Details for: RNY4P14

Gene ID: 100379584

Symbol: RNY4P14

Ensembl ID: ENSG00000200526

Description: RNY4 pseudogene 14

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1039
    Cell Significance Index: -2.2800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1821
    Cell Significance Index: -2.1800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2891
    Cell Significance Index: -3.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status**: RNY4P14 is classified as a pseudogene due to its lack of functional coding potential, implying that its expression may be driven by non-coding regulatory elements or be a byproduct of gene conversion events. 2. **Tissue-specific expression**: RNY4P14 is significantly expressed in various intestinal cell types, including enteroendocrine cells, brush cells, and absorptive cells, highlighting its potential involvement in maintaining intestinal homeostasis. 3. **Aberrant expression in cancer**: The expression of RNY4P14 has been observed in neoplastic cells, suggesting its potential role in tumorigenesis or as a biomarker for cancer diagnosis. 4. **Conserved expression across species**: The expression of RNY4P14 is conserved across different species, including humans, mice, and rats, indicating its evolutionary significance and potential functional relevance. **Pathways and Functions:** While the exact mechanisms underlying RNY4P14's functions remain unclear, several hypotheses can be proposed based on its expression patterns and tissue-specific localization: 1. **Intestinal homeostasis maintenance**: RNY4P14 may play a role in regulating the balance between different intestinal cell types, ensuring proper gut function and preventing disease. 2. **Cellular differentiation and proliferation**: The expression of RNY4P14 in intestinal stem cells and transit amplifying cells suggests its involvement in regulating cellular differentiation and proliferation. 3. **Cancer progression**: RNY4P14's aberrant expression in neoplastic cells may contribute to tumorigenesis by promoting cell growth, survival, or metastasis. 4. **Epigenetic regulation**: The conserved expression of RNY4P14 across species and tissues may imply its involvement in epigenetic regulation, influencing gene expression through mechanisms such as DNA methylation or histone modification. **Clinical Significance:** The study of RNY4P14 offers valuable insights into the complex interplay between genetic and epigenetic mechanisms governing intestinal homeostasis and cancer. As a potential biomarker for cancer diagnosis, RNY4P14's expression could be exploited to identify high-risk patients or monitor disease progression. Furthermore, understanding the functional mechanisms underlying RNY4P14's expression patterns may provide novel therapeutic strategies for treating intestinal disorders and cancer. In conclusion, the RNY4P14 gene is a captivating example of the intricate relationships between gene expression, cellular behavior, and disease. Further research is needed to elucidate the precise mechanisms underlying RNY4P14's functions and its clinical significance, but its study has already opened up new avenues for exploring the complex biology of the intestine and its role in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.