Details for: MIR122

Gene ID: 406906

Symbol: MIR122

Ensembl ID: ENSG00000284440

Description: microRNA 122

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0018
    Cell Significance Index: 0.0200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0012
    Cell Significance Index: -0.0100
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0022
    Cell Significance Index: -0.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** MIR122 is significantly expressed in various cell types, including neuronal receptor cells, smooth muscle myoblasts, lymphoid lineage-restricted progenitor cells, cardiac endothelial cells, pericytes, cardiac muscle myoblasts, and immature innate lymphoid cells. 2. **Stability:** MIR122 is known to be highly stable in the bloodstream, allowing it to act as a long-range regulator of gene expression. 3. **Regulatory Function:** MIR122 exerts its regulatory function by binding to target mRNAs, leading to their degradation or inhibition of translation. 4. **Target Genes:** The target genes of MIR122 are diverse, including those involved in immune response, cell signaling, and cellular homeostasis. **Pathways and Functions:** 1. **MicroRNA-Mediated Post-Transcriptional Gene Silencing:** MIR122 regulates gene expression by binding to target mRNAs, leading to their degradation or inhibition of translation. 2. **Extracellular Exosome and Extracellular Space:** MIR122 is packaged into exosomes, which are small extracellular vesicles that can transport MIR122 to distant cells, influencing gene expression in recipient cells. 3. **RISC Complex:** MIR122 interacts with the RNA-induced silencing complex (RISC), a protein complex that recognizes and binds to specific microRNAs, facilitating their regulatory function. 4. **Immune Response:** MIR122 plays a role in regulating immune response by modulating the expression of genes involved in cell signaling, cytokine production, and immune cell differentiation. **Clinical Significance:** 1. **Immune-Mediated Diseases:** Dysregulation of MIR122 has been implicated in various immune-mediated diseases, including multiple sclerosis, rheumatoid arthritis, and autoimmune hepatitis. 2. **Cancer:** MIR122 has been identified as a tumor suppressor in certain types of cancer, including liver cancer and multiple myeloma. 3. **Cardiovascular Diseases:** MIR122 has been linked to cardiovascular diseases, including cardiac arrhythmias and cardiac failure. 4. **Neurological Disorders:** MIR122 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, MIR122 is a critical regulator of immune response and cellular homeostasis, playing a key role in maintaining tissue balance and preventing disease. Further research is needed to fully elucidate the mechanisms by which MIR122 regulates gene expression and to explore its therapeutic potential in various disease states.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.