Details for: DNAJB1

Gene ID: 3337

Symbol: DNAJB1

Ensembl ID: ENSG00000132002

Description: DnaJ heat shock protein family (Hsp40) member B1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 578.2884
    Cell Significance Index: -89.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 364.4093
    Cell Significance Index: -92.4300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 237.2692
    Cell Significance Index: -97.7400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 227.2514
    Cell Significance Index: -92.3200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 208.0921
    Cell Significance Index: -98.2500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 200.3557
    Cell Significance Index: -103.0600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 146.5600
    Cell Significance Index: -98.3500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 98.9010
    Cell Significance Index: -94.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 77.6995
    Cell Significance Index: -95.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 30.7370
    Cell Significance Index: -82.3400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 27.4593
    Cell Significance Index: -84.3400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 25.1015
    Cell Significance Index: 266.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 24.7767
    Cell Significance Index: -97.7700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 19.5846
    Cell Significance Index: 115.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 11.4702
    Cell Significance Index: 328.8000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 6.8047
    Cell Significance Index: 52.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.6520
    Cell Significance Index: 852.7500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 5.2789
    Cell Significance Index: 67.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.5648
    Cell Significance Index: 120.0300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.0074
    Cell Significance Index: 70.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.2043
    Cell Significance Index: 259.9600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.1561
    Cell Significance Index: 17.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.8511
    Cell Significance Index: 87.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.7773
    Cell Significance Index: 785.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7185
    Cell Significance Index: 211.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.5420
    Cell Significance Index: 109.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.4129
    Cell Significance Index: 73.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3991
    Cell Significance Index: 192.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3498
    Cell Significance Index: 36.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3333
    Cell Significance Index: 240.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1044
    Cell Significance Index: 997.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0610
    Cell Significance Index: 579.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9474
    Cell Significance Index: 27.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9410
    Cell Significance Index: 32.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8371
    Cell Significance Index: 43.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8260
    Cell Significance Index: 163.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7841
    Cell Significance Index: 101.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7354
    Cell Significance Index: 34.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6870
    Cell Significance Index: 14.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6587
    Cell Significance Index: 49.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3426
    Cell Significance Index: 37.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2774
    Cell Significance Index: 55.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2403
    Cell Significance Index: 39.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2014
    Cell Significance Index: 34.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1816
    Cell Significance Index: 17.9600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1631
    Cell Significance Index: 8.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0732
    Cell Significance Index: 26.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0531
    Cell Significance Index: 40.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0476
    Cell Significance Index: 4.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0115
    Cell Significance Index: 15.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0107
    Cell Significance Index: -0.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0154
    Cell Significance Index: -0.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0218
    Cell Significance Index: -0.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0422
    Cell Significance Index: -79.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0604
    Cell Significance Index: -111.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0644
    Cell Significance Index: -99.1000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0663
    Cell Significance Index: -45.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0768
    Cell Significance Index: -56.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0769
    Cell Significance Index: -14.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0819
    Cell Significance Index: -60.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1044
    Cell Significance Index: -65.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1283
    Cell Significance Index: -72.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1430
    Cell Significance Index: -90.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1633
    Cell Significance Index: -10.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1979
    Cell Significance Index: -13.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2162
    Cell Significance Index: -98.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2312
    Cell Significance Index: -6.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2341
    Cell Significance Index: -10.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2790
    Cell Significance Index: -80.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2948
    Cell Significance Index: -62.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3788
    Cell Significance Index: -44.1500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5258
    Cell Significance Index: -60.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5334
    Cell Significance Index: -61.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5926
    Cell Significance Index: -39.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6558
    Cell Significance Index: -95.3300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6892
    Cell Significance Index: -7.8300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.7764
    Cell Significance Index: -2.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8187
    Cell Significance Index: -11.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9512
    Cell Significance Index: -99.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.9626
    Cell Significance Index: -39.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0064
    Cell Significance Index: -63.4300
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: -1.0223
    Cell Significance Index: -3.8100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.0440
    Cell Significance Index: -12.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.0642
    Cell Significance Index: -53.7800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.1072
    Cell Significance Index: -18.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.1083
    Cell Significance Index: -85.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1174
    Cell Significance Index: -35.7900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.1657
    Cell Significance Index: -10.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1699
    Cell Significance Index: -92.6600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.2124
    Cell Significance Index: -13.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.4288
    Cell Significance Index: -87.8200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.5193
    Cell Significance Index: -35.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.6306
    Cell Significance Index: -99.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.6532
    Cell Significance Index: -92.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.6749
    Cell Significance Index: -49.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.8247
    Cell Significance Index: -48.8100
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -1.9143
    Cell Significance Index: -7.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.0518
    Cell Significance Index: -75.3200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -2.0618
    Cell Significance Index: -31.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.0639
    Cell Significance Index: -91.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Chaperone Function:** DNAJB1 acts as a molecular chaperone, helping to maintain protein homeostasis by facilitating the proper folding of proteins and preventing protein aggregation. 2. **Heat Shock Response:** DNAJB1 is involved in the heat shock response, regulating the activity of heat shock transcription factor 1 (HSF1) and modulating the expression of heat shock proteins. 3. **Immune Regulation:** DNAJB1 is expressed in immune cells, including T cells and dendritic cells, and plays a role in regulating immune responses, including the activation of T cells and the presentation of antigens. 4. **Cellular Stress Response:** DNAJB1 is involved in the response to cellular stress, including the response to unfolded proteins and the regulation of autophagy. **Pathways and Functions:** 1. **Hsp70-Hsp90 Chaperone Cycle:** DNAJB1 interacts with Hsp70 and Hsp90 to regulate protein folding and chaperone activity. 2. **HSF1 Activation:** DNAJB1 modulates the activity of HSF1, a key transcription factor involved in the heat shock response. 3. **Immune Signaling Pathways:** DNAJB1 interacts with various molecular partners, including CD28, CD40, and CD80, to regulate immune signaling pathways, including the activation of T cells. 4. **Autophagy Regulation:** DNAJB1 plays a role in regulating autophagy, a cellular process involved in the degradation of damaged or dysfunctional proteins. **Clinical Significance:** 1. **Thyroid Disease:** Mutations in DNAJB1 have been associated with thyroid disease, including autoimmune thyroiditis and thyroid cancer. 2. **Immune-Mediated Disorders:** DNAJB1 has been implicated in the pathogenesis of immune-mediated disorders, including multiple sclerosis and rheumatoid arthritis. 3. **Protein Aggregation Diseases:** DNAJB1 may play a role in the pathogenesis of protein aggregation diseases, including Alzheimer's disease and Parkinson's disease. 4. **Cancer:** DNAJB1 has been identified as a potential oncogene, with overexpression observed in various types of cancer, including breast cancer and lung cancer. In conclusion, DNAJB1 is a multifunctional protein that plays a critical role in maintaining protein homeostasis and regulating cellular responses to stress. Its dysregulation has been implicated in various diseases, including thyroid disease, immune-mediated disorders, and protein aggregation diseases. Further studies are needed to fully elucidate the molecular mechanisms underlying the functions of DNAJB1 and its role in disease pathogenesis.

Genular Protein ID: 1377542848

Symbol: DNJB1_HUMAN

Name: DnaJ homolog subfamily B member 1

UniProtKB Accession Codes:

P25685 B4DX52

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 16 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 5 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1754405

Title: A human homologue of the Escherichia coli DnaJ heat-shock protein.

PubMed ID: 1754405

DOI: 10.1093/nar/19.23.6645

PubMed ID: 8250930

Title: Cloning of a cDNA for heat-shock protein hsp40, a human homologue of bacterial DnaJ.

PubMed ID: 8250930

DOI: 10.1006/bbrc.1993.2466

PubMed ID: 8975727

Title: Genomic cloning of a human heat shock protein 40 (Hsp40) gene (HSPF1) and its chromosomal localization to 19p13.2.

PubMed ID: 8975727

DOI: 10.1006/geno.1996.0653

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1586970

Title: Intracellular localization and partial amino acid sequence of a stress-inducible 40-kDa protein in HeLa cells.

PubMed ID: 1586970

DOI: 10.1247/csf.17.77

PubMed ID: 9499401

Title: Molecular chaperones as HSF1-specific transcriptional repressors.

PubMed ID: 9499401

DOI: 10.1101/gad.12.5.654

PubMed ID: 9920933

Title: The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity.

PubMed ID: 9920933

DOI: 10.1074/jbc.274.6.3797

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24318877

Title: Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.

PubMed ID: 24318877

DOI: 10.1074/jbc.m113.521997

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 8764402

Title: Nuclear magnetic resonance solution structure of the human Hsp40 (HDJ-1) J-domain.

PubMed ID: 8764402

DOI: 10.1006/jmbi.1996.0394

Sequence Information:

  • Length: 340
  • Mass: 38044
  • Checksum: 17545098B0C196DF
  • Sequence:
    • MGKDYYQTLG LARGASDEEI KRAYRRQALR YHPDKNKEPG AEEKFKEIAE AYDVLSDPRK 
REIFDRYGEE GLKGSGPSGG SGGGANGTSF SYTFHGDPHA MFAEFFGGRN PFDTFFGQRN 
GEEGMDIDDP FSGFPMGMGG FTNVNFGRSR SAQEPARKKQ DPPVTHDLRV SLEEIYSGCT 
KKMKISHKRL NPDGKSIRNE DKILTIEVKK GWKEGTKITF PKEGDQTSNN IPADIVFVLK 
DKPHNIFKRD GSDVIYPARI SLREALCGCT VNVPTLDGRT IPVVFKDVIR PGMRRKVPGE 
GLPLPKTPEK RGDLIIEFEV IFPERIPQTS RTVLEQVLPI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.