Details for: MIR4317

Gene ID: 100422840

Symbol: MIR4317

Ensembl ID: ENSG00000283532

Description: microRNA 4317

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: 0.0005
    Cell Significance Index: 0.0100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0015
    Cell Significance Index: -0.0200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MIR4317 is a microRNA, a class of small non-coding RNAs (sncRNAs) that play crucial roles in regulating gene expression post-transcriptionally. MicroRNAs are characterized by their ability to bind to complementary sequences on target messenger RNA (mRNA) transcripts, leading to their degradation or repression of translation. MIR4317 exhibits a high degree of conservation across various species, suggesting its evolutionary significance. Its expression profile is distinct from other microRNAs, with a high abundance in cells of the intestinal epithelium. **Pathways and Functions:** Research has implicated MIR4317 in several key signaling pathways that regulate intestinal homeostasis, including: 1. **Wnt/β-catenin pathway**: MIR4317 has been shown to modulate the activity of this critical signaling pathway, which is involved in cell proliferation, differentiation, and survival. Dysregulation of the Wnt/β-catenin pathway is associated with various cancers, including colorectal cancer. 2. **Notch signaling pathway**: MIR4317 has been found to interact with the Notch signaling pathway, which is essential for the regulation of cell fate decisions, including cell differentiation and proliferation. 3. **Inflammation response**: MIR4317 has been shown to regulate the expression of genes involved in the inflammatory response, including those encoding cytokines and chemokines. The functional significance of MIR4317 is multifaceted, with potential roles in: 1. **Maintenance of intestinal epithelial barrier function**: MIR4317 may help regulate the expression of genes involved in tight junction formation and barrier function. 2. **Cell differentiation and proliferation**: MIR4317 may influence the differentiation and proliferation of intestinal epithelial cells, including goblet and enteroendocrine cells. 3. **Inflammation and immune response**: MIR4317 may modulate the expression of genes involved in the inflammatory response, including those encoding cytokines and chemokines. **Clinical Significance:** The clinical significance of MIR4317 is an area of active research, with potential implications for the diagnosis and treatment of various gastrointestinal disorders, including: 1. **Colorectal cancer**: Dysregulation of the Wnt/β-catenin pathway and MIR4317 expression has been implicated in the development of colorectal cancer. 2. **Inflammatory bowel disease**: MIR4317 may play a role in the regulation of the inflammatory response in inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. 3. **Gastrointestinal motility disorders**: MIR4317 may influence the expression of genes involved in gastrointestinal motility, including those encoding smooth muscle and neural proteins. In conclusion, MIR4317 is a microRNA that plays a critical role in maintaining intestinal homeostasis and regulating various signaling pathways. Its dysregulation has been implicated in various gastrointestinal disorders, highlighting the need for further research into the clinical significance of MIR4317.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.