Details for: IGHVII 65 1

Gene ID: 28359

Symbol: IGHVII 65 1

Ensembl ID: ENSG00000253169

Description: immunoglobulin heavy variable (II)-65-1 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0031
    Cell Significance Index: 0.0800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0036
    Cell Significance Index: -0.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHVII 65 1 is a pseudogene, meaning it has undergone mutations that render it non-functional and non-essential for protein production. However, this does not preclude its potential regulatory functions. Its expression is limited to two cell types: plasmacytoid dendritic cells (pDCs) and double-negative thymocytes. pDCs are known for their role in antiviral immune responses, while double-negative thymocytes are precursor cells that will either differentiate into T cells or undergo apoptosis. The expression of IGHVII 65 1 in these cells suggests a specialized function that may be critical for their development or function. **Pathways and Functions:** The precise mechanisms by which IGHVII 65 1 regulates immune responses are unclear. However, its expression in pDCs and double-negative thymocytes suggests that it may play a role in the regulation of immune cell development and function. One possible function of IGHVII 65 1 is to modulate the signaling pathways that govern the development and differentiation of these cells. For example, IGHVII 65 1 may interact with other genes or proteins in the pDC or double-negative thymocyte to regulate the expression of key transcription factors or signaling molecules. **Clinical Significance:** The clinical significance of IGHVII 65 1 is still largely unknown. However, its restricted expression in pDCs and double-negative thymocytes may make it a valuable biomarker for identifying these cell subsets. Furthermore, the study of IGHVII 65 1 may provide insights into the molecular mechanisms that govern immune cell development and function, which could have implications for the treatment of immune-related disorders. For example, the identification of IGHVII 65 1 as a biomarker for pDCs may allow for the development of targeted therapies for antiviral or autoimmune diseases. In conclusion, IGHVII 65 1 is a pseudogene with a unique expression profile that warrants further investigation. Its restricted expression in pDCs and double-negative thymocytes suggests that it may play a critical role in regulating immune cell development and function. Further study of this gene may provide insights into the molecular mechanisms that govern immune responses and may lead to the development of targeted therapies for immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.