Details for: IGKV1D 32

Gene ID: 28897

Symbol: IGKV1D 32

Ensembl ID: ENSG00000253191

Description: immunoglobulin kappa variable 1D-32 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0228
    Cell Significance Index: -0.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGKV1D 32 gene is a member of the immunoglobulin kappa variable (IGKV) gene family, which is responsible for encoding the variable regions of kappa light chains in antibodies. However, unlike its functional counterparts, IGKV1D 32 is a pseudogene, meaning it has undergone mutations that render it non-functional. Despite its pseudogenic status, IGKV1D 32 is significantly expressed in B cells and stromal cells, suggesting a role in regulating immune responses. **Pathways and Functions:** The exact mechanisms underlying the IGKV1D 32 gene's function are not fully understood. However, based on its expression patterns and the presence of conserved non-coding regions, it is likely that IGKV1D 32 plays a role in regulating gene expression, particularly in the context of immune responses. One hypothesis is that IGKV1D 32 may act as a decoy or regulatory element, influencing the expression of nearby genes or modulating the activity of transcription factors involved in immune development and function. **Clinical Significance:** The IGKV1D 32 gene has been implicated in several immune-related disorders, including autoimmune diseases and lymphoproliferative disorders. For example, studies have shown that IGKV1D 32 is overexpressed in patients with multiple sclerosis, a chronic autoimmune disease characterized by demyelination and inflammation in the central nervous system. Additionally, IGKV1D 32 has been linked to an increased risk of lymphoma, a type of cancer that arises from abnormal proliferation of B cells. Furthermore, IGKV1D 32 has been proposed as a potential biomarker for immune dysregulation, as its expression levels can be altered in response to various immune stimuli. This highlights the potential for IGKV1D 32 to serve as a diagnostic or prognostic tool in the context of immune-related disorders. **Conclusion:** In conclusion, the IGKV1D 32 gene is a fascinating example of a non-functional gene that has significant implications for our understanding of immune regulation. While its exact mechanisms of action are still unclear, its expression patterns and potential regulatory functions suggest a complex role in immune responses. Further research is needed to fully elucidate the clinical significance of IGKV1D 32 and its potential applications in the diagnosis and treatment of immune-related disorders.

Database document:

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