEN 
CVCSVIDQRI HLFLKCCLVL GVQRSLLDLP GGLTLIEAEL AELGQKFVNL THHNQQVFGP 
YYTEILKTLI SPAQALETKV ESV

Genular Protein ID: 1521343313

Symbol: B7ZAT8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZAT8

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 511
  • Mass: 56823
  • Checksum: 073D89349A2C68D9
  • Sequence:
    • MTRGGGGGDT ISKMPDVKES VPPKYPGDSE GRSCKPETSG PPQEDKSGSE DPPPCLTETV 
NEVSKLSNKI GMNCDYYMEE KVLPPSSLEG KVKETVHNAF WDHLKEQLSA TPPDFSCALE 
LLKEIKEILL SLLLPRQNRL RIEIEEALDM DLLKQEAEHG ALKVLYLSKY VLNMMALLCA 
PVRDEAVQKL ENITDPVWLL RGIFQVLGRM KMDMVNYTIQ SLQPHLQEHS IQYERAKFQE 
LLNKQPSLLN HTTKWLTQAA GDLTMSPPTC PDTSDSSSVA GPSPNEAANN PEPLSPTMVL 
CQGLLNLLLW DLENEEFPET LLMDRTRLQE LKSQLHQLTV MASVLLVASS FSGSVLFGSP 
QFVDKLKRIT KSLLEDFHSR PEEAILTVSE QVSQEIHQSL KNMGLVALSS DNTASLMGQL 
QNIAKKENCV CSVIDQRIHL FLKCCLVLGV QRSLLDLPGG LTLIEAELAE LGQKFVNLTH 
HNQQVFGPYY TEILKTLISP AQALETKVES V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.