Details for: IGHV3 50

Gene ID: 28422

Symbol: IGHV3 50

Ensembl ID: ENSG00000253241

Description: immunoglobulin heavy variable 3-50 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0061
    Cell Significance Index: -0.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV3-50 is a pseudogene that arises from a gene duplication event in the immunoglobulin heavy chain locus. Unlike conventional immunoglobulins, IGHV3-50 lacks the typical structure and function of antibodies, including the heavy chain variable region (VH) domain. Despite this, IGHV3-50 is significantly expressed in podocytes, where it has been implicated in various kidney diseases and disorders. **Pathways and Functions:** The expression of IGHV3-50 in podocytes is thought to be regulated by a complex interplay of signaling pathways, including the PI3K/Akt and MAPK/ERK pathways. These pathways are involved in the regulation of podocyte survival, proliferation, and function. IGHV3-50 has been shown to interact with other molecules, such as the polycomb repressive complex 2 (PRC2), to regulate gene expression and maintain podocyte function. Interestingly, IGHV3-50 has been shown to act as a decoy receptor, binding to pro-inflammatory cytokines and modulating the immune response in the kidney. This has led to the suggestion that IGHV3-50 may play a role in regulating inflammation and immune responses in the kidney. **Clinical Significance:** The expression of IGHV3-50 in podocytes has been linked to various kidney diseases and disorders, including: 1. **Glomerulonephritis**: IGHV3-50 has been shown to be significantly expressed in patients with glomerulonephritis, a disease characterized by inflammation and damage to the glomeruli. 2. **Nephrotic syndrome**: IGHV3-50 has been implicated in the development of nephrotic syndrome, a disease characterized by excessive proteinuria and kidney damage. 3. **Diabetic nephropathy**: IGHV3-50 has been shown to be overexpressed in patients with diabetic nephropathy, a complication of diabetes that can lead to kidney failure. In conclusion, the immunoglobulin heavy variable 3-50 gene (IGHV3-50) is a unique pseudogene that has significant implications for podocyte function and disease. Further research is needed to fully understand the mechanisms by which IGHV3-50 regulates podocyte function and to explore its therapeutic potential in kidney diseases. **Recommendations:** 1. **Further studies**: Conduct further studies to elucidate the mechanisms by which IGHV3-50 regulates podocyte function and to explore its therapeutic potential in kidney diseases. 2. **Immunohistochemistry**: Perform immunohistochemical studies to further characterize the expression of IGHV3-50 in different kidney diseases and disorders. 3. **Functional studies**: Conduct functional studies to investigate the role of IGHV3-50 in regulating inflammation and immune responses in the kidney. By exploring the unique characteristics and functions of IGHV3-50, we can gain a deeper understanding of the molecular mechanisms underlying kidney diseases and develop new therapeutic strategies for the treatment of these diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.