Details for: MIR143

Gene ID: 406935

Symbol: MIR143

Ensembl ID: ENSG00000284182

Description: microRNA 143

Associated with

  • Actin cytoskeleton organization
    (GO:0030036)
  • Angiotensin-activated signaling pathway
    (GO:0038166)
  • Aorta smooth muscle tissue morphogenesis
    (GO:0060414)
  • Establishment or maintenance of cell type involved in phenotypic switching
    (GO:0044663)
  • Extracellular exosome
    (GO:0070062)
  • Extracellular space
    (GO:0005615)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna 3'-utr binding
    (GO:0003730)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of angiogenesis
    (GO:0016525)
  • Negative regulation of d-glucose import
    (GO:0046325)
  • Negative regulation of smooth muscle cell proliferation
    (GO:0048662)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of blood vessel endothelial cell migration
    (GO:0043536)
  • Positive regulation of pulmonary blood vessel remodeling
    (GO:1905111)
  • Positive regulation of vascular associated smooth muscle cell migration
    (GO:1904754)
  • Regulation of phenotypic switching
    (GO:1900239)
  • Regulation of smooth muscle contraction
    (GO:0006940)
  • Risc complex
    (GO:0016442)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0012
    Cell Significance Index: -0.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MIR143 is a microRNA that belongs to the miR-143 family, which is known for its involvement in regulating cell proliferation, differentiation, and survival. Its expression is highly specific to various cell types, including smooth muscle cells, endothelial cells, and immune cells. The gene is significantly expressed in tissues involved in cardiovascular development and disease, such as the aorta, pulmonary vessels, and cardiac tissue. **Pathways and Functions:** MIR143 is involved in several key biological pathways, including: 1. **Actin cytoskeleton organization:** MIR143 regulates the expression of genes involved in actin cytoskeleton organization, which is crucial for cell migration, differentiation, and survival. 2. **Angiotensin-activated signaling pathway:** MIR143 modulates the expression of genes involved in the angiotensin-activated signaling pathway, which regulates blood pressure and vascular tone. 3. **Aorta smooth muscle tissue morphogenesis:** MIR143 plays a critical role in the development and morphogenesis of smooth muscle cells in the aorta. 4. **Establishment or maintenance of cell type involved in phenotypic switching:** MIR143 regulates the expression of genes involved in phenotypic switching, allowing cells to adopt different phenotypes in response to changing environmental conditions. 5. **Extracellular exosome, Extracellular space, and Mirna-mediated post-transcriptional gene silencing:** MIR143 is involved in regulating the expression of genes involved in extracellular exosome formation, extracellular space, and microRNA-mediated post-transcriptional gene silencing. **Clinical Significance:** The dysregulation of MIR143 has been implicated in various cardiovascular diseases, including hypertension, atherosclerosis, and pulmonary hypertension. Its involvement in vascular development and remodeling highlights its potential as a therapeutic target for the treatment of these diseases. Additionally, MIR143's role in immune regulation and phenotypic switching suggests its potential involvement in autoimmune and inflammatory diseases. In conclusion, MIR143 is a multifaceted microRNA that plays a critical role in regulating various cellular processes, including immune response, angiogenesis, and vascular development. Its dysregulation has been implicated in various cardiovascular diseases, highlighting its potential as a therapeutic target for the treatment of these diseases. Further research is needed to fully elucidate the mechanisms by which MIR143 regulates gene expression and its clinical significance in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.