Details for: IGLVIV 53

Gene ID: 28762

Symbol: IGLVIV 53

Ensembl ID: ENSG00000253935

Description: immunoglobulin lambda variable (IV)-53 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0
    Marker Score: 0

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** IGLVIV53 is a pseudogene, meaning it has lost its functional gene structure due to mutations or other genetic events. Despite this, it retains some sequence similarity to its functional counterparts. 2. **Expression in stromal cells:** IGLVIV53 is significantly expressed in stromal cells, which are not typically associated with immune function. 3. **Location on the X chromosome:** IGLVIV53 is located on the X chromosome, which is a common site for pseudogenes due to the high frequency of gene conversion events. 4. **Limited sequence similarity:** IGLVIV53 has limited sequence similarity to its functional counterparts, suggesting that it may not play a significant role in immune function. **Pathways and Functions:** 1. **Stromal cell biology:** The expression of IGLVIV53 in stromal cells suggests that it may play a role in regulating stromal cell biology, including cell proliferation, differentiation, and survival. 2. **Immune microenvironment:** The presence of IGLVIV53 in stromal cells may influence the immune microenvironment by modulating the activity of immune cells, such as T cells and B cells. 3. **Gene regulation:** IGLVIV53 may act as a regulatory element, influencing the expression of other genes in the immune system. 4. **Evolutionary conservation:** Despite its pseudogene status, IGLVIV53 has been conserved across species, suggesting that it may have retained some functional significance. **Clinical Significance:** 1. **Cancer immunology:** The expression of IGLVIV53 in stromal cells has been observed in various types of cancer, including breast, lung, and colon cancer. Its role in the tumor microenvironment may be significant in modulating immune responses. 2. **Autoimmune diseases:** The presence of IGLVIV53 in stromal cells may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus, by influencing immune cell activity. 3. **Immunotherapy:** The study of IGLVIV53 may provide insights into the development of novel immunotherapies that target the stromal cell compartment. 4. **Gene therapy:** The use of IGLVIV53 as a gene therapy target may be explored to modulate immune responses in diseases characterized by dysregulated immune activity. In conclusion, the immunoglobulin lambda variable (IV)-53 pseudogene, IGLVIV53, is a gene that has garnered attention for its unique characteristics and potential implications in the immune system. Further research is needed to fully understand its role in the immune microenvironment and its clinical significance.

Database document:

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