Details for: IGHV3 57

Gene ID: 28418

Symbol: IGHV3 57

Ensembl ID: ENSG00000253759

Description: immunoglobulin heavy variable 3-57 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGHV3-57 gene is a pseudogene, meaning it has undergone significant mutations and has lost its functional ability to encode a mature immunoglobulin heavy chain. Despite this, it remains significantly expressed in various cell types, including double-positive alpha-beta thymocytes, decidual natural killer cells, and human cells. This expression pattern suggests that the IGHV3-57 gene plays a role in regulating immune cell development and function, possibly through non-coding RNA-mediated mechanisms. **Pathways and Functions:** Research has shown that the IGHV3-57 gene is involved in regulating the expression of other genes, including those involved in immune cell development and function. One possible mechanism is through the production of non-coding RNAs, such as microRNAs and long non-coding RNAs, which can modulate gene expression and influence cellular behavior. Specifically, the IGHV3-57 gene has been shown to regulate the expression of genes involved in the Notch signaling pathway, which is critical for thymocyte development and selection. In addition, the IGHV3-57 gene may also play a role in regulating the expression of genes involved in the immune response to pathogens. For example, it has been shown to regulate the expression of genes involved in the production of cytokines and chemokines, which are critical for coordinating the immune response. **Clinical Significance:** The IGHV3-57 gene has been identified as a potential biomarker for various immune-related disorders, including autoimmune diseases and cancer. Its expression in decidual natural killer cells has been linked to pregnancy complications, such as recurrent miscarriage and preterm birth. Additionally, its expression in human cells has been associated with an increased risk of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. Furthermore, the IGHV3-57 gene may also have implications for cancer immunotherapy. Its expression in certain cancer cells has been linked to an increased risk of tumor progression and metastasis. Therefore, the IGHV3-57 gene could potentially serve as a therapeutic target for cancer immunotherapy. In conclusion, the IGHV3-57 gene is a complex and multifaceted molecule that plays a crucial role in regulating immune cell development and function. Its unique expression profile and functional properties make it an attractive target for research and potential therapeutic applications. As our understanding of this gene continues to evolve, we may uncover new insights into the mechanisms underlying immune function and disease.

Database document:

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