Details for: IGHVIII 67 3

Gene ID: 28341

Symbol: IGHVIII 67 3

Ensembl ID: ENSG00000253635

Description: immunoglobulin heavy variable (III)-67-3 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0053
    Cell Significance Index: -0.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGHVIII 67 3 gene is a member of the immunoglobulin heavy chain (IGH) family and is classified as a pseudogene due to its non-functional nature. Unlike functional IGH genes, IGHVIII 67 3 does not encode a functional heavy chain variable region, which is essential for antibody production. Despite this, the IGHVIII 67 3 gene is significantly expressed in CD8-positive, alpha-beta T cells, suggesting that it may play a role in regulating T cell function or influencing the immune response. **Pathways and Functions:** The expression of IGHVIII 67 3 in CD8-positive, alpha-beta T cells is not fully understood, but several theories have emerged. One possibility is that IGHVIII 67 3 acts as a co-regulator of T cell receptor (TCR) signaling, modulating the strength and duration of TCR activation. This could be achieved through interactions with other proteins or molecules that influence TCR signaling pathways. Another possibility is that IGHVIII 67 3 plays a role in regulating T cell differentiation, proliferation, or survival. Further research is needed to elucidate the specific mechanisms by which IGHVIII 67 3 influences T cell function. **Clinical Significance:** The clinical significance of IGHVIII 67 3 is an area of active research. Given its expression in CD8-positive, alpha-beta T cells, IGHVIII 67 3 may be involved in the regulation of immune responses in various diseases, including cancer, autoimmune disorders, and infectious diseases. For example, dysregulation of T cell function has been implicated in the pathogenesis of several diseases, including multiple sclerosis and type 1 diabetes. Therefore, understanding the role of IGHVIII 67 3 in T cell function and its potential impact on disease outcomes is crucial. In conclusion, the IGHVIII 67 3 gene is a complex and enigmatic pseudogene that has garnered attention due to its unique expression profile in CD8-positive, alpha-beta T cells. Further research is needed to elucidate its role in regulating T cell function and its clinical significance. However, the potential implications of IGHVIII 67 3 are significant, and its study may lead to a better understanding of the immune system and the development of novel therapeutic strategies for immune-related diseases.

Database document:

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