Details for: RNY1P7

Gene ID: 100873806

Symbol: RNY1P7

Ensembl ID: ENSG00000207474

Description: RNY1 pseudogene 7

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.2212
    Cell Significance Index: 10.0800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3170
    Cell Significance Index: -6.9400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.6747
    Cell Significance Index: -7.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogenization:** RNY1P7 is a pseudogene, meaning it has undergone genetic mutations that have rendered it non-functional, likely due to the loss of its original coding sequence. 2. **Ubiquitous expression:** RNY1P7 is expressed in a wide range of intestinal cell types, including those involved in nutrient absorption, secretion, and immune responses. 3. **Significant expression in stem cells:** RNY1P7 is also expressed in intestinal crypt stem cells, which are crucial for maintaining the integrity and function of the intestinal epithelium. 4. **Expression in abnormal and neoplastic cells:** The expression of RNY1P7 in abnormal and neoplastic cells raises concerns about its potential role in the development and progression of intestinal diseases. **Pathways and Functions:** Despite its pseudogenized state, RNY1P7 may still be involved in various cellular processes, including: 1. **Regulation of stem cell self-renewal:** RNY1P7 may play a role in maintaining the balance between self-renewal and differentiation of intestinal stem cells. 2. **Modulation of immune responses:** RNY1P7 may influence the expression of genes involved in immune responses, potentially impacting the development of intestinal inflammation and immune-related diseases. 3. **Cell-cell communication:** RNY1P7 may be involved in cell-cell communication, influencing the behavior of neighboring cells in the intestinal epithelium. 4. **Gene regulation:** RNY1P7 may act as a regulator of gene expression, influencing the expression of genes involved in various cellular processes. **Clinical Significance:** The expression of RNY1P7 in various intestinal cell types and its potential involvement in stem cell self-renewal, immune responses, and cell-cell communication raise several clinical implications: 1. **Disease association:** The expression of RNY1P7 in abnormal and neoplastic cells may be associated with the development and progression of intestinal diseases, such as cancer. 2. **Therapeutic targeting:** RNY1P7 may serve as a potential therapeutic target for the treatment of intestinal diseases, particularly those involving abnormal cell growth and immune dysregulation. 3. **Stem cell biology:** The expression of RNY1P7 in intestinal stem cells may provide insights into the regulation of stem cell self-renewal and differentiation, potentially informing strategies for maintaining intestinal epithelial integrity. 4. **Immune system dysregulation:** The involvement of RNY1P7 in immune responses may shed light on the mechanisms underlying immune-related intestinal diseases, such as inflammatory bowel disease. In conclusion, the RNY1P7 gene, despite its pseudogenized state, has been found to be significantly expressed in various intestinal cell types, raising questions about its potential functional significance and clinical relevance. Further research is needed to fully elucidate the role of RNY1P7 in intestinal biology and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.