Details for: MIR17

Gene ID: 406952

Symbol: MIR17

Ensembl ID: ENSG00000284536

Description: microRNA 17

Associated with

  • Cellular response to hypoxia
    (GO:0071456)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Extracellular exosome
    (GO:0070062)
  • Extracellular space
    (GO:0005615)
  • Extracellular vesicle
    (GO:1903561)
  • Mirna-mediated gene silencing by inhibition of translation
    (GO:0035278)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mitochondrion
    (GO:0005739)
  • Mrna 3'-utr binding
    (GO:0003730)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of amyloid precursor protein biosynthetic process
    (GO:0042985)
  • Negative regulation of apoptosome assembly
    (GO:1905101)
  • Negative regulation of cellular senescence
    (GO:2000773)
  • Negative regulation of chemokine production
    (GO:0032682)
  • Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043154)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of hydrogen peroxide-mediated programmed cell death
    (GO:1901299)
  • Negative regulation of intrinsic apoptotic signaling pathway
    (GO:2001243)
  • Negative regulation of low-density lipoprotein particle clearance
    (GO:0010989)
  • Negative regulation of mitochondrial membrane permeability involved in apoptotic process
    (GO:1902109)
  • Negative regulation of osteoblast differentiation
    (GO:0045668)
  • Negative regulation of receptor-mediated endocytosis involved in cholesterol transport
    (GO:1905601)
  • Negative regulation of sprouting angiogenesis
    (GO:1903671)
  • Negative regulation of systemic arterial blood pressure
    (GO:0003085)
  • Negative regulation of toll-like receptor signaling pathway
    (GO:0034122)
  • Negative regulation of transforming growth factor beta receptor signaling pathway
    (GO:0030512)
  • Negative regulation of transporter activity
    (GO:0032410)
  • Negative regulation of vascular associated smooth muscle cell apoptotic process
    (GO:1905460)
  • Negative regulation of vascular endothelial growth factor production
    (GO:1904046)
  • Outflow tract morphogenesis
    (GO:0003151)
  • Positive regulation of blood pressure
    (GO:0045777)
  • Positive regulation of cardiac muscle cell apoptotic process
    (GO:0010666)
  • Positive regulation of cardiac muscle hypertrophy in response to stress
    (GO:1903244)
  • Positive regulation of connective tissue replacement involved in inflammatory response wound healing
    (GO:1904598)
  • Positive regulation of cytokine production involved in inflammatory response
    (GO:1900017)
  • Positive regulation of fat cell differentiation
    (GO:0045600)
  • Positive regulation of fibroblast proliferation
    (GO:0048146)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of hydrogen peroxide-mediated programmed cell death
    (GO:1901300)
  • Positive regulation of metalloendopeptidase activity
    (GO:1904685)
  • Positive regulation of phagocytosis
    (GO:0050766)
  • Positive regulation of pulmonary blood vessel remodeling
    (GO:1905111)
  • Positive regulation of smooth muscle hypertrophy
    (GO:1905149)
  • Positive regulation of vascular associated smooth muscle cell proliferation
    (GO:1904707)
  • Risc complex
    (GO:0016442)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **MicroRNA structure and function:** MIR17 is a 22-nucleotide long non-coding RNA that is processed from a hairpin precursor. It functions by binding to the 3'-untranslated region (3'-UTR) of its target mRNAs, leading to mRNA degradation or inhibition of translation. 2. **Target gene regulation:** MIR17 targets a wide range of genes involved in various cellular processes, including cell proliferation, differentiation, apoptosis, and inflammatory responses. 3. **Cell-type specificity:** MIR17 is significantly expressed in specific cell types, such as neuronal receptor cells, smooth muscle myoblasts, cardiac endothelial cells, and fibroblasts, highlighting its role in tissue-specific functions. 4. **Regulatory networks:** MIR17 interacts with multiple signaling pathways, including the RISC complex, extracellular vesicle-mediated communication, and the mitogen-activated protein kinase (MAPK) pathway. **Pathways and Functions:** 1. **Cellular response to hypoxia:** MIR17 regulates the expression of genes involved in hypoxia-inducible factor (HIF) signaling, modulating cellular adaptation to low oxygen levels. 2. **Inflammation and immune response:** MIR17 targets genes involved in inflammatory cytokine production, chemokine signaling, and innate immune response, influencing the development of inflammatory responses. 3. **Cell proliferation and differentiation:** MIR17 regulates the expression of genes involved in cell cycle progression, differentiation, and survival, impacting tissue development and homeostasis. 4. **Apoptosis and programmed cell death:** MIR17 modulates the expression of genes involved in apoptosis, influencing cell survival and death. 5. **Vascular development and remodeling:** MIR17 regulates the expression of genes involved in vascular development, angiogenesis, and remodeling, impacting blood pressure regulation and cardiovascular health. **Clinical Significance:** 1. **Cancer:** Aberrant expression of MIR17 has been linked to various cancers, including colorectal, lung, and breast cancers, highlighting its potential as a biomarker or therapeutic target. 2. **Cardiovascular disease:** MIR17's role in regulating vascular development and remodeling may contribute to the development of cardiovascular diseases, such as atherosclerosis and hypertension. 3. **Neurological disorders:** MIR17's involvement in neuronal development and function may contribute to the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Inflammatory disorders:** MIR17's regulatory role in inflammation may contribute to the development of inflammatory disorders, such as rheumatoid arthritis and asthma. In conclusion, microRNA-17 is a complex and multifaceted regulator of cellular processes, influencing various biological pathways and impacting tissue development and function. Further research is needed to fully elucidate the mechanisms by which MIR17 modulates its target genes and to explore its potential as a therapeutic target in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.