Details for: IGLV3 15

Gene ID: 28800

Symbol: IGLV3 15

Ensembl ID: ENSG00000253786

Description: immunoglobulin lambda variable 3-15 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0166
    Cell Significance Index: -0.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGLV3-15 is a pseudogene that belongs to the immunoglobulin lambda variable gene family. It is characterized by a high degree of degeneration, with a significant loss of functional exons and a high degree of similarity to non-coding regions. Despite its inactivation, IGLV3-15 is significantly expressed in B cells, which are the primary producers of antibodies in the immune system. This expression pattern suggests that IGLV3-15 may play a regulatory role in B cell development or function. **Pathways and Functions:** The exact pathways and functions of IGLV3-15 are not well understood, but several hypotheses have been proposed: 1. **Regulation of B cell development:** IGLV3-15 may play a role in regulating B cell development and maturation, influencing the expression of other genes involved in the immune process. 2. **Influence on antibody production:** As a pseudogene, IGLV3-15 may influence the production of antibodies by regulating the expression of other immunoglobulin genes. 3. **Modulation of immune responses:** IGLV3-15 may modulate immune responses by regulating the activity of other genes involved in the immune process, such as cytokine genes. **Clinical Significance:** While IGLV3-15 is not directly involved in antibody production, its expression in B cells suggests that it may have a role in regulating immune responses or influencing the function of other genes involved in the immune process. Further research is needed to fully understand the clinical significance of IGLV3-15 and its potential implications for immunological research. **Potential Implications:** The study of IGLV3-15 has several potential implications for immunological research: 1. **Understanding B cell regulation:** IGLV3-15 may provide insights into the regulation of B cell development and function, which could have implications for the treatment of B cell-related diseases, such as autoimmune disorders. 2. **Immunological tolerance:** IGLV3-15 may play a role in immunological tolerance, influencing the activity of other genes involved in the immune process. 3. **Cancer research:** The study of IGLV3-15 may provide insights into the development and progression of cancer, as aberrant expression of IGLV3-15 has been linked to certain types of cancer. In conclusion, the IGLV3-15 gene is a complex and enigmatic pseudogene that has significant implications for our understanding of the human immune system. Further research is needed to fully understand the role of IGLV3-15 in regulating immune responses and its potential implications for immunological research.

Database document:

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