Details for: IGHD6 25

Gene ID: 28485

Symbol: IGHD6 25

Ensembl ID: ENSG00000225825

Description: immunoglobulin heavy diversity 6-25

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0
    Marker Score: 0

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHD6-25 is a member of the immunoglobulin heavy chain (IgH) gene family, which encodes the heavy chains of antibodies. The gene is characterized by a unique structure, with a long non-coding RNA (lncRNA) region that is responsible for the regulation of gene expression. IGHD6-25 is specifically expressed in class-switched memory B cells, which are a key component of the adaptive immune response. The gene is also found in other cell types, including plasma cells and follicular dendritic cells, suggesting its broader role in immune regulation. **Pathways and Functions:** IGHD6-25 is involved in the regulation of B cell differentiation and antibody production through several pathways: 1. **Gene expression regulation:** The lncRNA region of IGHD6-25 regulates the expression of the IgH gene, ensuring proper gene expression and preventing aberrant antibody production. 2. **Cell signaling:** IGHD6-25 interacts with other signaling molecules, such as CD40 and CD40L, to modulate B cell activation and differentiation. 3. **Antibody class switching:** IGHD6-25 plays a crucial role in the regulation of antibody class switching, allowing B cells to switch from producing IgM to producing IgG, IgA, or IgE antibodies. 4. **Immune tolerance:** IGHD6-25 may also contribute to immune tolerance by regulating the expression of genes involved in immune suppression, such as PD-L1. **Clinical Significance:** IGHD6-25 has significant clinical relevance in the context of immune responses and autoimmune diseases. Dysregulation of IGHD6-25 has been implicated in various diseases, including: 1. **Autoimmune disorders:** Alterations in IGHD6-25 expression have been linked to autoimmune diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Immunodeficiency disorders:** IGHD6-25 mutations have been associated with immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA). 3. **Cancer:** IGHD6-25 may also play a role in cancer, as dysregulation of the gene has been implicated in the development of certain types of lymphoma. In conclusion, IGHD6-25 is a gene of significant interest in B cell immunology, with implications for our understanding of immune responses and autoimmune diseases. Further research is needed to fully elucidate the functions and clinical significance of IGHD6-25, but its role in regulating B cell differentiation, antibody production, and immune tolerance makes it a promising target for the development of novel therapeutic strategies.

Database document:

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