Details for: IGHD3 16

Gene ID: 28498

Symbol: IGHD3 16

Ensembl ID: ENSG00000211917

Description: immunoglobulin heavy diversity 3-16

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: B cell (CL0000236)
    Fold Change: 0.05
    Marker Score: 46
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.02
    Marker Score: 25

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Structure:** IGHD3-16 is a single copy gene located on chromosome 14, encoding a 3' untranslated region (UTR) and a 5' untranslated region (UTR). The gene is characterized by a unique 3' UTR, which is rich in GC-rich sequences, a hallmark of immunoglobulin genes. 2. **Expression Profile:** IGHD3-16 is highly expressed in B cells, plasma cells, and double-negative thymocytes, which are cells that have not yet undergone positive selection in the thymus. This expression profile suggests that IGHD3-16 is involved in B cell development and maturation. 3. **Functional Implications:** The expression of IGHD3-16 in plasma cells, which are the terminally differentiated form of B cells, suggests that this gene plays a role in the final stages of B cell development and antibody production. **Pathways and Functions:** 1. **V(D)J Recombination:** IGHD3-16 is involved in the V(D)J recombination process, which is responsible for generating the diverse antibody repertoire. The gene's unique 3' UTR and 5' UTR sequences are thought to be involved in the recombination process, facilitating the assembly of diverse IgH chains. 2. **B Cell Development:** IGHD3-16 is essential for B cell development, as it is expressed in double-negative thymocytes, which are cells that have not yet undergone positive selection in the thymus. The gene's expression in B cells and plasma cells suggests that it plays a role in the final stages of B cell development and maturation. 3. **Antibody Production:** IGHD3-16 is involved in the production of antibodies, as it is expressed in plasma cells, which are the terminally differentiated form of B cells. The gene's expression in plasma cells suggests that it plays a role in the final stages of antibody production. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations in the IGHD3-16 gene have been associated with immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA). Patients with XLA have defective B cell development and function, leading to impaired antibody production and increased susceptibility to infections. 2. **Cancer:** Aberrant expression of IGHD3-16 has been observed in certain types of cancer, such as follicular lymphoma. The gene's expression in cancer cells suggests that it may play a role in tumorigenesis and cancer progression. 3. **Vaccine Development:** IGHD3-16 is an important target for vaccine development, as it is involved in the production of antibodies. Understanding the function of this gene may lead to the development of more effective vaccines against infectious diseases. In conclusion, IGHD3-16 is a critical gene involved in B cell development, function, and antibody production. Its unique expression profile and functional implications make it an important target for understanding the mechanisms of immune responses and developing new therapies for immunodeficiency disorders and cancer.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.