Details for: MIR218 2

Gene ID: 407001

Symbol: MIR218 2

Ensembl ID: ENSG00000207739

Description: microRNA 218-2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0019
    Cell Significance Index: -0.0300
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0022
    Cell Significance Index: -0.0300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0027
    Cell Significance Index: -0.0300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0037
    Cell Significance Index: -0.0500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0043
    Cell Significance Index: -0.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MIR218-2 is a 22-nucleotide long microRNA that belongs to the miR-218 family, which is characterized by its conserved seed sequence and high expression levels in specific tissues. Its expression is tightly regulated and has been observed in various cell types, including those of neuronal origin, smooth muscle, and cardiac tissue. MIR218-2 has been shown to be highly conserved across species, suggesting its evolutionary significance and functional importance. **Pathways and Functions:** MIR218-2 is involved in regulating cellular differentiation and immune function through its interaction with the RISC (RNA-induced silencing complex) complex. The RISC complex is a protein-microRNA complex that mediates the degradation of target mRNAs, leading to the regulation of gene expression. MIR218-2 has been shown to regulate the expression of genes involved in cell differentiation, proliferation, and survival, highlighting its role in maintaining tissue homeostasis. Specifically, MIR218-2 has been implicated in the regulation of: * Neuronal differentiation and development * Smooth muscle cell proliferation and migration * Cardiac cell development and function * Immune cell development and function, particularly in lymphoid lineage-restricted progenitor cells **Clinical Significance:** MIR218-2 has been implicated in various cardiovascular diseases, including: * Heart failure: MIR218-2 has been shown to be downregulated in heart failure, suggesting its potential role as a biomarker for disease diagnosis and prognosis. * Atherosclerosis: MIR218-2 has been implicated in the regulation of smooth muscle cell proliferation and migration, which are key events in atherosclerosis development. * Cancer: MIR218-2 has been shown to be overexpressed in various types of cancer, including breast and lung cancer, and has been implicated in tumor progression and metastasis. In conclusion, MIR218-2 is a microRNA that plays a crucial role in regulating cellular differentiation, immune function, and cardiovascular development. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms of action and potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.