Details for: SPCS1

Gene ID: 28972

Symbol: SPCS1

Ensembl ID: ENSG00000114902

Description: signal peptidase complex subunit 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 497.1544
    Cell Significance Index: -77.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 290.0923
    Cell Significance Index: -73.5800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 229.3981
    Cell Significance Index: -94.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 207.8979
    Cell Significance Index: -84.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 200.8376
    Cell Significance Index: -94.8200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 184.0061
    Cell Significance Index: -94.6500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 141.9029
    Cell Significance Index: -95.2200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 89.8043
    Cell Significance Index: -85.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 74.0173
    Cell Significance Index: -91.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 24.4244
    Cell Significance Index: -96.3800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.3803
    Cell Significance Index: -68.7400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.5979
    Cell Significance Index: -52.5000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 5.4581
    Cell Significance Index: 42.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.0848
    Cell Significance Index: 237.0800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.5609
    Cell Significance Index: 42.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.2797
    Cell Significance Index: 244.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.2094
    Cell Significance Index: 440.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.0249
    Cell Significance Index: 545.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.8325
    Cell Significance Index: 1546.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.7317
    Cell Significance Index: 335.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.7218
    Cell Significance Index: 127.9200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.4797
    Cell Significance Index: 28.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.3794
    Cell Significance Index: 69.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.3558
    Cell Significance Index: 151.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.3539
    Cell Significance Index: 64.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.0652
    Cell Significance Index: 107.2800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.9889
    Cell Significance Index: 12.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.9435
    Cell Significance Index: 137.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.9378
    Cell Significance Index: 856.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.9070
    Cell Significance Index: 244.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.8251
    Cell Significance Index: 47.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.7680
    Cell Significance Index: 228.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.6714
    Cell Significance Index: 58.0800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6219
    Cell Significance Index: 33.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3594
    Cell Significance Index: 160.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2967
    Cell Significance Index: 68.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.2500
    Cell Significance Index: 213.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1822
    Cell Significance Index: 74.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7674
    Cell Significance Index: 152.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6288
    Cell Significance Index: 16.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5715
    Cell Significance Index: 114.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4711
    Cell Significance Index: 24.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2464
    Cell Significance Index: 88.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2362
    Cell Significance Index: 38.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2339
    Cell Significance Index: 177.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1870
    Cell Significance Index: 137.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1853
    Cell Significance Index: 35.2600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1645
    Cell Significance Index: 3.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0269
    Cell Significance Index: 0.4500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0163
    Cell Significance Index: 0.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0013
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0053
    Cell Significance Index: -3.8900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0275
    Cell Significance Index: -51.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0439
    Cell Significance Index: -4.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0486
    Cell Significance Index: -30.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0603
    Cell Significance Index: -111.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0724
    Cell Significance Index: -111.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0846
    Cell Significance Index: -115.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1126
    Cell Significance Index: -71.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1176
    Cell Significance Index: -66.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.1279
    Cell Significance Index: -88.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1600
    Cell Significance Index: -33.7100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1883
    Cell Significance Index: -4.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1912
    Cell Significance Index: -86.7700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2012
    Cell Significance Index: -3.5600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2525
    Cell Significance Index: -29.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2687
    Cell Significance Index: -77.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.3564
    Cell Significance Index: -35.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4019
    Cell Significance Index: -46.0400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4323
    Cell Significance Index: -4.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4392
    Cell Significance Index: -12.5900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4680
    Cell Significance Index: -53.4200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5457
    Cell Significance Index: -13.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5500
    Cell Significance Index: -33.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5596
    Cell Significance Index: -81.3500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.5656
    Cell Significance Index: -8.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5706
    Cell Significance Index: -20.0500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.6622
    Cell Significance Index: -8.4800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.6837
    Cell Significance Index: -14.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7019
    Cell Significance Index: -43.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7021
    Cell Significance Index: -8.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7433
    Cell Significance Index: -41.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7875
    Cell Significance Index: -62.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8355
    Cell Significance Index: -23.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8697
    Cell Significance Index: -27.8600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9130
    Cell Significance Index: -24.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9237
    Cell Significance Index: -96.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9294
    Cell Significance Index: -24.8600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.9797
    Cell Significance Index: -8.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.0287
    Cell Significance Index: -69.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.1157
    Cell Significance Index: -85.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.1969
    Cell Significance Index: -25.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.3801
    Cell Significance Index: -18.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3985
    Cell Significance Index: -85.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.8282
    Cell Significance Index: -80.8700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.8427
    Cell Significance Index: -54.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.8495
    Cell Significance Index: -39.3900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.9811
    Cell Significance Index: -29.6900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.0755
    Cell Significance Index: -35.7800
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -2.0917
    Cell Significance Index: -23.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Signal peptidase complex subunit**: SPCS1 is a subunit of the signal peptidase complex, an enzyme complex responsible for the removal of signal peptides from precursor proteins, allowing them to target specific cellular compartments. 2. **Peptide hormone processing**: SPCS1 plays a critical role in the maturation and secretion of peptide hormones, such as ghrelin, GLP-1, and GIP, which regulate various physiological processes, including appetite, glucose metabolism, and inflammation. 3. **Immunological significance**: SPCS1 is highly expressed in immune cells, including IgA plasma cells and mature T cells, suggesting its involvement in immune regulation and response to pathogens. **Pathways and Functions:** 1. **Signal peptide processing**: SPCS1 is involved in the removal of signal peptides from precursor proteins, allowing them to target specific cellular compartments. 2. **Peptide hormone synthesis, secretion, and inactivation**: SPCS1 is essential for the maturation and secretion of peptide hormones, including ghrelin, GLP-1, and GIP. 3. **Immune regulation**: SPCS1 is highly expressed in immune cells, suggesting its involvement in immune regulation and response to pathogens. 4. **Infectious disease**: SPCS1 is involved in the replication and transcription of viruses, including the respiratory syncytial virus (RSV). 5. **Metabolism of proteins**: SPCS1 is involved in the processing and degradation of proteins, including peptide hormones and viral proteins. **Clinical Significance:** 1. **Metabolic disorders**: Abnormalities in SPCS1 expression or function may contribute to metabolic disorders, such as diabetes and obesity, by disrupting peptide hormone regulation. 2. **Immune disorders**: Dysregulation of SPCS1 in immune cells may contribute to immune disorders, such as autoimmune diseases and cancer. 3. **Viral infections**: SPCS1 is involved in the replication and transcription of viruses, including RSV, highlighting its potential as a therapeutic target for viral infections. 4. **Cancer**: Abnormalities in SPCS1 expression or function may contribute to cancer development and progression by disrupting peptide hormone regulation and immune response. In conclusion, SPCS1 is a multifunctional gene that plays a critical role in signal peptide processing, peptide hormone regulation, and immune regulation. Its dysregulation may contribute to various metabolic and immune disorders, and its potential as a therapeutic target for viral infections and cancer highlights its importance in understanding human disease.

Genular Protein ID: 3232605555

Symbol: SPCS1_HUMAN

Name: Signal peptidase complex subunit 1

UniProtKB Accession Codes:

Q9Y6A9 B3KNF8 Q9BVW1 X6R2S6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 2 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 8632014

Title: Membrane topology of the 12- and the 25-kDa subunits of the mammalian signal peptidase complex.

PubMed ID: 8632014

DOI: 10.1074/jbc.271.7.3925

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24023390

Title: Large-scale top down proteomics of the human proteome: membrane proteins, mitochondria, and senescence.

PubMed ID: 24023390

DOI: 10.1074/mcp.m113.030114

PubMed ID: 24009510

Title: Signal peptidase complex subunit 1 participates in the assembly of hepatitis C virus through an interaction with E2 and NS2.

PubMed ID: 24009510

DOI: 10.1371/journal.ppat.1003589

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27383988

Title: A CRISPR screen defines a signal peptide processing pathway required by flaviviruses.

PubMed ID: 27383988

DOI: 10.1038/nature18625

PubMed ID: 29593046

Title: Host Factor SPCS1 Regulates the Replication of Japanese Encephalitis Virus through Interactions with Transmembrane Domains of NS2B.

PubMed ID: 29593046

DOI: 10.1128/jvi.00197-18

PubMed ID: 34388369

Title: Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage.

PubMed ID: 34388369

DOI: 10.1016/j.molcel.2021.07.031

Sequence Information:

  • Length: 169
  • Mass: 18298
  • Checksum: 65F180938A9BEF1E
  • Sequence:
    • MARGGDTGCT GPSETSASGA AAIALPGLEG PATDAQCQTL PLTVLKSRSP SPRSLPPALS 
CPPPQPAMLE HLSSLPTQMD YKGQKLAEQM FQGIILFSAI VGFIYGYVAE QFGWTVYIVM 
AGFAFSCLLT LPPWPIYRRH PLKWLPVQES STDDKKPGER KIKRHAKNN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.