Details for: HBAP1

Gene ID: 3041

Symbol: HBAP1

Ensembl ID: ENSG00000225323

Description: hemoglobin subunit alpha pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.3241
    Cell Significance Index: 3.8700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2249
    Cell Significance Index: -2.3000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2700
    Cell Significance Index: -2.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HBAP1 is a pseudogene, meaning it has undergone mutations that render it non-functional and unable to produce a protein. Despite its pseudogenic status, HBAP1 exhibits a distinct expression profile, with significantly high levels detected in enterocytes, stromal cells, and primitive red blood cells. These cell types are not typically associated with the expression of HBA1 or HBA2, the functional alpha subunits of hemoglobin. The expression of HBAP1 in these cells suggests a potential role in regulating cellular processes, such as differentiation, proliferation, or survival. **Pathways and Functions:** The mechanisms underlying HBAP1's expression and function remain poorly understood. However, several hypotheses can be proposed based on its tissue-specific expression patterns: 1. **Regulation of cell differentiation:** HBAP1 may play a role in guiding the differentiation of enterocytes and stromal cells, influencing the development of the intestinal epithelium or the stromal microenvironment. 2. **Modulation of red blood cell development:** The expression of HBAP1 in primitive red blood cells could be linked to the regulation of erythropoiesis, potentially influencing the production of functional hemoglobin or the differentiation of red blood cells. 3. **Influence on cellular signaling pathways:** HBAP1 may interact with signaling pathways that regulate cellular responses to environmental cues, such as oxidative stress or inflammation. This could have implications for the development and maintenance of immune tissues. **Clinical Significance:** While the clinical significance of HBAP1 remains unclear, its expression in enterocytes and stromal cells suggests potential implications for: 1. **Gastrointestinal disorders:** Alterations in HBAP1 expression may contribute to the pathogenesis of gastrointestinal diseases, such as inflammatory bowel disease (IBD) or colorectal cancer. 2. **Immunological disorders:** The role of HBAP1 in regulating immune cell development and function could have implications for the understanding and treatment of autoimmune disorders or immunodeficiencies. 3. **Cancer research:** The expression of HBAP1 in primitive red blood cells raises questions about its potential involvement in cancer development, particularly in hematological malignancies. In conclusion, the study of HBAP1 has revealed a complex and intriguing gene with unconventional expression patterns and potential roles in the regulation of cellular processes. Further research is needed to fully elucidate the functions and clinical significance of HBAP1, but its discovery highlights the importance of considering pseudogenes in the context of human biology and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.