Details for: OR4A1P

Gene ID: 8596

Symbol: OR4A1P

Ensembl ID: ENSG00000254408

Description: olfactory receptor family 4 subfamily A member 1 pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** OR4A1P is a pseudogene, meaning it has lost its functional coding sequence, likely due to mutations or deletions. 2. **Olfactory receptor family 4 subfamily A membership:** OR4A1P is part of the olfactory receptor family 4 subfamily A, which is primarily involved in detecting odorant molecules. 3. **Significant expression in stromal cells:** OR4A1P is expressed in stromal cells, which are non-hematopoietic cells that provide structural and biochemical support to the immune system. 4. **Limited functional data:** Due to its pseudogene status, there is limited functional data available on OR4A1P, and its role in immune regulation remains speculative. **Pathways and Functions:** While the exact mechanisms of OR4A1P are unclear, its expression in stromal cells suggests a potential role in modulating immune responses. Several pathways may be involved: 1. **Immune cell modulation:** OR4A1P may influence the behavior of immune cells, such as T cells and dendritic cells, by regulating their activation, proliferation, or differentiation. 2. **Cytokine production:** OR4A1P may modulate the production of cytokines, which are signaling molecules that coordinate immune responses. 3. **Stromal cell function:** OR4A1P may regulate the function of stromal cells, including their ability to support immune cell development and function. **Clinical Significance:** The OR4A1P gene has potential implications in various immunological disorders, including: 1. **Immune-related diseases:** OR4A1P may play a role in modulating immune responses in autoimmune diseases, such as rheumatoid arthritis or multiple sclerosis. 2. **Cancer:** OR4A1P may influence the immune microenvironment in cancer, potentially impacting tumor growth or progression. 3. **Infectious diseases:** OR4A1P may modulate the immune response to infections, such as tuberculosis or HIV. In conclusion, while the OR4A1P gene is currently a pseudogene with limited functional data, its expression in stromal cells suggests a potential role in immune regulation. Further research is needed to elucidate the mechanisms of OR4A1P and its clinical significance in various immunological disorders.

Database document:

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