Details for: DNAJB1

Gene ID: 3337

Symbol: DNAJB1

Ensembl ID: ENSG00000132002

Description: DnaJ heat shock protein family (Hsp40) member B1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.55
    Marker Score: 3562
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.27
    Marker Score: 5564
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.75
    Marker Score: 127679.5
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.53
    Marker Score: 3013.5
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.48
    Marker Score: 2491.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.47
    Marker Score: 9745
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.39
    Marker Score: 33581
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 3.39
    Marker Score: 2568
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.31
    Marker Score: 3533
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.3
    Marker Score: 14130
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.04
    Marker Score: 4991
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3
    Marker Score: 4618
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.97
    Marker Score: 1528.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.92
    Marker Score: 1988
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.87
    Marker Score: 2085
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.81
    Marker Score: 6386
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.76
    Marker Score: 21565
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.71
    Marker Score: 5410
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.69
    Marker Score: 1344
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.68
    Marker Score: 17403
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.65
    Marker Score: 140207
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.65
    Marker Score: 2230
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.65
    Marker Score: 2212
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.62
    Marker Score: 956.5
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.61
    Marker Score: 1170
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.6
    Marker Score: 6343
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.54
    Marker Score: 4768
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.51
    Marker Score: 2140
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.51
    Marker Score: 1571
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.5
    Marker Score: 2632.5
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.5
    Marker Score: 946
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.5
    Marker Score: 775
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 2.47
    Marker Score: 1061
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.47
    Marker Score: 1061
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 2.45
    Marker Score: 5509
  • Cell Name: neural cell (CL0002319)
    Fold Change: 2.44
    Marker Score: 1177
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.41
    Marker Score: 4312.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.39
    Marker Score: 4170
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.38
    Marker Score: 8812
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.37
    Marker Score: 1364
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.36
    Marker Score: 20352
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.35
    Marker Score: 2215
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.33
    Marker Score: 3300.5
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.33
    Marker Score: 1703
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.32
    Marker Score: 1651
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.32
    Marker Score: 1541
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.32
    Marker Score: 3195
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.31
    Marker Score: 2795
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.31
    Marker Score: 2051
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.3
    Marker Score: 7259
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.26
    Marker Score: 1458
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.26
    Marker Score: 1513
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.25
    Marker Score: 7074
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.25
    Marker Score: 2705
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.25
    Marker Score: 937
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.24
    Marker Score: 4671
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.22
    Marker Score: 3276
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.2
    Marker Score: 1473
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.2
    Marker Score: 1172.5
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 2.19
    Marker Score: 1004
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.19
    Marker Score: 2048
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.17
    Marker Score: 801
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.17
    Marker Score: 13853
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.17
    Marker Score: 2265
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.16
    Marker Score: 5264.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.16
    Marker Score: 3647.5
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.15
    Marker Score: 1890
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.15
    Marker Score: 3089
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.15
    Marker Score: 1321
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.13
    Marker Score: 509.5
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.13
    Marker Score: 494.5
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.11
    Marker Score: 2297.5
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.11
    Marker Score: 714
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.11
    Marker Score: 5511
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.09
    Marker Score: 23509.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.09
    Marker Score: 868.5
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.06
    Marker Score: 936
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.05
    Marker Score: 3486.5
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 2.05
    Marker Score: 476.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.04
    Marker Score: 506
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 2.02
    Marker Score: 445
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 2.02
    Marker Score: 407.5
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 2.01
    Marker Score: 611
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2
    Marker Score: 26372
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.99
    Marker Score: 2405
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.99
    Marker Score: 423.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.99
    Marker Score: 20012
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.99
    Marker Score: 3230
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.97
    Marker Score: 2437
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.96
    Marker Score: 1897.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.96
    Marker Score: 2087
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.95
    Marker Score: 1889
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.95
    Marker Score: 1312
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.95
    Marker Score: 515.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.94
    Marker Score: 1867.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.93
    Marker Score: 476
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.93
    Marker Score: 2838
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.93
    Marker Score: 1105
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.92
    Marker Score: 506
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.92
    Marker Score: 938

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Other Information

**Key characteristics:** - It is a chaperone protein that helps to protect proteins from denaturation and aggregation. - It is highly expressed in cells that are exposed to heat stress, such as thyroid follicular cells, uterine smooth muscle cells, fibroblasts, and skeletal muscle satellite stem cells. - It is a key regulator of the heat shock response by binding to heat shock proteins (Hsp70 and Hsp90) and facilitating their interaction with DNAJB1. - It also regulates the expression of other heat shock proteins, including Hsp11 and Hsp27. **Pathways and functions:** - DNAJB1 binds to Hsp70 and Hsp90 chaperones, which protects them from aggregation and degradation. - It also binds to DNA, which is a common target for heat shock proteins. - This binding recruits DNAJB1 to the site of heat stress, where it helps to regulate gene expression and protein folding. - In addition to its role in the heat shock response, DNAJB1 has been shown to regulate cell growth, differentiation, and apoptosis. **Clinical significance:** - Mutations in the DNAJB1 gene have been linked to several human diseases, including amyotrophic lateral sclerosis (ALS), cancer, and heart disease. - Studies of DNAJB1 knockout mice have shown that they are more susceptible to heat stress-induced cell death. - Therefore, DNAJB1 is a promising target for the development of new drugs for treating heat stress-related diseases.

Genular Protein ID: 1377542848

Symbol: DNJB1_HUMAN

Name: DnaJ homolog subfamily B member 1

UniProtKB Accession Codes:

P25685 B4DX52

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 16 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 11 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 5 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1754405

Title: A human homologue of the Escherichia coli DnaJ heat-shock protein.

PubMed ID: 1754405

DOI: 10.1093/nar/19.23.6645

PubMed ID: 8250930

Title: Cloning of a cDNA for heat-shock protein hsp40, a human homologue of bacterial DnaJ.

PubMed ID: 8250930

DOI: 10.1006/bbrc.1993.2466

PubMed ID: 8975727

Title: Genomic cloning of a human heat shock protein 40 (Hsp40) gene (HSPF1) and its chromosomal localization to 19p13.2.

PubMed ID: 8975727

DOI: 10.1006/geno.1996.0653

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1586970

Title: Intracellular localization and partial amino acid sequence of a stress-inducible 40-kDa protein in HeLa cells.

PubMed ID: 1586970

DOI: 10.1247/csf.17.77

PubMed ID: 9499401

Title: Molecular chaperones as HSF1-specific transcriptional repressors.

PubMed ID: 9499401

DOI: 10.1101/gad.12.5.654

PubMed ID: 9920933

Title: The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity.

PubMed ID: 9920933

DOI: 10.1074/jbc.274.6.3797

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24318877

Title: Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.

PubMed ID: 24318877

DOI: 10.1074/jbc.m113.521997

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 8764402

Title: Nuclear magnetic resonance solution structure of the human Hsp40 (HDJ-1) J-domain.

PubMed ID: 8764402

DOI: 10.1006/jmbi.1996.0394

Sequence Information:

  • Length: 340
  • Mass: 38044
  • Checksum: 17545098B0C196DF
  • Sequence:
    • MGKDYYQTLG LARGASDEEI KRAYRRQALR YHPDKNKEPG AEEKFKEIAE AYDVLSDPRK 
REIFDRYGEE GLKGSGPSGG SGGGANGTSF SYTFHGDPHA MFAEFFGGRN PFDTFFGQRN 
GEEGMDIDDP FSGFPMGMGG FTNVNFGRSR SAQEPARKKQ DPPVTHDLRV SLEEIYSGCT 
KKMKISHKRL NPDGKSIRNE DKILTIEVKK GWKEGTKITF PKEGDQTSNN IPADIVFVLK 
DKPHNIFKRD GSDVIYPARI SLREALCGCT VNVPTLDGRT IPVVFKDVIR PGMRRKVPGE 
GLPLPKTPEK RGDLIIEFEV IFPERIPQTS RTVLEQVLPI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.